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1. 发明申请

WO2018113743A1 POLYPEPTIDES HAVING LYSOZYME ACTIVITY, POLYNUCLEOTIDES ENCODING SAME AND USES AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：WO2018113743A1
公开(公告)日：2018-06-28
申请号：PCT/CN2017/117753
申请日：2017-12-21
申请人： NOVOZYMES A/S , LIU, Ye
发明人： LIU, Ye , KLAUSEN, Mikkel , SCHNORR, Kirk Matthew , SKOV, Lars Kobberoee , NYMAND-GRARUP, Soeren , COHN, Marianne, Thorup , OLSEN, Peter, Bjarke , LI, Ming
IPC分类号： C12N9/36 , A61K38/47
摘要： Animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity are disclosed. Polypeptides having lysozyme activity, polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides are also provided.

2. 发明申请

WO2011117397A1 THERMOSTABLE PHYTASE VARIANTS 审中-公开
标题翻译：热稳定的植物变种
公开(公告)号：WO2011117397A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054640
申请日：2011-03-25
申请人： NOVOZYMES A/S , DE MARIA, Leonardo , SKOV, Lars Kobberoee , SKJOET, Michael
发明人： DE MARIA, Leonardo , SKOV, Lars Kobberoee , SKJOET, Michael
IPC分类号： A23K1/165 , A23L1/03 , C12N9/16 , C12P7/06
CPC分类号： C12P7/06 , A23K10/10 , A23K10/14 , A23K50/75 , C12N9/16 , C12Y301/03008 , Y02E50/17
摘要： The present invention relates to a method for producing phytase variants has at least 70% identity to a phytase derived from Buttiauxella and comprises at least one additional disulfide bond as compared to this phytase. These phytase variants have modified, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an modified glycosylation pattern. The invention also relates to the variants produced, DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及一种生产植酸酶变体的方法与来自Buttiauxella的植酸酶具有至少70％的同一性，并且与该植酸酶相比包含至少一个另外的二硫键。这些植酸酶变体具有修饰的，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。本发明还涉及所生产的变体，编码这些植酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

3. 发明申请

WO2009130285A1 POLYPEPTIDES HAVING ORGANOPHOSPHOROUS HYDROLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有有机磷酸酯活性的多肽和编码其的多核苷酸
公开(公告)号：WO2009130285A1
公开(公告)日：2009-10-29
申请号：PCT/EP2009/054906
申请日：2009-04-23
申请人： NOVOZYMES A/S , LASSEN, Soeren Flensted , DANIELSEN, Steffen , OESTERGAARD, Lars Henrik , SKOV, Lars Kobberoee
发明人： LASSEN, Soeren Flensted , DANIELSEN, Steffen , OESTERGAARD, Lars Henrik , SKOV, Lars Kobberoee
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A62D3/02 , A62D2101/02 , A62D2101/04 , A62D2101/26 , C12N15/8257 , C12N15/8259
摘要： The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有有机磷水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

4. 发明申请

WO2008092901A2 POLYPEPTIDES HAVING PHYTASE ACTIVTY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有植酸酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2008092901A2
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051137
申请日：2008-01-30
申请人： NOVOZYMES A/S
发明人： SJOEHOLM, Carsten , LASSEN, Soeren Flensted , SKOV, Lars Kobberoee , DE MARIA, Leonardo
IPC分类号： A01H5/00 , C12N9/16 , C12N15/82 , C12N15/55
CPC分类号： C12N9/16 , A23L33/18 , C12N15/8243 , C12P7/06 , Y02E50/17
摘要： The present invention relates to polypeptides having phytase activity. These polypeptides have an amino acid sequence which has at least 70% identity to either of three phytases derived from the bacterium Buttiauxella, and which comprises at least one of the following amino acids at the position indicated: 119N, 120L, and/or 121E. These phytases have an improved specific activity. Additional specific amino acid substitutions are also disclosed which characterize and distinguish additional phytases of the invention having improved properties such as temperature and/or pH stability, pH activity profile, temperature activity profile, substrate profile, improved performance in animal feed in vitro or in vivo . The invention also relates to isolated polynucleotides encodingthe polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有肌醇六磷酸酶活性的多肽。这些多肽具有与源自细菌布丘氏菌的三种肌醇六磷酸酶中的任一种具有至少70％同一性的氨基酸序列，并且在所示位置包含至少一个以下氨基酸：119N，120L和/或121E。这些植酸酶具有改善的比活性。还公开了另外的特定氨基酸取代，其表征和区分具有改善的性质例如温度和/或pH稳定性，pH活性曲线，温度活性曲线，底物曲线，体外动物饲料中改善的性能的本发明的另外的肌醇六磷酸酶或 in vivo 。本发明还涉及编码所述多肽的分离的多核苷酸，包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

5. 发明申请

WO2010128115A1 DFPASE ENZYMES FROM OCTOPUS VULGARIS 审中-公开
标题翻译：来自OCTOPUS VULGARIS的DFPASE ENZYMES
公开(公告)号：WO2010128115A1
公开(公告)日：2010-11-11
申请号：PCT/EP2010/056204
申请日：2010-05-06
申请人： NOVOZYMES A/S , DANIELSEN, Steffen , SKOV, Lars Kobberoee , LEITE, Ricardo , LAIZE, Vincent , DA FONSECA, M Leonor Cancela
发明人： DANIELSEN, Steffen , SKOV, Lars Kobberoee , LEITE, Ricardo , LAIZE, Vincent , DA FONSECA, M Leonor Cancela
IPC分类号： C12N9/16
CPC分类号： C12N9/16
摘要： The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有有机磷水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

6. 发明申请

WO2010034835A2 HAFNIA PHYTASE VARIANTS 审中-公开
标题翻译： HAFNIA植物变种
公开(公告)号：WO2010034835A2
公开(公告)日：2010-04-01
申请号：PCT/EP2009/062539
申请日：2009-09-28
申请人： NOVOZYMES A/S
发明人： LASSEN, Soeren Flensted , SKOV, Lars Kobberoee , DE MARIA, Leonardo , FRIIS, Esben Peter , MATSUI, Tomoko , NOERGAARD, Allan , VIND, Jesper
IPC分类号： C12N9/16 , A23K1/165
CPC分类号： C12N9/16 , A23K20/189 , A23K50/30 , A23K50/75 , Y02E50/17
摘要： The present invention relates to phytases having at least 76% identity to a phytase derived from Hafnia alvei and comprises at least one modification in the amino acid sequence thereof. These phytase variants have modified, preferably improved, properties, such as, reduced protease sensitiliby, preferably they exhibit improved properties in respect of thermal performance, such as heat-stability (temperature stability, thermostability), steam stability, pelleting stability and/or temperature profile; and/or protease stability, in particular pepsin stability, pH profile, specific activity, substrate specificity, performance in animal feed(such as an improved release and/or degradation of phytate), susceptibility to glycation, and/or glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of thei r production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及与来源于Hafnia alvei的肌醇六磷酸酶具有至少76％同一性且在氨基酸中包含至少一个修饰的肌醇六磷酸酶其酸序列。这些肌醇六磷酸酶变体具有改性，优选改进的性质，例如降低的蛋白酶敏感性，优选它们在热性能方面表现出改进的性能，例如热稳定性（温度稳定性，热稳定性），蒸汽稳定性，造粒稳定性和/或温度简介; 和/或蛋白酶稳定性，特别是胃蛋白酶稳定性，pH曲线，比活性，底物特异性，动物饲料中的性能（如植酸盐的改善的释放和/或降解），对糖化的敏感性和/或糖基化模式。本发明还涉及编码这些肌醇六磷酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

7. 发明申请

WO2008116878A1 HAFNIA PHYTASE 审中-公开
公开(公告)号：WO2008116878A1
公开(公告)日：2008-10-02
申请号：PCT/EP2008/053561
申请日：2008-03-26
申请人： NOVOZYMES A/S
发明人： LASSEN, Soeren Flensted , SJOEHOLM, Carsten , SKOV, Lars Kobberoee
IPC分类号： C12N15/55 , A23L1/03 , C12N9/16 , C12N15/82
CPC分类号： C12N9/16 , A23K20/147 , A23K20/174 , A23K20/189 , A23K50/00 , A23K50/30 , A23K50/75 , A23K50/80 , A23L33/18 , C12Y301/01004 , C12Y301/01005 , C12Y301/03008 , C12Y301/03026 , C12Y301/04003 , C12Y301/04004 , C12Y302/01001 , C12Y302/01004 , C12Y302/01006 , C12Y302/01008 , C12Y302/01022 , C12Y302/01032 , C12Y302/01089 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to isolated polypeptides having phytase activity and isolated polynucleotides encoding the polypeptides. The polypeptides are related to a phytase derived from Hafnia alvei, the amino acid sequence of which is shown in the appended sequence listing as SEQ ID NO: 10. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides, in particular within animal feed.
摘要翻译：本发明涉及具有植酸酶活性的分离的多肽和编码多肽的分离的多核苷酸。多肽与源自Hafnia alvei的植酸酶相关，其氨基酸序列在附加的序列表中显示为SEQ ID NO：10。本发明还涉及核酸构建体，载体和宿主细胞，其包含多核苷酸为以及用于产生和使用多肽的方法，特别是在动物饲料中。

8. 发明申请

WO2018113745A1 POLYPEPTIDES HAVING LYSOZYME ACTIVITY, POLYNUCLEOTIDES ENCODING SAME AND USES AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：WO2018113745A1
公开(公告)日：2018-06-28
申请号：PCT/CN2017/117765
申请日：2017-12-21
申请人： NOVOZYMES A/S , LI, Ming
发明人： LI, Ming , KLAUSEN, Mikkel , SCHNORR, Kirk Matthew , NYMAND-GRARUP, Soren , OLSEN, Peter Bjarke , COHN, Marianne Thorup , OLINSKI, Robert Piotr , MORANT, Marc Dominique , LIU, Ye , SKOV, Lars Kobberoee , SKOVLUND, Dominique Aubert , HAN, Bucong
IPC分类号： A61K38/47 , C12N9/24 , C12N9/36 , C12N15/56 , C11D3/386
摘要： Provided are animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. Provived are polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

9. 发明申请

WO2017000922A1 ANIMAL FEED COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：动物饲料组合物及其用途
公开(公告)号：WO2017000922A1
公开(公告)日：2017-01-05
申请号：PCT/CN2016/088362
申请日：2016-07-04
申请人： NOVOZYMES A/S , LIU, Ye
发明人： LIU, Ye , SCHNORR, Kirk Matthew , KIEMER, Lars , SKOV, Lars Kobberoee , SANDVANG, Dorthe Hoej , COHN, Marianne Thorup , LI, Ming
IPC分类号： A23K1/00 , C07K14/005 , C12N15/56
CPC分类号： A61K38/47 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , A23K50/80 , C12N9/2462 , C12Y302/01017
摘要： The present invention provides animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. The invention also provides polypeptides having lysozyme activity, polynucleotides encoding the polypeptides as well as methods of producing and using the polypeptides.
摘要翻译：本发明提供了包含一种或多种具有溶菌酶活性的多肽的动物饲料或动物饲料添加剂。本发明还提供了具有溶菌酶活性的多肽，编码多肽的多核苷酸以及产生和使用多肽的方法。

10. 发明申请

WO2011117406A1 THERMOSTABLE PHYTASE VARIANTS 审中-公开
标题翻译：热稳定的植物变种
公开(公告)号：WO2011117406A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054652
申请日：2011-03-25
申请人： NOVOZYMES A/S , DE MARIA, Leonardo , SKOV, Lars Kobberoee , SKJOET, Michael
发明人： DE MARIA, Leonardo , SKOV, Lars Kobberoee , SKJOET, Michael
IPC分类号： C12N9/16 , C12N15/82 , C12N15/55 , A01H5/00
CPC分类号： C12N9/16 , A23K20/147 , A23K20/189 , A23K50/10 , A23K50/30 , A23K50/75 , A23K50/80 , A23L33/10 , A23L33/15 , A23L33/16 , A23V2002/00 , C12N15/8243 , C12P7/06 , Y02A40/818 , Y02E50/17
摘要： The present invention relates to a phytase which has at least 70% identity to a phytase derived from E. coli and comprises at least one modification as compared to this phytase. These phytase variants have modified, preferably improved,properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an modified glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译：本发明涉及与源自大肠杆菌的植酸酶具有至少70％同一性的植酸酶，并且与该植酸酶相比包含至少一种修饰。这些植酸酶变体具有修饰的，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如，在动物饲料和动物饲料添加剂中。

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