专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007132962A1 SEPARATION METHOD OF NUCLEATED CELLS DERIVED FROM BONE MARROW FOR BONE FORMATION 审中-公开
标题翻译：用于骨形成的骨髓衍生的核细胞的分离方法
公开(公告)号：WO2007132962A1
公开(公告)日：2007-11-22
申请号：PCT/KR2006/002434
申请日：2006-06-23
申请人： SEWON CELLONTECH CO., LTD. , PARK, Hyun-Shin , JANG, Jae-Deog , LEE, Sae-Bom , CHANG, Cheong-Ho
发明人： PARK, Hyun-Shin , JANG, Jae-Deog , LEE, Sae-Bom , CHANG, Cheong-Ho
IPC分类号： C12N5/08
CPC分类号： C12N5/0654 , A61K35/28
摘要： The present invention relates to a method for separating bone marrow-derived nucleated cells for bone formation. The method comprises: the steps of: washing bone marrow; lysing red blood cells in the bone marrow; neutralizing the bone marrow lysate; purifying nucleated cells from the neutralized bone marrow; and mixing the nucleated cells with a maintenance buffer for bone formation. According to the invention, bone marrow-derived nucleated cells, which can be grafted into a site in need of bone formation or bone defect treatment, can be separated in a rapid and convenient manner. As a result, bone formation in emergency patients or patients, who require repeated surgical operations, can be effectively achieved by separating the nucleated cells for bone formation in surgical locations in a convenient and rapid manner and injecting the separated cells into the patients.
摘要翻译：本发明涉及用于分离用于骨形成的骨髓衍生的有核细胞的方法。该方法包括：洗涤骨髓; 裂解骨髓中的红细胞; 中和骨髓裂解物; 从中和骨髓中纯化有核细胞; 并将有核细胞与用于骨形成的维持缓冲液混合。根据本发明，可以以快速方便的方式分离可以移植到需要骨形成或骨缺损处理的部位的骨髓衍生的有核细胞。结果，需要重复外科手术的急诊患者或患者的骨形成可以通过以方便和快速的方式分离外科手术位置中的骨形成核细胞并将分离的细胞注射入患者中来有效地实现。

2. 发明申请

WO2010005133A1 MANUFACTURING METHOD OF COLLAGEN GEL COMPOSITION FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的胶原凝胶组合物的制备方法
公开(公告)号：WO2010005133A1
公开(公告)日：2010-01-14
申请号：PCT/KR2008/004287
申请日：2008-07-23
申请人： SEWON CELLONTECH CO., LTD. , JANG, Jae-Deog , KIM, Hun , YU, Ji-Chul , YEO, Se-Geun , KIM, Tae-Hyoung , PARK, Hyun-Shin , KIM, Seon-Ae , KIM, Jang-Hoon , KIM, Seong-Soo
发明人： JANG, Jae-Deog , KIM, Hun , YU, Ji-Chul , YEO, Se-Geun , KIM, Tae-Hyoung , PARK, Hyun-Shin , KIM, Seon-Ae , KIM, Jang-Hoon , KIM, Seong-Soo
IPC分类号： A61K47/42 , A61P19/10 , A61K9/26 , C07K14/78 , A61L27/24
CPC分类号： A61L27/24 , A61L27/12 , A61L27/3804 , A61L27/3847 , A61L27/46 , A61L27/52 , A61L27/56
摘要： Disclosed herein is a method for preparing a collagen gel composition for bone regeneration comprising collecting bone marrow from animal tissues and isolating nucleated cells from the bone marrow; and mixing the nucleated cells and a bio-matrix composed of type I collagen and apatite.
摘要翻译：本文公开了一种制备用于骨再生的胶原凝胶组合物的方法，包括从动物组织收集骨髓并从骨髓中分离有核细胞; 并将有核细胞和由I型胶原和磷灰石组成的生物基质混合。

3. 发明申请

WO2006135123A1 BONE FORMATION COMPOSITION COMPOSED OF MIXTURE OF OSTEOBLAST AND BIO-MATRIX AND ITS MANUFACTURING METHOD 审中-公开
标题翻译：骨质疏松和生物基质混合物的骨形成组合物及其制造方法
公开(公告)号：WO2006135123A1
公开(公告)日：2006-12-21
申请号：PCT/KR2005/002006
申请日：2005-06-27
申请人： SEWON CELLONTECH CO., LTD. , JANG, Jae-Deog , PARK, Hyun-Shin , CHANG, Cheong-Ho , JUNG, Soo-Jin , LEE, Sae-Bom , KO, Chang-Kwon
发明人： JANG, Jae-Deog , PARK, Hyun-Shin , CHANG, Cheong-Ho , JUNG, Soo-Jin , LEE, Sae-Bom , KO, Chang-Kwon
IPC分类号： A61K35/28
CPC分类号： A61K35/32 , A61K35/12 , A61K38/4833 , A61L27/3821 , A61L27/3847 , A61L27/3895 , A61L2430/02 , C12N5/0654 , C12N2533/56
摘要： Provided is a composition for bone formation using a mixture of an osteoblast and a bio-matrix, and a method for preparing the same. The methods comprises isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in DMEM (Dulbecco's Modified Eagle's Medium) or α-MEM (Minimum Essential Medium, Alpha Modification) to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with a bio-matrix to prepare an osteoblast therapeutic agent. In accordance with the present invention, it is possible to realize a bone formation method, resulting in no clinical graft rejection via injection of an osteoblast and bio-matrix mixture for bone formation into a site where bone formation is sought, and being capable of achieving effective and rapid bone formation via injection of a composition which was shaped to a certain extent, so as to alleviate problems associated with probability of bone tissue formation in unwanted regions resulting from escape of injected osteoblasts from the targeted site for bone formation and then propagation thereof to other sites via the blood stream, which are caused by injection of an osteoblast suspension.
摘要翻译：提供使用成骨细胞和生物基质的混合物的骨形成用组合物及其制备方法。所述方法包括从骨组织中分离成骨细胞并在DMEM（Dulbecco's Modified Eagle's Medium）或a-MEM（Minimum Essential Medium，Alpha Modification）中培养/增殖分离的成骨细胞以制备成骨细胞悬液; 并将所得的成骨细胞悬浮液与生物基质混合以制备成骨细胞治疗剂。根据本发明，可以实现骨形成方法，通过将成骨细胞和用于骨形成的生物基质混合物注射到寻找骨形成的部位，并且能够实现骨形成方法通过注射成形到一定程度的组合物来有效且快速地进行骨形成，以便减轻由注射的成骨细胞从用于骨形成的靶位点逃逸而导致的不希望的区域中骨组织形成的可能性的问题，然后传播通过注射成骨细胞悬浮液引起的血液流向其他部位。

4. 发明申请

WO2007123288A1 APPARATUS FOR OPERATING SYRINGE PISTON 审中-公开
标题翻译：操作注射器活塞的装置
公开(公告)号：WO2007123288A1
公开(公告)日：2007-11-01
申请号：PCT/KR2006/002117
申请日：2006-06-02
申请人： SEWON CELLONTECH CO., LTD. , KIM, Seok-Jung , CHANG, Cheong-Ho , JANG, Jae-Deog , PARK, Hyun-Shin , LEE, Sae-Bom , BYUN, Kyoung-Phil
发明人： KIM, Seok-Jung , CHANG, Cheong-Ho , JANG, Jae-Deog , PARK, Hyun-Shin , LEE, Sae-Bom , BYUN, Kyoung-Phil
IPC分类号： A61M5/315
CPC分类号： A61B17/8822 , A61M5/315
摘要： Disclosed is an apparatus for operating a syringe piston. The apparatus includes a syringe mounting section for fixedly mounting a syringe, in which a screw hole is formed at an upper head part of the syringe mounting section, and a piston press unit having a screw bar, which is screw-coupled into the screw hole so that the syringe piston press unit is movable up and down along the screw hole, wherein the piston press unit presses a syringe piston with a constant pressure such that a predetermined amount of contents is precisely injected into a human body from the syringe. The syringe filled with medical cement is attached to the syringe mounting section and the syringe piston is moved downward without moving upward when the user rotates the piston press unit having the screw bar, so medical cement contained in the syringe is extruded from the syringe with a constant pressure, so that a predetermined amount of medical cement is precisely injected into a human body. Thus, the apparatus significantly improves quality and reliability of products, thereby providing consumers with high satisfaction and a good impression.
摘要翻译：公开了一种用于操作注射器活塞的装置。该装置包括用于固定安装注射器的注射器安装部分，其中在注射器安装部分的上部头部形成有螺纹孔，以及具有螺杆的活塞压力单元，该螺杆被螺纹连接到螺钉孔中使得注射器活塞压力单元沿着螺钉孔上下移动，其中活塞压力单元按压恒定压力的注射器活塞，使得从注射器将预定量的内容物精确地注入人体内。当使用者旋转具有螺杆的活塞压榨单元时，装有医用水泥的注射器被安装到注射器安装部分，并且注射器活塞向下移动而不会向上移动，因此包含在注射器中的医用胶水从注射器被挤出恒定压力，从而将预定量的医用水泥精确地注入人体内。因此，该设备显着提高了产品的质量和可靠性，从而为消费者提供了很高的满意度和良好的印象。

5. 发明申请

WO2006135126A1 OSTEOBLAST COMPOSITION OF SEMI-SOLIDIFIED MIXED FIBRIN FOR BONE FRACTURE AGGLUTINATION AND ITS MANUFACTURING METHOD 审中-公开
标题翻译：用于骨折治疗的半固定混合纤维的OSTEOBLAST组合物及其制造方法
公开(公告)号：WO2006135126A1
公开(公告)日：2006-12-21
申请号：PCT/KR2005/002531
申请日：2005-08-03
申请人： SEWON CELLONTECH CO., LTD. , PARK, Hyun-Shin , JANG, Jae-Deog , CHANG, Cheong-Ho , JUNG, Soo-Jin , LEE, Sae-Bom , KO, Chang-Kwon
发明人： PARK, Hyun-Shin , JANG, Jae-Deog , CHANG, Cheong-Ho , JUNG, Soo-Jin , LEE, Sae-Bom , KO, Chang-Kwon
IPC分类号： A61K35/32
CPC分类号： A61K35/32 , A61K38/363 , A61K38/4833 , A61K2300/00
摘要： Provided are a semi-solid osteoblast composition containing fibrin for bone union and a method for preparing the same. The method comprises isolating osteoblasts from a bone tissue and culturing/proliferating the isolated osteoblasts in DMEM (Dulbecco's Modified Eagle's Medium) or α -MEM Minimum Essential Medium, Alpha Modification) to prepare an osteoblast suspension; and mixing the resulting osteoblast suspension with an coagulation factor to prepare an osteoblast therapeutic agent. In accordance with the present invention having the above-mentioned construction, it is possible to achieve bone grafting capable of performing bone union having no clinical graft rejection and uniform distribution of osteoblasts via injection of an osteoblasts and fibrin mixture into affected parts for bone union, and effective and rapid bone union via constant injection of a semi-solid osteoblast composition into affected parts.
摘要翻译：本发明提供含有用于骨结合的纤维蛋白的半固体成骨细胞组合物及其制备方法。该方法包括从骨组织中分离成骨细胞并在DMEM（Dulbecco's Modified Eagle's Medium）或-MEM Minimum Essential Medium，Alpha Modification）中培养/增殖分离的成骨细胞以制备成骨细胞悬液; 并将所得的成骨细胞悬浮液与凝血因子混合以制备成骨细胞治疗剂。根据具有上述结构的本发明，可以通过将成骨细胞和纤维蛋白混合物注入受影响的部位进行骨结合，实现能够进行无临床移植物排斥和成骨细胞均匀分布的骨结合的骨移植，并通过将半固体成骨细胞组合物持续注射到受影响的部位中来有效和快速的骨结合。

6. 发明申请

WO2008035832A1 BONE REGENERATION CELL COMPOSITION AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：骨再生细胞组成及其制造方法
公开(公告)号：WO2008035832A1
公开(公告)日：2008-03-27
申请号：PCT/KR2006/003791
申请日：2006-09-25
申请人： SEWON CELLONTECH CO., LTD. , JANG, Jae-Deog , BYUN, Kyoung-Phil , LEE, Sae-Bom , PARK, Hyun-Shin , KIM, Jang-Hoon , CHANG, Cheong-Ho
发明人： JANG, Jae-Deog , BYUN, Kyoung-Phil , LEE, Sae-Bom , PARK, Hyun-Shin , KIM, Jang-Hoon , CHANG, Cheong-Ho
IPC分类号： A61K35/28
CPC分类号： A61K35/28
摘要： Provided is a cell composition for promoting bone formation which is capable of achieving local or systemic bone regeneration by subjecting cells having osteogenic capacity to surface treatment using a hyaluronic acid and injecting the thus-treated cells into a circulation system of target animals; and a method for preparing the same. The method comprises isolating cells having osteogenic capacity from bone marrow; culturing and proliferating the isolated cells in DMEM (Dulbecco's Modified Eagle's Medium) or α-MEM (Minimum Essential Medium, Alpha Modification) to thereby prepare a cell suspension having osteogenic capacity; and mixing the resulting cell suspension having osteogenic capacity with a bio-matrix to perform cell-surface treatment for improving the viability of the cells having osteogenic capacity and the mobility/anchorage thereof into bone cavities, thereby preparing a cell therapy product having osteogenic capacity having osteogenic capacity.
摘要翻译：本发明提供一种用于促进骨形成的细胞组合物，其能够通过使用透明质酸对具有成骨能力的细胞进行表面处理并将这样处理的细胞注射到目标动物的循环系统中来实现局部或全身骨再生; 及其制备方法。该方法包括从骨髓分离具有成骨能力的细胞; 培养和增殖分离的细胞在DMEM（Dulbecco's Modified Eagle's Medium）或a-MEM（最低限度培养基，Alpha修饰）中，从而制备具有成骨能力的细胞悬浮液; 并将所得到的具有成骨能力的细胞悬浮液与生物基质混合以进行细胞表面处理，以改善具有成骨能力的细胞的存活力及其迁移/锚定到骨腔中，从而制备具有成骨能力的细胞治疗产品，成骨能力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式