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1. 发明申请

WO2011116090A1 ANTI-NERVE GROWTH FACTOR (NGF) ANTIBODY COMPOSITIONS 审中-公开
标题翻译：抗神经生长因子（NGF）抗体组合物
公开(公告)号：WO2011116090A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028659
申请日：2011-03-16
申请人： ABBOTT RESEARCH B.V. , FRAUNHOFER, Wolfgang , CHARI, Ravi , KUMAR, Vineet , SAEDLER, Rainer , SIEDLER, Michael , STINE, William, B. , WEBER, Carsten
发明人： FRAUNHOFER, Wolfgang , CHARI, Ravi , KUMAR, Vineet , SAEDLER, Rainer , SIEDLER, Michael , STINE, William, B. , WEBER, Carsten
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , C07K16/22
CPC分类号： C07K16/22 , A61K39/39591 , A61K47/183 , C07K2317/53 , C07K2317/94
摘要： The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders.
摘要翻译：本发明涉及抗NGF抗体及其抗原结合片段的稳定组合物及其在预防和/或治疗其中NGF活性有害的各种疾病和病症（例如疼痛障碍）中的用途。

2. 发明申请

WO2005120595A2 IN SITU HARDENING PASTE, ITS MANUFACTURING AND USE 审中-公开
标题翻译：在SITU硬化膏，其制造和使用
公开(公告)号：WO2005120595A2
公开(公告)日：2005-12-22
申请号：PCT/EP2005/006204
申请日：2005-06-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , POMPE, Cornelius
发明人： HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , POMPE, Cornelius
IPC分类号： A61L27/00
CPC分类号： A61L27/46 , A61F2/28 , A61F2/4601 , A61F2002/2817 , A61F2002/30062 , A61F2002/30583 , A61F2002/30766 , A61F2210/0004 , A61F2210/0085 , A61F2310/00293 , A61L27/446 , A61L27/48 , A61L27/502 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/414 , A61L2300/43
摘要： An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the filed' of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation.
摘要翻译：开发了含有有机或无机填充材料，生物可降解聚合物和水溶性聚合物增塑剂的原位硬化浆料作为在组织再生领域具有支架特性的活性剂的递送系统。硬化浆料足够机械稳定，可用作骨和软骨替代基质。所有组分都是完全生物相容的，优选是生物可再吸收的并经过非肠道应用的认证。肽和蛋白质的持续释放可以通过组合物和工艺设计来调节。本发明包括一种药物组合物，其包含本发明的糊剂，并且涉及所述糊剂用于制备用于骨增大，用于治疗骨缺损，用于治疗退行性和创伤性椎间盘疾病，用于治疗骨骼的药物组合物的用途开裂或用于窦底抬高。

3. 发明申请

WO2005120454A2 COMPOSITE MATERIAL FOR USE AS PROTEIN CARRIER 审中-公开
标题翻译：用作蛋白载体的复合材料
公开(公告)号：WO2005120454A2
公开(公告)日：2005-12-22
申请号：PCT/EP2005/006206
申请日：2005-06-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas
发明人： HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas
IPC分类号： A61K9/00
CPC分类号： A61L27/54 , A61L27/26 , A61L27/42 , A61L2300/252 , A61L2300/414 , A61L2300/602
摘要： The present invention relates to a material having osteoinductive and osteoconductive properties in vivo comprising a ceramic carrier, preferably containing calcium phosphate, and an active agent, preferably an osteoinductive protein / peptide or a drug, and a polymer, wherein the active agent is homogeneously coated on the carrier and within the polymer, which is preferably a degradable polymer. Said polymer modulates the release kinetic of the active agent and protects same from degradation to prolong the half-life in vivo. Moreover, the present invention relates to a method for the production of a material having osteoinductive and osteoconductive properties in vivo.
摘要翻译：本发明涉及在体内具有骨诱导和骨传导性质的材料，其包含优选含有磷酸钙的陶瓷载体，以及活性剂，优选骨诱导蛋白/肽或药物和聚合物，其中活性剂均匀地涂覆在载体上和聚合物内，其优选是可降解聚合物。所述聚合物调节活性剂的释放动力学并保护其免受降解以延长体内半衰期。此外，本发明涉及一种在体内生产具有骨诱导和骨传导性质的材料的方法。

4. 发明申请

WO2005120595A3 IN SITU HARDENING PASTE, ITS MANUFACTURE AND USE 审中-公开
标题翻译：在SITU硬化膏，其制造和使用
公开(公告)号：WO2005120595A3
公开(公告)日：2006-05-26
申请号：PCT/EP2005006204
申请日：2005-06-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND KLAUS , SIEDLER MICHAEL , SCHUETZ ANDREAS , POMPE CORNELIUS , FRIESS WOLFGANG
发明人： HELLERBRAND KLAUS , SIEDLER MICHAEL , SCHUETZ ANDREAS , POMPE CORNELIUS , FRIESS WOLFGANG
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/00 , A61L27/12 , A61L27/34 , A61L27/44 , A61L27/46 , A61L27/48 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L27/46 , A61F2/28 , A61F2/4601 , A61F2002/2817 , A61F2002/30062 , A61F2002/30583 , A61F2002/30766 , A61F2210/0004 , A61F2210/0085 , A61F2310/00293 , A61L27/446 , A61L27/48 , A61L27/502 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/414 , A61L2300/43
摘要： An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the filed' of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation.
摘要翻译：开发了含有有机或无机填充材料，生物可降解聚合物和水溶性聚合物增塑剂的原位硬化浆料作为在组织再生领域具有支架特性的活性剂的递送系统。硬化浆料足够机械稳定，可用作骨和软骨替代基质。所有组分都是完全生物相容的，优选是生物可再吸收的并经过非肠道应用的认证。肽和蛋白质的持续释放可以通过组合物和工艺设计来调节。本发明包括一种药物组合物，其包含本发明的糊剂，并且涉及所述糊剂用于制备用于骨增大，用于治疗骨缺损，用于治疗退行性和创伤性椎间盘疾病，用于治疗骨骼的药物组合物的用途开裂或用于窦底抬高。

5. 发明申请

WO2005089829A3 COATED IMPLANTS, THEIR MANUFACTURING AND USE THEREOF 审中-公开
公开(公告)号：WO2005089829A3
公开(公告)日：2005-09-29
申请号：PCT/EP2005/002506
申请日：2005-03-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , SCHIMKAT, Bernd , WIEDENMANN-SCHLEMBACH, Karin
发明人： HELLERBRAND, Klaus , SIEDLER, Michael , SCHÜTZ, Andreas , SCHIMKAT, Bernd , WIEDENMANN-SCHLEMBACH, Karin
IPC分类号： B65B55/00
摘要： The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container. Moreover said packaging container relates to the use of said method of coating a packaging container for improving and/or controlling the distribution coefficient of the substance to be coated on said device between said container and said device Furthermore, the present invention encompasses a coated device, preferably an implant, obtainable by a method according to the present invention. The present invention also relates to the use of said method of coating devices for improving the homogeneous distribution of the coating on the device. Finally, the present invention relates to the use of said method of coating a packaging container for improving and/or controlling the distribution coefficient of the substance to be coated on said device between said container and said device.

6. 发明申请

WO2008000488A1 BIOMATERIAL CONTAINING DEGRADATION STABILIZED POLYMER 审中-公开
标题翻译：含生物降解稳定聚合物
公开(公告)号：WO2008000488A1
公开(公告)日：2008-01-03
申请号：PCT/EP2007/005752
申请日：2007-06-28
申请人： SCIL TECHNOLOGY GMBH , FRIESS, Wolfgang , HELLERBRAND, Klaus , HERBERG, Samuel , POMPE, Cornelius , SCHUETZ, Andreas , SIEDLER, Michael
发明人： FRIESS, Wolfgang , HELLERBRAND, Klaus , HERBERG, Samuel , POMPE, Cornelius , SCHUETZ, Andreas , SIEDLER, Michael
IPC分类号： A61L27/58 , A61L27/50
CPC分类号： C08L67/04 , A61L27/505 , A61L27/58
摘要： The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.
摘要翻译：本发明涉及包含水结合剂的聚合物基材料，而水结合剂以足以化学和/或物理吸收和/或吸附水的量存在以防止聚合物降解。它还涉及包含增塑剂或有机溶剂的聚合物基材料以及包含第二聚合物和/或活性剂的材料的多组分材料或复合材料。此外，本发明涉及制备包含材料的聚合物的方法和用于制备用于治疗骨，软骨和/或牙周缺陷的药物组合物的材料的用途。本发明还包括使用聚合物材料的试剂盒。此外，本发明包括水粘合剂用于抑制包含材料的聚合物的水诱导降解的用途，用于在包含聚合物的材料中诱导血块稳定性并增加包含材料的聚合物的储存稳定性，其中水结合剂在施加材料之前不被去除。

7. 发明申请

WO2005120454A3 COMPOSITE MATERIAL FOR USE AS PROTEIN CARRIER 审中-公开
标题翻译：用作蛋白载体的复合材料
公开(公告)号：WO2005120454A3
公开(公告)日：2006-04-06
申请号：PCT/EP2005006206
申请日：2005-06-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND KLAUS , SIEDLER MICHAEL , SCHUETZ ANDREAS
发明人： HELLERBRAND KLAUS , SIEDLER MICHAEL , SCHUETZ ANDREAS
IPC分类号： A61K9/00 , A61L27/26 , A61L27/42 , A61L27/54
CPC分类号： A61L27/54 , A61L27/26 , A61L27/42 , A61L2300/252 , A61L2300/414 , A61L2300/602
摘要： The present invention relates to a material having osteoinductive and osteoconductive properties in vivo comprising a ceramic carrier, preferably containing calcium phosphate, and an active agent, preferably an osteoinductive protein / peptide or a drug, and a polymer, wherein the active agent is homogeneously coated on the carrier and within the polymer, which is preferably a degradable polymer. Said polymer modulates the release kinetic of the active agent and protects same from degradation to prolong the half-life in vivo. Moreover, the present invention relates to a method for the production of a material having osteoinductive and osteoconductive properties in vivo.
摘要翻译：本发明涉及在体内具有骨诱导和骨传导性质的材料，其包含优选含有磷酸钙的陶瓷载体，以及活性剂，优选骨诱导蛋白/肽或药物和聚合物，其中活性剂均匀地涂覆在载体上和聚合物内，其优选是可降解聚合物。所述聚合物调节活性剂的释放动力学并保护其免受降解以延长体内半衰期。此外，本发明涉及一种在体内生产具有骨诱导和骨传导性质的材料的方法。

8. 发明申请

WO2007068489A3 A MOLDABLE BIOMATERIAL FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的可模制生物材料
公开(公告)号：WO2007068489A3
公开(公告)日：2007-08-02
申请号：PCT/EP2006012082
申请日：2006-12-14
申请人： SCIL TECHNOLOGY GMBH , SIEDLER MICHAEL , HELLERBRAND KLAUS , SCHUETZ ANDREAS , KRUEGER SABRINA
发明人： SIEDLER MICHAEL , HELLERBRAND KLAUS , SCHUETZ ANDREAS , KRUEGER SABRINA
IPC分类号： A61L27/12 , A61L27/56
CPC分类号： A61L27/56 , A61L27/58
摘要： The present invention is directed to a moldable biomaterial comprising a particulate solid porous material and a biodegradable paste material. The paste material and the particulate solid porous material form a matrix usable for the replacement or augmentation of bone. In various embodiments the matrix has a high structural integrity, which does not immediately or shortly after implantation collapse into an amorphous non-porous mass, maintains its porosity after implantation, shows biphasic degradation after implantation and/or has a good resistance against being washed out when it is applied to a wet opened implant site. Active agents can be incorporated in the moldable biomaterial of the present invention, such as bone growth factors. Kits, implants, method of manufacturing as well as medicinal uses are also provided.
摘要翻译：本发明涉及包含颗粒状固体多孔材料和可生物降解的糊状材料的可模制生物材料。糊剂材料和颗粒状固体多孔材料形成可用于替换或增加骨骼的基质。在各种实施方案中，基质具有高结构完整性，其在植入后不立即或不短时间内塌陷成无定形非多孔物质，在植入后保持其孔隙度，在植入后显示双相降解和/或具有良好的抗冲刷性当它被应用到湿开放的植入部位时。活性剂可以掺入本发明的可模制生物材料中，例如骨生长因子。还提供了套件，植入物，制造方法以及医药用途。

9. 发明申请

WO2005089829A2 COATED IMPLANTS, THEIR MANUFACTURING AND USE THEREOF 审中-公开
标题翻译：有涂层的植物，他们的制造和使用
公开(公告)号：WO2005089829A2
公开(公告)日：2005-09-29
申请号：PCT/EP2005002506
申请日：2005-03-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND KLAUS , SIEDLER MICHAEL , SCHUETZ ANDREAS , SCHIMKAT BERND , WIEDENMANN-SCHLEMBACH KARIN
发明人： HELLERBRAND KLAUS , SIEDLER MICHAEL , SCHUETZ ANDREAS , SCHIMKAT BERND , WIEDENMANN-SCHLEMBACH KARIN
IPC分类号： A61B17/72 , A61B17/80 , A61B17/86 , A61B19/00 , A61B19/02 , A61C8/00 , A61F2/00 , A61J1/00 , A61L27/28 , A61L27/34 , A61L27/54 , A61L31/08 , A61L31/10 , A61L31/16 , B05C3/00 , B05C3/02 , B65B55/00 , A61L31/00
CPC分类号： A61L27/54 , A61B17/72 , A61B17/7291 , A61B17/80 , A61B17/865 , A61B17/866 , A61B50/30 , A61C8/0012 , A61C8/0013 , A61C8/0087 , A61F2/0077 , A61F2240/001 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2420/02 , B05C3/02 , B65B55/00 , C23C10/20 , C23C26/00
摘要： The present invention relates to a method of coating of a device, preferably implants, with a substance comprising the steps of (a) contacting said device into a solution of said substrate or substance, and (b) drying said device while being submerged in said solution. The present invention also relates to a packaging container for a device, preferably an implant. Said packaging container being adapted such that said device is coatable within said packaging container. Moreover, the present invention relates to a method of coating the inner surfaces of a packaging container for a device, preferably implants, to be coated by a substance, comprising the steps of (a) siliconizing said inner surfaces of said container using a silicone emulsion, and (b) heat-curing to form a baked-in silicone layer on said inner surfaces of said container. Moreover said packaging container relates to the use of said method of coating a packaging container for improving and/or controlling the distribution coefficient of the substance to be coated on said device between said container and said device Furthermore, the present invention encompasses a coated device, preferably an implant, obtainable by a method according to the present invention. The present invention also relates to the use of said method of coating devices for improving the homogeneous distribution of the coating on the device. Finally, the present invention relates to the use of said method of coating a packaging container for improving and/or controlling the distribution coefficient of the substance to be coated on said device between said container and said device.
摘要翻译：本发明涉及一种用物质涂覆装置，优选植入物的方法，包括以下步骤：（a）使所述装置接触所述基底或物质的溶液，和（b）干燥所述装置同时浸没在所述解。本发明还涉及用于装置，优选植入物的包装容器。所述包装容器适于使得所述装置可涂覆在所述包装容器内。此外，本发明涉及一种涂覆用于待被物质涂覆的装置，优选植入物的包装容器的内表面的方法，包括以下步骤：（a）使用硅氧烷乳液将所述容器的内表面硅化（b）热固化以在所述容器的所述内表面上形成烘烤的硅氧烷层。此外，所述包装容器涉及使用所述涂覆包装容器的方法来改进和/或控制所述容器与所述装置之间的所述装置上待涂覆物质的分配系数。此外，本发明包括涂覆装置，优选为可通过根据本发明的方法获得的植入物。本发明还涉及所述涂布装置的方法用于改进装置上涂层的均匀分布的用途。最后，本发明涉及涂覆包装容器的所述方法的用途，所述包装容器用于改进和/或控制所述容器与所述装置之间的所述装置上待涂覆物质的分配系数。

10. 发明申请

WO2009090189A1 POWDERED PROTEIN COMPOSITIONS AND METHODS OF MAKING SAME 审中-公开
标题翻译：粉末蛋白质组合物及其制备方法
公开(公告)号：WO2009090189A1
公开(公告)日：2009-07-23
申请号：PCT/EP2009/050385
申请日：2009-01-14
申请人： ABBOTT GmbH & Co.KG , ADLER, Michael , KRAUSE, Hans-Juergen , SIEDLER, Michael , LASSNER, Peter , LEE, Geoffrey
发明人： ADLER, Michael , KRAUSE, Hans-Juergen , SIEDLER, Michael , LASSNER, Peter , LEE, Geoffrey
IPC分类号： A61K9/14 , A61K9/16 , A61K31/70 , A61K31/715 , A61K38/02 , A61K39/00 , A61K47/26
CPC分类号： A61K31/70 , A61K9/1605 , A61K31/715 , A61K39/39591 , A61K47/26 , C07K16/241 , C07K2317/55
摘要： A method for preparing a protein or peptide powder is provided that includes spray drying a solution including more than, e.g., about 50 mg/mL of a protein or peptide (e.g., an antibody or antigen binding protion thereof), and at least one excipient. Also provided are stable powdered compositions including a protein and an excipient having less than, e.g., about 6% residual moisture.
摘要翻译：提供了一种制备蛋白质或肽粉末的方法，其包括喷雾干燥包含超过例如约50mg / mL蛋白质或肽（例如，抗体或其抗原结合蛋白）的溶液，以及至少一种赋形剂。还提供了稳定的粉末状组合物，其包括具有小于例如约6％残留水分的蛋白质和赋形剂。

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