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1. 发明申请

WO2008151155A2 POLARIZATION-SENSITIVE SPECTRAL INTERFEROMETRY 审中-公开
标题翻译：极化敏感光谱干涉仪
公开(公告)号：WO2008151155A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065570
申请日：2008-06-02
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , VOLCANO CORPORATION , MILNER, Thomas, E. , KEMP, Nathaniel, J. , KIM, Eunha
发明人： MILNER, Thomas, E. , KEMP, Nathaniel, J. , KIM, Eunha
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B3/102 , G01B9/02004 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： A polarization sensitive spectral interferometer apparatus and method for analyzing a sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample.
摘要翻译：一种用于分析样品的偏振敏感光谱干涉仪装置和方法。偏振敏感光谱干涉仪装置和方法确定样品的偏振特性。

2. 发明申请

WO2008086219A9 HEMOGLOBIN CONTRAST IN ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY FOR DIAGNOSING DISEASED TISSUE, CANCERS, AND THE LIKE 审中-公开
公开(公告)号：WO2008086219A9
公开(公告)日：2008-07-17
申请号：PCT/US2008/050293
申请日：2008-01-04
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , VOLCANO CORPORATION, INC. , FELDMAN, Marc, D. , MILNER, Thomas, E. , OH, Jung-hwan
发明人： FELDMAN, Marc, D. , MILNER, Thomas, E. , OH, Jung-hwan
IPC分类号： A61B17/52 , A61B5/00
摘要： A novel contrast mechanism for diagnosing diseased tissue using Ultrasound, Doppler Ultrasonography, Optical Coherence Tomography, or optical Doppler tomography coupled with an externally applied temporally oscillating high-strength magnetic field.

3. 发明申请

WO2021207628A1 APPARATUS AND METHODS FOR ACQUISITION OF MICROBIOPSY TISSUE SAMPLES USING A LASER 审中-公开
公开(公告)号：WO2021207628A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/026620
申请日：2021-04-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： MILNER, Thomas, E. , KING, Jason, B. , KATTA, Nitesh , TUNNELL, James, W.
IPC分类号： A61B18/20 , A61B18/18 , A61B18/22 , A61F9/007 , A61F9/008
摘要： Apparatus and methods for tissue excision. In certain aspects, the apparatus and methods include an annular converging laser beam. The annular converging laser beam can be directed to a surface of a tissue and displace a portion of the tissue in a single or multiple laser pulses. In particular aspects, the dosimetry of the laser beam (e.g. the beam shape, pulse energy and pulse duration) can be controlled to eject the portion of the tissue in a manner to reduce damage to the displaced tissue and the surrounding tissue.

4. 发明申请

WO2010085652A2 SYSTEMS AND METHODS FOR ALTERING VISUAL ACUITY 审中-公开
标题翻译：用于改变视觉敏锐度的系统和方法
公开(公告)号：WO2010085652A2
公开(公告)日：2010-07-29
申请号：PCT/US2010/021814
申请日：2010-01-22
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , WELCH, Ashley, J. , VINCELETTE, Rebecca, L. , RYLANDER, Henry Grady, III , MILNER, Thomas, E.
发明人： WELCH, Ashley, J. , VINCELETTE, Rebecca, L. , RYLANDER, Henry Grady, III , MILNER, Thomas, E.
IPC分类号： A61B3/00 , A61B3/103 , A61B3/028
CPC分类号： F41H13/0056 , F41H13/0087
摘要： Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject.
摘要翻译：提供了用于改变成像系统的调制传递函数的方法，系统和设备。所描述的方法，系统和装置可以用于临时改变对象的视敏度。

5. 发明申请

WO2009023635A1 FORWARD-IMAGING OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEMS AND PROBE 审中-公开
标题翻译：前向成像光学相干（OCT）系统和探头
公开(公告)号：WO2009023635A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/072805
申请日：2008-08-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , VOLCANO CORPORATION , KARTHIK, Kumar , CONDIT, Jonathan, C. , KEMP, Nathaniel, J. , MILNER, Thomas, E. , ZHANG, Xiaojing
发明人： KARTHIK, Kumar , CONDIT, Jonathan, C. , KEMP, Nathaniel, J. , MILNER, Thomas, E. , ZHANG, Xiaojing
IPC分类号： G01B9/02
CPC分类号： G02B3/12 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B2562/0233 , A61B2562/028 , A61B2562/0285 , A61B2562/12 , B82Y20/00 , G01B9/02091 , G01B11/02 , G01B2290/65 , G01N21/4795 , G02B3/14 , G02B26/0833 , G02B26/105 , G02B2207/101 , G02B2207/109
摘要： Provided are forward-imaging optical coherence tomography (OCT) systems and probes.
摘要翻译：提供了前向成像光学相干断层扫描（OCT）系统和探针。

6. 发明申请

WO2004096049A3 CATHETER IMAGING PROBE AND METHOD 审中-公开
公开(公告)号：WO2004096049A3
公开(公告)日：2004-11-11
申请号：PCT/US2004/012773
申请日：2004-04-23
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FELDMAN, Marc, D. , MILNER, Thomas, E. , CHEN, Shaochen , KIM, Jeehyun , HAN, Li-Hsin , OH, Jung-Hwan , LEE, Ho
发明人： FELDMAN, Marc, D. , MILNER, Thomas, E. , CHEN, Shaochen , KIM, Jeehyun , HAN, Li-Hsin , OH, Jung-Hwan , LEE, Ho
IPC分类号： A61B6/00
摘要： The probe (100) comprises a conduit (110) through which energy is transmitted having a first portion (120) through which the conduit (110) extends and a second portion (130) which rotates relative to conduit (110) to redirect the energy from the conduit (110).

7. 发明申请

WO2017099755A1 SPECTRALLY-ENCODED HIGH-EXTINCTION POLARIZATION MICROSCOPE AND METHODS OF USE 审中-公开
标题翻译：光谱编码的高灭活极化显微镜及其使用方法
公开(公告)号：WO2017099755A1
公开(公告)日：2017-06-15
申请号：PCT/US2015/064750
申请日：2015-12-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： MILNER, Thomas, E. , YIN, Biwei , KUHN, Jeffrey, Russel , POENIE, Martin
IPC分类号： G02B21/00
CPC分类号： G02B21/0092 , G01J4/00 , G01J2004/001 , G02B21/367
摘要： Described herein is a polarization microscope that uses spectral-encoding of the polarization state for cellular imaging. The spectral-encoded polarization microscope is both sufficiently fast for cellular imaging and is compatible with high extinction optics required to image molecular structures and assemblies. The spectral-encoded microscope allows for the polarization state of light presented to the specimen to sample discrete states over the entirety of the Poincaré sphere while simultaneously giving a null measurement of the observed cellular birefringence. Sampling over the entire Poincaré sphere allows the microscope to determine of specimen phase retardation due to both linear and circular birefringence. The spectral-encoded polarization microscope can be operated in a slightly off-null state that will improve signal-to- noise.
摘要翻译：这里描述的是使用偏振状态的光谱编码用于细胞成像的偏振显微镜。光谱编码的偏振显微镜对于细胞成像来说足够快，并且与对分子结构和组件成像所需的高消光光学器件兼容。光谱编码显微镜允许呈现给样品的光的偏振状态在整个Poincar＆Eacute上对离散状态进行采样; 同时给出观察到的细胞双折射的空测量。在整个Poincar＆Eacute上进行抽样; 球体允许显微镜确定由于线性和圆形双折射引起的标本相位延迟。光谱编码的偏振显微镜可以在稍微偏离空状态下工作，以改善信噪比。

8. 发明申请

WO2009052481A1 OPTICAL COHERENCE TOMOGRAPHY CELL DETECTION 审中-公开
标题翻译：光学相干细胞检测
公开(公告)号：WO2009052481A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080477
申请日：2008-10-20
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , MILNER, Thomas, E.
发明人： MILNER, Thomas, E.
IPC分类号： A61B5/05
CPC分类号： A61B5/0066 , A61B5/0035 , A61B5/026 , A61B5/0261 , A61B5/0275 , A61B5/05 , A61B5/0515 , A61B5/6852 , A61B5/725 , A61B8/06 , A61B8/13 , A61B8/488 , A61B2576/00 , A61N2/02 , G01N21/1717 , G01N21/4795
摘要： Medical diagnostic imaging, in particular imaging blood flow using magneto-motive optical Doppler tomography (MMODT), Optical Coherence Tomography, or Ultrasound, which combines an externally applied temporally oscillating high-strength magnetic field with ODT, OCT, or Ultrasound Accurate determination of location and flow velocity of moving particles in highly scattering media, such as blood flow, is important for medical diagnostics Numerous non-invasive approaches have been developed using techniques such as Doppler ultrasound, conventional angiography, laser Doppler flowmetry and magnetic resonance angiography Ultrasound is directed into the body of the patient and red blood cells, which are suspended in the blood plasma, scatter the ultrasonic energy back towards the receiver or transducer The transducer then converts the back-scattered ultrasonic energy into an electrical signal that is processed in some known manner to determine the presence of a flow and an estimate of the flow velocity.
摘要翻译：医学诊断成像，特别是使用磁动力学光学多普勒断层扫描（MMODT），光学相干断层扫描或超声波成像血流，其将外部施加的时间振荡的高强度磁场与ODT，OCT或超声波组合精确确定位置并且高度散射介质（如血液流动）中的移动颗粒的流速对于医学诊断是重要的。已经使用诸如多普勒超声，常规血管造影，激光多普勒血流计和磁共振血管造影术的技术开发了许多非侵入性方法。超声被引导到悬挂在血浆中的患者身体和红细胞将超声波能量分散回接收器或换能器。然后，换能器将反向散射的超声能量转换成以一些已知方式处理的电信号确定流的存在和流的估计速度。

9. 发明申请

WO2007021948A3 SYSTEMS, DEVICES, AND METHODS FOR OPTICALLY CLEARING TISSUE 审中-公开
公开(公告)号：WO2007021948A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/031401
申请日：2006-08-12
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , RYLANDER, Christopher, G. , MILNER, Thomas, E. , STUMPP, Oliver , NELSON, J., Stuart
发明人： MILNER, Thomas, E. , STUMPP, Oliver , NELSON, J., Stuart
IPC分类号： A61B18/20
摘要： Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated.

10. 发明申请

WO2006128167A2 OPTICAL COHERENCE TOMOGRAPHIC DETECTION OF CELLS AND COMPOSITIONS 审中-公开
标题翻译：光学相干电镜检测细胞和组成
公开(公告)号：WO2006128167A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020903
申请日：2006-05-26
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FELDMAN, Mark, D. , MILNER, Thomas, E. , OH, Jung-Hwan , MEHMET, Cilingiroglu
发明人： FELDMAN, Mark, D. , MILNER, Thomas, E. , OH, Jung-Hwan , MEHMET, Cilingiroglu
IPC分类号： A61M16/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0261 , A61B5/0275 , A61B5/0515 , A61B5/416 , A61B8/06 , A61B8/13 , G01N21/1717 , G01N21/4795
摘要： Provided herein are systems and methods for the detection of cells and compositions using optical coherence tomography.
摘要翻译：本文提供了使用光学相干断层扫描检测细胞和组合物的系统和方法。

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