专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004052365A2 INHIBITION OF INFLAMATION USING ALPHA 7 RECEPTOR-BINDING CHOLINERGIC AGONISTS 审中-公开
标题翻译：使用ALPHA 7受体结合胆碱酯酸激酶的抑制作用
公开(公告)号：WO2004052365A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038708
申请日：2003-12-05
申请人： NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE , TRACEY, Kevin, J. , WANG, Hong
发明人： TRACEY, Kevin, J. , WANG, Hong
IPC分类号： A61K31/444
CPC分类号： G01N33/6863 , A61K31/00 , A61K31/439 , A61K31/444 , A61K31/46 , G01N33/9406 , G01N2333/525 , G01N2333/54 , Y02A50/385 , Y02A50/411
摘要： Methods of inhibiting release of a proinflammatory cytokine from a macrophage are provided. The methods comprise treating the macrophage with a cholinergic agonist in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from the macrophage, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for inhibiting an inflammatory cytokine cascade in a patient are also provided. The methods comprise treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for determining whether a compound is a cholinergic agonist reactive with an α7 nicotinic receptor are also provided. The methods comprise determining whether the compound inhibits release of a proinflammatory cytokine from a mammalian cell. Additionally, methods for determining whether a compound is a cholinergic antagonist reactive with an α7 nicotinic receptor are provided. These methods comprise determining whether the compound reduces the ability of a cholinergic agonist to inhibit the release of a proinflammatory cytokine from a mammalian cell. Oligonucleotides or mimetics capable of inhibiting attenuation of lipopolysaccharide-induced TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are also provided. The oligonucleotides or mimetics consist essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 receptor. Additionally, methods of inhibiting attenuation of TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are provided. These methods comprise treating the macrophage with the above-described oligonucleotide or mimetic.
摘要翻译：提供了抑制促炎细胞因子从巨噬细胞释放的方法。所述方法包括用足以减少从巨噬细胞释放的促炎细胞因子的量的胆碱能激动剂处理巨噬细胞，其中胆碱能激动剂对α7烟碱受体具有选择性。还提供了用于抑制患者中炎性细胞因子级联的方法。所述方法包括用足以抑制炎性细胞因子级联的量的胆碱能激动剂治疗患者，其中胆碱能激动剂对α7烟碱受体具有选择性。还提供了确定化合物是否是与α7烟碱受体反应的胆碱能激动剂的方法。所述方法包括确定化合物是否抑制来自哺乳动物细胞的促炎细胞因子的释放。另外，提供了确定化合物是否是与α7烟碱受体反应的胆碱能拮抗剂的方法。这些方法包括确定该化合物是否降低胆碱能激动剂抑制促炎细胞因子从哺乳动物细胞释放的能力。还提供了能够抑制巨噬细胞暴露于胆碱能激动剂时从哺乳动物巨噬细胞中减少脂多糖诱导的TNF释放的寡核苷酸或模拟物。寡核苷酸或模拟物基本上由与α7受体的mRNA互补的大于5个核苷酸长的序列组成。此外，提供了在将巨噬细胞暴露于胆碱能激动剂时抑制TNF释放从哺乳动物巨噬细胞的减少的方法。这些方法包括用上述寡核苷酸或模拟物处理巨噬细胞。

2. 发明申请

WO2015142605A2 POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：聚合纳米粒子及其制备方法和使用方法
公开(公告)号：WO2015142605A2
公开(公告)日：2015-09-24
申请号：PCT/US2015/020086
申请日：2015-03-12
申请人： MERCK SHARP & DOHME CORP. , BIND THERAPEUTICS, INC. , SUNG, Young Ho , TROIANO, Greg , WANG, Hong , FIGUEIREDO, Maria , LAM, Michael, H. , MCGREGOR, Caroline
发明人： SUNG, Young Ho , TROIANO, Greg , WANG, Hong , FIGUEIREDO, Maria , LAM, Michael, H. , MCGREGOR, Caroline
IPC分类号： A61K9/51 , A61K31/4745
CPC分类号： A61K31/4375 , A61K9/0053 , A61K9/5123 , A61K9/5153
摘要： Described herein are polymeric nanoparticles that comprise 8-[4-(1-amino-cyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]-triazolo-[3,4-f][1,6]-naphthyridin-3-one, or a pharmaceutically acceptable salt thereof, and methods of making and using such nanoparticles.
摘要翻译：本文描述的是包含8- [4-（1-氨基 - 环丁基）苯基] -9-苯基-2H- [1,2,4]三唑并[3,4-f] [1,6] - 萘啶-3-酮或其药学上可接受的盐，以及制备和使用这些纳米颗粒的方法。

3. 发明申请

WO2012070909A2 APPARATUS AND METHOD FOR MANAGING HOT CELL DEVICES 审中-公开
标题翻译：用于管理热室设备的装置和方法
公开(公告)号：WO2012070909A2
公开(公告)日：2012-05-31
申请号：PCT/KR2011/009064
申请日：2011-11-25
申请人： SAMSUNG ELECTRONICS CO., LTD. , WANG, Hong , LIANG, Huarui
发明人： WANG, Hong , LIANG, Huarui
IPC分类号： H04W52/02 , H04B7/26
CPC分类号： H04W52/0206 , H04W48/06 , H04W64/003 , H04W84/045 , H04W92/20 , Y02D70/00 , Y02D70/1222 , Y02D70/1242 , Y02D70/1262 , Y02D70/164
摘要： A method for managing hot cell devices includes receiving at least one of location information of at least one hot cell device, type information of at least one hot cell, location information of at least one terminal and uplink signal energy of at least one terminal measured by a hot cell device. The method also includes determining a hot cell device to be opened using the at least one of the location information of at least one hot cell device, the type information of at least one hot cell, the location information of at least one terminal and the uplink signal energy of at least one terminal. In addition, the method includes transmitting a message instructing the hot cell device to open.
摘要翻译：一种用于管理热点设备的方法，包括：接收至少一个热点设备的位置信息，至少一个热点小区的类型信息，至少一个终端的位置信息和上行链路信号中的至少一个由热电池装置测量的至少一个终端的能量。该方法还包括使用至少一个热小区设备的位置信息，至少一个热小区的类型信息，至少一个终端的位置信息和上行链路的至少一个来确定要打开的热小区设备至少一个终端的信号能量。另外，该方法包括发送指示热单元设备打开的消息。

4. 发明申请

WO2011142567A2 HANDOVER METHOD SUPPORTING TERMINAL MOBILITY 审中-公开
标题翻译：支持终端移动的切换方法
公开(公告)号：WO2011142567A2
公开(公告)日：2011-11-17
申请号：PCT/KR2011/003438
申请日：2011-05-09
申请人： SAMSUNG ELECTRONICS CO., LTD. , LIANG, Huarui , WANG, Hong , XU, Lixiang
发明人： LIANG, Huarui , WANG, Hong , XU, Lixiang
IPC分类号： H04W36/32 , H04W36/14
CPC分类号： H04W76/064 , H04W8/082 , H04W28/04 , H04W28/06 , H04W36/08 , H04W48/02 , H04W72/00 , H04W76/19 , H04W76/34
摘要： A handover method for supporting terminal mobility is provided. Before a target core network node updates bearer information according to a target base station to which a User Equipment (UE) performs the handover, an access control determination procedure is added. According to the access control determination information provided by the target base station, if it is determined that the bearer supporting a Selected Internet Protocol (IP) Traffic Offload (SIPTO) or Local IP Access (LIPA) service is permitted to perform the handover, the target core network node updates the bearer information. If it is determined that the bearer supporting the SIPTO or LIPA service is not allowed to perform the handover, the handover failure is notified with respect to the bearer not allowed to perform the handover, and the bearer information is not updated, thus the wasted signaling resource and wireless resource are reduced. Alternatively, during the handover to the target network by the UE or after the handover to the target network, the bearer release or deactivation is performed for the bearer not allowed to perform the handover, so that the UE can re-initiate the bearer establishment process with respect to the bearer not allowed to perform the handover, thus an optimized bearer is established and the Quality of Service (QoS) is ensured.
摘要翻译：提供了一种用于支持终端移动性的切换方法。在目标核心网节点根据用户设备（UE）执行切换的目标基站更新承载信息之前，添加访问控制确定过程。根据由目标基站提供的访问控制确定信息，如果确定支持选定的因特网协议（IP）流量卸载（SIPTO）或本地IP访问（LIPA））服务的承载被执行切换，则目标核心网节点更新承载信息。如果确定支持SIPTO或LIPA业务的承载不允许执行切换，就不允许执行切换的承载通知切换失败，并且不更新承载信息，从而浪费信令资源和无线资源减少。或者，在UE切换到目标网络期间或在切换到目标网络之后，对不允许执行切换的承载执行承载释放或去激活，使得UE可以重新发起承载建立过程对于不允许执行切换的承载，由此建立优化的承载并且确保服务质量（QoS）。

5. 发明申请

WO2011136530A2 APPARATUS AND METHOD FOR X2 INTERFACE SETUP AND CELL SWITCHING IN MOBILE COMMUNICATION SYSTEM 审中-公开
标题翻译：用于移动通信系统中的X2接口设置和小区切换的装置和方法
公开(公告)号：WO2011136530A2
公开(公告)日：2011-11-03
申请号：PCT/KR2011/003011
申请日：2011-04-26
申请人： SAMSUNG ELECTRONICS CO., LTD. , WANG, Hong , XU, Lixiang
发明人： WANG, Hong , XU, Lixiang
IPC分类号： H04W92/20 , H04W36/08 , H04W36/30 , H04W36/04
CPC分类号： H04W36/0061 , H04W36/0033 , H04W84/045 , H04W92/20
摘要： A method and an apparatus for setting up an X2 interface setup are provided. The method includes transmitting, by a first Base Station (BS), an X2 interface setup request to a second BS, wherein the X2 interface setup request comprises an access mode of a Closed Subscriber Group (CSG) supported by a cell in the first BS, and transmitting, by the second BS, an X2 interface response message to the first BS, wherein the X2 interface response message comprises the access mode of the CSG supported by the cell in the second BS.
摘要翻译：提供了一种用于设置X2接口设置的方法和设备。该方法包括由第一基站（BS）向第二BS发送X2接口建立请求，其中X2接口建立请求包括由第一BS中的小区支持的封闭用户组（CSG）的接入模式，并且由所述第二BS向所述第一BS发送X2接口响应消息，其中，所述X2接口响应消息包括由所述第二BS中的所述小区支持的所述CSG的接入模式。

6. 发明申请

WO2011041373A1 POSITIVELY-CHARGED POLY (D,L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES AND FABRICATION METHODS OF THE SAME 审中-公开
标题翻译：正电荷聚（D，L-柠檬酰 - 甘氨酸）纳米颗粒及其制备方法
公开(公告)号：WO2011041373A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050665
申请日：2010-09-29
申请人： EYEGATE PHARMACEUTICALS, INC. , MOSLEMY, Peyman , WANG, Hong , PATANE, Michael
发明人： MOSLEMY, Peyman , WANG, Hong , PATANE, Michael
IPC分类号： A61K31/497
CPC分类号： A61K31/497 , A61K9/0048 , A61K9/5123 , A61K9/5153 , A61K9/5192
摘要： The present technology provides compositions with positively-charged poly(d,l-lactide- co-glycolide) nanoparticles capable of releasing a bioactive substance in a body tissue for extended periods of time, as well as methods for manufacture of the same and methods for prophylactic and therapeutic treatment of a subject in need thereof.
摘要翻译：本技术提供能够长时间释放身体组织中的生物活性物质的带正电荷的聚（d，l-丙交酯 - 共 - 乙交酯）纳米颗粒的组合物，以及其制备方法和方法预防和治疗需要的对象。

7. 发明申请

WO2010128815A3 METHOD FOR SUPPORTING PDN GW SELECTION 审中-公开
标题翻译：用于支持PDN GW选择的方法
公开(公告)号：WO2010128815A3
公开(公告)日：2010-11-11
申请号：PCT/KR2010/002898
申请日：2010-05-07
申请人： SAMSUNG ELECTRONICS CO., LTD. , LIANG, Huarui , WANG, Hong , XU, Lixiang , LI, Xiaoqiang
发明人： LIANG, Huarui , WANG, Hong , XU, Lixiang , LI, Xiaoqiang
IPC分类号： H04L12/28 , H04L12/66
摘要： A method for supporting PDN GW selection, comprising the following steps of: receiving by an MME a local route optimization service request information; searching by the MME the IP address of a PDN GW which supports local route optimization according to the IP address of a PDN GWh; sending by the MME a bearer request establishment message to the PHN GWh. The method of the present invention can ensure core network equipment to find PDN GW correctly while HeNB system supports local route optimization.
摘要翻译：一种支持PDN GW选择的方法，包括以下步骤：MME接收本地路由优化服务请求信息; MME根据PDN GWh的IP地址，查找支持本地路由优化的PDN GW的IP地址; 由MME发送承载请求建立消息到PHN GWh。本发明的方法可以保证核心网设备正确找到PDN GW，而HeNB系统支持本地路由优化。

8. 发明申请

WO2010117227A2 METHOD OF AND SYSTEM FOR PERFORMING ACCESS CONTROL AND RADIO RESOURCE MANAGEMENT ENTITY 审中-公开
标题翻译：执行访问控制和无线电资源管理实体的方法和系统
公开(公告)号：WO2010117227A2
公开(公告)日：2010-10-14
申请号：PCT/KR2010/002179
申请日：2010-04-09
申请人： SAMSUNG ELECTRONICS CO., LTD. , LIANG, Huarui , XU, Lixiang , WANG, Hong
发明人： LIANG, Huarui , XU, Lixiang , WANG, Hong
IPC分类号： H04W74/02 , H04W28/16
CPC分类号： H04W76/066 , H04W8/18 , H04W36/22 , H04W48/06 , H04W76/36 , H04W84/045 , H04W88/02
摘要： The present invention discloses a method of and system for performing the access control as well as a radio resource management entity. The method includes: detecting, by a hybrid radio resource management entity, an access control trigger event; determining, by the hybrid radio resource management entity, a non-closed subscriber group, CSG, User Equipment to be removed; disconnecting, by the hybrid radio resource management entity, the connection with the non-CSG User Equipment to be removed. In accordance with the present invention, a hybrid radio resource management entity is able to control the access of User Equipment, so as to guarantee the access of CSG User Equipment.
摘要翻译：本发明公开了一种执行访问控制的方法和系统以及无线电资源管理实体。该方法包括：通过混合无线资源管理实体检测访问控制触发事件; 由所述混合无线资源管理实体确定要去除的非封闭用户组，CSG，用户设备; 由混合无线资源管理实体断开与要删除的非CSG用户设备的连接。根据本发明，混合无线资源管理实体能够控制用户设备的接入，以保证CSG用户设备的接入。

9. 发明申请

WO2010096212A2 TECHNIQUES FOR APPLYING MAR REDUCING OVERCOATS TO ARTICLES HAVING LAYER STACKS DISPOSED THEREON 审中-公开
标题翻译：适用于减少覆盖物的物品的技术应用于其中处理的堆叠堆垛的文章
公开(公告)号：WO2010096212A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/020411
申请日：2010-01-08
申请人： GUARDIAN INDUSTRIES CORP. , BLACKER, Richard , WANG, Hong
发明人： BLACKER, Richard , WANG, Hong
IPC分类号： B32B9/04 , C23C16/00 , C23C16/54
CPC分类号： C23C16/4485 , B05D1/60 , B05D1/62 , B05D5/08 , Y10T428/31504
摘要： Certain example embodiments of this invention relate to techniques for applying an overcoat (e.g., which may include an organic material) to a coated article having a layer slack already disposed thereon in order to reduce the potential for surface marring. An evacuative process may be used to deposit the mar reducing overcoat. The coated article including the mar-reducing overcoat has a contact angle greater than, and a surface friction less than, a contact angle and a surface friction of the single- or multi-layer stack supported by the substrate alone. Any marring due to cat-scratching or the like preferably would not be visible at 4x magnification following application of the mar reducing overcoat.
摘要翻译：本发明的某些示例性实施方案涉及将外涂层（例如，其可以包括有机材料）施加到已经设置在其上的层松弛的涂覆制品以减少表面损坏的可能性的技术。可以使用抽真空方法来沉积减少外涂层。包括减少外涂层的涂覆制品具有大于单独层或多层叠层支撑的单层或多层叠层的接触角和小于接触角和表面摩擦力的接触角。由于刮擦刮擦等引起的任何损坏，优选在施加防缩性外涂层之后，在4倍放大率下不可见。

10. 发明申请

WO2008073368A1 PEPTIDE-BASED HAIR PROTECTANTS 审中-公开
标题翻译：基于基于肽的护发素
公开(公告)号：WO2008073368A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/025223
申请日：2007-12-10
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , BECK, William, A. , O'BRIEN, John, P. , WANG, Hong
发明人： BECK, William, A. , O'BRIEN, John, P. , WANG, Hong
IPC分类号： A61K47/48 , C07K7/08
CPC分类号： A61Q17/04 , A61K8/64 , A61K47/62 , A61K2800/57 , A61K2800/94 , A61Q5/12
摘要： Peptide-based hair protectants, formed by coupling at least one hair-binding peptide with at least one sunscreen agent, are described. The hair-binding peptide portion of the peptide-based hair protectant binds to hair with high affinity, thus keeping the sunscreen agent attached to the hair for long lasting protection. Hair care compositions comprising the peptide-based hair protectants are also described.
摘要翻译：描述了通过将至少一种毛发结合肽与至少一种防晒剂偶联形成的基于肽的护发剂。基于肽的头发保护剂的头发结合肽部分以高亲和力结合头发，从而保持防晒剂附着在头发上以获得长期保护。还描述了包含基于肽的头发保护剂的护发组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式