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1. 发明申请

WO2012174276A3 COMPRESSION DEVICE 审中-公开
公开(公告)号：WO2012174276A3
公开(公告)日：2012-12-20
申请号：PCT/US2012/042510
申请日：2012-06-14
申请人： PORTABLE THERAPEUTIX, LLC , SCHUBERT, Shai Yehoshua
发明人： SCHUBERT, Shai Yehoshua
IPC分类号： A61H23/04 , A61F13/06 , A61F13/10 , A61F7/00
摘要： Described are improved apparatus and devices for intermittently and sequentially compressing a body site and methods for using said apparatus and devices, especially for site specific treatment to achieve a desired temperature of the underlying tissue. The apparatus includes a first segment cooperative with a fluid chamber, the fluid chamber adapted for inflation by fluid; and a second segment cooperative with the first segment, the second segment housing a temperature sensitive material, wherein the temperature sensitive material is uniquely compartmentalized in the second segment.

2. 发明申请

WO2008121422A2 IMPLANTABLE CELL MATRIX COMPOSITION FOR DELIVERY OF BIOACTIVE COMPOUNDS 审中-公开
标题翻译：用于输送生物化合物的可植入细胞基质组合物
公开(公告)号：WO2008121422A2
公开(公告)日：2008-10-09
申请号：PCT/US2008/004311
申请日：2008-04-01
申请人： MOMA THERAPEUTICS , SCHUBERT, Shai, Yehoshua
发明人： SCHUBERT, Shai, Yehoshua
IPC分类号： C12N5/00
CPC分类号： A61L27/3804 , A01K67/0271 , A01K2207/30 , A01K2227/105 , A01K2267/0375 , A61L27/3839 , A61L27/52
摘要： This invention relates to methods and compositions for cell therapy which employ monocytic cells (e.g., monocytes) placed in a matrix, which can then be implanted at a selected site in the body and deliver localized, controlled doses of therapeutic products produced and secreted by the monocytes. The invention further relates to kits and methods for creating and using the matrix containing the monocytic cells.
摘要翻译：本发明涉及使用放置在基质中的单核细胞（例如单核细胞）的细胞疗法的方法和组合物，其然后可以植入体内选定的部位并递送局部控制剂量的治疗产物产生和分泌的治疗产品单核细胞。本发明还涉及用于产生和使用含有单核细胞的基质的试剂盒和方法。

3. 发明申请

WO2009020651A4 MATERIALS AND METHODS FOR TREATING SKELETAL SYSTEM DAMAGE AND PROMOTING SKELETAL SYSTEM REPAIR AND REGENERATION 审中-公开
公开(公告)号：WO2009020651A4
公开(公告)日：2009-02-12
申请号：PCT/US2008/009543
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , NG, Yin, Shan , TJIN THAM SJIN, Robert , SCHUBERT, Shai , BIRKHEAD, James, Richard
发明人： NUGENT, Helen, Marie , NG, Yin, Shan , TJIN THAM SJIN, Robert , SCHUBERT, Shai , BIRKHEAD, James, Richard
IPC分类号： A61L27/38
摘要： Disclosed herein are materials and methods suitable for treating injured, damaged or diseased mineralized and non-mineralized skeletal tissues, including bones, joints, tendons, ligaments, cartilage and/or other non-mineralized skeletal tissues. The affected structure can be treated by contacting a surface of the skeletal element at or adjacent to or in the vicinity of an area of injury, damage or disease with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected structure. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the affected structure. The composition can be a flexible planar material or a flowable composition.

4. 发明申请

WO2010060104A3 IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION 审中-公开
标题翻译：可植入的脂质体嵌入基质组合物，其用途以及聚己内酯作为用于组织再生的支架
公开(公告)号：WO2010060104A3
公开(公告)日：2010-10-28
申请号：PCT/US2009065797
申请日：2009-11-24
申请人： MOMA THERAPEUTICS , SCHUBERT SHAI YEHOSHUA
发明人： SCHUBERT SHAI YEHOSHUA
IPC分类号： A61K51/12 , A61K38/00 , A61K38/39 , A61L27/52 , A61L27/54
CPC分类号： A61L27/54 , A61K48/0016 , A61L27/18 , A61L27/222 , A61L27/24 , A61L27/3804 , A61L27/44 , A61L27/48 , A61L27/52 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/426 , A61L2300/438 , A61L2300/45 , A61L2300/626 , A61L2400/06 , C08L67/04
摘要： In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.
摘要翻译：在各种实施方案中，本发明描述了用于在应用治疗的位置局部重编程细胞的材料和方法。本发明可以用于替代丢失的细胞或恢复由于疾病，损伤或遗传缺陷而损坏的组织的功能。在不同的实施方案中，治疗包括用脂质体包埋的半固体水凝胶。脂质体可以含有效应分子或分子。当吞噬细胞如单核细胞渗入水凝胶时，它们遇到脂质体并将携带效应分子的脂质体并入细胞中。在一些实施方案中，效应分子可以是编码特定蛋白质例如转录因子的表达的遗传物质，其表达可以启动细胞的重编程。在其他实施方案中，效应分子可以诱导血管生成。在其他实施方案中，效应分子是肿瘤抗原。基质可以含有其他效应分子，其被设计为将特定细胞吸引至基质。随着基质降解或从基质中主动迁移，细胞可从基质中释放。细胞还可以保留在基质中，并保留分子，如蛋白质和激素，通过基质材料扩散到周围组织。

5. 发明申请

WO2010093753A1 DEVICES AND METHODS FOR MANIPULATING CIRCULATION IN THE CIRCULATORY SYSTEM OF A PATIENT 审中-公开
标题翻译：用于在患者循环系统中控制循环的装置和方法
公开(公告)号：WO2010093753A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023832
申请日：2010-02-11
申请人： PERFUZIA MEDICAL, INC. , BRINK-DANAN, Sagi , SCHUBERT, Shai, Y.
发明人： BRINK-DANAN, Sagi , SCHUBERT, Shai, Y.
IPC分类号： A61F13/00
CPC分类号： A61F13/0203 , A61F13/00051 , A61F2013/00174 , A61F2013/00523 , A61F2013/00646 , A61F2013/00919 , A61H23/04 , A61H2201/165 , A61H2205/10 , A61M1/0088
摘要： A device for manipulating circulation in the circulatory system of the body of a subject is disclosed. The device includes a flexible support dimensioned for covering a section of the body of the subject, a vibration inducing element embedded in or attached to the support. The support includes a patch and an attachment layer on the patch. The attachment layer includes a biocompatible adhesive suitable for attaching the patch to skin on the section of the body of the subject. The vibration inducing element is positioned in or on the support such that the vibration inducing element can transmit vibrations to the skin when the patch is adhered to the skin on the section of the body of the subject.
摘要翻译：公开了一种用于操纵被检体的循环系统中循环的装置。该装置包括尺寸适于覆盖被检体的主体的一部分的柔性支撑件，嵌入或附接到支撑件的振动元件。支持包括补丁上的补丁和附件层。附着层包括适于将贴片附着到受试者身体部分上的皮肤的生物相容性粘合剂。振动诱导元件定位在支撑件中或支撑件上，使得当贴片粘附到被检体的身体部分上的皮肤时，振动引发元件可以向皮肤传递振动。

6. 发明申请

WO2009020651A3 MATERIALS AND METHODS FOR TREATING SKELETAL SYSTEM DAMAGE AND PROMOTING SKELETAL SYSTEM REPAIR AND REGENERATION 审中-公开
标题翻译：治疗骨骼系统损伤和促进骨骼系统修复和再生的材料和方法
公开(公告)号：WO2009020651A3
公开(公告)日：2010-01-21
申请号：PCT/US2008009543
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , NG YIN SHAN , TJIN THAM SJIN ROBERT , SCHUBERT SHAI , BIRKHEAD JAMES RICHARD
发明人： NUGENT HELEN MARIE , NG YIN SHAN , TJIN THAM SJIN ROBERT , SCHUBERT SHAI , BIRKHEAD JAMES RICHARD
IPC分类号： A61L27/38
CPC分类号： A61L27/3843 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/45
摘要： Disclosed herein are materials and methods suitable for treating injured, damaged or diseased mineralized and non-mineralized skeletal tissues, including bones, joints, tendons, ligaments, cartilage and/or other non-mineralized skeletal tissues. The affected structure can be treated by contacting a surface of the skeletal element at or adjacent to or in the vicinity of an area of injury, damage or disease with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected structure. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the affected structure. The composition can be a flexible planar material or a flowable composition.
摘要翻译：本文公开了适用于治疗受损，受损或患病矿化和非矿化骨骼组织（包括骨，关节，肌腱，韧带，软骨和/或其他非矿化骨骼组织）的材料和方法。受影响的结构可以通过将骨骼元件的表面与伤口，损伤或疾病的区域相邻或邻近地用可植入材料接触来治疗。可植入材料包含生物相容性基质和细胞，并且其量可有效治疗受影响的结构。包含生物相容性基质和植入其中或其上的细胞的组合物可用于治疗受影响的结构。该组合物可以是柔性平面材料或可流动组合物。

7. 发明申请

WO2009020650A3 MATERIALS AND METHODS FOR TREATING AND MANAGING WOUNDS AND THE EFFECTS OF TRAUMA 审中-公开
标题翻译：治疗和管理伤口的材料和方法以及TRAUMA的作用
公开(公告)号：WO2009020650A3
公开(公告)日：2009-04-02
申请号：PCT/US2008009540
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , BOLLINGER STEPHEN A , EDELMAN ELAZER R , SCHUBERT SHAI , NG YIN SHAN , TJIN THAM SJIN ROBERT
发明人： NUGENT HELEN MARIE , BOLLINGER STEPHEN A , EDELMAN ELAZER R , SCHUBERT SHAI , NG YIN SHAN , TJIN THAM SJIN ROBERT
IPC分类号： A61K35/12 , A61F2/06 , A61L27/38 , A61L29/16 , A61P17/02
CPC分类号： A61K35/44 , A61K35/36 , A61L24/0005 , A61L24/0015 , A61L27/3808 , A61L27/3813 , A61L27/3886 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2400/06
摘要： Disclosed herein are materials and methods suitable for treating traumatic injury sites resulting from wounds, surgery or other tissue disruption. Traumatic injury sites can be treated by contacting a surface of a traumatic injury at or adjacent or in the vicinity of an area of injury or damage with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the traumatic injury site. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the traumatic injury site. The composition can be a flexible planar material or a flowable composition.
摘要翻译：本文公开了适用于治疗由伤口，手术或其他组织破裂引起的创伤性损伤部位的材料和方法。创伤性损伤部位可以通过在损伤或损伤区域附近或附近与可植入材料接触创伤性损伤的表面进行治疗。可植入材料包括生物相容性基质和细胞，并且是有效治疗创伤性损伤部位的量。包含生物相容性基质和植入其中或其上的细胞的组合物可用于治疗创伤性损伤部位。组合物可以是柔性平面材料或可流动组合物。

8. 发明申请

WO2009020650A2 MATERIALS AND METHODS FOR TREATING AND MANAGING WOUNDS AND THE EFFECTS OF TRAUMA 审中-公开
标题翻译：治疗和处理创伤的材料和方法以及创伤的影响
公开(公告)号：WO2009020650A2
公开(公告)日：2009-02-12
申请号：PCT/US2008/009540
申请日：2008-08-08
申请人： PERVASIS THERAPEUTICS, INC. , NUGENT, Helen, Marie , BOLLINGER, Stephen, A. , EDELMAN, Elazer, R. , SCHUBERT, Shai , NG, Yin, Shan , TJIN THAM SJIN, Robert
发明人： NUGENT, Helen, Marie , BOLLINGER, Stephen, A. , EDELMAN, Elazer, R. , SCHUBERT, Shai , NG, Yin, Shan , TJIN THAM SJIN, Robert
IPC分类号： A61K35/12 , A61L27/38 , A61L29/16 , A61F2/06 , A61P17/02
CPC分类号： A61K35/44 , A61K35/36 , A61L24/0005 , A61L24/0015 , A61L27/3808 , A61L27/3813 , A61L27/3886 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2400/06
摘要： Disclosed herein are materials and methods suitable for treating traumatic injury sites resulting from wounds, surgery or other tissue disruption. Traumatic injury sites can be treated by contacting a surface of a traumatic injury at or adjacent or in the vicinity of an area of injury or damage with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the traumatic injury site. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the traumatic injury site. The composition can be a flexible planar material or a flowable composition.
摘要翻译：本文公开的是适用于治疗由伤口，手术或其他组织破坏引起的创伤性损伤部位的材料和方法。创伤性损伤部位可以通过使用可植入材料在损伤或损伤区域处或其附近或附近接触创伤性损伤的表面来治疗。可植入材料包含生物相容性基质和细胞，并且其量可有效治疗创伤性损伤部位。包含生物相容性基质和植入其中或其上的细胞的组合物可用于治疗创伤性损伤部位。该组合物可以是柔性平面材料或可流动组合物。

9. 发明申请

WO2008121422A3 IMPLANTABLE CELL MATRIX COMPOSITION FOR DELIVERY OF BIOACTIVE COMPOUNDS 审中-公开
标题翻译：用于递送生物活性化合物的可植入的细胞基质组合物
公开(公告)号：WO2008121422A3
公开(公告)日：2008-11-20
申请号：PCT/US2008004311
申请日：2008-04-01
申请人： MOMA THERAPEUTICS , SCHUBERT SHAI YEHOSHUA
发明人： SCHUBERT SHAI YEHOSHUA
IPC分类号： C12N5/00 , A61K47/00 , A61L27/00
CPC分类号： A61L27/3804 , A01K67/0271 , A01K2207/30 , A01K2227/105 , A01K2267/0375 , A61L27/3839 , A61L27/52
摘要： This invention relates to methods and compositions for cell therapy which employ monocytic cells (e.g., monocytes) placed in a matrix, which can then be implanted at a selected site in the body and deliver localized, controlled doses of therapeutic products produced and secreted by the monocytes. The invention further relates to kits and methods for creating and using the matrix containing the monocytic cells.
摘要翻译：本发明涉及用于细胞治疗的方法和组合物，其使用放置在基质中的单核细胞（例如单核细胞），然后可将其植入体内选定的部位并递送局部控制剂量的治疗产物，单核细胞。本发明还涉及用于产生和使用含有单核细胞的基质的试剂盒和方法。

10. 发明申请

WO2012116038A3 ACTUATOR FOR DELIVERY OF VIBRATORY STIMULATION TO AN AREA OF THE BODY AND METHOD OF APPLICATION 审中-公开
标题翻译：振动刺激传递到身体区域的执行器和应用方法
公开(公告)号：WO2012116038A3
公开(公告)日：2012-12-27
申请号：PCT/US2012026068
申请日：2012-02-22
申请人： PERFUZIA MEDICAL INC , SCHUBERT SHAI Y , BRINK-DANAN SAGI
发明人： SCHUBERT SHAI Y , BRINK-DANAN SAGI
IPC分类号： A61H1/00
CPC分类号： A61H1/00 , A61H23/02 , A61H23/0245 , A61H2201/0207 , A61H2201/0214 , A61H2201/10 , A61H2201/165 , A61H2201/1695 , A61H2201/5007 , A61H2230/00 , A61H2230/208 , A61H2230/255 , A61H2230/505 , A61H2230/605 , A61H2230/655
摘要： An actuator is disclosed for delivering mechanical vibrations to the body of a subject. The actuator includes a piezoelectric element, electrodes in electrical or wireless communication with an electrical source and the piezoelectric element to drive the piezoelectric element, a polymeric protective layer encapsulating the piezoelectric element and at least part of the electrodes, and an enclosure attached to the protective layer and defining a space between the protective layer and the enclosure allowing desired modes of vibration to develop across a surface of the protective layer that encapsulated the piezoelectric element. The actuator can include a skin attachment article having a mounting pad for attaching to the skin of the subject and for attaching the actuator and having a cover that overlies the actuator and the mounting pad when the article is attached to the skin of the subject.
摘要翻译：公开了一种用于将机械振动传递到对象身体的致动器。致动器包括压电元件，与电源电和/或无线连通的电极和驱动压电元件的压电元件，封装压电元件和电极的至少一部分的聚合物保护层以及附接到保护件并且在保护层和外壳之间限定空间，从而允许在封装压电元件的保护层的表面上形成期望的振动模式。该致动器可以包括皮肤附接物品，该皮肤附接物品具有安装垫，用于附接到对象的皮肤并用于附接致动器并且具有当物品附接到对象的皮肤上时覆盖致动器和安装垫的覆盖物。

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