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1. 发明申请

WO2010115052A2 INDUCED PLURIPOTENT STEM CELLS 审中-公开
标题翻译：诱导的大脑干细胞
公开(公告)号：WO2010115052A2
公开(公告)日：2010-10-07
申请号：PCT/US2010029704
申请日：2010-04-01
申请人： MCLEAN HOSPITAL CORP , KIM DOHOON , KIM CHUN-HYUNG , KIM KWANG-SOO
发明人： KIM DOHOON , KIM CHUN-HYUNG , KIM KWANG-SOO
IPC分类号： C12N5/074 , C07K7/06 , C07K14/47 , C12N5/10 , C12N15/12
CPC分类号： C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606
摘要： The present invention concerns the delivery of certain reprogramming factor proteins into cells, such as differentiated somatic cells, in order to induce the epi-genetic reprogramming of the cell so it becomes a pluripotent stem cell. The reprogramming factor protein(s) may be Sox2, Klf4, Oct3/4, c-Myc, Lin28, Nanog, or any protein with reprogramming (-enhancing) activity. These proteins may be linked recombinantly or chemically to a cell penetrating peptide that helps facilitate the introduction of these proteins into the target cell and may be preferably expressed in mammalian cells to maintain them in active forms. Accordingly, the present method of inducing pluripotent stem cell (iPS) formation avoids the use of viral or DNA-based expression vectors or the expression of reprogramming factor genes within target cells, which are known to be harmful to the host target cell and cause cancer.
摘要翻译：本发明涉及将某些重编程因子蛋白递送到诸如分化的体细胞的细胞中，以便诱导细胞的上皮重编程，从而使其成为多能干细胞。重编程因子蛋白可以是Sox2，Klf4，Oct3 / 4，c-Myc，Lin28，Nanog或具有重新编程（增强）活性的任何蛋白质。这些蛋白质可以重组或化学地连接到细胞穿透肽上，这有助于促进将这些蛋白质引入靶细胞，并且可优选在哺乳动物细胞中表达以维持它们为活性形式。因此，本发明的诱导多能干细胞（iPS）形成的方法避免了使用基于病毒或DNA的表达载体或靶细胞内重编程因子基因的表达，这已知对宿主靶细胞有害并导致癌症。

2. 发明申请

WO2004029064A1 (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF 审中-公开
标题翻译：（+） - （1-膦酰基-2-甲基-2-环丙基）甲基核苷衍生物的转移异构体，其制备方法及其抗病毒剂的用途
公开(公告)号：WO2004029064A1
公开(公告)日：2004-04-08
申请号：PCT/KR2003/001932
申请日：2003-09-22
申请人： LG LIFE SCIENCES LTD. , CHOI, Jong-Ryoo , HWANG, Jae-Taeg , CHO, Dong-Gyu , ROH, Kee-Yoon , KIM, Chun-Hyung , KIM, Chung-Mi , HAN, Min-Joon , KIM, Jeong-Min , CHO, Woo-Young , KIM, Gyoung-Won , Ahn, Sinbyoung
发明人： CHOI, Jong-Ryoo , HWANG, Jae-Taeg , CHO, Dong-Gyu , ROH, Kee-Yoon , KIM, Chun-Hyung , KIM, Chung-Mi , HAN, Min-Joon , KIM, Jeong-Min , CHO, Woo-Young , KIM, Gyoung-Won , Ahn, Sinbyoung
IPC分类号： C07F9/6561
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
摘要： The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
摘要翻译：本发明涉及可用作抗病毒剂（特别是针对乙型肝炎病毒）的式（1）的（1-膦基甲氧基-2-烷基环丙基）甲基核苷衍生物的（+） - 反式异构体，其药学上可接受的盐，其水合物或溶剂化物，以及制备式（1）化合物的立体异构体的方法和用于治疗病毒性疾病（特别是针对乙型肝炎病毒）的组合物，其包含（+） - 反式异构体式（1）的化合物，其药学上可接受的盐，水合物或溶剂合物作为活性物质。

3. 发明申请

WO2010115052A3 INDUCED PLURIPOTENT STEM CELLS 审中-公开
公开(公告)号：WO2010115052A3
公开(公告)日：2010-10-07
申请号：PCT/US2010/029704
申请日：2010-04-01
申请人： THE MCLEAN HOSPITAL CORPORATION , KIM, Dohoon , KIM, Chun-Hyung , KIM, Kwang-Soo
发明人： KIM, Dohoon , KIM, Chun-Hyung , KIM, Kwang-Soo
IPC分类号： C12N5/074 , C12N5/10 , C12N15/12 , C07K14/47 , C07K7/06
摘要： The present invention concerns the delivery of certain reprogramming factor proteins into cells, such as differentiated somatic cells, in order to induce the epi-genetic reprogramming of the cell so it becomes a pluripotent stem cell. The reprogramming factor protein(s) may be Sox2, Klf4, Oct3/4, c-Myc, Lin28, Nanog, or any protein with reprogramming (-enhancing) activity. These proteins may be linked recombinantly or chemically to a cell penetrating peptide that helps facilitate the introduction of these proteins into the target cell and may be preferably expressed in mammalian cells to maintain them in active forms. Accordingly, the present method of inducing pluripotent stem cell (iPS) formation avoids the use of viral or DNA-based expression vectors or the expression of reprogramming factor genes within target cells, which are known to be harmful to the host target cell and cause cancer.

4. 发明申请

WO2007098047A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：用于治疗帕金森病的方法和组合物
公开(公告)号：WO2007098047A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/004172
申请日：2007-02-15
申请人： THE MCLEAN HOSPITAL CORPORATION , KIM, Deog, Joong , KIM, Chun, Hyung , KIM, Kwang, Soo
发明人： KIM, Deog, Joong , KIM, Chun, Hyung , KIM, Kwang, Soo
IPC分类号： A61K31/4706
CPC分类号： A61K31/4706
摘要： The invention features methods and kits for treating or inhibiting the development of Parkinson's Disease by administering 7-chloro-4-aminoquinoline compounds, e.g., amodiaquine or glafenine. Stem cells are also useful in the methods of the invention and may be administered separately from or together with 7-chloro-4-aminoquinoline compounds. The invention further features methods of identifying additional chemical compounds that are useful in the treatment or inhibition of the development of Parkinson's Disease.
摘要翻译：本发明的特征在于通过施用7-氯-4-氨基喹啉化合物，例如阿莫地喹或格拉芬而治疗或抑制帕金森病发展的方法和试剂盒。干细胞也可用于本发明的方法，并且可以与7-氯-4-氨基喹啉化合物分开或一起施用。本发明还涉及鉴定可用于治疗或抑制帕金森病发展的其它化学化合物的方法。

5. 发明申请

WO2004029064A8 (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF 审中-公开
标题翻译：（+） - （1-膦酰基-2-甲基-2-环丙基）甲基核苷衍生物的转移异构体，其制备方法及其抗病毒剂的用途
公开(公告)号：WO2004029064A8
公开(公告)日：2005-05-19
申请号：PCT/KR0301932
申请日：2003-09-22
申请人： LG LIFE SCIENCES LTD , CHOI JONG-RYOO , HWANG JAE-TAEG , CHO DONG-GYU , ROH KEE-YOON , KIM CHUN-HYUNG , KIM CHUNG-MI , HAN MIN-JOON , KIM JEONG-MIN , CHO WOO-YOUNG , KIM GYOUNG-WON , AHN SINBYOUNG
发明人： CHOI JONG-RYOO , HWANG JAE-TAEG , CHO DONG-GYU , ROH KEE-YOON , KIM CHUN-HYUNG , KIM CHUNG-MI , HAN MIN-JOON , KIM JEONG-MIN , CHO WOO-YOUNG , KIM GYOUNG-WON , AHN SINBYOUNG
IPC分类号： C07F9/40 , C07F9/6512 , C07F9/6561 , A61K31/675 , C07F9/6509
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
摘要： The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
摘要翻译：本发明涉及可用作抗病毒剂（特别是针对乙型肝炎病毒）的式（1）的（1-膦基甲氧基-2-烷基环丙基）甲基核苷衍生物的（+） - 反式异构体，其药学上可接受的盐，水合物或溶剂合物，以及制备式（1）化合物的立体异构体的方法和用于治疗病毒性疾病（特别是针对乙型肝炎病毒）的组合物，其包含（+） - 反式异构体式（1）的化合物，其药学上可接受的盐，水合物或溶剂合物作为活性物质。

6. 发明申请

WO1994025486A1 IMPROVED HCV DIAGNOSTIC AGENTS 审中-公开
标题翻译：改进的HCV诊断试剂
公开(公告)号：WO1994025486A1
公开(公告)日：1994-11-10
申请号：PCT/KR1994000040
申请日：1994-04-29
申请人： LUCKY LIMITED , CHO, Joong, Myung , CHOI, Deog, Young , KIM, Chun, Hyung , SO, Hong, Seob , YANG, Jae, Young , KIM, In, Soo , KIM, Joo, Ho
发明人： LUCKY LIMITED
IPC分类号： C07K13/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , G01N33/5767 , Y10S530/811 , Y10S530/826
摘要： The present invention relates to the epitopes of hepatitis C virus (HCV) core protein and non-structural 3 protein (NS3), and the epitopes of envelope protein, epitopes of non-structural 4 protein, and the epitopes of HCV non-structural 5 protein and a recombinant protein comprising the same; processes for producing the recombinant proteins; an agent for diagnosing antibodies against hepatitis C virus in a putative serum sample, which comprises said recombinant proteins; and a process for diagnosing hepatitis C by using the agent.
摘要翻译：本发明涉及丙型肝炎病毒（HCV）核心蛋白和非结构性3蛋白（NS3）的表位，以及包膜蛋白的表位，非结构性4蛋白的表位，以及HCV非结构性5结构的表位蛋白质和包含其的重组蛋白质; 生产重组蛋白的方法; 用于在推定的血清样品中诊断丙型肝炎病毒抗体的试剂，其包含所述重组蛋白; 以及通过使用该药剂来诊断丙型肝炎的过程。

7. 发明申请

WO2012138190A3 COMPOSITION CONTAINING JETBEAD EXTRACTS 审中-公开
标题翻译：含有JETBEAD提取物的组合物
公开(公告)号：WO2012138190A3
公开(公告)日：2013-01-10
申请号：PCT/KR2012002653
申请日：2012-04-06
申请人： KOREA RES INST OF BIOSCIENCE , KIM WON GON , HAN BAEK SOO , KIM KYOUNG SHIM , KIM KWANG SOO , KIM CHUN HYUNG , JUNG HOE YUN , KANG YOUNG MI , SOHN MI JIN
发明人： KIM WON GON , HAN BAEK SOO , KIM KYOUNG SHIM , KIM KWANG SOO , KIM CHUN HYUNG , JUNG HOE YUN , KANG YOUNG MI , SOHN MI JIN
IPC分类号： A61K36/73 , A61K36/86 , A61P25/16 , A61P25/28
CPC分类号： A61K36/73 , A61K36/738
摘要： The present invention relates to a pharmaceutical composition containing jetbead extracts as active ingredients for preventing or treating Parkinson's disease, wherein the jetbead extracts are obtained by performing extraction on the stem of the jetbead using an organic solvent. The present invention also relates to food additives which contain jetbead extracts as active ingredients and which exhibit the effects of preventing or treating Parkinson's disease. The jetbead extracts of the present invention may prevent or treat Parkinson's disease without producing any particular side effects, and therefore can be widely used for more safely treating Parkinson's disease.
摘要翻译：本发明涉及含有喷射提取物作为预防或治疗帕金森病的活性成分的药物组合物，其中通过使用有机溶剂在喷射珠的茎上进行萃取而获得喷射珠提取物。本发明还涉及含有喷射提取物作为活性成分并且具有预防或治疗帕金森病的作用的食品添加剂。本发明的喷射提取物可以预防或治疗帕金森病，而不产生任何特定的副作用，因此可广泛用于更安全地治疗帕金森病。

8. 发明申请

WO2007098047A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：用于治疗帕金森病的方法和组合物
公开(公告)号：WO2007098047A3
公开(公告)日：2008-11-06
申请号：PCT/US2007004172
申请日：2007-02-15
申请人： MCLEAN HOSPITAL CORP , KIM DEOG JOONG , KIM CHUN HYUNG , KIM KWANG SOO
发明人： KIM DEOG JOONG , KIM CHUN HYUNG , KIM KWANG SOO
IPC分类号： A61K31/4706
CPC分类号： A61K31/4706
摘要： The invention features methods and kits for treating or inhibiting the development of Parkinson's Disease by administering 7-chloro-4-aminoquinoline compounds, e.g., amodiaquine or glafenine. Stem cells are also useful in the methods of the invention and may be administered separately from or together with 7-chloro-4-aminoquinoline compounds. The invention further features methods of identifying additional chemical compounds that are useful in the treatment or inhibition of the development of Parkinson's Disease.
摘要翻译：本发明的特征在于通过施用7-氯-4-氨基喹啉化合物，例如阿莫地喹或格拉芬而治疗或抑制帕金森病发展的方法和试剂盒。干细胞也可用于本发明的方法，并且可以与7-氯-4-氨基喹啉化合物分开或一起施用。本发明还涉及鉴定可用于治疗或抑制帕金森病发展的其它化学化合物的方法。

9. 发明申请

WO2007095352A3 DIAGNOSIS AND TREATMENT OF ATTENTIONAL DISORDERS 审中-公开
公开(公告)号：WO2007095352A3
公开(公告)日：2007-08-23
申请号：PCT/US2007/004113
申请日：2007-02-14
申请人： THE MC LEAN HOSPITAL CORPORATION , KIM, Kwang-Soo , KIM, Chun-Hyung
发明人： KIM, Kwang-Soo , KIM, Chun-Hyung
IPC分类号： C12Q1/68 , C07H21/04
摘要： This invention features methods and compositions useful for the treatment and diagnosis of attentional disorders including attention deficit hyperactivity disorder (ADHD). Also disclosed are methods for identifying compounds useful for such therapy.

10. 发明申请

WO2007095352A2 DIAGNOSIS AND TREATMENT OF ATTENTIONAL DISORDERS 审中-公开
标题翻译：诊断和治疗注意事项
公开(公告)号：WO2007095352A2
公开(公告)日：2007-08-23
申请号：PCT/US2007004113
申请日：2007-02-14
申请人： MC LEAN HOSPITAL CORP , KIM KWANG-SOO , KIM CHUN-HYUNG
发明人： KIM KWANG-SOO , KIM CHUN-HYUNG
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： This invention features methods and compositions useful for the treatment and diagnosis of attentional disorders including attention deficit hyperactivity disorder (ADHD). Also disclosed are methods for identifying compounds useful for such therapy.
摘要翻译：本发明的特征在于可用于治疗和诊断包括注意缺陷多动障碍（ADHD）在内的注意障碍的方法和组合物。还公开了鉴定可用于此类治疗的化合物的方法。

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