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    • 1. 发明申请
    • AN ANTI-INFLAMMATORY COMPOSITION FOR THE TREATMENT OF ACUTE JOINT INFLAMMATION AND A PROCESS FOR PREPARATION THEREOF
    • 用于治疗急性关节炎的抗炎组合物及其制备方法
    • WO2018033891A1
    • 2018-02-22
    • PCT/IB2017/055025
    • 2017-08-19
    • AUREA BIOLABS PRIVATE LIMITED
    • GOPI, SreerajCOVILAKAM, Karthik Varma AyiranazhiGEORGE, Robin
    • A61K36/00
    • The present invention discloses an anti-inflammatory composition comprising turmeric alcohol extract, beta caryophyllene, 3-o-acetyl-11-keto-beta-boswellic acid, extract obtained from Kaempferia galangal and turmeric water extract. The present invention also describes a process of preparing the composition containing these extracts, which mainly involves extracting curcumin alcohol extract from turmeric, extracting gum resin from Boswellia serrata , AKBA is isolated from the extracted gum resin and complexed with phospholipid, beta-caryophyllene is isolated from Piper nigrum by steam distillation and subjected to fractionation for purification, flavonoids rich aqueous extract is extracted from Kaempferia galangal and turmeric water extract powder is obtained from Curcuma longa . The extracts are combined together to form a complete natural matrix, homogenized and subjected to spray drying to obtain a uniform mixture in a powdered form. The composition is useful as an anti-inflammatory agent in treatment of conditions such as acute joint pain and osteoarthritis.
    • 本发明公开了一种抗炎组合物,其包含姜黄醇提取物,β-石竹烯,3-o-乙酰基-11-酮基-β-乳香酸,从Kaempferia获得的提取物 >高良姜和姜黄水提取物。 本发明还描述了一种制备含有这些提取物的组合物的方法,其主要包括从姜黄中提取姜黄素醇提取物,从齿叶乳香提取树胶脂,从提取的树胶脂中分离出AKBA并与 通过水蒸汽蒸馏从Piper nigrum分离β-磷脂,β-石竹烯并进行分馏纯化,从Kaempferia高良姜中提取富含黄酮类的水提取物并获得姜黄水提取物粉末 来自Curcuma longa 。 将提取物合并在一起形成完整的天然基质,均化并喷雾干燥以获得粉末形式的均匀混合物。 该组合物可用作治疗诸如急性关节疼痛和骨关节炎等疾病的抗炎剂。
    • 4. 发明申请
    • A PROCESS FOR PREPARATION OF BIOAVAILABLE WHITE CURCUMIN - A UNIQUE BLEND OF HYDROGENATED CURCUMINOIDS
    • 一种制备可生物降解的白矾石的方法 - 加氢的UR O A A UE IDS IDS
    • WO2016097914A1
    • 2016-06-23
    • PCT/IB2015/059348
    • 2015-12-04
    • AUREA BIOLABS PRIVATE LIMITED
    • GOPI, SreerajJACOB, JobyGEORGE, Robin
    • A61K31/045A61K31/05C07C57/42C07C57/72C07C209/26
    • A61K31/121A23L33/105A23V2002/00A61K47/6951C07C41/20C07C45/62C08B37/0015C07C43/23C07C49/225
    • The present invention discloses a process for preparation of white curcumin from purified curcuminoids. The curcuminoids are obtained by solvent extraction and crystallization of dried turmeric powder. The autoclave is charged with ethyl acetate and the 95% purity curcuminoids mixture is added to and stirred for uniformity at room temperature. 5% (w/w) of 10% palladium carbon is added to the reaction mixture and allowed for hydrogenation in the presence of hydrogen gas at 2 lbps pressure and stirred continuously for 15 hours. Once the reaction is completed, the reaction mixture is filtered and washed with ethyl acetate. The ethyl acetate is distilled off and crude mass is stirred with water to obtain a solid precipitate. Finally, the solid obtained is filtered and dried to pale brown crystals of white curcumin. White curcumin is encapsulated with beta- cyclodextrin, which exhibited increased bioavailability. White curcumin also exhibited anti-oxidant and chemopreventive activities.
    • 本发明公开了一种从纯化姜黄素制备白姜黄素的方法。 姜黄素通过溶剂萃取和结晶的姜黄粉得到。 向高压釜中加入乙酸乙酯,并将95%纯度的姜黄色调混合物加入并在室温下搅拌均匀。 将5%(w / w)的10%钯碳加入到反应混合物中,并在氢气存在下以2l / s压力进行氢化并连续搅拌15小时。 一旦反应完成,将反应混合物过滤并用乙酸乙酯洗涤。 蒸馏除去乙酸乙酯,将粗物质与水一起搅拌,得到固体沉淀物。 最后,将得到的固体过滤并干燥成白色姜黄素的淡棕色晶体。 白色姜黄素用β-环糊精包封,其呈现出增加的生物利用度。 白姜黄素还具有抗氧化和化学预防作用。