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1. 发明申请

WO2009046198A3 SUSTAINED DELIVERY OF COMPSTATIN ANALOGS FROM GELS 审中-公开
标题翻译：从凝胶中持续输送COMPSTATIN类似物
公开(公告)号：WO2009046198A3
公开(公告)日：2009-07-16
申请号：PCT/US2008078593
申请日：2008-10-02
申请人： POTENTIA PHARMACEUTICALS INC , FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
发明人： FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
IPC分类号： A61K9/10 , A61K9/52 , A61K38/08 , A61K38/10 , A61P27/02
CPC分类号： A61K9/0051 , A61K38/12 , A61K47/42
摘要： The present invention features the sustained delivery of compstatin analog and, optionally, an additional active agent, by release from a macroscopic, gel-like deposit formed by administering a liquid solution containing the compstatin analog to an extravascular location in the body of a mammalian subject such as the vitreous chamber.
摘要翻译：本发明的特征在于通过将含有坎普他汀类似物的液体溶液施用至哺乳动物受试者体内的血管外位置而形成的宏观凝胶样沉积物释放坎普他汀类似物和任选地另外的活性剂的持续递送如玻璃体腔。

2. 发明申请

WO2007024782A2 COMPOSITIONS PROVIDING TOLERANCE TO MULTIPLE HERBICIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：提供多种除草剂的耐受性的组合物及其使用方法
公开(公告)号：WO2007024782A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032606
申请日：2006-08-22
申请人： PIONEER HI BRED INT , DU PONT , MCCUTCHEN BILLY FRED , CASTLE LINDA A , CHICOINE TIMOTHY K , CHO HYEON-JE , CLAUS JON S , GREEN JERRY M , GUIDA ANTHONY D JR , HAZEL CHRISTINE B , HECKERT MATTHEW J , HEGSTAD JEFFREY M , HUTCHISON JAMES M , LIU DONGLONG , LU ALBERT L , MEHRE WAYNE J , MOY YORK , OLSON PAUL D , PEEPLES KENNETH A , SAUNDERS DAVID W , VOGT MARK D , WILKINSON JACK Q , WONG JAMES F H
发明人： MCCUTCHEN BILLY FRED , CASTLE LINDA A , CHICOINE TIMOTHY K , CHO HYEON-JE , CLAUS JON S , GREEN JERRY M , GUIDA ANTHONY D JR , HAZEL CHRISTINE B , HECKERT MATTHEW J , HEGSTAD JEFFREY M , HUTCHISON JAMES M , LIU DONGLONG , LU ALBERT L , MEHRE WAYNE J , MOY YORK , OLSON PAUL D , PEEPLES KENNETH A , SAUNDERS DAVID W , VOGT MARK D , WILKINSON JACK Q , WONG JAMES F H
IPC分类号： A63B20060101 , A63B69/00 , A63B69/36 , A63B71/06
CPC分类号： C12N15/8274 , C12N9/1092 , C12N9/88 , C12N15/8205 , C12N15/8209 , C12N15/8216 , C12N15/8271 , C12N15/8275 , C12N15/8278 , C12N15/8286 , Y02A40/162
摘要： Methods and compositions are provided related to improved plants that are tolerant to more than one herbicide. Particularly, the invention provides plants that are tolerant of glyphosate and are tolerant to at least one ALS inhibitor, and methods of use thereof. The glyphosate/ALS inhibitor-tolerant plants comprise a polynucleotide that encodes a polypeptide that confers tolerance to glyphosate and a polynucleotide that encodes an ALS inhibitor-tolerant polypeptide. In specific embodiments, a plant of the invention expresses a GAT polypeptide and an HRA polypeptide. Methods to control weeds, improve plant yield, and increase transformation efficiencies are provided.
摘要翻译：提供了与多于一种除草剂耐受的改良植物相关的方法和组合物。特别地，本发明提供耐受草甘膦并且对至少一种ALS抑制剂具有耐受性的植物及其使用方法。草甘膦/ ALS抑制剂耐受性植物包含编码赋予草甘膦耐受性的多肽的多核苷酸和编码耐ALS抑制剂多肽的多核苷酸。在具体实施方案中，本发明的植物表达GAT多肽和HRA多肽。提供了控制杂草，提高植物产量和提高转化效率的方法。

3. 发明申请

WO2006042252A3 VIRAL COMPLEMENT CONTROL PROTEINS FOR EYE DISORDERS 审中-公开
标题翻译：眼睛疾病的病毒补体控制蛋白
公开(公告)号：WO2006042252A3
公开(公告)日：2007-02-08
申请号：PCT/US2005036547
申请日：2005-10-08
申请人： POTENTIA PHARMECEUTICALS INC , FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
发明人： FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
IPC分类号： A61K38/16 , A61P27/02
CPC分类号： A61K38/162 , C07K14/005 , C07K2319/33 , C12N2710/24122
摘要： The present invention provides compositions and methods for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration or choroidal neovascularization. Certain of the compositions comprise a poxvirus complement control protein or a complement binding fragment or variant thereof (e.g. vaccina complement control protein VCP or smallpox inhibitor of completent enzymes SPICE) . Other compositions comprise a poxvirus complement control protein linked to a moiety that binds to a component present on or at the surface of cell or noncellular molecular entity, e.g., a component present in the eye of a subject at risk of or suffering from age related macular degeneration or a related condition or choroidal neovascularization. Certain of the methods comprise administering a poxvirus complement control protein or complement binding fragment or variant thereof to a subject. Compositions are disclosed which comprise a complement inhibitor an a soluble in situ gel -forming excipient (preferable soluble collagen) .
摘要翻译：本发明提供用于治疗和/或预防年龄相关性黄斑变性和涉及黄斑变性或脉络膜新生血管形成的其它病症的组合物和方法。某些组合物包含痘病毒补体对照蛋白或其补体结合片段或变体（例如疫苗补体对照蛋白VCP或完全酶SPICE的天花抑制剂）。其他组合物包含与结合存在于细胞或非细胞分子实体的表面或其表面上的组分连接的部分的痘病毒补体对照蛋白，例如存在于患有年龄相关性黄斑的风险的患者的眼睛中的组分变性或相关病症或脉络膜新生血管形成。某些方法包括向受试者施用痘病毒补体对照蛋白或补体结合片段或其变体。公开了包含补体抑制剂，可溶于原位的凝胶形成赋形剂（优选可溶性胶原）的组合物。

4. 发明申请

WO2010135717A3 COMPLEMENT ASSAYS AND USES THEREOF 审中-公开
标题翻译：补充测定及其用途
公开(公告)号：WO2010135717A3
公开(公告)日：2011-04-21
申请号：PCT/US2010035871
申请日：2010-05-21
申请人： POTENTIA PHARMACEUTICALS INC , ZHANG ZHOUNING , FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
发明人： ZHANG ZHOUNING , FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
IPC分类号： G01N33/53 , C07K16/18 , G01N33/577
CPC分类号： G01N33/566 , C07K16/18 , G01N33/564 , G01N33/6893 , G01N2333/4716 , G01N2800/16 , G01N2800/164 , G01N2800/50 , G01N2800/52 , G01N2800/7042
摘要： The present invention provides methods for assessing complement activation and methods for assessing the ability of an agent or condition of interest to modulate complement activation. The present invention provides methods for assessing whether a subject has or is at increased risk of developing a complement-mediated disorder, e.g., age-related macular degeneration (AMD). Also provided are kits containing materials useful for performing the methods.
摘要翻译：本发明提供了用于评估补体活化的方法和用于评估调节补体活化的药剂或感兴趣条件的能力的方法。本发明提供了评估受试者是否具有发展补体介导的病症（例如年龄相关性黄斑变性（AMD））的风险增加的方法。还提供了包含用于执行该方法的材料的试剂盒。

5. 发明申请

WO2009121065A3 MODULATION AND REPLETION/ENHANCEMENT OF THE COMPLEMENT SYSTEM FOR TREATMENT OF TRAUMA 审中-公开
标题翻译： TRAUMA治疗补充系统的调整和复制/增强
公开(公告)号：WO2009121065A3
公开(公告)日：2010-03-18
申请号：PCT/US2009038807
申请日：2009-03-30
申请人： APELLIS AG , FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
发明人： FRANCOIS CEDRIC , DESCHATELETS PASCAL , OLSON PAUL
IPC分类号： A61K38/10 , A61K38/08 , A61K38/16 , A61K39/395 , A61P25/18
CPC分类号： A61K9/0019 , A61K38/12 , A61K38/162 , A61K38/1725 , A61K38/177
摘要： The present invention features the use of selected complement activation inhibitor(s) for treating an individual who has suffered a severe injury. The complement activation inhibitor acts at or above the level of C3 activation and does not significantly deplete or irreversibly inhibit complement activation. Also provided are compositions and methods for repleting and/or enhancing complement activation capacity in a subject who has suffered a traumatic injury.
摘要翻译：本发明的特征在于使用选择的补体活化抑制剂来治疗遭受严重损伤的个体。补体激活抑制剂起作用或高于C3激活水平，并且不显着消耗或不可逆地抑制补体活化。还提供了在遭受创伤性损伤的受试者中补充和/或增强补体活化能力的组合物和方法。

6. 发明申请

WO2008097525A2 LOCAL COMPLEMENT INHIBITION FOR TREATMENT OF COMPLEMENT-MEDIATED DISORDERS 审中-公开
标题翻译：用于治疗补充介入性疾病的局部补充抑制
公开(公告)号：WO2008097525A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/001483
申请日：2008-02-05
申请人： POTENTIA PHARMACEUTICALS, INC. , FRANCOIS, Cedric , DESCHATELETS, Pascal , OLSON, Paul
发明人： FRANCOIS, Cedric , DESCHATELETS, Pascal , OLSON, Paul
CPC分类号： A61K39/3955 , A61K38/12 , A61K38/17 , A61K45/06 , C07K7/64 , C07K14/435
摘要： The present invention features the local administration of complement inhibitors for treatment of complement-mediated disorders. In certain embodiments the invention features inhibiting activation of one or more locally produced complement proteins. The invention provides sustained release formulations and devices comprising a complement inhibitor and methods of use thereof.
摘要翻译：本发明的特征在于用于治疗补体介导的病症的补体抑制剂的局部施用。在某些实施方案中，本发明特征在于抑制一种或多种局部产生的补体蛋白的活化。本发明提供持续释放制剂和包含补体抑制剂的装置及其使用方法。

7. 发明申请

WO2007084765A3 INJECTABLE COMBINATION THERAPY FOR EYE DISORDERS 审中-公开
公开(公告)号：WO2007084765A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/001649
申请日：2007-01-19
申请人： POTENTIA PHARMACEUTICALS, INC. , DESCHATELETS, Pascal , OLSON, Paul
发明人： DESCHATELETS, Pascal , OLSON, Paul
IPC分类号： A61P27/02 , A61F2/14 , A61K47/06 , A61K39/395 , A61K38/17 , A61K31/00 , A61K9/00
摘要： The present invention provides composition, methods, and articles of manufacture for treating an eye disorder, e.g., a disorder characterized by macular degeneration, choroidal neovascularization, or retinal neovascularization. One method of the invention comprises the step of: administering first and second therapeutic agents to the subject's eye in a single procedure, wherein the first therapeutic agent provides rapid improvement in the condition of the subject's eye and the second therapeutic agent is administered as a sustained release formulation of the second therapeutic agent. For example, the first and second therapeutic agents are administered by intravitreal injection. The first therapeutic agent may be dissolved in a liquid medium located in the syringe and the sustained formulation of the second therapeutic agent may comprise an ocular implant or plurality of particles located in the needle. The therapeutic agents may be selected from the group consisting of angiogenesis inhibors and complement inhibitors.

8. 发明申请

WO2007024866A3 METHODS AND COMPOSITIONS FOR THE EXPRESSION OF A POLYNUCLEOTIDE OF INTEREST 审中-公开
公开(公告)号：WO2007024866A3
公开(公告)日：2007-03-01
申请号：PCT/US2006/032792
申请日：2006-08-22
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E.I. DU PONT DE NEMOURS AND COMPANY , MCCUTCHEN, Billy, Fred , HAZEL, Christine, B. , LIU, Donglong , LU, Albert, L. , MEHRE, Wayne, J. , OLSON, Paul, D. , WONG, James, F. H.
发明人： MCCUTCHEN, Billy, Fred , HAZEL, Christine, B. , LIU, Donglong , LU, Albert, L. , MEHRE, Wayne, J. , OLSON, Paul, D. , WONG, James, F. H.
IPC分类号： C12N15/82
摘要： Methods and compositions for expressing a polynucleotide of interest are provided. Compositions comprise an enhancer domain set forth in SEQ ID NO: 1, 10, 15, or 16 and active variants and fragments thereof. Further provided are DNA constructs comprising at least one transcriptional enhancer sequence comprising the nucleotide sequence set forth in SEQ ID NO:1, 10, 15, or 16 or an active variant or fragment thereof, operably linked to a heterologous promoter. Such chimeric transcription regulatory regions can be operably linked any polynucleotide of interest. Further provided are cells, plants, plant parts, and germplasm comprising the DNA construct. Methods of using the chimeric transcriptional regulatory region are also provided. In specific embodiments, methods of expressing a polynucleotide of interest, including for example, sequences that confer tolerance to herbicides, and methods to select a cell having the DNA construct are provided.

9. 发明申请

WO2007024782A3 COMPOSITIONS PROVIDING TOLERANCE TO MULTIPLE HERBICIDES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007024782A3
公开(公告)日：2007-03-01
申请号：PCT/US2006/032606
申请日：2006-08-22
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY , MCCUTCHEN, Billy, fred , CASTLE, Linda, A. , CHICOINE, Timothy, K. , CHO, Hyeon-je , CLAUS, Jon, S. , GREEN, Jerry, M. , GUIDA, Anthony, D., Jr. , HAZEL, Christine, B. , HECKERT, Matthew, J. , HEGSTAD, Jeffrey, M. , HUTCHISON, James, M. , LIU, Donglong , LU, Albert, L. , MEHRE, Wayne, J. , MOY, York , OLSON, Paul, D. , PEEPLES, Kenneth, A. , SAUNDERS, David, W. , VOGT, Mark, D. , WILKINSON, Jack, Q. , WONG, James, F., H.
发明人： MCCUTCHEN, Billy, fred , CASTLE, Linda, A. , CHICOINE, Timothy, K. , CHO, Hyeon-je , CLAUS, Jon, S. , GREEN, Jerry, M. , GUIDA, Anthony, D., Jr. , HAZEL, Christine, B. , HECKERT, Matthew, J. , HEGSTAD, Jeffrey, M. , HUTCHISON, James, M. , LIU, Donglong , LU, Albert, L. , MEHRE, Wayne, J. , MOY, York , OLSON, Paul, D. , PEEPLES, Kenneth, A. , SAUNDERS, David, W. , VOGT, Mark, D. , WILKINSON, Jack, Q. , WONG, James, F., H.
IPC分类号： C12N15/82
摘要： Methods and compositions are provided related to improved plants that are tolerant to more than one herbicide. Particularly, the invention provides plants that are tolerant of glyphosate and are tolerant to at least one ALS inhibitor, and methods of use thereof. The glyphosate/ALS inhibitor-tolerant plants comprise a polynucleotide that encodes a polypeptide that confers tolerance to glyphosate and a polynucleotide that encodes an ALS inhibitor-tolerant polypeptide. In specific embodiments, a plant of the invention expresses a GAT polypeptide and an HRA polypeptide. Methods to control weeds, improve plant yield, and increase transformation efficiencies are provided.

10. 发明申请

WO2014047509A1 NANOCOMPOSITES FOR IMAGING AND DRUG DELIVERY 审中-公开
标题翻译：用于成像和药物递送的纳米复合体
公开(公告)号：WO2014047509A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/061035
申请日：2013-09-20
申请人： NUVOX PHARMA, L.L.C. , KYPHA INC. , UNGER, Evan C. , MARINELLI, Ed , EL MEHDI, Delphine , OLSON, Paul K.
发明人： UNGER, Evan C. , MARINELLI, Ed , EL MEHDI, Delphine , OLSON, Paul K.
IPC分类号： A61K9/51 , A61K9/127
CPC分类号： A61K47/48869 , A61K31/00 , A61K31/573 , A61K38/13 , A61K47/543 , A61K47/60 , A61K47/64 , A61K47/6911 , A61K47/6925 , A61K49/0032 , A61K49/0054 , A61K49/0082 , A61K49/0093 , C12N15/1136 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： A composition (100) which includes a shell (120) comprising at least one lipid, wherein said shell defines an enclosed space, a gas (110) disposed within the enclosed space, and a coating (130) of a polyalkylene glycol attached to and extending outwardly from lipid shell.
摘要翻译：一种组合物（100），其包括包含至少一种脂质的壳体（120），其中所述壳体限定封闭空间，设置在封闭空间内的气体（110）和附着到其上的聚亚烷基二醇的涂层（130）从脂壳向外延伸。

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