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1. 发明申请

WO2007065128A2 HUMAN ALPHA-DEFENSINS INHIBIT INTERLEUKIN-1BETA RELEASE 审中-公开
标题翻译：人类α-防御素抑制白细胞介素-1β释放
公开(公告)号：WO2007065128A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/061404
申请日：2006-11-30
申请人： AUBURN UNIVERSITY , SHI, Jishu , AONO, Shelly , LU, Wuyuan
发明人： SHI, Jishu , AONO, Shelly , LU, Wuyuan
IPC分类号： A61K38/17 , A61P29/00
CPC分类号： A61K38/1709
摘要： Human α-defensins are inhibitors of interleukin-lβ post transitional processing and release. Interleukin-lβ is a key cytokine involved in the initiation and amplification of the 5 inflammatory process, including the inflammation of diseases such as Crohn's Disease and Ulcerative Colitis. Particularly, human neutrophil defensin-1 (HNP-I) produced mainly by neutrophils, and human α-defensin 5(HD-5) produced by Paneth cells has been found to block interleukin-lβ post transitional processing and release. Thus, a pharmaceutical composition and method for treating inflammation in the mammalian tissues is herein disclosed. The pharmaceutical composition is a therapeutic supplementation of a metabolic pathway to reduce inflammation comprising a human α-defensins in a therapeutically effective amount or an amide, ester or salt thereof and a pharmaceutically effective carrier. The method for treating inflammation in mammalian tissues includes administering a human α-defensins to a mammal in an amount effective to inhibit the post translational processing and release of interleukin-lβ.
摘要翻译：人α-防御素是白细胞介素-1β过渡后加工和释放的抑制剂。白细胞介素-1β是参与启动和扩增炎性过程的关键细胞因子，包括克罗恩氏病和溃疡性结肠炎等疾病的炎症。特别是，已经发现主要由嗜中性粒细胞产生的人嗜中性粒细胞防御素-1（HNP-1）和由潘氏细胞产生的人α-防御素5（HD-5）阻断白细胞介素-1β在过渡后处理和释放。因此，本文公开了用于治疗哺乳动物组织中的炎症的药物组合物和方法。所述药物组合物是治疗性补充代谢途径以减轻炎症，所述炎症包含治疗有效量的人α-防御素或其酰胺，酯或盐以及药学上有效的载体。用于治疗哺乳动物组织炎症的方法包括以有效抑制白介素-1β的翻译后加工和释放的量向哺乳动物施用人α-防御素。

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