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1. 发明申请

WO2006107273A8 COMPOUNDS HAVING PROGESTOGENIC ACTIVITY AND THEIR USE 审中-公开
标题翻译：具有致孕活性的化合物及其用途
公开(公告)号：WO2006107273A8
公开(公告)日：2006-12-28
申请号：PCT/SG2005000116
申请日：2005-04-06
申请人： UNIV SINGAPORE , YONG EU LEONG , LIM LIS SA ELISSA , SHEN PING , GONG YINHAN
发明人： YONG EU LEONG , LIM LIS SA ELISSA , SHEN PING , GONG YINHAN
IPC分类号： A61K31/343 , A61K31/381 , A61K31/407 , A61K36/00 , A61P5/30 , C07D487/02 , C07D491/02 , C07D493/22 , C07D495/02 , C07D497/02 , C07D498/02 , C07D513/02
CPC分类号： A61K36/236 , A61K31/343 , A61K31/381 , A61K31/407 , C07D493/04 , C07D493/10
摘要： The invention relates to compounds having progestogenic activity and to their use. The invention discloses a compound having the general formula (I) wherein Y, Y', X and X' are independently selected from the group consisting of O, S and N; R 1 is selected from the group consisting of optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C4-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally substituted C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 )alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 5 -C 10 )aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are independently selected from the group consisting of hydrogen, optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally substituted C 1-6 thioalkyl, optionally substituted C 5-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally substituted C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 )alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 5 -C 10 )aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; ---- indicates an optional double bond.
摘要翻译：本发明涉及具有孕激素活性的化合物及其用途。本发明公开了具有通式（I）的化合物，其中Y，Y'，X和X'独立地选自O，S和N; R 1选自任选取代的C 1-8烷基，任选取代的C 2-6烯基，任选取代的C 1-6烷基，炔基，任选取代的C 1-6烷氧基，任选取代的C 1-6硫代烷基，任选取代的C 4-10芳基，任选取代的C 6-12芳基，烷基芳基，任选取代的C 1-6烷基氨基，任选取代的C 1-6烷基羰基，任选取代的C 1-6烷基磺酰氨基，任选取代的（C 1 -C 6）烷基亚磺酰基，任选取代的C 1-6烷基羰基氨基，任选取代的杂（C 5 -C 5）芳基，羟基，卤素，氰基，硝基，氨基，甲酰基和巯基; R SUB 3，SUB 3，SUB 4，SUB 5，SUB 6，SUB和 R 7独立地选自氢，任选取代的C 1-8烷基，任选取代的C 2-6烯基，任选取代的取代的C 2-6炔基，任选取代的C 1-6烷氧基，任选取代的C 1-6硫代烷基，任选取代的C≡C1-6烷基， 5-10芳基，任选取代的C 6-11烷基芳基，任选取代的C 1-6烷基氨基，任选取代的C 1-6烷基，任选取代的C 1-6烷基磺酰氨基，任选取代的（C 1 -C 6）烷基亚磺酰基，任选取代的C 1 -C 4烷基磺酰基，任选取代的杂芳基，羟基，卤素，氰基，硝基，氨基，甲酰基和巯基; ----表示可选的双键。

2. 发明申请

WO2006107273A1 COMPOUNDS HAVING PROGESTOGENIC ACTIVITY AND THEIR USE 审中-公开
标题翻译：具有原发性活性的化合物及其使用
公开(公告)号：WO2006107273A1
公开(公告)日：2006-10-12
申请号：PCT/SG2005/000116
申请日：2005-04-06
申请人： NATIONAL UNIVERSITY OF SINGAPORE , YONG, Eu Leong , LIM, Lis Sa Elissa , SHEN, Ping , GONG, YinHan
发明人： YONG, Eu Leong , LIM, Lis Sa Elissa , SHEN, Ping , GONG, YinHan
IPC分类号： A61K31/343 , A61P5/30 , A61K31/381 , A61K31/407 , A61K36/00 , C07D495/02 , C07D487/02 , C07D491/02 , C07D493/22 , C07D497/02 , C07D498/02 , C07D513/02
CPC分类号： A61K36/236 , A61K31/343 , A61K31/381 , A61K31/407 , C07D493/04 , C07D493/10
摘要： The invention relates to compounds having progestogenic activity and to their use. The invention discloses a compound having the general formula (I) wherein Y, Y', X and X' are independently selected from the group consisting of O, S and N; R 1 is selected from the group consisting of optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally substituted C1-6 thioalkyl, optionally substituted C4-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally substituted C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 )alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 5 -C 10 )aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are independently selected from the group consisting of hydrogen, optionally substituted C 1-8 alkyl, optionally substituted C 2-6 alkenyl, optionally substituted C 2-6 alkynyl, optionally substituted C 1-6 alkoxy, optionally substituted C 1-6 thioalkyl, optionally substituted C 5-10 aryl, optionally substituted C 6-11 alkylaryl, optionally substituted C 1-6 alkylamino, optionally substituted C 1-6 alkylcarbonyl, optionally substituted C 1-6 alkylsulfonamino, optionally substituted (C 1 -C 6 )alkylsulfinyl, optionally substituted C 1-6 alkylcarbonylamino, optionally substituted hetero(C 5 -C 10 )aryl, hydroxyl, halogen, cyano, nitro, amino, formyl, and thiol; ---- indicates an optional double bond.
摘要翻译：本发明涉及具有孕激素活性及其应用的化合物。本发明公开了具有通式（I）的化合物，其中Y，Y'，X和X'独立地选自O，S和N; R 1选自任选取代的C 1-8 - 烷基，任选取代的C 2-6 - 烯基，任选取代的C 1 -C 6 - 任选取代的C 1-6烷氧基，任选取代的C 1-6硫烷基，任选取代的C 4-10芳基，任选取代的C 6-11 - 烷基芳基，任选取代的C 1-6烷基氨基，任选取代的C 1-6烷基羰基，任选取代的C 1-6烷基亚磺酰氨基，任选取代的（C 1 -C 6 -C 6）烷基亚磺酰基，任选取代的C 1-6烷基羰基氨基，任选取代的杂（C 5 -C 6 - 芳基，羟基，卤素，氰基，硝基，氨基，甲酰基和硫醇; R 2，R 3，R 4，R 5，R 6和R 5， R 7独立地选自氢，任选取代的C 1-8 - 烷基，任选取代的C 2-6 - 烯基，任选地取代的C 2-6 - 炔基，任选取代的C 1-6烷氧基，任选取代的C 1-6烷硫基，任选取代的C 1 -C 6 - 任选取代的C 6-11烷基芳基，任选取代的C 1-6烷基氨基，任选取代的C 1-6 - 任选取代的C 1 -C 6烷基亚磺酰基，任选取代的C 1 -C 6烷基亚磺酰基，任选取代的C 1 -C 6烷基亚磺酰基， 1-6烷基羰基氨基，任选取代的杂原子（C 5 -C 10）芳基，羟基，卤素，氰基，硝基，氨基，甲酰基和硫醇; ----表示可选双键。

3. 发明申请

WO2004017983A1 METHOD FOR THE PREPARATION OF PHYTOPROGESTOGENIC EXTRACTS FROM RHIZOMA LIGUSTICUM CHUANXIONG AND USES THEREOF 审中-公开
标题翻译：从枸杞子中制备生物发酵提取物的方法及其用途
公开(公告)号：WO2004017983A1
公开(公告)日：2004-03-04
申请号：PCT/SG2003/000195
申请日：2003-08-20
申请人： NATIONAL UNIVERSITY OF SINGAPORE , YONG, Eu, Leong , LIM, Lis Sa, Elissa , BUTLER, Mark, Stuart
发明人： YONG, Eu, Leong , LIM, Lis Sa, Elissa , BUTLER, Mark, Stuart
IPC分类号： A61K35/78
CPC分类号： A61K36/236 , G01N33/743 , G01N2500/10
摘要： A method of extracting phytoprogestogenic compounds from herbs and their use in preparing a medicament for treating humans requiring progesterone replacement or supplement. Assay systems to quantify progesterone and progestogenic receptor activity and a method for assembling a kit for the assays are also provided.
摘要翻译：从草药中提取植物诱发化合物的方法及其在制备用于治疗需要孕酮替代或补充的人的药物中的用途。还提供了用于量化孕酮和孕激素受体活性的测定系统和用于组装用于测定的试剂盒的方法。

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