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1. 发明申请

WO2012054297A2 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 审中-公开
标题翻译：具有可折叠框架的INTRAGASTRIC植入物
公开(公告)号：WO2012054297A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056167
申请日：2011-10-13
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P. , BABKES, Mitchell H. , SCHWAB, Justin J. , MUDD, Christopher S. , HOOVER, Jason
发明人： DOMINGUEZ, Zachary P. , BABKES, Mitchell H. , SCHWAB, Justin J. , MUDD, Christopher S. , HOOVER, Jason
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了口腔肥胖治疗装置及其操作的相关方法，其占据胃内空间和/或刺激胃壁。口腔肥胖治疗装置和相关方法旨在帮助患者维持健康的体重。这些装置的特征包括经口插入并且没有侵入性手术，没有相关的患者侵入性手术风险，并且没有实质性的患者不适。这些装置的使用寿命可能与材料有关，因为这些装置在酸性胃中具有长期生存能力，但意图持续一年或更长时间。这些装置具有能够在尺寸上变化的能力，并且期望自动致动，因为它们使用内部马达或致动器改变形状和/或体积。装置的变化特征有助于防止人的胃部对种植体进行补偿，例如有时会发生静态的胃内装置。

2. 发明申请

WO2012054519A2 REACTIVE INTRAGASTRIC IMPLANT DEVICES 审中-公开
标题翻译：反应性入口植入装置
公开(公告)号：WO2012054519A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056761
申请日：2011-10-18
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , BABKES, Mitchell H.
发明人： DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , BABKES, Mitchell H.
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： Transoral three-dimensionally orthogonal intragastric spring systems, devices, methods of operation and manufacture are provided. A transoral three-dimensionally orthogonal intragastric spring system and/or device (and related methods of manufacture and operation) may reduce obesity or weight by stimulating the stomach walls of the patient. The three- dimensionally orthogonal intragastric spring device may be a purely mechanical device comprising a flexible body which in response to an input force in one direction, may deform and cause a resultant displacement in an orthogonal direction, thereby exerting a pressure on the inner stomach walls of the patient. Alternatively, a three-dimensionally orthogonal intragastric spring device may include a variable size balloon configured to occupy volume in the patient's stomach, thereby reducing the amount of space in the patient's stomach.
摘要翻译：提供经口三维正交的胃内弹簧系统，装置，操作和制造方法。经口三维正交的胃内弹簧系统和/或装置（以及相关的制造和手术方法）可以通过刺激患者的胃壁来减轻肥胖或体重。三维正交的胃内弹簧装置可以是纯粹的机械装置，其包括柔性体，其响应于一个方向上的输入力而变形并导致在正交方向上的合成位移，从而对内壁壁施加压力的病人。或者，三维正交的胃内弹簧装置可以包括构造成占据患者胃中的体积的可变大小的气囊，从而减少患者胃中的空间量。

3. 发明申请

WO2012054413A3 SPACE-FILLING INTRAGASTRIC IMPLANTS WITH FLUID FLOW 审中-公开
公开(公告)号：WO2012054413A3
公开(公告)日：2012-04-26
申请号：PCT/US2011/056608
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J.
IPC分类号： A61F5/00
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Also, certain devices slow gastric emptying by blocking or otherwise impeding flow through the pyloric sphincter. A number of devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.

4. 发明申请

WO2012054598A2 NON-INFLATABLE GASTRIC IMPLANTS AND SYSTEMS 审中-公开
标题翻译：不可燃气体植入物和系统
公开(公告)号：WO2012054598A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056880
申请日：2011-12-02
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , HOOVER, Jason
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , HOOVER, Jason
CPC分类号： A61F5/0036 , A61F5/0089
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, or the greater and lesser curvatures in the middle of the stomach, to stimulate satiety-inducing nerves. Some devices may combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖症治疗的各种被动胃内植入装置。这种被动装置不会自主地改变形状，而是在胃内反应以引起饱腹感。这些装置可能占据胃内的体积，从而降低进气能力。另外，装置可以接触胃内的区域，例如围绕食管括约肌的贲门，或胃中部的较大和较小的曲率，以刺激饱腹引起的神经。一些装置可以组合这些饱腹感诱发特征中的两种或更多种。公开了植入物的方法，包括压缩输送管内的装置并且经由食道经过胃内部署的装置经过前进。相反的移除设备。

5. 发明申请

WO2012051108A2 RE-SHAPING INTRAGASTRIC IMPLANTS 审中-公开
标题翻译：重新形成的INTRAGASTRIC植入
公开(公告)号：WO2012051108A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/055598
申请日：2011-10-10
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , RAVEN, Joseph S.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , RAVEN, Joseph S.
IPC分类号： A61F5/00
CPC分类号： A61F5/0036
摘要： The present application provides implantable intragastric devices for the treatment of obesity. The intragastric devices advantageously act as a volume-occupying device, and is able to survive implantation in a patient's stomach for a year or longer. In addition, the intragastric devices may be configured to stimulate an inner stomach wall and/or temporarily block the pylorus to slow gastric emptying and/or be rotationally variant, thereby encouraging different stimulation points on the inner wall of the stomach and limiting the stomach's ability to adapt over long term implantation. The intragastric devices may reshape the stomach cavity, such as by pushing on opposite sides so as to "planarize" the stomach. For instance, the device may be an inflated disk, or an implantable loop or a springy coil that may be straightened for delivery/extraction yet assume the loop or coil shape upon implant.
摘要翻译：本申请提供了用于治疗肥胖症的可植入胃内装置。胃内装置有利地用作体积占用装置，并且能够在患者的胃中植入一年或更长时间。此外，胃内装置可构造成刺激胃内壁和/或暂时阻塞幽门以减缓胃排空和/或旋转变化，从而促进胃内壁上的不同刺激点并限制胃的能力以适应长期植入。胃内装置可以重塑胃腔，例如通过推动相对侧以便“平面化” 胃。例如，该装置可以是充气盘，或者可植入环或弹性线圈，其可以被拉直以用于递送/提取，但是在植入时呈现环或线圈形状。

6. 发明申请

WO2012125700A2 SELF-ADJUSTING GASTRIC BAND 审中-公开
标题翻译：自我调节胃带
公开(公告)号：WO2012125700A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029041
申请日：2012-03-14
申请人： ALLERGAN, INC. , SNOW, Sean , BABKES, Mitchell H. , BORRELL, Marcos , DEUEL, Christopher R. , DOMINGUEZ, Zachary P. , FRANKLIN, Ethan , HONARYAR, Babak , TORJESEN, Erik
发明人： SNOW, Sean , BABKES, Mitchell H. , BORRELL, Marcos , DEUEL, Christopher R. , DOMINGUEZ, Zachary P. , FRANKLIN, Ethan , HONARYAR, Babak , TORJESEN, Erik
IPC分类号： A61F5/00 , A61B5/00
CPC分类号： A61F5/0056
摘要： Generally described herein are automatic, self-adjusting, gastric banding systems and improvements thereof, that are capable of automatically relaxing and contracting in response to a large bolus passing through the area of a patient's stomach constricted by a gastric band. Alternatively, and/or in addition in one or more embodiments, the gastric banding systems described herein may also help prevent pouch dilatation and/or erosion. The apparatus and systems described herein aid in facilitating obesity control and/or treating obesity-related diseases while generally being non-invasive once implanted. Furthermore, certain embodiments of the self-adjusting gastric banding systems disclosed herein are automatically adjustable without complicated fluid control mechanisms, flow rate limiting devices, and/or valves. The automatic adjustments may also be made in response to other changes in the patient's esophageal-gastric junction, for example, in response to size, shape, and or location changes.
摘要翻译：这里一般描述的是自动的，自我调节的胃束带系统及其改进，其能够响应于大丸通过患者胃的区域而自动松弛和收缩，所述胃受到胃带。可替代地和/或另外在一个或多个实施例中，本文所述的胃束带系统还可以帮助防止囊扩张和/或侵蚀。本文所述的装置和系统有助于促进肥胖控制和/或治疗肥胖相关疾病，而一旦植入则通常是非侵入性的。此外，本文公开的自调节胃束带系统的某些实施例可自动调节而无需复杂的流体控制机构，流量限制装置和/或阀。例如，响应于患者的食管 - 胃交界处的其他变化，响应于尺寸，形状和/或位置变化，也可以进行自动调整。

7. 发明申请

WO2012054522A2 ANCHORED NON-PIERCING DUODENAL SLEEVE AND DELIVERY SYSTEMS 审中-公开
标题翻译：锚定式非连接套管和输送系统
公开(公告)号：WO2012054522A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056765
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
IPC分类号： A61F5/00
CPC分类号： A61F5/0079 , A61F5/0076
摘要： An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.
摘要翻译：公开了一种用于肥胖症治疗的胃内植入物。该装置通过提供十二指肠套管来延缓消化，并且还可以通过限制通过幽门括约肌的流动来减缓胃排空。植入物包括细长的可轴向压缩的十二指肠套管，其具有在近端上的非组织刺穿锚固件，其大小设置在十二指肠球囊内。锚固件可以具有相反方向的锚固凸缘以抵抗两个方向的迁移。套筒还可以具有倒钩肋，以抵抗近端移动回到胃中。一种植入物的方法包括塌缩/压缩装置，并将其经过食道通过其前端部署在十二指肠内。可溶解的护套可以限制植入物用于递送，并且在植入时自然地溶解。相反，可能会发生植入物的移除。

8. 发明申请

WO2012054514A2 INTRAGASTRIC IMPLANTS WITH DUODENAL ANCHORS 审中-公开
标题翻译：带有DUODENAL锚杆的INTRAGASTRIC植入物
公开(公告)号：WO2012054514A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056753
申请日：2011-10-18
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P. , RAVEN, Joseph S. , BABKES, Mitchell H.
发明人： DOMINGUEZ, Zachary P. , RAVEN, Joseph S. , BABKES, Mitchell H.
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036 , A61F5/0079
摘要： Intragastric fluid transfer devices and related methods for operation thereof are disclosed. The intragastric fluid transfer devices and related methods are intended to assist a patient in maintaining a healthy body weight by stimulating the inner stomach walls and/or the inner duodenum walls. Features of the intragastric fluid transfer device include insertion of the devices transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these intragastric fluid transfer devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer.
摘要翻译：公开了胃内液体输送装置及其操作方法。胃内液体输送装置和相关方法旨在通过刺激内部胃壁和/或十二指肠内壁来帮助患者维持健康体重。胃内液体输送装置的特征包括经皮和无侵入性手术的装置插入，无相关患者的侵入性手术风险，并且没有实质的患者不适。这些胃内液体输送装置的使用寿命可以依赖于在酸性胃内的长期生存性，但是持续一年或更长时间。

9. 发明申请

WO2012054411A2 UPPER STOMACH GASTRIC IMPLANTS 审中-公开
标题翻译：上部胃癌植入物
公开(公告)号：WO2012054411A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056606
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P.
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may provide slowed entry into the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Some devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse. The implants are formed of materials that permit the implant to be compressed into a substantially linear transoral delivery configuration and that will resist degradation over a period of at least six months within the stomach.
摘要翻译：公开了用于肥胖治疗的各种被动胃内植入装置。这种被动装置不会自动改变形状，而是在胃内反应以引起饱腹感。这些装置可能会减缓进入胃部的速度，从而降低进气量。另外，装置可以接触胃内的区域，例如围绕食道括约肌的贲门，以刺激引起饱腹感的神经。一些装置结合了两种或更多种这些引起饱腹感的特征。公开了植入方法，包括压缩输送管内的装置并且经由食道经口腔推进装置以部署在胃内。反过来拆除设备。植入物由允许植入物被压缩成基本上线性的经口输送构造并且在胃内至少六个月内抵抗降解的材料形成。

10. 发明申请

WO2012054410A3 INTRAGASTRIC IMPLANTS WITH MULTIPLE FLUID CHAMBERS 审中-公开
公开(公告)号：WO2012054410A3
公开(公告)日：2012-04-26
申请号：PCT/US2011/056605
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , OLROYD, Craig , D'AUGUSTA, Jonathan M.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , OLROYD, Craig , D'AUGUSTA, Jonathan M.
IPC分类号： A61F5/00 , A61B10/00
摘要： An intragastric obesity treatment implant promotes a feeling of satiety in the patient by contacting the insides of the stomach wall, reducing the space in the stomach, or otherwise reducing the amount of food consumed. One intragastric obesity treatment implant two inflatable balloons coupled via a flow restrictor through which fluid may flow in response to peristaltic motions of a patient's stomach. Additionally, one implant comprises a pumping chamber coupled to a reservoir, where the pumping chamber moves stomach fluids into the reservoir in response to peristaltic motions of the patient's stomach.

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