专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007003386A1 IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS 审中-公开
标题翻译：咪唑吡啶衍生物作为酸性尿素拮抗剂
公开(公告)号：WO2007003386A1
公开(公告)日：2007-01-11
申请号：PCT/EP2006/006410
申请日：2006-06-28
申请人： GLAXO GROUP LIMITED , BAMFORD, Mark, James , ELLIOTT, Richard, Leonard , GIBLIN, Gerard, Martin, Paul , NAYLOR, Antoinette , PANCHAL, Terence, Aaron , TAKLE, Andrew, Kenneth , WITHERINGTON, Jason
发明人： BAMFORD, Mark, James , ELLIOTT, Richard, Leonard , GIBLIN, Gerard, Martin, Paul , NAYLOR, Antoinette , PANCHAL, Terence, Aaron , TAKLE, Andrew, Kenneth , WITHERINGTON, Jason
IPC分类号： C07D471/04 , A61K31/435 , A61P1/00
CPC分类号： C07D471/04
摘要： This invention relates to newly identified imidazopyridine compounds of formula (I), to the use of such compounds in therapy and to their production.
摘要翻译：本发明涉及新确定的式（I）咪唑并吡啶化合物，用于治疗及其制备中的这些化合物。

2. 发明申请

WO2003022840A1 PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS 审中-公开
标题翻译：吡啶衍生物作为RAF激酶抑制剂
公开(公告)号：WO2003022840A1
公开(公告)日：2003-03-20
申请号：PCT/EP2002/009946
申请日：2002-09-05
申请人： SMITHKLINE BEECHAM PLC , BAMFORD, Mark, James , DEAN, David, Kenneth , NAYLOR, Antoinette , TAKLE, Andrew, Kenneth , WILSON, David, Matthew
发明人： BAMFORD, Mark, James , DEAN, David, Kenneth , NAYLOR, Antoinette , TAKLE, Andrew, Kenneth , WILSON, David, Matthew
IPC分类号： C07D405/14
CPC分类号： C07D405/04 , C07D405/14
摘要： Compounds (I) and their use as pharmaceuticals particularly as Raf Kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物（I）及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。

3. 发明申请

WO1994002489A1 CEPHALOSPORINS AND 1-CARBA-1-DETHIA CEPHALOSPORINS 审中-公开
标题翻译： CEPHALOSPORINS和1-CARBA-1-DETHIA CEPHALOSPORINS
公开(公告)号：WO1994002489A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001523
申请日：1993-07-23
申请人： SMITHKLINE BEECHAM PLC , BURTON, George , GASSON, Brian, Charles , NAYLOR, Antoinette
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D501/00
CPC分类号： C07D501/00 , C07D463/22 , Y02P20/55
摘要： A compound of formula (I) or a salt thereof, wherein: R is hydrogen, methoxy or formamido; R is an acyl group; CO2R is a carboxy group or a carboxylate anion, or R is a readily removable carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; X is S, SO, SO2 or CH2; R is a bicyclic group (a), where m is 1 or 2; wherein one of Y or Z is O, S, SO or SO2 and the other is CH2, and wherein R may be unsubstituted or may have one or more optional substituents R . The compounds of formula (I) have antibacterial activity. Processes for making them and formulations including them are described.
摘要翻译：式（I）化合物或其盐，其中：R 1是氢，甲氧基或甲酰氨基; R 2是酰基; CO 2 R 3是羧基或羧酸根阴离子，或R 3是容易除去的羧基保护基或药学上可接受的成盐基团或体内可水解的酯基; X是S，SO，SO 2或CH 2; R 4是双环基团（a），其中m是1或2; 其中Y或Z中的一个是O，S，SO或SO 2，另一个是CH 2，并且其中R 4可以是未取代的或可以具有一个或多个任选的取代基R 5。式（I）化合物具有抗菌活性。描述制备它们的方法和包括它们的制剂。

4. 发明申请

WO1993025551A1 3-SUBSTITUTED CARBACEPHEMS 审中-公开
标题翻译： 3-取代的碳水化合物
公开(公告)号：WO1993025551A1
公开(公告)日：1993-12-23
申请号：PCT/GB1993001092
申请日：1993-05-26
申请人： SMITHKLINE BEECHAM PLC , BURTON, George , NAYLOR, Antoinette
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D463/00
CPC分类号： C07D463/22 , Y02P20/55
摘要： A compound of formula (I) or a salt thereof, wherein R is hydrogen, methoxy or formamido; R is an acyl group, in particular that of an antibacterially active cephalosporin; CO2R is a carboxy group or a carboxylate anion, or R is a readily removable carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R represents hydrogen or up to four substituents, which may be present on any of the carbon atoms in the ring system shown, selected from alkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, amino, alkylamino, acylamino, dialkylamino, CO2R, CONR2, SO2NR2 where R is hydrogen or alkyl, aryl and heterocyclyl, which may be the same or different and wherein any R alkyl substituent is optionally substituted by one or more substituents selected from the list from which R is selected; Y is O, S, SO or SO2; and m is 1 or 2, a process for its preparation, use as an antibiotic and intermediates thereto.
摘要翻译：式（I）化合物或其盐，其中R 1是氢，甲氧基或甲酰氨基; R 2是酰基，特别是抗菌活性头孢菌素的酰基; CO 2 R 3是羧基或羧酸根阴离子，或R 3是容易除去的羧基保护基或药学上可接受的成盐基团或体内可水解的酯基; R 4表示氢或至多四个取代基，其可以存在于所示的环体系中的任何碳原子上，所述环系统选自烷基，烯基，炔基，烷氧基，羟基，卤素，氨基，烷基氨基，酰氨基，二烷基氨基， CO 2 R，CONR 2，SO 2 NR 2，其中R是氢或烷基，芳基和杂环基，其可以相同或不同，并且其中任何R 4烷基取代基任选被一个或多个选自以下的取代基取代：其中R 4，被选中 Y是O，S，SO或SO 2; m为1或2，其制备方法，用作抗生素及其中间体。

5. 发明申请

WO1998005659A1 AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE 审中-公开
标题翻译：用于抗生素使用的亚氨基卡巴林多灵菌衍生物
公开(公告)号：WO1998005659A1
公开(公告)日：1998-02-12
申请号：PCT/EP1997004166
申请日：1997-07-29
申请人： SMITHKLINE BEECHAM PLC , TAKLE, Andrew, Kenneth , HUNT, Eric , NAYLOR, Antoinette
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D453/02
CPC分类号： C07D203/08 , C07C271/32 , C07C271/36 , C07C271/64 , C07C271/66 , C07C281/02 , C07C307/06 , C07C311/08 , C07C311/39 , C07C311/53 , C07C317/44 , C07C323/60 , C07C331/14 , C07C2601/02 , C07C2601/14 , C07C2603/82 , C07D203/20 , C07D207/16 , C07D209/08 , C07D211/62 , C07D213/40 , C07D213/70 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/38 , C07D241/24 , C07D249/04 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/113 , C07D277/36 , C07D277/80 , C07D285/06 , C07D285/125 , C07D295/088 , C07D295/205 , C07D295/215 , C07D307/10 , C07D307/66 , C07D307/68 , C07D317/66 , C07D333/34 , C07D333/38 , C07D401/06 , C07D417/06 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/08 , C07D487/08 , C07D513/04 , C07H15/24
摘要： Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R is vinyl or ethyl; and R is a group R , R CH2-, or R R C=CH-; wherein each of R and R is an azabicyclic ring system or R and R together with the carbon atom to which they are attached form an azabicyclic ring system, are useful in the prevention and treatment of microbial infections.
摘要翻译：式（3）的化合物及其药学上可接受的盐和衍生物，其中R 1是乙烯基或乙基; R 2是基团R 3，R 4 CH 2 - 或R 5 R 6 C = CH-; 其中R 3和R 4各自为氮杂双环系统或R 5和R 6与它们所连接的碳原子一起形成氮杂双环体系，可用于预防和治疗的微生物感染。

6. 发明申请

WO2007003386A9 IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS 审中-公开
标题翻译：咪唑吡啶衍生物作为酸性尿素拮抗剂
公开(公告)号：WO2007003386A9
公开(公告)日：2008-09-18
申请号：PCT/EP2006006410
申请日：2006-06-28
申请人： GLAXO GROUP LTD , BAMFORD MARK JAMES , ELLIOTT RICHARD LEONARD , GIBLIN GERARD MARTIN PAUL , NAYLOR ANTOINETTE , PANCHAL TERENCE AARON , TAKLE ANDREW KENNETH , WITHERINGTON JASON
发明人： BAMFORD MARK JAMES , ELLIOTT RICHARD LEONARD , GIBLIN GERARD MARTIN PAUL , NAYLOR ANTOINETTE , PANCHAL TERENCE AARON , TAKLE ANDREW KENNETH , WITHERINGTON JASON
IPC分类号： C07D471/04 , A61K31/435 , A61P1/00
CPC分类号： C07D471/04
摘要： This invention relates to newly identified imidazopyridine compounds of formula (I), to the use of such compounds in therapy and to their production.
摘要翻译：本发明涉及新确定的式（I）咪唑并吡啶化合物，用于治疗及其制备中的这些化合物。

7. 发明申请

WO2003022833A1 PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS 审中-公开
标题翻译：吡蚜酮和吡咯作为RAF激酶抑制剂
公开(公告)号：WO2003022833A1
公开(公告)日：2003-03-20
申请号：PCT/EP2002/009945
申请日：2002-09-05
申请人： SMITHKLINE BEECHAM PLC , DEAN, David, Kenneth , NAYLOR, Antoinette , TAKLE, Andrew, Kenneth , WILSON, David, Matthew
发明人： DEAN, David, Kenneth , NAYLOR, Antoinette , TAKLE, Andrew, Kenneth , WILSON, David, Matthew
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/44 , A61K31/505 , C07D405/04 , C07D405/14
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物及其作为药物的用途，特别是作为用于治疗神经外伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂的用途。

8. 发明申请

WO2008107455A1 INDAZOLES USED TO TREAT ESTROGEN RECEPTOR BETA MEDIATED DISORDERS 审中-公开
标题翻译：用于治疗雌激素受体β受体介导的疾病的药物
公开(公告)号：WO2008107455A1
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052664
申请日：2008-03-05
申请人： GLAXO GROUP LIMITED , JOHNSON, Christopher, Norbert , JONES, David, G , LIANG, Xi , MACPHERSON, David, Timothy , MILLER, Aaron, B , NAYLOR, Antoinette , STANWAY, Steven, James , TAKLE, Andrew, Kenneth , TRANI, Giancarlo
发明人： JOHNSON, Christopher, Norbert , JONES, David, G , LIANG, Xi , MACPHERSON, David, Timothy , MILLER, Aaron, B , NAYLOR, Antoinette , STANWAY, Steven, James , TAKLE, Andrew, Kenneth , TRANI, Giancarlo
IPC分类号： C07D231/56 , A61K31/416 , A61P3/00 , A61P25/00 , A61P29/00
CPC分类号： C07D231/56
摘要： The present invention relates to novel indazole derivatives (I) having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译：本发明涉及具有药理活性的新的吲唑衍生物（I），其制备方法，含有它们的组合物和这些化合物在治疗雌激素受体β介导的疾病中的用途。

9. 发明申请

WO2006100119A1 DERIVATIVES OF IMIDAZO (1,2-A) PYRIDINE USEFUL AS MEDICAMENTS FOR TREATING GASTROINTESTINAL DISEASES 审中-公开
标题翻译：咪达唑（1,2-A）吡啶的衍生物作为治疗胃肠疾病的药物有用
公开(公告)号：WO2006100119A1
公开(公告)日：2006-09-28
申请号：PCT/EP2006/002952
申请日：2006-03-22
申请人： GLAXO GROUP LIMITED , BAMFORD , Mark, James , ELLIOTT, Richard, Leonard , GIBLIN, Gerard, Martin, Paul , NAYLOR, Antoinette , WITHERINGTON, Jason , PANCHAL, Terence, Aaron , DEMONT, Emmanuel, Hubert
发明人： BAMFORD , Mark, James , ELLIOTT, Richard, Leonard , GIBLIN, Gerard, Martin, Paul , NAYLOR, Antoinette , WITHERINGTON, Jason , PANCHAL, Terence, Aaron , DEMONT, Emmanuel, Hubert
IPC分类号： A61K31/4353 , C07D471/04 , A61P1/04
CPC分类号： C07D471/04
摘要： This invention relates to newly identified imidazopyridine compounds of formula (I), to the use of such compounds in therapy and to their production.
摘要翻译：本发明涉及新确定的式（I）咪唑并吡啶化合物，用于治疗及其制备中的这些化合物。

10. 发明申请

WO2003022836A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS RAF INHIBITORS 审中-公开
标题翻译：含氮杂环化合物及其作为RAF抑制剂的用途
公开(公告)号：WO2003022836A1
公开(公告)日：2003-03-20
申请号：PCT/EP2002/009942
申请日：2002-09-05
申请人： SMITHKLINE BEECHAM PLC , BAMFORD, Mark, James , DEAN, David, Kenneth , NAYLOR, Antoinette , TAKLE, Andrew, Kenneth , WILSON, David, Matthew
发明人： DEAN, David, Kenneth , NAYLOR, Antoinette , TAKLE, Andrew, Kenneth , WILSON, David, Matthew
IPC分类号： C07D401/14
CPC分类号： C07D451/04 , C07D405/04 , C07D405/14 , C07D409/04
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式