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1. 发明申请

WO2008033558A2 TISSUE CLOSURE, DELIVERY DEVICE AND METHOD OF USE 审中-公开
标题翻译：组织闭合，输送装置及其使用方法
公开(公告)号：WO2008033558A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/020131
申请日：2007-09-17
申请人： VASCULAR PRECISION , BENJAMIN, Elad , THOMAS, Jonathan , PIENKNAGURA, Carla , SAFA, Bauback
发明人： BENJAMIN, Elad , THOMAS, Jonathan , PIENKNAGURA, Carla , SAFA, Bauback
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/068 , A61B17/0684 , A61B2017/00637 , A61B2017/00668 , A61B2017/00867 , A61B2017/0641 , A61B2017/22038 , A61B2017/320044
摘要： A tissue closure assembly and a closure delivery device are provided for closing incisions in a target tissue, such as an artery, vein, fascia or hollow organ. The closure delivery device has a closure deployment mechanism within an elongated cylindrical body with an expanding dilator tip and a control handle with an actuation mechanism for sequentially actuating the expanding dilator tip and the closure deployment mechanism. A lumen locator and anchor mechanism has a guidewire and back bleed lumen, an expandable anchor and, optionally, an arteriotomy cutting blade. Various embodiments of tissue closure assemblies are provided having a first and second tissue closure component for attaching to the target tissue on either side of an intended arteriotomy site and means for approximating the first and second tissue closure component and locking them together to seal the arteriotomy after performing a transluminal procedure through the arteriotomy.
摘要翻译：提供组织封闭组件和闭合递送装置，用于封闭目标组织（例如动脉，静脉，筋膜或中空器官）中的切口。封闭物递送装置具有在细长圆柱形本体内的封闭展开机构，其具有扩张扩张器尖端和具有致动机构的控制手柄，用于顺序地致动膨胀扩张器尖端和封闭件展开机构。管腔定位器和锚定机构具有导丝和回流出腔，可扩张锚和任选的动脉切开切割刀片。提供组织闭合组件的各种实施例，其具有第一和第二组织闭合部件，用于附接到预定的动脉切开术部位的任一侧上的靶组织，以及用于近似第一和第二组织闭合部件并将其锁定在一起以密封动脉切开术的装置，通过动脉切开术进行经腔手术。

2. 发明申请

WO2006128017A3 DEVICES AND METHODS FOR THE CONTROLLED FORMATION AND CLOSURE OF VASCULAR OPENINGS 审中-公开
标题翻译：用于控制形成和封闭血管开口的装置和方法
公开(公告)号：WO2006128017A3
公开(公告)日：2009-04-30
申请号：PCT/US2006020496
申请日：2006-05-24
申请人： UNIV LELAND STANFORD JUNIOR , BENJAMIN ELAD , GOBER MICHAEL ELLIOT , PEINKNAGURA CARLA , SAFA BAUBACK , THOMAS JONATHAN MOULTON
发明人： BENJAMIN ELAD , GOBER MICHAEL ELLIOT , PEINKNAGURA CARLA , SAFA BAUBACK , THOMAS JONATHAN MOULTON
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/068 , A61B2017/00637 , A61B2017/00663 , A61B2017/00867 , A61B2017/0641 , A61B2017/0649
摘要： The present invention includes systems, devices and methods for percutaneously forming an aperture within a tissue structure or vessel and closing the aperture in a manner which optimizes hemostasis and healing. The invention in one aspect includes implantable devices which are used to seal the tissue aperture upon closure of the aperture after a percutaneous or endovascular procedure.
摘要翻译：本发明包括用于在组织结构或容器内经皮形成孔并以优化止血和愈合的方式闭合孔的系统，装置和方法。本发明在一个方面包括可植入装置，其用于在经皮或血管内手术之后封闭孔时密封组织孔。

3. 发明申请

WO2008027366A3 DEVICES AND METHODS FOR CREATING AND CLOSING CONTROLLED OPENINGS IN TISSUE 审中-公开
标题翻译：用于创建和关闭组织中的控制开口的装置和方法
公开(公告)号：WO2008027366A3
公开(公告)日：2008-08-07
申请号：PCT/US2007018895
申请日：2007-08-28
申请人： VASCULAR PREC , THOMAS JONATHAN , BENJAMIN ELAD , PIENKNAGURA CARLA , SAFA BAUBACK
发明人： THOMAS JONATHAN , BENJAMIN ELAD , PIENKNAGURA CARLA , SAFA BAUBACK
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/3203 , A61B17/3417 , A61B18/082 , A61B18/1492 , A61B2017/00637 , A61B2017/00659 , A61B2017/00867 , A61B2017/0498 , A61B2017/22038 , A61B2017/320052 , A61B2018/00345 , A61B2018/00404 , A61B2018/00601 , A61F2/064
摘要： Devices and methods for creating and closing controlled, shaped openings in tissue, such as blood vessel walls or fascia layers, utilize an implantable access and closure device, or access port, with an aperture that demarcates a desired location for the opening in the tissue. Incision means for creating an opening through the tissue may include a crescent or arc-shaped heating element; a cutting wire; a water jet; or a cutting edge that is integrated into the access port. A self-sealing incision is also described. Closure means to seal the arteriotomy or other opening and provide hemostasis may include a net, patch, ring or wire that is deployed externally to the vessel, covering the arteriotomy site. Another closure means comprises a stent, or tube-like closure mechanism that is inserted through the arteriotomy site and deployed within the vessel. A side opening allows a procedure sheath to enter the blood vessel. After the procedure, the closure mechanism is rotated within the vessel so that the side opening is no longer aligned with the arteriotomy.
摘要翻译：用于创建和关闭组织（例如血管壁或筋膜层）中受控的成形开口的装置和方法利用可植入的入口和闭合装置或进入端口，该孔具有划定组织中的开口的期望位置的孔。用于产生穿过组织的开口的切口装置可包括新月形或弧形加热元件; 切割线水射流或集成到接入端口中的切削刃。还描述了自密封切口。闭合意味着密封动脉切开术或其他开口并且提供止血可以包括部署在血管外部的网，贴片，环或电线，覆盖动脉切开术部位。另一闭合装置包括一个支架或管状闭合机构，其插入通过动脉切开术部位并且部署在血管内。侧开口允许手术护套进入血管。在该过程之后，闭合机构在容器内旋转，使得侧开口不再与动脉切开术对齐。

4. 发明申请

WO2008033558A3 TISSUE CLOSURE, DELIVERY DEVICE AND METHOD OF USE 审中-公开
标题翻译：组织封闭，递送装置和使用方法
公开(公告)号：WO2008033558A3
公开(公告)日：2008-07-31
申请号：PCT/US2007020131
申请日：2007-09-17
申请人： VASCULAR PREC , BENJAMIN ELAD , THOMAS JONATHAN , PIENKNAGURA CARLA , SAFA BAUBACK
发明人： BENJAMIN ELAD , THOMAS JONATHAN , PIENKNAGURA CARLA , SAFA BAUBACK
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B17/068 , A61B17/0684 , A61B2017/00637 , A61B2017/00668 , A61B2017/00867 , A61B2017/0641 , A61B2017/22038 , A61B2017/320044
摘要： A tissue closure assembly and a closure delivery device are provided for closing incisions in a target tissue, such as an artery, vein, fascia or hollow organ. The closure delivery device has a closure deployment mechanism within an elongated cylindrical body with an expanding dilator tip and a control handle with an actuation mechanism for sequentially actuating the expanding dilator tip and the closure deployment mechanism. A lumen locator and anchor mechanism has a guidewire and back bleed lumen, an expandable anchor and, optionally, an arteriotomy cutting blade. Various embodiments of tissue closure assemblies are provided having a first and second tissue closure component for attaching to the target tissue on either side of an intended arteriotomy site and means for approximating the first and second tissue closure component and locking them together to seal the arteriotomy after performing a transluminal procedure through the arteriotomy.
摘要翻译：提供组织闭合组件和闭合物递送装置用于闭合目标组织例如动脉，静脉，筋膜或中空器官中的切口。封闭物输送装置具有在细长圆柱形本体内的封闭物展开机构，该扩张扩张器末端和控制手柄具有用于顺序地致动扩张扩张器顶端和封闭物展开机构的致动机构。管腔定位器和锚固机构具有导丝和背部排出管腔，可膨胀锚定件和可选的动脉切口切割刀片。提供了组织闭合组件的各种实施例，该组件闭合组件具有第一和第二组织闭合部件，用于连接到目标动脉切口部位的任一侧上的目标组织，以及用于接近第一和第二组织闭合部件并将它们锁定在一起以密封动脉切口通过动脉切口进行透腔手术。

5. 发明申请

WO2008027366A2 DEVICES AND METHODS FOR CREATING AND CLOSING CONTROLLED OPENINGS IN TISSUE 审中-公开
标题翻译：用于在组织中制造和封闭受控开口的装置和方法
公开(公告)号：WO2008027366A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018895
申请日：2007-08-28
申请人： VASCULAR PRECISION , THOMAS, Jonathan , BENJAMIN, Elad , PIENKNAGURA, Carla , SAFA, Bauback
发明人： THOMAS, Jonathan , BENJAMIN, Elad , PIENKNAGURA, Carla , SAFA, Bauback
IPC分类号： A61B17/02
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/3203 , A61B17/3417 , A61B18/082 , A61B18/1492 , A61B2017/00637 , A61B2017/00659 , A61B2017/00867 , A61B2017/0498 , A61B2017/22038 , A61B2017/320052 , A61B2018/00345 , A61B2018/00404 , A61B2018/00601 , A61F2/064
摘要： Devices and methods for creating and closing controlled, shaped openings in tissue, such as blood vessel walls or fascia layers, utilize an implantable access and closure device, or access port, with an aperture that demarcates a desired location for the opening in the tissue. Incision means for creating an opening through the tissue may include a crescent or arc-shaped heating element; a cutting wire; a water jet; or a cutting edge that is integrated into the access port. A self-sealing incision is also described. Closure means to seal the arteriotomy or other opening and provide hemostasis may include a net, patch, ring or wire that is deployed externally to the vessel, covering the arteriotomy site. Another closure means comprises a stent, or tube-like closure mechanism that is inserted through the arteriotomy site and deployed within the vessel. A side opening allows a procedure sheath to enter the blood vessel. After the procedure, the closure mechanism is rotated within the vessel so that the side opening is no longer aligned with the arteriotomy.
摘要翻译：用于在组织（例如血管壁或筋膜层）中创建和闭合受控的成形开口的装置和方法利用可植入的进入和闭合装置或进入端口，其具有划分期望的在组织中的位置。用于形成穿过组织的开口的切口装置可以包括月牙形或弧形加热元件; 切割线; 水射流; 或集成到接入端口中的切割边缘。还描述了自密封切口。闭合意味着密封动脉切口或其他开口并提供止血，可包括在血管外部展开的覆盖动脉切口部位的网，贴片，环或线。另一种闭合装置包括支架或管状闭合机构，其通过动脉切口部位插入并在血管内部署。侧面开口允许手术鞘进入血管。手术后，关闭机构在血管内旋转，使侧开口不再与动脉切口对齐。

6. 发明申请

WO2006128017A2 DEVICES AND METHODS FOR THE CONTROLLED FORMATION AND CLOSURE OF VASCULAR OPENINGS 审中-公开
标题翻译：用于控制形成和封闭血管开口的装置和方法
公开(公告)号：WO2006128017A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020496
申请日：2006-05-24
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BENJAMIN, Elad , GOBER, Michael, Elliot , PEINKNAGURA, Carla , SAFA, Bauback , THOMAS, Jonathan, Moulton
发明人： BENJAMIN, Elad , GOBER, Michael, Elliot , PEINKNAGURA, Carla , SAFA, Bauback , THOMAS, Jonathan, Moulton
IPC分类号： B32B27/12
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/068 , A61B2017/00637 , A61B2017/00663 , A61B2017/00867 , A61B2017/0641 , A61B2017/0649
摘要： The present invention includes systems, devices and methods for percutaneously forming an aperture within a tissue structure or vessel and closing the aperture in a manner which optimizes hemostasis and healing. The invention in one aspect includes implantable devices which are used to seal the tissue aperture upon closure of the aperture after a percutaneous or endovascular procedure.
摘要翻译：本发明包括用于在组织结构或容器内经皮形成孔并以优化止血和愈合的方式闭合孔的系统，装置和方法。本发明在一个方面包括可植入装置，其用于在经皮或血管内手术之后封闭孔时密封组织孔。

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