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    • 5. 发明申请
    • ORGANOPOLYSILOXANE COMPOSITION AND A CURED PRODUCT THEREOF
    • 有机聚硅氧烷组合物及其固化产物
    • WO2013069523A1
    • 2013-05-16
    • PCT/JP2012/078271
    • 2012-10-25
    • SHIN-ETSU CHEMICAL CO., LTD.
    • IKENO, MasayukiMATSUDA, Tsuyoshi
    • C08L83/14C08L83/05C08G77/50
    • C08L83/14C08G77/12C08G77/20C08G77/50
    • The present invention provides an organopolysiloxane composition comprising (A) a mixture of (A-1) an organopolysiloxane which has unsaturated aliphatic groups each bonded to a silicon atom at each of the both terminals and at least one silmethylene bond in the molecule, (A-2) an organopolysiloxane which has an unsaturated aliphatic group bonded to a silicon atom at only one terminal and at least one silmethylene bond in the molecule, and (A-3) an organopolysiloxane which has at least one silmethylene bond in the molecule and no unsaturated aliphatic group bonded to a silicon atom at any of the terminals; (B) an organohydrogenpolysiloxane which has at least three hydrogen atoms each bonded to a silicon atom in the molecule and (C) a catalytic amount of a hydrosilylation catalyst, and a cured product obtained by curing the composition.
    • 本发明提供了一种有机基聚硅氧烷组合物,其包含(A)(A-1)具有不饱和脂族基团的有机聚硅氧烷的混合物,所述有机聚硅氧烷各自与两个末端的硅原子键合和分子中的至少一个硅亚甲基键 -2)具有不饱和脂族基团的有机聚硅氧烷,其分子中仅具有一个末端的硅原子和至少一个二亚甲基键,和(A-3)分子中具有至少一个硅亚甲基键的有机聚硅氧烷, 任何一个末端与硅原子键合的不饱和脂族基团; (B)具有至少三个分别与硅原子键合的氢原子的有机氢聚硅氧烷和(C)催化量的氢化硅烷化催化剂,以及通过固化该组合物得到的固化物。
    • 9. 发明申请
    • A SUSTAINED-RELEASE SOLID MEDICAMENT FORM AND A METHOD FOR THE PREPARATION THEREFOF
    • 持续释放固体药物形式及其制备方法
    • WO1989005634A1
    • 1989-06-29
    • PCT/JP1988000258
    • 1988-03-11
    • SHIN-ETSU CHEMICAL CO., LTD.SEKIGAWA, FujioKOKUBO, HiroyasuONDA, Yoshiro
    • SHIN-ETSU CHEMICAL CO., LTD.
    • A61K09/52
    • A61K9/5078A61K9/1676
    • Different from conventional sustained-release granular solid medicament form of which each granule has a structure formed of a core granule containing a pharmaceutically effective ingredient and a coating layer thereon for controlling the releasing rate of the effective ingredient, each granule of the inventive medicament form has a structure formed of a core granule mainly composed of an excipient and a coating layer thereon of a cellulose ether insoluble in hot water and the pharmaceutically effective ingredient is contained in the coating layer of the cellulose ether. The granules are prepared by coating core granules of an excipient with a coating liquid which is a hot aqueous dispersion of a powdery cellulose ether insoluble in hot water and contains the pharmaceutically effective ingredient dissolved or dispersed therein. If necessary, the granules are provided with an overcoating layer of a wax-like material to further improve the controllability of the releasing rate of the effective ingredient.
    • 与常规的缓释颗粒状固体药物形式不同,其中每个颗粒具有由含有药学有效成分的核心颗粒形成的结构和其上的涂层,用于控制有效成分的释放速率,本发明药物形式的每个颗粒具有 在纤维素醚的涂层中含有由主要由赋形剂构成的核心颗粒和其上不溶于热水的纤维素醚和其药学上有效成分的涂层形成的结构。 通过涂覆赋形剂的核心颗粒来制备颗粒,所述涂布液是不溶于热水的粉末状纤维素醚的热水分散体,并含有溶解或分散在其中的药学有效成分。 如果需要,颗粒设置有蜡状材料的外涂层,以进一步提高有效成分的释放速率的可控性。