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1. 发明申请

WO2020016192A1 DEVICE FOR GENERATING MECHANICAL SHEAR WAVES INSIDE A SOFT MATERIAL, SHEAR WAVE IMAGING APPARATUS FOR THE SAME 审中-公开
公开(公告)号：WO2020016192A1
公开(公告)日：2020-01-23
申请号：PCT/EP2019/069042
申请日：2019-07-15
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE LÉON-BÉRARD
发明人： SUN, Zhishen , CATHELINE, Stefan
IPC分类号： A61B8/08 , A61B5/00 , A61B5/05 , A61B5/053 , A61B5/055 , G01R33/563
摘要： The present invention relates to the field of acoustic imaging of soft materials, such as shear wave elastography. A method for generating shear waves in a soft material includes placing at least one patch including a metallic material along and in contact with an external boundary of a soft material, and applying a variable magnetic field on the patch using an electromagnet, in order to generate eddy currents circulating inside each metal strip and a Lorentz force imparting an oscillation movement of the patch.

2. 发明申请

WO2022248613A1 COMPUTER-IMPLEMENTED METHOD AND APPARATUS FOR CHARACTERIZING A FLEXIBLE TUBE 审中-公开
公开(公告)号：WO2022248613A1
公开(公告)日：2022-12-01
申请号：PCT/EP2022/064318
申请日：2022-05-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE LEON BERARD , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE QUINZE-VINGTS
发明人： ATLAN, Michael , CATHELINE, Stefan , LALOY-BORGNA, Gabrielle , PUYO, Léo
IPC分类号： A61B3/10 , A61B3/12 , A61F2/06
摘要： This computer-implemented method allows assessing the shear elasticity modulus of a flexible tube, such as a blood vessel. In the field of medicine, this allows assessing whether a blood vessel is at risk of breakage or tearing. In the case of an artificial tube to be implanted in a patient's body, this allows verifying that this tube is compatible with the patient's body. The method includes the following further steps: a) obtaining (1002) a first dataset relating to spatiotemporal deformations of the tube; b) detecting and storing (1004) a wall inner surface of the tube and its diameter (D); c) identifying (1006) a number of transverse sections (Sij) of the tube; d) computing (1008) an average particle velocity (Vij) over each section; e) computing (1010) a wave propagation speed (C2) of an antisymmetric wave (W2); f) based on the wave propagation speed (C2) and on the diameter (D), assessing (1012) the shear elasticity modulus (μ) of the tube.

3. 发明申请

WO2015128409A1 SHEAR WAVE GENERATION METHOD, SHEAR WAVE IMAGING METHOD AND THERMAL MAPPING OR TREATING METHOD UTILIZING SUCH A GENERATION METHOD AND INSTALLATION FOR GENERATING AT LEAST ONE SHEAR WAVE 审中-公开
标题翻译：剪切波生成方法，剪切波形成像方法和使用这种生成方法的热绘制或处理方法和用于产生至少一个剪切波的安装
公开(公告)号：WO2015128409A1
公开(公告)日：2015-09-03
申请号：PCT/EP2015/054002
申请日：2015-02-26
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1
发明人： CATHELINE, Stefan , SOUCHON, Rémi , ZORGANI, Ali , CHAPELON, Jean-Yves
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52 , G01S15/89
CPC分类号： A61B8/485 , A61B5/0066 , A61B5/015 , A61B5/055 , A61B8/4416 , A61B8/4466 , A61B8/4477 , A61B8/4488 , G01S7/52022 , G01S15/8918 , G01S15/8977
摘要： This method for generating at least one shear wave in a target region of a soft solid, includes at least the following steps: a) generating (1002, 1004, 1006) at least one shear wave (SW 1 , SW 2 , SW 3 ) in the target region; b) detecting (1003, 1005, 1007) a propagation pattern (P1) of the least one shear wave in the target region; c) proceeding (1008) to a time reversal of the detected propagation pattern; and d) submitting (1011) the target region to an inverted excitation set of forces based on the temporally inverted propagation pattern. Step a) (1002, 1004) is implemented by generating at least two shear waves with at least a first source of shear waves (SW 1 , SW' 1 ) and at least a second source of shear waves (SW 2 , SW' 2 ). Step b) is implemented with a detector unit (10) which includes a row (10) of ultrasonic transducers (Ti) aligned on a first direction (X10) perpendicular to a detection direction (Di) of each ultrasonic transducer or a single ultrasonic transducer movable along a first direction (X) perpendicular to its detection direction. During step b), a first propagation pattern (P1) is detected (1003) when only the first source is active and a second propagation pattern (P2) is detected (1005) when only the second source is active. During step c), the first and second propagation patterns (P1, P2) are time-reversed (1008, 1009) independently from each other in order to generate, respectively, a first reverse excitation scheme (Ρ1') and a second reverse excitation scheme (Ρ2'). At step d), the first source is controlled (1011) with the first reverse excitation scheme (Ρ1') to generate at least a first modified shear wave (SW' 1 ) and, simultaneously, the second source is controlled with the second reverse excitation scheme (Ρ2') to generate at least a second modified shear wave (SW' 2 ), whereas the shear waves are focused at a given point of the target region.
摘要翻译：用于在软固体的目标区域中产生至少一个剪切波的该方法至少包括以下步骤：a）产生目标中的至少一个剪切波（SW1，SW2，SW3）（1002,1004,1006）地区; b）检测（1003,1005,1007）目标区域中的至少一个剪切波的传播模式（P1）; c）进行（1008）到检测到的传播模式的时间反转; 以及d）基于时间反转的传播模式将目标区域（1011）提交给反向激励力集合。步骤a）（1002,1004）通过产生具有至少第一剪切波源（SW1，SW'1）和至少第二切割源（SW2，SW'2）的至少两个剪切波来实现。步骤b）由检测器单元（10）实现，检测器单元（10）包括在垂直于每个超声换能器的检测方向（Di）的第一方向（X10）上排列的超声波换能器（Ti）的行（10）或单个超声换能器沿着与其检测方向垂直的第一方向（X）可移动。在步骤b）期间，当仅第二源处于活动状态时仅检测到第一传播模式（P2）被检测到第一传播模式（P2）（1005））时，检测到第一传播模式（P1）（1003）。在步骤c）期间，第一和第二传播模式（P1，P2）彼此独立地时间反转（1008,1009），以分别产生第一反向激励方案（Ρ1'）和第二反向激励方案（Ρ2'）。在步骤d），用第一反向激励方案（Ρ1'）控制第一源（1011）以产生至少第一修改剪切波（SW'1），并且同时第二源被控制在第二反向激励方案（Ρ2'）以产生至少第二修改剪切波（SW'2），而剪切波被聚焦在目标区域的给定点。

4. 发明申请

WO2017089511A1 METHOD FOR DETERMINING A MECHANICAL PROPERTY OF A LAYERED SOFT MATERIAL 审中-公开
标题翻译：确定层状软材料机械性能的方法
公开(公告)号：WO2017089511A1
公开(公告)日：2017-06-01
申请号：PCT/EP2016/078761
申请日：2016-11-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE LÉON-BÉRARD
发明人： CATHELINE, Stefan , CHAPELON, Jean-Yves , LAFON, Cyril
IPC分类号： G01N29/04 , A61B8/08 , G01S7/52
CPC分类号： G01N29/041 , A61B8/085 , A61B8/0858 , A61B8/4444 , A61B8/485 , A61B8/5223 , A61N7/02 , A61N2007/0052 , A61N2007/0095 , G01N2291/0231 , G01N2291/0427 , G01S7/52022 , G01S7/52042 , G01S15/8922 , G01S15/8927
摘要： This method for determining a mechanical property of a layered soft material, includes steps of a) generating an ultrasound wave (W1) focused towards a first point (P1) of the material, said wave, upon interacting with a layer of said material, generating in turn a Lamb (L1) wave propagating into said layer of the material, b) measuring, at a second point (P2) of the material belonging to said layer, a physical parameter of the generated Lamb wave, c) automatically determining the mechanical property of the layered soft material, based on the measured physical parameter. Step a) is performed by exciting a first ultrasonic transducer (401) with a first excitation signal (S401) during at most 50 ms, step b) is performed by exciting a second ultrasonic transducer (402) with a second excitation signal (S402) during at most 0,5 ms, to generate multiple excitation ultrasound waves (W2) focused towards said second point (P2) and, then, collecting multiple reflected waves (W2') emitted in response, said first and second ultrasonic transducers each comprises an oscillator having a quality factor equal to or superior to 100, preferably equal or superior to 1000.
摘要翻译：这种用于确定分层软材料的机械性质的方法包括以下步骤：a）产生朝向材料的第一点（P1）聚焦的超声波（W1），所述波在相互作用时与所述材料的层一起产生传播到所述材料层中的Lamb（L1）波，b）在属于所述层的材料的第二点（P2）处测量所产生的羔羊的物理参数波，c）基于测量的物理参数自动确定分层软材料的机械性能。步骤a）通过在至多50ms期间用第一激励信号（S401）激励第一超声换能器（401）来执行，步骤b）通过用第二激励信号激励第二超声换能器（402）来执行（S402）在至多0.5ms期间，产生朝向所述第二点（P2）聚焦的多个激发超声波（W2），然后收集作为响应而发射的多个反射波（W2'），所述第一和第二超声波换能器各自包括振荡器的品质因数等于或高于100，最好等于或高于1000.

5. 发明申请

WO2023002227A1 METHODS AND SYSTEMS FOR MODIFYING ELASTICITY PROPERTIES OF A TARGET IN A SOFT MATERIAL 审中-公开
公开(公告)号：WO2023002227A1
公开(公告)日：2023-01-26
申请号：PCT/IB2021/000503
申请日：2021-07-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE LEO BERARD , UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL) , UNIVERSITE JEAN MONNET SAINT ETIENNE , CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE
发明人： LAFON, Cyril , CATHELINE, Stefan , THURET, Gilles , LAFOND, Maxime , GAIN, Philippe
IPC分类号： A61B8/08 , A61N7/00 , A61B3/10 , A61F9/007
摘要： The invention relates to a method for modifying elasticity properties of a soft material using ultrasound waves. The invention is particularly applicable to the human eye for the treatment of presbyopia by non-invasively modifying the stiffness of the crystalline lens. Ultrasound pulses generated with an ultrasonic transducer, such as a HIFU transducer, are focused on a target region of the material. The ultrasound pulses create cavitation bubbles in the target region, thus reducing the stiffness of the material.

6. 发明申请

WO2015004224A1 SHEAR WAVE IMAGING METHOD AND INSTALLATION FOR COLLECTING INFORMATION ON A SOFT SOLID 审中-公开
标题翻译：剪切波形成像方法和软件收集信息的安装
公开(公告)号：WO2015004224A1
公开(公告)日：2015-01-15
申请号：PCT/EP2014/064794
申请日：2014-07-10
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE CLAUDE BERNARD LYON 1
发明人： CATHELINE, Stefan , CHAPELON, Jean-Yves , SOUCHON, Rémi , GRASLAND-MONGRAIN, Pol , LAFON, Cyril
IPC分类号： G01R33/563 , A61B5/05 , A61B5/053 , A61B8/08
CPC分类号： A61B5/0051 , A61B5/05 , A61B5/0536 , A61B5/055 , A61B8/485 , G01R33/56358
摘要： This shear wave imaging method, for collecting information on a target region (R) of a soft solid (S), comprises at least the steps a) of generating at least one shear wave (SW) in the target region, and b) of detecting a propagation pattern of the shear wave in the target region. Step a) is realized by applying to particles of the target region (R) some Lorentz forces resulting from an electric field (E) and from a magnetic field (B). At least one of the electric field (E) and the magnetic field (B) is variable in time, with a central frequency (f o ) between 1 Hz and 10 kHz. Alternatively, both the electric and magnetic fields (E, B) are variable in time, with a central difference frequency (∆f o ) between 1 Hz and 10 kHz. The shear wave imaging installation comprises a first system (4, 7) for generating at least one shear wave (SW) in the target region (R) and a second system (10) for detecting a propagation pattern of the shear wave. The first system includes first means (4) to apply an electric field (E) through the target region (R) and second means (7) to apply a magnetic field (B) through the target region. The first and second means are configured to apply to particles of the target region some Lorentz forces resulting from the electric field (E) and the magnetic field (B), where at least one of these fields is a quantity variable in time, with a central frequency (f o ) between 1 Hz and 10 kHz, or both fields are quantities variable in time, with a central difference frequency (∆f o ) between 1 Hz and 10 kHz.
摘要翻译：用于收集关于软固体（S）的目标区域（R）的信息的该剪切波成像方法至少包括在目标区域中产生至少一个剪切波（SW）的步骤a），以及b）检测目标区域中的剪切波的传播模式。步骤a）通过向目标区域（R）的粒子施加一些由电场（E）和磁场（B）产生的洛伦兹力来实现。电场（E）和磁场（B）中的至少一个在时间上是可变的，中心频率（fo）在1Hz和10kHz之间。或者，电场和磁场（E，B）在时间上是可变的，中心差频率（Δfo）在1Hz和10kHz之间。剪切波成像设备包括用于在目标区域（R）中产生至少一个剪切波（SW）的第一系统（4,7）和用于检测剪切波的传播模式的第二系统（10）。第一系统包括通过目标区域（R）和第二装置（7）施加电场（E）的第一装置（4），以通过目标区域施加磁场（B）。第一和第二装置被配置为向目标区域的颗粒施加由电场（E）和磁场（B）产生的一些洛伦兹力，其中这些场中的至少一个是时间上的变量，其中 1 Hz至10 kHz之间的中心频率（fo），或两个场均为时间可变的量，中心频率（Δfo）介于1 Hz和10 kHz之间。

7. 发明申请

WO2020070535A1 DEVICES AND METHODS FOR TREATING A BREATHING-RELATED SLEEP DISORDER, METHODS OF USE AND CONTROL PROCESSES FOR SUCH A DEVICE 审中-公开
公开(公告)号：WO2020070535A1
公开(公告)日：2020-04-09
申请号：PCT/IB2018/001232
申请日：2018-10-03
申请人： BREAS MEDICAL AB , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (EPST) , UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL) , CENTRE LEON-BERARD
发明人： MENGUY, Didier , CHAPELON, Jean-Yves , CATHELINE, Stefan , ZORGANI, Ali
IPC分类号： A61H23/02 , A61H2201/1609 , A61H2201/1619 , A61H2201/1623 , A61H2201/165 , A61H2201/5005 , A61H2201/5058 , A61H2230/065 , A61H2230/085 , A61H2230/105 , A61H2230/206 , A61H2230/208 , A61H2230/405 , A61H2230/425 , A61H23/0263
摘要： The present teachings relate to a device and a method for treating a subject, wherein an actuator is configured for external mechanical contact with the subject, wherein a control unit is configured to control the actuator to provide at least one burst of a primary vibration, and wherein the primary vibration has one or several frequencies, or a frequency varying, within an operative frequency range contained in a range from 5 Hz to 1000 Hz, in order for the device to generate a shear wave which propagates inside the body of the subject. In addition, the present teachings relate to use of a device of the present teachings to treat a breathing-related sleep disorder, including snoring, OSA, UARS, or OHS.

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