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1. 发明申请

WO2011096897A1 FUNCTIONALISED ANTIFOULING COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：功能性抗反应化合物及其用途
公开(公告)号：WO2011096897A1
公开(公告)日：2011-08-11
申请号：PCT/SG2011/000052
申请日：2011-02-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , MARITIME AND PORT AUTHORITY OF SINGAPORE , CHAI, Christina Li Lin , BURKETT, Brendan Adrian , TEO, Serena Lay Ming , RITTSCHOF, Daniel , LEE, Serena Siew Chen , DICKINSON, Gary Howard , HONG, Han
发明人： CHAI, Christina Li Lin , BURKETT, Brendan Adrian , TEO, Serena Lay Ming , RITTSCHOF, Daniel , LEE, Serena Siew Chen , DICKINSON, Gary Howard , HONG, Han
IPC分类号： C07D295/185 , C07C233/11 , C07C233/08 , C09D5/16
CPC分类号： C09D5/1668 , A01N25/10 , A01N37/18 , C07C233/11 , C07C235/34 , C07D295/185 , C07D295/192 , C08F120/34 , C09D5/14 , C09D5/1625 , C09D5/165
摘要： The present invention relates to derivatives of α, α-disubstituted amide compounds which comprise a substituted aryl at the α carbon such that the substituent provides a means for attachment or incorporation of the compound to or in a polymer. The provision of such a substituent on the aryl has surprisingly been found not only to permit attachment to or incorporation in a polymer but also retention of useful antifouling activity. In embodiments, the substituent is selected from hydroxyl, ethers, esters, carboxyls, alkylsilyls and alkenyls. Experiments demonstrate that antifouling activity can be as good or better as the corresponding unsubstituted compound and that polymers functionalised so as to include or be formed from the substituted compound can be used to reduce settlement.
摘要翻译：本发明涉及在碳上包含取代的芳基的α-二取代酰胺化合物的衍生物，使得取代基提供了将化合物连接或引入到聚合物中的方法。在芳基上提供这样的取代基已经令人惊奇地发现，不仅允许附着或掺入聚合物中，而且保留有用的防污活性。在实施方案中，取代基选自羟基，醚，酯，羧基，烷基甲硅烷基和烯基。实验证明防污活性可以与相应的未取代的化合物一样好或更好，并且可以使用官能化以包含或由取代的化合物形成的聚合物来减少沉降。

2. 发明申请

WO2009139729A1 ANTIFOULING COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：防化合物及其用途
公开(公告)号：WO2009139729A1
公开(公告)日：2009-11-19
申请号：PCT/SG2009/000175
申请日：2009-05-18
申请人： NATIONAL UNIVERSITY OF SINGAPORE , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MARITIME AND PORT AUTHORITY OF SINGAPORE , TEO, Lay Ming, Serena , RITTSCHOF, Daniel , JAMESON, Felicity , CHAI, Christina , CHEN, Chia Lung , LEE, Siew Chen, Serina
发明人： TEO, Lay Ming, Serena , RITTSCHOF, Daniel , JAMESON, Felicity , CHAI, Christina , CHEN, Chia Lung , LEE, Siew Chen, Serina
IPC分类号： C09D5/16 , C09D7/12
CPC分类号： C07D295/185 , C07D211/46 , C07D211/52 , C08K5/3435 , C09D5/1625 , C09D7/63
摘要： The present invention relates to the use of compounds which have the following general formula (I), wherein R 1 and R 2 are independently selected from optionally substituted aryl, optionally substituted C 1 to C 12 alkyl and H; and R 3 and R 4 are independently selected from hydroxy, optionally substituted C 1 to C 6 alkyl, optionally substituted phenyl and H, in a method of preventing or reducing fouling, particularly in the marine environment. The compounds of the present invention have the considerable advantage of providing the antifouling coating market with an organic alternative to the existing technology which relies heavily on the addition of copper to obtain significant antifouling effects. The compounds we have developed may be used as cheap, easy to prepare additives that do not contain metals and therefore have reduced toxicity in marine environment.
摘要翻译：本发明涉及具有以下通式（I）的化合物的用途，其中R 1和R 2独立地选自任选取代的芳基，任选取代的C 1至C 12烷基和H; 并且特别是在海洋环境中，R3和R4独立地选自羟基，任意取代的C1至C6烷基，任选取代的苯基和H，以防止或减少结垢。本发明的化合物具有相当大的优点，即为防污涂料市场提供有选择的替代现有技术，其主要依赖于添加铜以获得显着的防污效果。我们开发的化合物可以用作廉价，易于制备不含金属的添加剂，因此在海洋环境中具有降低的毒性。

3. 发明申请

WO2008156691A1 ANITCOAGULANTS AS ANTIFOULING AGENTS 审中-公开
标题翻译： ANITCOAGULANTS作为防伪剂
公开(公告)号：WO2008156691A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007433
申请日：2008-06-13
申请人： DUKE UNIVERSITY , RITTSCHOF, Daniel , DICKINSON, Gary, H. , ORIHUELA De Diaz, Beatriz , HOLM, Eric, R.
发明人： RITTSCHOF, Daniel , DICKINSON, Gary, H. , ORIHUELA De Diaz, Beatriz , HOLM, Eric, R.
IPC分类号： C09D5/16
CPC分类号： C09D5/1606
摘要： Methods and compositions are provided for the reduction of fouling of objects present in marine environments. The methods and compositions include anticoagulants, such as, for example, glycosaminoglycans, coumarin- type molecules, metal chelators, plasminogen activators and platelet inhibitors. The methods include reducing marine fouling, comprising incorporating an anticoagulant compound into a marine coating. In addition, the methods include identifying compounds useful for reducing marine fouling, comprising measuring either blood coagulation or barnacle cement polymerization in the presence and absence of the compound, wherein a reduction in the blood coagulation or the barnacle cement polymerization in the presence of the compound identifies the compound as useful for reducing marine fouling. The coagulation or the polymerization can be measured by a serine protease activity or a transglutaminase activity.
摘要翻译：提供的方法和组合物用于减少存在于海洋环境中的物体的结垢。所述方法和组合物包括抗凝血剂，例如糖胺聚糖，香豆素型分子，金属螯合剂，纤溶酶原激活剂和血小板抑制剂。所述方法包括减少海洋污染，包括将抗凝血剂化合物掺入海洋涂料中。此外，所述方法包括鉴定可用于减少海洋结垢的化合物，包括在化合物存在和不存在下测量血液凝固或藤壶水泥聚合，其中在化合物存在下凝血或藤壶水泥聚合的减少鉴定该化合物对减少海洋污染有用。凝血或聚合可以通过丝氨酸蛋白酶活性或转谷氨酰胺酶活性来测量。

4. 发明申请

WO1994008904A1 ANTIFOULING COATING COMPOSITION AND METHOD 审中-公开
标题翻译：防喷涂组合物和方法
公开(公告)号：WO1994008904A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009762
申请日：1993-10-13
申请人： DUKE UNIVERSITY , GERHART, Donald, John , RITTSCHOF, Daniel , HOOPER, Irving, R. , CLARE, Anthony, Simon
发明人： DUKE UNIVERSITY
IPC分类号： C02F01/50
CPC分类号： C09D5/1625 , A01N35/06 , A01N43/08 , A01N43/12 , A01N43/90 , C02F1/50
摘要： Certain compounds are disclosed as being useful as marine or fresh water antifoulant compounds to be used in protective carrier compositions such as film forming polymer to protect fish nets, boats, pilings, and piers. The compounds are selected from those of formulae (1, 2, 3, 4, 5, 6, 7, 8, 9).
摘要翻译：公开了某些化合物可用作海洋或淡水防污化合物，用于保护载体组合物如成膜聚合物以保护鱼网，船，桩和墩。化合物选自式（1,2,3,4,5,6,7,8,9）的化合物。

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