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1. 发明申请

WO1997010011A1 DRUG RELEASE STENT COATING PROCESS 审中-公开
标题翻译：药物释放固体涂层工艺
公开(公告)号：WO1997010011A1
公开(公告)日：1997-03-20
申请号：PCT/US1996014195
申请日：1996-09-05
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , DING, Ni , HELMUS, Michael, N.
IPC分类号： A61L27/00
CPC分类号： A61L31/16 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2210/0014 , A61F2250/0067 , A61L27/227 , A61L31/10 , A61L31/141 , A61L33/0011 , A61L2300/222 , A61L2300/236 , A61L2300/406 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2300/622 , A61L2420/02 , C08L71/02 , C08L83/04 , C08L83/00 , C08L83/08 , C08L5/00 , C08L75/04
摘要： A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prostheses are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.
摘要翻译：公开了一种涂覆可植入的开放格子金属支架假体的方法，其包括依次施加多个相对较薄的涂层组合物的外层，所述涂层组合物包含未固化的聚合物硅氧烷材料和交联剂的溶剂混合物以及细分的生物活性物质，可能是受控的平均颗粒尺寸，以在每个支架表面上形成涂层。涂层在原位固化，并且涂覆的固化的假体在包括优选的氩气等离子体预处理和暴露于γ辐射电子束，环氧乙烷，蒸汽的步骤中被灭菌。

2. 发明申请

WO1996023834A1 PROCESS FOR HYDROPHILICIZATION OF HYDROPHOBIC POLYMERS 审中-公开
标题翻译：疏水聚合物的疏水化方法
公开(公告)号：WO1996023834A1
公开(公告)日：1996-08-08
申请号：PCT/IB1996000034
申请日：1996-01-15
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , HELMUS, Michael, N. , HOSTETTLER, Fritz , DING, Ni
IPC分类号： C08J07/04
CPC分类号： C08J7/123 , C08J7/04 , C08J7/047 , C08J7/12 , C08J2315/00 , C08J2475/00
摘要： A process for rendering the surfaces of polymeric plastic or rubber materials, which are intrinsically non-polar or only slightly polar, and hydrophobic, polar or more polar, and hydrophilic, so that amine-containing functional groups, and ultimately, a durable tenaciously adhering, slippery polyurethane or polyurethane-urea hydrogel coating may subsequently be applied to the polymer surface, is disclosed. The process involves dual plasma-treatment of a polymeric plastic or rubber substrate material; the first treatment being with an oxygen-containing plasma gas, to affix hydroxyl, carboxyl and carbonyl groups to the substrate surface, thereby rendering the surface more polar and activated; and the second treatment being with a nitrogen-containing plasma gas, to affix amine and amino groups to the substrate surface to make it more hydrophilic and reactive toward terminal isocyanate groups of a polyurethane or polyurethane/urea prepolymer adduct intermediate tie-coat which is subsequently applied to the substrate surface and then converted to a tenaciously adhering, slippery hydrogel coating. The process is especially suited to the hydrophilicization of intrinsically non-polar and hydrophobic polymeric plastic materials, such as polyethylenes, nylons-11 and nylons-12.
摘要翻译：使本体非极性或仅极微小的聚合物塑料或橡胶材料表面的方法，以及疏水，极性或更极性和亲水性的方法，使得含胺官能团，最终持久坚固地粘附，可以随后将光滑的聚氨酯或聚氨酯 - 尿素水凝胶涂层施加到聚合物表面。该方法涉及聚合物塑料或橡胶基材材料的双等离子体处理; 用含氧等离子体气体进行第一次处理，将羟基，羧基和羰基粘合到基材表面，从而使表面更加极性和活化; 并且第二次处理是用含氮等离子体气体，以将胺和氨基固定在基材表面上，使其对聚氨酯或聚氨酯/脲预聚物加合物中间粘结层的末端异氰酸酯基团更亲水并具有反应性施加到基材表面，然后转化成坚固粘附，滑滑的水凝胶涂层。该方法特别适用于本征非极性和疏水性聚合物塑料材料如聚乙烯，尼龙-11和尼龙-12的亲水化。

3. 发明申请

WO1996004951A1 NON-COEXTRUSION METHOD OF MAKING MULTI-LAYER ANGIOPLASTY BALLOONS 审中-公开
标题翻译：制造多层血管平滑肌的非共同方法
公开(公告)号：WO1996004951A1
公开(公告)日：1996-02-22
申请号：PCT/IB1995000597
申请日：1995-07-31
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , ROYCHOWDHURY, Suranjan
IPC分类号： A61M25/00
CPC分类号： A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： A non-coextrusion process for making multi-layer angioplasty balloons involves pre-forming separate parisons (10, 12) and then concentrically disposing the plural parisons to form a composite parison which is then subjected to a blow-molding process. The resulting balloon can have its properties tailored by appropriate selection of the particular plastics to be used for the multiple parisons.
摘要翻译：用于制备多层血管成形术球囊的非共挤出方法包括预先形成分离的型坯（10,12），然后同心地设置多个型坯以形成复合型坯，然后将其进行吹塑过程。所得到的球囊可以通过适当选择用于多个型坯的特定塑料来调整其性能。

4. 发明申请

WO1994023781A1 DILATATION CATHETER HAVING SOFT BUMPER TIP 审中-公开
标题翻译：带有软垫带的松紧带
公开(公告)号：WO1994023781A1
公开(公告)日：1994-10-27
申请号：PCT/US1994001908
申请日：1994-03-03
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , GOODIN, Richard, Lee
IPC分类号： A61M25/00
CPC分类号： A61M25/1025 , A61M25/008 , A61M25/1027 , A61M25/1034 , A61M2025/0081 , A61M2025/1093
摘要： A balloon dilatation catheter (10) is disclosed having a multisectioned inner tube (20) having a soft bumper tip (23), a multisectioned outer tube (30) and a balloon (40) with its distal neck connected to the bumper tip (23) and its proximal neck connected to the outer tube (30). The various sections of the inner tube (20) and outer tube (30) may be formed from different materials or different grades of the same material. In addition, each section may have different outer diameters. The outer tube (30) is bonded directly to the inner tube (20) at the distal end of the outer tube (30). Preferably this bond is accomplished by thermal bonding.
摘要翻译：公开了一种球囊扩张导管（10），其具有多段内管（20），其具有软保险杠顶端（23），多段外管（30）和气囊（40），其远端颈部连接到保险杠顶端），其近端颈部连接到外管（30）。内管（20）和外管（30）的各个部分可以由不同材料或不同等级的相同材料形成。此外，每个部分可以具有不同的外径。外管（30）在外管（30）的远端处直接接合到内管（20）。优选地，该结合是通过热粘合实现的。

5. 发明申请

WO1991019528A1 TRACKING GUIDEWIRE 审中-公开
标题翻译：跟踪指南
公开(公告)号：WO1991019528A1
公开(公告)日：1991-12-26
申请号：PCT/US1991003509
申请日：1991-05-17
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , SHOCKEY, Rick, L.
IPC分类号： A61M29/00
CPC分类号： A61M25/09025 , A61B2017/22042 , A61B2017/22044 , A61M29/00 , A61M2025/09175
摘要： A guidewire and guidewire assembly (10) for placement within a blood vessel for penetrating an occlusion therein. The guidewire comprises a length of flexible wire (12) having a concentric lumen (14) running its entire length and a distal end portion (20) having an arcuate tip (22) and a diameter greater than that of the wire immediately proximal thereto. The guidewire assembly comprises the guidewire described along with a flexible stylet (32) substantially the same length as the flexible wire and disposed within the lumen of the wire. In operation, the distal end portion is positioned in the blood vessel against an occlusion, and a dottering action is thereafter provided whereby the distal end portion repeatedly impinges on the occlusion until penetration of the occlusion occurs.
摘要翻译：导线和导丝组件（10），用于放置在血管内用于穿透其中的闭塞。所述导丝包括具有延伸其整个长度的同心内腔（14）的长度的柔性线（12），以及具有弓形尖端（22）并且直径大于紧邻其上的线的直径的远端部分（20）。导丝组件包括与柔性探针（32）一起描述的导丝，该柔性探针（32）与柔性线基本上具有相同的长度并且设置在线的内腔中。在操作中，远端部分位于血管中以抵抗闭塞，此后提供点动作用，由此远端部分重复地撞击阻塞，直到发生闭塞渗透。

6. 发明申请

WO1996023601A1 HYDROGEL COATINGS CONTAINING A POLYURETHANE-UREA POLYMER HYDROGEL COMMINGLED WITH A POLY(N-VINYLPYRROLIDONE) POLYMER HYDROGEL 审中-公开
标题翻译：含有聚（N-乙烯基吡咯烷酮）聚合物水凝胶的聚氨酯 - 尿素聚合物氢化物的水凝胶涂层
公开(公告)号：WO1996023601A1
公开(公告)日：1996-08-08
申请号：PCT/IB1996000032
申请日：1996-01-15
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , FORMAN, Michael, R. , HELMUS, Michael, N. , HOSTETTLER, Fritz , DING, Ni , RHUM, David
IPC分类号： B05D07/02
CPC分类号： B05D7/52 , A61L29/085 , A61L31/10 , B05D7/02 , B05D7/16 , C08G18/10 , C08G18/4833 , C08G18/755 , C08G18/758 , C08G2210/00 , C08G2270/00 , C09D175/12 , Y10T428/31551 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31587 , Y10T428/31605 , A61L29/145 , C08L75/00 , C08L39/06 , A61L31/145 , C08G18/2865 , C08L2666/02
摘要： Slippery, hydrophilic coating compositions of a polyurethane/urea prepolymer adduct intermediate commingled with at least one dissimilar hydrogel polymer precursor, and materials composed of a polymeric plastic or rubber substrate or a metallic substrate with a slippery hydrogel coating of a polyurethane/urea prepolymer adduct intermediate and at least one dissimilar hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：与至少一种不同的水凝胶聚合物前体混合的聚氨酯/脲预聚合物加合物中间体的滑爽的亲水涂料组合物，以及由聚合物塑料或橡胶基材或具有聚氨酯/脲预聚物加合物中间体的光滑水凝胶涂层的金属基材组成的材料和其上的至少一种不相似的水凝胶，使得涂层组合物顽固地粘附到基底上。涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。水凝胶涂层能够被干燥以促进其已经被施加到的装置的储存，并且可以立即重新激活以供以后通过暴露于水中使用。

7. 发明申请

WO1995025558A1 ANGIOPLASTY DEVICE 审中-公开
标题翻译：放射性装置
公开(公告)号：WO1995025558A1
公开(公告)日：1995-09-28
申请号：PCT/IB1995000079
申请日：1995-02-03
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , FORMAN, Michael, R. , HELMUS, Michael, N. , LAPTEWICZ, Joseph, E.
IPC分类号： A61M25/01
CPC分类号： A61M25/104 , A61M2025/0186 , A61M2025/09141 , A61M2025/1015 , A61M2025/1093
摘要： This invention relates to an angioplasty device (10) that is formed from a hollow metallic tube (20), a balloon (30) affixed adjacent the distal end of the tube (20) and being in fluid communication with the lumen (22) of the tube (20), a flexible distal segment connected to the distal end of the tube and a removable hub (40) connected adjacent to the proximal end of the tube (20). The tube (20) is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this angioplasty device (10).
摘要翻译：本发明涉及一种由中空金属管（20）形成的血管成形术装置（10），邻近管（20）远端固定并与管腔（22）流体连通的球囊（30）管（20），连接到管的远端的柔性远端段和与管（20）的近端相邻连接的可移除的轮毂（40）。管（20）优选由镍 - 钛合金等超弹性材料形成。本发明还涉及使用该血管成形术装置（10）的各种方法。

8. 发明申请

WO1994016637A1 SURGICAL DEPTH MEASURING INSTRUMENT AND METHOD 审中-公开
标题翻译：手术深度测量仪器和方法
公开(公告)号：WO1994016637A1
公开(公告)日：1994-08-04
申请号：PCT/US1993011645
申请日：1993-12-07
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , MAKOWER, Joshua , THATCHER, Robert, J. , VAN TASSEL, Robert, A.
IPC分类号： A61B19/00
CPC分类号： A61M25/06 , A61B2090/062
摘要： A device for measuring the depth below skin level of a blood vessel that has been punctured in the course of a catheterization or other interventional vascular procedure comprises a tubular member (18) having a proximal end (20) and a distal end (22) portion that is preferably tapered to a small outer diameter. The lumen (24, 26) may have a stepped diameter extending between the proximal and distal ends (20, 22). A first portion of the lumen (26) is distally located and is of a diameter generally equal to the diameter of a guidewire with which the measuring device is used. The second segment of the lumen (24) is of a substantially larger diameter. A side entry port (32) is made through the wall of the tubular member (18) at the distal base of the larger diameter section of the lumen (24). Graduated markings on the side wall of the tubular member (18) extend from the side entry port (32) toward the proximal end (20) of the instrument. When the instrument is fed over a guidewire into a puncture wound formed through the skin and into an artery, the wall of the artery can be accurately located relative to the skin's surface by noting the graduated markings on the exterior of the tube (18) at the point where blood flow enters the side entry port (32) and fills the larger diameter lumen (24). Rather than having two coaxially disposed lumens as above, the tubular member may have a double lumen (32, 40), one extending the entire length for accommodating the guidewire and the other extending between the tube's proximal end and the side entry port (42).
摘要翻译：用于测量在导管插入术或其它介入血管手术过程中被刺穿的血管皮肤水平以下深度的装置包括具有近端（20）和远端（22）部分的管状构件（18）优选地锥形到小的外径。内腔（24,26）可以具有在近端和远端（20,22）之间延伸的阶梯直径。管腔（26）的第一部分在远侧位置并且其直径大致等于使用测量装置的导丝的直径。管腔（24）的第二段具有基本上更大的直径。在入口（24）的较大直径部分的远端基部处，通过管状构件（18）的壁制成侧入口（32）。管状构件（18）的侧壁上的刻度标记从侧入口（32）朝向仪器的近端（20）延伸。当仪器通过导丝进入通过皮肤形成的穿刺伤口并进入动脉时，可以通过在管（18）的外部注意分级标记，使动脉壁相对于皮肤表面精确定位血流进入侧入口（32）并填充较大直径的腔（24）的点。不管如上所述具有两个同轴布置的腔，管状构件可以具有双腔（32,40），一个延伸整个长度以容纳导丝，另一个在管的近端和侧入口（42）之间延伸，。

9. 发明申请

WO1994013350A1 TRACKING GUIDEWIRE 审中-公开
标题翻译：跟踪指南
公开(公告)号：WO1994013350A1
公开(公告)日：1994-06-23
申请号：PCT/US1993011794
申请日：1993-12-10
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , SHOCKEY, Rick, L. , VANCE, Jeffrey, D.
IPC分类号： A61M25/01
CPC分类号： A61M29/00 , A61B2017/22042 , A61B2017/22044 , A61M25/09025 , A61M2025/09175
摘要： A guidewire (10) for placement within a blood vessel for penetrating an occlusion therein. The guidewire (1) comprises a length of flexible wire (12) having a lumen extending therethrough. The distal end of the guidewire (10) is generally arcuate and has a diameter greater than that of the wire (12) immediately proximal thereto. A flexible stylet (32) substantially the same length as the flexible wire (12) may be disposed within the lumen of the wire (12). The stylet (32) and the guidewire (10) have locking means (19, 18), such as Luer locking threads. In operation, the arcuate distal end of the guidewire (10) is positioned in the blood vessel against an occlusion, and a dottering action is thereafter provided whereby the arcuate distal end of the guidewire (10) repeatedly impinges on the occlusion until penetration of the occlusion occurs.
摘要翻译：一种用于放置在血管内用于穿透其中的闭塞的导丝（10）。导丝（1）包括具有延伸穿过其中的内腔的一段柔性线（12）。导丝（10）的远端大体上是弓形的，其直径大于紧靠其上的线（12）的直径。与软线（12）基本上相同长度的柔性探针（32）可设置在线（12）的内腔内。探针（32）和导丝（10）具有锁定装置（19,18），例如Luer锁定螺纹。在操作中，导线（10）的弓形远端位于血管中以抵抗闭塞，此后提供点状作用，由此导线（10）的弓形远端重复地撞击闭塞，直到穿透发生闭塞。

10. 发明申请

WO1993022986A1 ESOPHAGEAL STENT AND DELIVERY TOOL 审中-公开
标题翻译：食管和交付工具
公开(公告)号：WO1993022986A1
公开(公告)日：1993-11-25
申请号：PCT/US1993001966
申请日：1993-03-10
申请人： SCHNEIDER (USA) INC.
发明人： SCHNEIDER (USA) INC. , JOHNSON, Liann, M. , THOMPSON, Richard, J. , SCHOLL, John, A.
IPC分类号： A61F02/06
CPC分类号： A61F2/90 , A61F2/0077 , A61F2/07 , A61F2/852 , A61F2/95 , A61F2/966 , A61F2002/072 , A61F2002/821 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665 , A61F2210/0076 , A61F2220/0033 , A61F2220/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0063 , A61F2250/0097 , A61M2025/0008
摘要： A radially self-expanding stent (90) particularly suited for treating esophageal strictures, includes a medial region (92) and proximal and distal cuffs (94, 96) having diameters greater than the medial region (92) diameter when the stent (90) is in the relaxed state. A silicone coating circumscribes the medial region (92), but the cuffs (94, 96) are not coated and retain their open weave construction. As a result, the cuffs (94, 96) remain particularly well suited to immediately contact esophageal wall tissue and resist stent migration, while the silicone coated medial region (92) provides a barrier to tumor ingrowth, and has an enhanced radial restoring force to maintain an open passageway in the esophagus. A deployment device (16) for the stent (90) includes an interior catheter (26) surrounded by the stent (90) and having an esophageal dilation feature (28), along with an exterior catheter (18) that radially compresses the stent (90). A low durometer sleeve (54), fixed to the interior tube (26) and in surface engagement with the compressed stent (90), tends to fix the axial position of the stent (90) relative to the interior catheter (26) whenever the exterior catheter (18) is moved axially relative to the inner catheter (26). Consequently, precision in stent placement and the ability to recapture a partially deployed stent are enhanced.
摘要翻译：特别适用于治疗食管狭窄的径向自扩张支架（90）包括当支架（90）具有直径大于中间区域（92）直径的直径的中间区域（92）和近端和远端袖带（94,96）处于放松状态。硅胶涂层限定了中间区域（92），但是袖口（94,96）没有涂覆并保持其开放的编织结构。结果，袖带（94,96）特别适合于立即接触食管壁组织并抵抗支架移动，而硅氧烷涂覆的内侧区域（92）为肿瘤向内生长提供屏障，并具有增强的径向恢复力在食管中保持开放的通道。用于支架（90）的展开装置（16）包括由支架（90）包围并具有食管扩张特征（28）的内部导管（26），以及径向压缩支架的外部导管（18） 90）。固定到内管（26）并与压缩支架（90）表面接合的低硬度套筒（54）倾向于相对于内导管（26）固定支架（90）的轴向位置，只要外导管（18）相对于内导管（26）轴向移动。因此，增强了支架放置的精度和再次部分展开的支架的能力。

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