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1. 发明申请

WO2009049171A2 SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN URINE 审中-公开
标题翻译：用于鉴定尿中细菌的系统
公开(公告)号：WO2009049171A2
公开(公告)日：2009-04-16
申请号：PCT/US2008079533
申请日：2008-10-10
申请人： POCARED DIAGNOSTICS LTD , INGBER GAL , ATTERBURY WILLIAM G , BARNES RUSSELL H , BOYD DOUGLAS E , DENNIS JOSEPH D , GURFINKEL JONATHAN , HOLLEY DAVE , HUCKABY STEVEN E , KLAUSING THOMAS A , LAUDO JOHN S , SADESKI KEVIN , SCHAEFER JASON A , SCOTT K BRYAN , STILLMAN CAROL , TALBERT SHERWOOD , TALLARICO JOHN
发明人： INGBER GAL , ATTERBURY WILLIAM G , BARNES RUSSELL H , BOYD DOUGLAS E , DENNIS JOSEPH D , GURFINKEL JONATHAN , HOLLEY DAVE , HUCKABY STEVEN E , KLAUSING THOMAS A , LAUDO JOHN S , SADESKI KEVIN , SCHAEFER JASON A , SCOTT K BRYAN , STILLMAN CAROL , TALBERT SHERWOOD , TALLARICO JOHN
IPC分类号： C12Q1/04 , G01N33/49
CPC分类号： G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
摘要： A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
摘要翻译：一种用于进行微生物（例如尿样中的细菌）的鉴定和定量的系统，其包括：1）用于容纳四个一次性部件的几个一次性盒，所述一次性部件包括离心管，具有1ml体积的移液管尖端，第二移液管尖端具有0.5ml体积，以及光学杯或比色杯; 2）样本处理器，用于接收一次性盒并处理尿样，包括将处理后的尿样转移到光杯; 以及3）光学分析器，用于接收一次性盒并配置成分析尿样中的微生物的类型和数量。在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析器中使用含有处理过的尿液样品的光学杯或比色皿用于识别和量化处理中存在的微生物的类型尿样。

2. 发明申请

WO2009100197A3 SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于在生物样品中鉴定细菌的系统
公开(公告)号：WO2009100197A3
公开(公告)日：2009-11-12
申请号：PCT/US2009033186
申请日：2009-02-05
申请人： POCARED DIAGNOSTICS LTD , INGBER GAL , ATTERBURY WILLIAM G , HOLLEY DAVE , LAUDO JOHN S , SCHAEFER JASON A , TALBERT SHERWOOD , TALLARICO JOHN , KLAUSING THOMAS A
发明人： INGBER GAL , ATTERBURY WILLIAM G , HOLLEY DAVE , LAUDO JOHN S , SCHAEFER JASON A , TALBERT SHERWOOD , TALLARICO JOHN , KLAUSING THOMAS A
IPC分类号： G01N35/02 , G01N21/03 , G01N33/569
CPC分类号： G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
摘要翻译：本发明涉及一种用于对微生物（例如生物样品中的细菌）进行鉴定和定量的系统。更具体地说，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色皿的系统; 包括光学读取器和热控制器的光学系统; 光学分析仪; 一个冷却系统; 和一个改进的光谱仪。该系统可以利用样本处理器中的一次性盒和光学分析器中的光学杯或比色皿。

3. 发明申请

WO2011035304A3 SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于在生物样品中鉴定细菌的系统
公开(公告)号：WO2011035304A3
公开(公告)日：2011-08-04
申请号：PCT/US2010049658
申请日：2010-09-21
申请人： POCARED DIAGNOSTICS LTD , INGBER GAL , ATTERBURY WILLIAM G , HOLLEY DAVE , KLAUSING THOMAS A , LAUDO JOHN S , SCHAEFER JASON A , TALBERT SHERWOOD , TALLARICO JOHN
发明人： INGBER GAL , ATTERBURY WILLIAM G , HOLLEY DAVE , KLAUSING THOMAS A , LAUDO JOHN S , SCHAEFER JASON A , TALBERT SHERWOOD , TALLARICO JOHN
IPC分类号： G01N35/02 , C12M1/38 , C12Q1/04 , C12Q1/06
CPC分类号： G01N35/025 , B04B9/14 , G01N2035/00504 , G01N2035/0434 , G01N2035/0458
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.
摘要翻译：本发明涉及一种用于对微生物（例如生物样品中的细菌）进行鉴定和定量的系统。更具体地说，本发明涉及一种包括冷却，加热和风扇装置的系统，用于在测试期间保持样品的预定最佳温度; 视觉的，圆周的和轴向的对准系统，用于对准转盘内的样品; 用于将样品从旋转式传送器传送到离心机的传送系统; 使离心机的旋转振动最小化的平衡系统; 样品容纳系统的安全系统和防倾翻设计; 用于分配缓冲盐水溶液的液体分配臂; 以及排出口，用于将从样品中除去的液体排出并处理至系统外部的位置。

4. 发明申请

WO2008107881A3 ANTIBIOTIC SENSITIVITY TESTING METHOD 审中-公开
标题翻译：抗生素敏感性测试方法
公开(公告)号：WO2008107881A3
公开(公告)日：2010-02-18
申请号：PCT/IL2008000283
申请日：2008-03-05
申请人： POCARED DIAGNOSTICS LTD , INGBER GAL , GURFINKEL JONATHAN
发明人： INGBER GAL , GURFINKEL JONATHAN
IPC分类号： C12N1/20
CPC分类号： G01N33/9446
摘要： The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the bacteria in the bacterial sample; obtaining a control sample from the bacterial sample; placing the bacterial sample in solutions containing the set of antibiotics; determining concentration of bacteria in the respective antibiotic solutions; determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration; and comparing the growth curves for the respective antibiotic solutions with a growth curve determined from the control sample. An identification and quantification system may be used to select the set of antibiotics, and further may be used in the steps of determining concentration of bacteria in the respective antibiotic solutions and determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration.
摘要翻译：该方法包括几个步骤，包括获得细菌样品; 鉴定细菌样品中的细菌类型; 根据细菌样本中细菌的特征选择一组抗生素; 从细菌样品获得对照样品; 将细菌样品置于含有该组抗生素的溶液中; 确定各抗生素溶液中细菌的浓度; 基于确定的细菌浓度确定各抗生素溶液的生长曲线; 并将各抗生素溶液的生长曲线与从对照样品确定的生长曲线进行比较。可以使用识别和定量系统来选择该组抗生素，并且还可以用于确定各抗生素溶液中细菌浓度的步骤，并且基于确定的细菌浓度确定各抗生素溶液的生长曲线。

5. 发明申请

WO2007019462A3 SYSTEM AND METHOD FOR THE IDENTIFICATION AND QUANTIFICATION OF A BIOLOGICAL SAMPLE SUSPENDED IN A LIQUID 审中-公开
标题翻译：用于液体中悬浮的生物样品的鉴定和定量的系统和方法
公开(公告)号：WO2007019462A3
公开(公告)日：2007-07-12
申请号：PCT/US2006030765
申请日：2006-08-08
申请人： POCARED DIAGNOSIS LTD , BARNES RUSSELL H , INGBER GAL , GURFINKEL JONATHAN
发明人： BARNES RUSSELL H , INGBER GAL , GURFINKEL JONATHAN
IPC分类号： G01J3/44 , G01J3/40 , G01N35/00
CPC分类号： G01N21/6486 , G01N21/21 , G01N21/31 , G01N21/51 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6482 , G01N2021/6491 , G01N2201/0612 , G01N2201/129 , G01N2201/1293
摘要： A system for the identification and quantification of a biological sample suspended in a liquid includes a fluorescence excitation module with at least one excitation light source; a sample interface module optically coupled to the fluorescence excitation module for positioning a biological sample to receive excitation light from the at least one excitation light source; a fluorescence emission module optically coupled to the sample interface module and comprising at least one detection device for detecting fluorescence excitation-emission matrices of the biological sample; and a computer module operatively coupled to the fluorescence emission module. The computer module performs multivariate analysis on the fluorescence excitation-emission matrices of the biological sample to identify and quantify the biological sample. The multivariate analysis may comprise extended partial least squared analysis for identification and quantification of the biological sample. A method for the identification and quantification of a biological sample suspended in a liquid is also provided.
摘要翻译：用于鉴定和定量悬浮在液体中的生物样品的系统包括具有至少一个激发光源的荧光激发模块; 光学耦合到所述荧光激发模块的样品接口模块，用于定位生物样品以接收来自所述至少一个激发光源的激发光; 光学耦合到所述样品接口模块并且包括用于检测所述生物样品的荧光激发发射基质的至少一个检测装置的荧光发射模块; 以及可操作地耦合到所述荧光发射模块的计算机模块。计算机模块对生物样品的荧光激发发射基质进行多变量分析，以鉴定和定量生物样品。多变量分析可以包括用于生物样品的鉴定和定量的扩展的部分最小二乘分析。还提供了用于鉴定和定量悬浮在液体中的生物样品的方法。

6. 发明申请

WO2012061451A3 OPTICAL CUP 审中-公开
标题翻译：光学杯
公开(公告)号：WO2012061451A3
公开(公告)日：2012-06-28
申请号：PCT/US2011058881
申请日：2011-11-02
申请人： POCARED DIAGNOSTICS INC , INGBER GAL
发明人： INGBER GAL
IPC分类号： C12M1/34 , C12M1/18 , C12M1/24 , C12Q1/04
CPC分类号： G01N21/0303 , B01L3/508 , B01L3/5085 , B01L2200/025 , B01L2200/028 , B01L2200/12 , B01L2300/0809 , B01L2300/0851 , B01L2300/0858 , B01L2300/168 , C12M41/36 , G01N21/6452 , G01N35/025 , G01N2021/0321 , G01N2021/0382 , G01N2021/6469 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449
摘要： The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
摘要翻译：本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或比色杯的系统; 其中所述壁成角度以允许所述光的更好的涂覆和更好的条纹，包括光学读取器和热控制器的光学系统; 光学分析仪; 冷却系统; 和改进的光谱仪。该系统可以利用样品处理器中的一次性盒，以及光学分析仪中的光学杯或反应杯。

7. 发明申请

WO2012103174A2 IRIS CONTROL SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于诱导生物样品中细菌鉴定的IRIS控制系统
公开(公告)号：WO2012103174A2
公开(公告)日：2012-08-02
申请号：PCT/US2012022488
申请日：2012-01-25
申请人： POCARED DIAGNOSTICS INC , INGBER GAL
发明人： INGBER GAL
IPC分类号： C12M1/34 , C12M1/12 , C12M1/42 , C12Q1/04
CPC分类号： G01N21/07 , G01N21/31 , G01N2201/063
摘要： A system and a method for optimizing an iris setting, used in combination with a lamp, for each excitation wavelength for each carousel run in an apparatus for identifying and measuring bacteria in biological samples. The system includes a feedback control loop positioned between a filter wheel and an optical cup for measuring the intensity level of the excitation wavelength, and feeding this information to an iris having an iris setting control device such that the iris setting may be adjusted based upon the measured intensity level to control and optimize the level of light fed to the filter wheel from the lamp. The iris setting can be adjusted so that the level of light fed to the filter wheel remains constant during the lifetime of the lamp and to ensure that the level of light fed to the sample remains below the level at which photo-bleaching occurs.
摘要翻译：用于在用于识别和测量生物样品中的细菌的装置中运行的每个转盘的每个激发波长优化与灯组合使用的虹膜设置的系统和方法。该系统包括位于滤光轮和光学杯之间的反馈控制回路，用于测量激发波长的强度水平，并将该信息馈送到具有光圈设置控制装置的光圈，使得可以基于测量强度水平以控制和优化从灯进入滤光轮的光的水平。可以调节光圈设置，使得在灯的寿命期间馈送到滤光轮的光的水平保持恒定，并且确保馈送到样品的光的水平保持低于发生光漂白的水平。

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