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    • 7. 发明申请
    • NEW TABLETTABLE FORMULATION OF LUTEIN AND/OR ZEAXANTHIN
    • 新叶黄素和/或黄芩素的片剂
    • WO2017168005A1
    • 2017-10-05
    • PCT/EP2017/057812
    • 2017-04-03
    • DSM IP ASSETS B.V.
    • ESTRELLA, AntonioFUNDA, ElgerMISIC, ZdravkaSCHAEFER, ChristianBECK, MarkusSCHLEGEL, BerndURBAN, Kai
    • A61K9/20A61K9/16A23L2/39
    • The present invention is directed towards a solid formulation comprising a milled carotenoid, at least one hydrocolloid, a glucose syrup, sucrose and at least one water- soluble antioxidant (preferably sodium ascorbate), wherein the carotenoid is selected from the group consisting of lutein and zeaxanthin and any mixture thereof, wherein the hydrocolloid is selected from the group consisting of modified food starches and any mixtures thereof, and wherein the milled carotenoid has the following particle size distribution: D [3,2] in the range of from 0.6 to 1.5 μm and D [v, 0.5] in the range of from 1.1 to 3.5 μm, all D values as measured by laser diffraction (Malvern Instruments Ltd, Malvern, UK, Mastersizer 3000) according to the Fraunhofer scattering model. This solid formulation is in form of granules which are used for dietary supplements and pharmaceuticals, such as e.g. multi-vitamin and/or multi-mineral tablets. Surprisingly these tablets show a low compression loss.
    • 本发明涉及包含研磨的类胡萝卜素,至少一种水解胶体,葡萄糖浆,蔗糖和至少一种水溶性抗氧化剂(优选抗坏血酸钠)的固体制剂,其中类胡萝卜素是 选自由叶黄素和玉米黄质及其任何混合物组成的组,其中水解胶体选自改性食物淀粉及其任何混合物,并且其中研磨的类胡萝卜素具有以下粒度分布:D [3,2] 根据Fraunhofer的激光衍射(Malvern Instruments Ltd,Malvern,UK,Mastersizer 3000)测量的所有D值在0.6至1.5μm的范围内并且D [v,0.5]在1.1至3.5μm的范围内 散射模型。 该固体制剂为用于膳食补充剂和药物的颗粒形式,例如, 多种维生素和/或多种矿物质片剂。 令人惊讶的是这些药片的压缩损失很低。