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1. 发明申请

WO2009098518A3 HYDROGEL COMPOSITES AND WOUND DRESSINGS 审中-公开
标题翻译： HYDROGEL复合材料和连衣裙
公开(公告)号：WO2009098518A3
公开(公告)日：2010-07-08
申请号：PCT/GB2009050121
申请日：2009-02-06
申请人： FIRST WATER LTD , MUNRO HUGH SEMPLE , ANDREWS PHILIP , JEFFREY CHARLES
发明人： MUNRO HUGH SEMPLE , ANDREWS PHILIP , JEFFREY CHARLES
IPC分类号： A61L15/22 , A61F13/00 , A61L15/60
CPC分类号： A61L15/22 , A61L15/60
摘要： The present invention provides an absorbent hydrogel composite for use in the manufacture of an article for application to a fluid-emitting surface, e.g. a wound, the composite having a laminar structure comprising first and second layers, the first layer being a surface contacting layer comprising a porous net structure having a surface contacting face and an outwardly directed face, the second layer comprising a low-crosslinked absorbent hydrogel disposed over the outwardly directed face of the first layer and arranged so that in use it is in fluid flow communication with the surface through apertures of the net structure.
摘要翻译：本发明提供一种用于制造用于流体发射表面的制品的吸收性水凝胶复合材料，所述复合材料具有包括第一和第二层的层状结构，所述第一层是包括具有表面接触面和向外指向表面的多孔网结构的表面接触层，所述第二层包含低交联吸收性水凝胶在第一层的向外指向的表面上并且布置成使得在使用中它通过网状结构的孔与表面流体连通。

2. 发明申请

WO1995013083A1 NOVEL PEPTIDES FOR HEPARIN AND LOW MOLECULAR WEIGHT HEPARIN ANTICOAGULATION REVERSAL 审中-公开
标题翻译： HEPARIN和低分子量HEPARIN抗体逆转的新肽
公开(公告)号：WO1995013083A1
公开(公告)日：1995-05-18
申请号：PCT/US1994012981
申请日：1994-11-10
申请人： UNIVERSITY OF MICHIGAN, THE BOARD OF REGENTS , WAKEFIELD, Thomas, W. , STANLEY, James, C. , ANDREWS, Philip, C.
发明人： UNIVERSITY OF MICHIGAN, THE BOARD OF REGENTS
IPC分类号： A61K37/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/001 , C07K14/46
摘要： Less toxic agents for reversal of heparin or low molecular weight heparin anticoagulation which are synthetic protamine-like polycationic peptides having a total cationic charge which is less than that of n-protamine. In preferred embodiments, arginine residues of n-protamine are replaced with lysine residues for ease of manufacture. Selective positively charged arginine residues have been replaced with an uncharged amino acid residue or its analog, such as glycine or glutamine, in order to reduce the total cationic charge on the polycationic peptide to the range of about [+14] to [+18], preferably [+16] to [+18]. In specific embodiments, there are sequences of 29 and 32 amino acid residues wherein 4 to 5 clusters of 2 to 4 positively charged amino acids are separated by 2 to 6 neutral amino acids. The C-terminus and the N-terminus can be modified to mitigate against in vivo degradation by carboxypeptidases and aminopeptidases. Another modification, specifically use of alpha -helix forming amino acids, such as glutamic acid, further promotes anticoagulation reversal.
摘要翻译：用于逆转肝素或低分子量肝素抗凝剂的毒性较小的药物是具有小于正精蛋白的总阳离子电荷的合成鱼精蛋白样聚阳离子肽。在优选的实施方案中，为了易于制造，将n-鱼精蛋白的精氨酸残基替换为赖氨酸残基。选择性带正电的精氨酸残基已被不带电荷的氨基酸残基或其类似物（如甘氨酸或谷氨酰胺）替代，以便将聚阳离子肽上的总阳离子电荷降低至约[+ 14]至[+ 18] ，优选[+ 16]至[+ 18]。在具体实施方案中，存在29和32个氨基酸残基的序列，其中2至4个带正电荷的氨基酸的4至5个簇被2至6个中性氨基酸分开。可以修饰C-末端和N-末端以减轻羧肽酶和氨基肽酶的体内降解。另一个修改，特别是使用α-螺旋形成氨基酸，如谷氨酸，进一步促进抗凝反转。

3. 发明申请

WO1994004176A1 NOVEL PEPTIDES FOR HEPARIN ANTICOAGULATION REVERSAL 审中-公开
标题翻译： HEPARIN抗体逆转的新肽
公开(公告)号：WO1994004176A1
公开(公告)日：1994-03-03
申请号：PCT/US1992006829
申请日：1992-08-14
申请人： UNIVERSITY OF MICHIGAN , WAKEFIELD, Thomas, W. , STANLEY, James, C. , ANDREWS, Philip, C.
发明人： UNIVERSITY OF MICHIGAN
IPC分类号： A61K37/02
CPC分类号： C07K14/46 , A61K38/00 , C07K14/001
摘要： Less toxic agents for reversal of heparin anticoagulation which are synthetic protamine-like polycationic peptides having a total cationic charge which is less than that of n-protamine. In preferred embodiments, arginine residues of n-protamine are replaced with lysine residues for ease of manufacture. Selective positively charged arginine residues have been replaced with an uncharged amino acid residue or its analog, such as glycine or glutamine, in order to reduce the total cationic charge on the polycationic peptide to the range of about +14 to +18, preferably +16. In specific embodiments, there are sequences of 29 amino acid residues wherein 4 to 5 clusters of 2 to 4 positively charged amino acids are separated by 2 to 6 neutral amino acids.
摘要翻译：具有逆转肝素抗凝剂的毒性较小的药物，其是具有小于正精蛋白的总阳离子电荷的合成鱼精蛋白样聚阳离子肽。在优选的实施方案中，为了易于制造，将n-鱼精蛋白的精氨酸残基替换为赖氨酸残基。选择性带正电的精氨酸残基已被不带电荷的氨基酸残基或其类似物如甘氨酸或谷氨酰胺替代，以便将聚阳离子肽上的总阳离子电荷降低至约+14至+18，优选+16 。在具体实施方案中，存在29个氨基酸残基的序列，其中2至4个带正电荷的氨基酸的4至5个簇被2至6个中性氨基酸分离。

4. 发明申请

WO2007113453A1 ABSORBENT HYDROGEL COMPOSITES 审中-公开
标题翻译：吸收水凝胶复合材料
公开(公告)号：WO2007113453A1
公开(公告)日：2007-10-11
申请号：PCT/GB2006/001218
申请日：2006-04-03
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , ANDREWS, Philip , SAINA GARCIA, Susana
发明人： MUNRO, Hugh, Semple , ANDREWS, Philip , SAINA GARCIA, Susana
IPC分类号： A61L15/60 , A61L15/26 , A61L15/42
CPC分类号： A61L15/26 , A61L15/42 , A61L15/60
摘要： The invention provides an absorbent material or article comprising an absorbent hydrogel composite sheet. The sheet includes an absorbent layer part having two major faces which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a second part which comprises a flexible plasticised hydrophilic polymer matrix having a relatively continuous internal structure. The second part may be associated with the layer part such that the second part infiltrates some but not all of the cellular voids of the absorbent layer part over a major face of the absorbent layer part. Alternatively, the second part may be associated with the layer part such that the second part overlies a major face of the absorbent layer part. By this arrangement, some but not all of the absorbent layer part is effectively exposed for absorption of external water or other fluid through the side of the sheet corresponding to that said major face of the absorbent layer.
摘要翻译：本发明提供了一种包含吸收性水凝胶复合片材的吸收材料或制品。片材包括具有两个主表面的吸收层部分，其包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，和包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的第二部分。第二部分可以与层部分相关联，使得第二部分在吸收层部分的主表面上渗透吸收层部分的一些但不是全部的细胞空隙。或者，第二部分可以与层部分相关联，使得第二部分覆盖在吸收层部分的主表面上。通过这种布置，一些但不是全部的吸收层部分被有效地暴露以吸收外部水或其它流体通过与吸收层的所述主面对应的片材的侧面。

5. 发明申请

WO1994006810A1 OLIGONUCLEOTIDES HAVING UNIVERSAL NUCLEOSIDE SPACERS 审中-公开
标题翻译：具有通用核苷酸间隔物的寡核苷酸
公开(公告)号：WO1994006810A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008391
申请日：1993-09-07
申请人： BERGSTROM, Donald, Eugene , ANDREWS, Philip, Charles , NICHOLS, Ruthann , ZHANG, Peiming
IPC分类号： C07H05/04
CPC分类号： C07H21/00 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/056 , C07H19/24
摘要： Oligonucleotides are made having at least ten nucleosides, at least two of which are A, T, G or C and at least one is a universal nucleoside.
摘要翻译：制备具有至少10个核苷的寡核苷酸，其中至少2个是A，T，G或C，并且至少一个是通用核苷。

6. 发明申请

WO2009019485A3 A WOUND DRESSING 审中-公开
标题翻译：一个勇敢的衣服
公开(公告)号：WO2009019485A3
公开(公告)日：2010-01-07
申请号：PCT/GB2008002689
申请日：2008-08-06
申请人： FIRST WATER LTD , MUNRO HUGH SEMPLE , ANDREWS PHILIP
发明人： MUNRO HUGH SEMPLE , ANDREWS PHILIP
IPC分类号： A61L15/42 , A61L15/24 , A61L15/26 , A61L15/60
CPC分类号： A61L15/60 , A61L15/42
摘要： The present invention provides a wound dressing comprising (i) an absorbent layer portion capable of absorbing wound exudates and arranged to receive wound exudates in use, the absorbent layer portion comprising a hydrogel; and (ii) a backing layer which overlies the absorbent layer portion to a side, which, in use, is directed away from the wound, and wherein the backing layer has a moisture vapour transmission rate (MVTR) of from about 300 to about 1100 g/m2/24hours.
摘要翻译：本发明提供了一种伤口敷料，其包括（i）吸收层部分，其能够吸收伤口渗出物并被布置成在使用中接收伤口渗出物，所述吸收层部分包含水凝胶; 和（ii）背衬层，其在吸收层部分的一侧上覆盖，所述侧面在使用中指向远离伤口，并且其中背衬层具有约300至约1100的湿气透过率（MVTR）克/平方米/ 24小时。

7. 发明申请

WO2009019485A2 A WOUND DRESSING 审中-公开
标题翻译：一个勇敢的衣服
公开(公告)号：WO2009019485A2
公开(公告)日：2009-02-12
申请号：PCT/GB2008/002689
申请日：2008-08-06
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , ANDREWS, Philip
发明人： MUNRO, Hugh, Semple , ANDREWS, Philip
IPC分类号： A61L15/42 , A61L15/60
CPC分类号： A61L15/60 , A61L15/42
摘要： The present invention provides a wound dressing comprising (i) an absorbent layer portion capable of absorbing wound exudates and arranged to receive wound exudates in use, the absorbent layer portion comprising a hydrogel; and (ii) a backing layer which overlies the absorbent layer portion to a side, which, in use, is directed away from the wound, and wherein the backing layer has a moisture vapour transmission rate (MVTR) of from about 300 to about 1100 g/m 2 /24hours.
摘要翻译：本发明提供了一种伤口敷料，其包括（i）吸收层部分，其能够吸收伤口渗出物并被布置成在使用中接收伤口渗出物，所述吸收层部分包含水凝胶; 和（ii）背衬层，其在吸收层部分的一侧上覆盖，所述侧面在使用中指向远离伤口，并且其中背衬层具有约300至约1100的湿气透过率（MVTR）克/平方米/ 24小时。

8. 发明申请

WO2007113452A1 ABSORBENT MATERIALS AND ARTICLES 审中-公开
标题翻译：吸收材料和文章
公开(公告)号：WO2007113452A1
公开(公告)日：2007-10-11
申请号：PCT/GB2006/001217
申请日：2006-04-03
申请人： FIRST WATER LIMITED , MUNRO, Hugh, Semple , ANDREWS, Philip , SAINZ GARCIA, Susana
发明人： MUNRO, Hugh, Semple , ANDREWS, Philip , SAINZ GARCIA, Susana
IPC分类号： A61F13/00
CPC分类号： A61F13/00991 , A61F13/00042 , A61F13/0206 , A61F13/0276 , A61F2013/00157 , A61F2013/00238 , A61F2013/00251 , A61F2013/00519 , A61F2013/00548 , A61F2013/00676 , A61F2013/0074 , A61F2013/00744 , A61F2013/00859 , A61F2013/0091 , A61F2013/00927
摘要： An absorbent material comprises a flexible, skin-conformable, moisture-absorbent sheet member, optionally a net member in sheet form overlying and associated with the absorbent sheet member on at least one face thereof, and a hydrogel disposed on at least one of the net members, when present, and the absorbent sheet member in an amount of less than about 500 g of hydrogel per square metre per face, wherein the aqueous saline absorbency rate of the absorbent material through the face on which the hydrogel is disposed is less than about 300 seconds. Absorbent articles comprising the absorbent material and methods of manufacturing the material or articles are also described.
摘要翻译：一种吸收材料包括柔性的，适合皮肤的吸湿性片材构件，可选地，片状的网状构件在其至少一个表面上覆盖并与吸收性片材构件相关联，并且水凝胶设置在至少一个网成分，当存在时，吸收性片材的用量小于约500g每平方米每平方米的水凝胶，其中吸收材料通过其上设置水凝胶的面的盐水吸收率低于约 300秒还描述了包含吸收材料的吸收制品和制造材料或制品的方法。

9. 发明申请

WO2010007436A3 COMPOSITIONS FOR USE AS OR IN WOUND DRESSINGS 审中-公开
公开(公告)号：WO2010007436A3
公开(公告)日：2010-01-21
申请号：PCT/GB2009/050870
申请日：2009-07-16
申请人： FIRST WATER LIMITED , MUNRO, Hugh Semple , ANDREWS, Philip
发明人： MUNRO, Hugh Semple , ANDREWS, Philip
IPC分类号： A61L15/22 , A61L15/28 , A61L15/42 , A61L15/60
摘要： The present invention provides a composition for the treatment of a wound, the composition comprising: a first layer, which comprises a porous, optionally hydrophilic material capable of absorbing fluid from the wound at least in part by capilliary action, a second layer comprising an absorbent hydrogel, the first layer being associated with the second layer, wherein, in the treatment, the first layer is disposed closer to the wound than the second layer and the composition modulates the concentration of dissolved ions in the fluid in the wound. The present invention further provides uses of the composition and methods of making the composition.

10. 发明申请

WO2010007436A2 COMPOSITIONS FOR USE AS OR IN WOUND DRESSINGS 审中-公开
标题翻译：组合物用作或在连衣裙中使用
公开(公告)号：WO2010007436A2
公开(公告)日：2010-01-21
申请号：PCT/GB2009050870
申请日：2009-07-16
申请人： FIRST WATER LTD , MUNRO HUGH SEMPLE , ANDREWS PHILIP
发明人： MUNRO HUGH SEMPLE , ANDREWS PHILIP
IPC分类号： A61L15/22 , A61L15/28 , A61L15/42 , A61L15/60
CPC分类号： A61L15/60 , A61L15/425
摘要： The present invention provides a composition for the treatment of a wound, the composition comprising: a first layer, which comprises a porous, optionally hydrophilic material capable of absorbing fluid from the wound at least in part by capilliary action, a second layer comprising an absorbent hydrogel, the first layer being associated with the second layer, wherein, in the treatment, the first layer is disposed closer to the wound than the second layer and the composition modulates the concentration of dissolved ions in the fluid in the wound. The present invention further provides uses of the composition and methods of making the composition.
摘要翻译：本发明提供了一种用于治疗伤口的组合物，该组合物包括：第一层，其包含多孔的，任选亲水的材料，其能够至少部分地通过毛细作用从伤口吸收流体;第二层，包含吸收剂水凝胶，所述第一层与所述第二层相关联，其中在所述处理中，所述第一层被设置为比所述第二层更靠近所述伤口，并且所述组合物调节所述伤口中流体中的溶解离子的浓度。本发明还提供组合物的用途和制备该组合物的方法。

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