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    • 7. 发明申请
    • FORCE-INDUCED MAGNETIZATION CONTRAST FOR DIAGNOSIS AND IMAGING
    • 力诱导磁化对比诊断和成像
    • WO2012012596A2
    • 2012-01-26
    • PCT/US2011/044780
    • 2011-07-21
    • UNIVERSITY OF HOUSTON SYSTEMXU, ShoujunYAO, Li
    • XU, ShoujunYAO, Li
    • G01N33/53G01N27/72G01N33/58
    • A61K49/1872G01N33/5014G01N33/532G01N33/54326
    • A method of detecting target molecules comprising; conjugating a first magnetic particle to a first ligand to form a first magnetic particle ligand conjugate; adding the conjugate to a sample containing target molecules to form a mixture comprising, the free conjugate and conjugate-target molecule binding pairs; measuring a first magnetization of the mixture; subjecting the mixture to a first force; measuring a second magnetization value of the mixture; subtracting the second magnetization value from the first magnetization value to calculate a first force-induced magnetization contrast; subjecting the mixture to a second force; measuring a third magnetization of the mixture; and subtracting the third magnetization value from the second magnetization value to calculate a second force-induced magnetization contrast.
    • 检测靶分子的方法,包括: 将第一磁性颗粒与第一配体缀合以形成第一磁性颗粒配体缀合物; 将缀合物加入到含有目标分子的样品中以形成包含游离缀合物和缀合物 - 目标分子结合对的混合物; 测量混合物的第一磁化强度; 使混合物经受第一作用力; 测量混合物的第二磁化值; 从第一磁化值中减去第二磁化值以计算第一力引起的磁化对比度; 使混合物受到第二力; 测量混合物的第三磁化强度; 并从第二磁化值中减去第三磁化值以计算第二力引起的磁化对比度。