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1. 发明申请

WO2011063903A1 APPLIKATOR ZUM AUFTRAGEN EINER RADIOAKTIVEN SUBSTANZ AUF EIN BIOLOGISCHES GEWEBE 审中-公开
标题翻译： APPLICATOR用于将放射性物质到生物组织
公开(公告)号：WO2011063903A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/006971
申请日：2010-11-16
申请人： ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG , CIPRIANI, Cesidio , DESANTIS, Maria , BICHLMAIER, Max , FÖRG, Siegfried , TUOMO, Nikula , HARFENSTELLER, Mark , BUCK, Oliver
发明人： CIPRIANI, Cesidio , DESANTIS, Maria , BICHLMAIER, Max , FÖRG, Siegfried , TUOMO, Nikula , HARFENSTELLER, Mark , BUCK, Oliver
IPC分类号： A61N5/10 , A61M35/00 , G21F7/06
CPC分类号： A61N5/1001 , A61N5/10 , A61N2005/1021 , G21F3/00
摘要： Applikator zum Auftragen einer radioaktiven Substanz auf ein biologisches Gewebe, wobei der Applikator einen Behälter zur Aufnahme der radioaktiven Substanz, eine mit dem Behälter verbindbare Applikationseinrichtung, mit der die Substanzverbindung auf das Gewebe aufgetragen werden kann, und zumindest einen Teil einer Fördereinrichtung aufweist, mit der die radioaktive Substanz vom Behälter in die Applikationseinrichtung zugeführt werden kann, wenn die Applikationseinrichtung mit dem Behälter verbunden ist.
摘要翻译：施用器用于将放射性物质到生物组织中，涂抹器，包括一个容器，用于接收放射性物质，可连接与该物质组合可被施加到织物上的容器应用程序装置中，以及至少一个输送器的一部分，与所述放射性物质可以从容器中供给到涂敷装置当应用设备被连接到所述容器。

2. 发明申请

WO2018138744A1 COMPOSITION, DEVICE AND METHOD FOR CONFORMATIONAL INTRA-TISSUE BETA BRANCHYTHERAPY 审中-公开
公开(公告)号：WO2018138744A1
公开(公告)日：2018-08-02
申请号：PCT/IT2017/000292
申请日：2017-12-22
申请人： DESANTIS, Maria , CIPRIANI, Cesidio
发明人： DESANTIS, Maria , CIPRIANI, Cesidio
IPC分类号： A61K9/00 , A61K47/38 , A61P35/00 , A61K51/06 , A61B6/00 , A61N5/10
摘要： It is claimed the invention of a composition and a device to be used in medical therapy as a containment matrix in conformational intra-tissue beta brachytherapy. The composition is made so as to form a gel which can be injected intra-tissue without toxicity in the organism, holding in suspension during injection the particulate of a beta-emitting brachytherapy composition, and forming after injection a solid deposit that immobilizes the radiotherapeutic composition in the injection bolus, to prevent migration of the radioactive product into the surrounding tissues. The composition is injected with an apparatus dedicated to percutaneous intra-tissue injection comprising a 7-degree robotic apparatus, an automatic injection device under pressure, a needles system to provide the therapeutic composition application in the tissue to be treated with minimal trauma. An advanced software system is also included that allows interfacing between diagnostic imaging data, robotic arm movement scheduling, and composition dose distribution, in order to optimize the distribution of the radiotherapeutic doses of the composition into the tissue to be treated, according to a targeted individual therapeutic strategy. Additionally a method for using the invention for the application in human or animal medicine is claimed.

3. 发明申请

WO2018138744A8 COMPOSITION, DEVICE AND METHOD FOR CONFORMATIONAL INTRA-TISSUE BETA BRACHYTHERAPY 审中-公开
公开(公告)号：WO2018138744A8
公开(公告)日：2018-08-02
申请号：PCT/IT2017/000292
申请日：2017-12-22
申请人： DESANTIS, Maria , CIPRIANI, Cesidio
发明人： DESANTIS, Maria , CIPRIANI, Cesidio
IPC分类号： A61K9/00 , A61K47/38 , A61P35/00 , A61K51/06 , A61B6/00 , A61N5/10
摘要： It is claimed the invention of a composition and a device to be used in medical therapy as a containment matrix in conformational intra-tissue beta brachytherapy. The composition is made so as to form a gel which can be injected intra-tissue without toxicity in the organism, holding in suspension during injection the particulate of a beta-emitting brachytherapy composition, and forming after injection a solid deposit that immobilizes the radiotherapeutic composition in the injection bolus, to prevent migration of the radioactive product into the surrounding tissues. The composition is injected with an apparatus dedicated to percutaneous intra-tissue injection comprising a 7-degree robotic apparatus, an automatic injection device under pressure, a needles system to provide the therapeutic composition application in the tissue to be treated with minimal trauma. An advanced software system is also included that allows interfacing between diagnostic imaging data, robotic arm movement scheduling, and composition dose distribution, in order to optimize the distribution of the radiotherapeutic doses of the composition into the tissue to be treated, according to a targeted individual therapeutic strategy. Additionally a method for using the invention for the application in human or animal medicine is claimed.

4. 发明申请

WO2012168047A1 SCHICHTAUFBAU ZUR EPIDERMALEN RADIONUKLIDTHERAPIE 审中-公开
标题翻译：层规格表皮放射性核素
公开(公告)号：WO2012168047A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/059108
申请日：2012-05-16
申请人： ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG , DESANTIS, Maria , BUCK, Oliver , CIPRIANI, Cesidio
发明人： DESANTIS, Maria , BUCK, Oliver , CIPRIANI, Cesidio
IPC分类号： A61N5/10
CPC分类号： A61N5/1029
摘要： Die vorliegende Erfindung betrifft einen Schichtaufbau zur epidermalen Radionuklidtherapie (Brachytherapie) eines Patienten, mit einer, aus Patientensicht proximalen, Haftschicht zum Anbringen des Schichtaufbaus auf einer zu behandelnden Hautoberfläche des Patienten; einer aus Patientensicht in distaler Richtung über der Haftschicht angeordneten flexiblen, transparenten Trägerschicht; sowie wenigstens einer auf der Trägerschicht angeordneten radionuklidhaltigen Emissionsschicht; wobei die Haftschicht und die Trägerschicht hinsichtlich ihrer Bestandteile und Dicke so ausgebildet sind, dass sie im Wesentlichen für ß- und γ-Strahlung durchlässig sind. Der erfindungsgemäße Schichtaufbau eignet sich besonders zur radiotherapeutischen Behandlung des Basalzellkarzinoms (BCC) und des Plattenepithelkarzinoms (SCC). Mit Hilfe des erfindungsgemäßen Schichtaufbaus können tumorbedingte, geometrisch anspruchsvolle Hautläsionen, wie sie z.B. am äußeren Rand der Ohrmuschel, dem Augenbereich oder über die Nasolabialfalte hinweg auftreten, mühelos behandelt werden. Dabei liegt stets eine konstante Strahlendosis über die gesamte Läsion an, da sich die Strahlungsquelle überall im selben Abstand zur zu behandelnden Hautoberfläche befindet.
摘要翻译：本发明涉及一种用于患者的表皮放射性核素治疗（近距离放射治疗）的层叠结构，具有从患者的角度来看的近端，用于在皮肤表面的层结构的连接的粘合剂层要治疗的患者的; 从视图中在所述粘合剂层中的远侧方向上的患者设置柔性透明支撑层; 和布置在所述载体层的放射性核素发射层上的至少一个; 其中所述粘合剂层和所述载体层是相对于它们的成分和厚度来形成，使得它们基本上是透明的SS和？ - 辐射。根据本发明的层结构为基底细胞癌（BCC）和鳞状细胞癌（SCC）的放疗治疗特别有用。用本发明的层状结构的帮助下可能肿瘤相关，几何苛刻皮肤损伤，如，例如，在耳廓上的外边缘，在时间的鼻唇沟眼睛区域或发生，容易地处理。在整个病变辐射的恒定剂量总是上，作为围绕相同的距离辐射源待治疗皮肤表面。

5. 发明申请

WO2009109327A3 METHOD AND PRODUCT FOR OBTAINING THIN RADIOACTIVE LAYERS TO BE USED IN RADIATION DOSIMETRY AND IN MEDICINE 审中-公开
标题翻译：用于获得放射性剂量和药物中使用的放射性物质层的方法和产品
公开(公告)号：WO2009109327A3
公开(公告)日：2010-04-08
申请号：PCT/EP2009001377
申请日：2009-02-26
申请人： ITM ISOTOPEN TECHNOLOGIEN MUEN , CIPRIANI CESIDIO , DESANTIS MARIA
发明人： CIPRIANI CESIDIO , DESANTIS MARIA
IPC分类号： A61K51/12
CPC分类号： A61N5/1001 , A61K51/1217 , A61N2005/1019
摘要： In the present invention a method and a product useful for the fabrication of radioactive sources in thin layer are proposed. In the presented method, differently form the sources currently used in radiation dosimetry and in classical brachytherapy, the obtained sources are mouldable, can easily assume different shapes and thicknesses, can be safely used without contamination. By starting from a solution containing a radioactive isotope, a solid matrix is obtained, in which the radioactive isotope is embedded; the matrix in which the isotope is immobilized is sufficiently flexible and variable to adapt to different surfaces and substrates. The matrix which encloses the radioactive isotope is chosen in order to be chemically compatible with the embedded isotope, and to ensure a homogeneity of the imparted dose. The radioactive sources obtained in this way can be used in the fabrication of calibration sources, and in the field of the therapy of tumours.
摘要翻译：在本发明中，提出了一种用于制造薄层放射源的方法和产品。在所提出的方法中，不同地形成目前在辐射剂量学和经典近距离放射疗法中使用的来源，所得到的来源是可模制的，可以容易地呈现不同的形状和厚度，可以安全地使用而没有污染。从包含放射性同位素的溶液开始，获得固体基质，其中嵌入放射性同位素; 其中固定有同位素的基质具有足够的柔韧性和可变性以适应不同的表面和底物。选择包围放射性同位素的基质，以便与嵌入的同位素化学相容，并确保赋予剂量的均匀性。以这种方式获得的放射源可用于校准源的制造和肿瘤治疗领域。

6. 发明申请

WO2009109327A2 METHOD AND PRODUCT FOR OBTAINING THIN RADIOACTIVE LAYERS TO BE USED IN RADIATION DOSIMETRY AND IN MEDICINE 审中-公开
标题翻译：用于获得放射性剂量和药物中使用的放射性物质层的方法和产品
公开(公告)号：WO2009109327A2
公开(公告)日：2009-09-11
申请号：PCT/EP2009/001377
申请日：2009-02-26
申请人： ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG , CIPRIANI, Cesidio , DESANTIS, Maria
发明人： CIPRIANI, Cesidio , DESANTIS, Maria
IPC分类号： A61K51/12
CPC分类号： A61N5/1001 , A61K51/1217 , A61N2005/1019
摘要： In the present invention a method and a product useful for the fabrication of radioactive sources in thin layer are proposed. In the presented method, differently form the sources currently used in radiation dosimetry and in classical brachytherapy, the obtained sources are mouldable, can easily assume different shapes and thicknesses, can be safely used without contamination. By starting from a solution containing a radioactive isotope, a solid matrix is obtained, in which the radioactive isotope is embedded; the matrix in which the isotope is immobilized is sufficiently flexible and variable to adapt to different surfaces and substrates. The matrix which encloses the radioactive isotope is chosen in order to be chemically compatible with the embedded isotope, and to ensure a homogeneity of the imparted dose. The radioactive sources obtained in this way can be used in the fabrication of calibration sources, and in the field of the therapy of tumours.
摘要翻译：在本发明中，提出了一种用于制造薄层放射源的方法和产品。在所提出的方法中，不同地形成目前在辐射剂量学和经典近距离放射疗法中使用的来源，所得到的来源是可模制的，可以容易地呈现不同的形状和厚度，可以安全地使用而没有污染。从包含放射性同位素的溶液开始，获得固体基质，其中嵌入放射性同位素; 其中固定有同位素的基质具有足够的柔韧性和可变性以适应不同的表面和底物。选择包围放射性同位素的基质，以便与嵌入的同位素化学相容，并确保赋予剂量的均匀性。以这种方式获得的放射源可用于校准源的制造和肿瘤治疗领域。

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