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1. 发明申请

WO0103647A3 MICROBIAL PROCESS FOR PREPARING PRAVASTATIN 审中-公开
标题翻译：制备PRAVASTINTIN的微生物方法
公开(公告)号：WO0103647A3
公开(公告)日：2001-06-28
申请号：PCT/US0019384
申请日：2000-07-11
申请人： IVAX CORP , JEKKEL ANTONIA , AMBRUS GABOR , ILKOY EVA , HORVATH ILDIKO , KONYA ATTILA , SZABO ISTVAN MIHALY , NAGY ZSUZSANNA , HORVATH GYULA , MOZES JULIANNA , BARTA ISTVAN , SOMOGYI GYORGY , SALAT JANOS , BOROS SANDOR
发明人： JEKKEL ANTONIA , AMBRUS GABOR , ILKOY EVA , HORVATH ILDIKO , KONYA ATTILA , SZABO ISTVAN MIHALY , NAGY ZSUZSANNA , HORVATH GYULA , MOZES JULIANNA , BARTA ISTVAN , SOMOGYI GYORGY , SALAT JANOS , BOROS SANDOR
IPC分类号： C12P7/62 , C07C69/30 , C12P1/04 , C12P7/42 , C12P17/06 , C12R1/29 , C12R1/31 , C07C69/74 , C07C61/12 , C07C67/02
CPC分类号： C12R1/29 , C12P7/42 , C12P17/06
摘要： The present invention relates to a new microbial process for the preparation of the compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of the strain able to 6 beta -hydroxylate a compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion, which comprises cultivating a strain of the genera Micromonospora able to 6 beta -hydroxylate a compound of the general formula (II), wherein R is as defined above, on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts at 25-32 DEG C, thereafter feeding the substrate to be transformed into the developed culture, then fermenting the substrate until the end of bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.
摘要翻译：本发明涉及由通式（II）化合物制备式（I）化合物的新微生物方法，其中R +代表碱金属或铵离子，通过浸没培养菌株能够在有氧发酵中通过式（II）的化合物6β-羟基化并且通过分离和纯化在生物转化过程中形成的式（I）的产物，该方法包括培养一种小单孢菌属在含有可同化的碳源和氮源和无机盐的营养培养基中，在25-32℃下能够将通式（II）的化合物（其中R +如上所定义）6β-羟基化，然后将待转化的底物喂入显影的培养物中，然后发酵底物直至生物转化结束，然后从培养液中分离式（I）化合物，并且如果需要，将其纯化。

2. 发明申请

WO0121607A3 PROCESS FOR THE PREPARATION OF MYCOPHENOLIC ACID AND DERIVATIVES THEREOF 审中-公开
标题翻译：制备麦芽酚酸及其衍生物的方法
公开(公告)号：WO0121607A3
公开(公告)日：2001-09-07
申请号：PCT/HU0000099
申请日：2000-09-22
申请人： GYOGYSZERKUTATO INTEZET , BARTA ISTVAN , BOROS SANDOR , AMBRUS GABOR , HORVATH GYULA , SZABO ANTAL , SZABO ISTVAN MIHALY , JEKKEL ANTONIA , KONYA ATTILA , MOZES JULIANNA , SALAT JANOS , SOMOGYI GYOERGY
发明人： BARTA ISTVAN , BOROS SANDOR , AMBRUS GABOR , HORVATH GYULA , SZABO ANTAL , SZABO ISTVAN MIHALY , JEKKEL ANTONIA , KONYA ATTILA , MOZES JULIANNA , SALAT JANOS , SOMOGYI GYOERGY
IPC分类号： C07D307/88 , C12P17/04
CPC分类号： C12P17/04 , C07D307/88
摘要： The invention relates to a microbiological process for the preparation of compounds of general formula (I), wherein R1 means methyl or hydroxymethyl group and R2 stands for hydroxyl or amino group, which comprises growing a Penicillium waksmani fungal strain able to biosynthesising mycophenolic acid on a culture medium containing assimilable carbon and nitrogen sources as well as mineral salts at 22 DEG C to 30 DEG C, separating the compound of general formula (I), wherein R1 means methyl group and R2 stands for hydroxyl group, from the fermentation broth and, if desired, purifying it and, if desired, bioconverting it a) by using the cultures of Streptomyces griseoruber No. 1/6 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms as Streptomyces sp. No. 1/6 under No. NCAIM (P)B 001275 to prepare a compound of general formula (I), wherein R1 means methyl group and R2 stands for amino group; or b) by using the cultures of Streptomyces resistomycificus No. 1/28 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms under No. NCAIM (P)B 001276 to prepare a compound of general formula (I), wherein R1 means hydroxymethyl group and R2 stands for amino group on a culture medium containing assimilable carbon and nitrogen sources as well as mineral salts under submerged, aerated conditions up to completion of the bioconversion, then separating the compound of general formula (I) formed from the culture and, if desired, purifying it.
摘要翻译：本发明涉及制备通式（I）化合物的微生物方法，其中R1表示甲基或羟甲基，R2代表羟基或氨基，其包括生长青霉菌真菌菌株能够在含有可同化碳源和氮源的培养基以及22℃至30℃的无机盐中生物合成霉酚酸，分离通式（I）的化合物，其中R1表示甲基，R2表示羟基，如果需要，对其进行纯化，如果需要，将其生物转化为a）通过使用保藏在国家农业部收集的灰霉链霉菌（Streptomyces griseoruber）1/6放线菌菌株的培养物工业微生物作为在NCAIM（P）B 001275号下的链霉菌（Streptomyces sp。）1/6，制备通式（I）的化合物，其中R1表示甲基，R2表示氨基; 或b）通过使用在NCAIM（P）B 001276号国家农业和工业微生物收集库保藏的依赖于链霉菌链霉菌（Streptomyces）的1/28放线菌菌株的培养物来制备通式（I）化合物，其中R1表示羟甲基，R2代表含有可同化碳源和氮源的培养基上的氨基，以及在浸没的充气条件下直至生物转化完成的矿物盐，然后将通式 I）由培养物形成，如果需要，可以纯化。

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