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1. 发明授权

US10183983B2 Nucleic acids encoding fusion proteins comprising PDGF and VEGF binding portions and methods of using thereof 有权
公开(公告)号：US10183983B2
公开(公告)日：2019-01-22
申请号：US15471725
申请日：2017-03-28
申请人： Genzyme Corporation
发明人： Peter Pechan , Jeffery Ardinger , Hillard Rubin , Samuel Wadsworth , Abraham Scaria
IPC分类号： C12N15/62 , C12N15/63 , C12N15/06 , C12N15/86 , C12N15/861 , C07K14/71 , A61K38/00
摘要： The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral particles as well as methods of using the same are also provided.

2. 发明授权

US08722987B2 Soybean cultivar S100143 有权
标题翻译：大豆品种S100143
公开(公告)号：US08722987B2
公开(公告)日：2014-05-13
申请号：US13558967
申请日：2012-07-26
申请人： Justin T. Mason
发明人： Justin T. Mason
IPC分类号： A01H5/00 , A01H5/10 , A01H4/00 , A01H1/00 , A01H1/06 , C12N15/82 , C12N5/04 , C12N15/06
CPC分类号： C11B1/00 , A01H5/10
摘要： A soybean cultivar designated S100143 is disclosed. The invention relates to the seeds of soybean cultivar S100143, to the plants of soybean cultivar S100143, to the plant parts of soybean cultivar S100143, and to methods for producing progeny of soybean cultivar S100143. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100143. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100143, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100143 with another soybean cultivar.
摘要翻译：公开了一种称为S100143的大豆品种。本发明涉及大豆品种S100143的种子，大豆品种S100143的植物，大豆品种S100143的植物部位，以及大豆品种S100143的后代的生产方法。本发明还涉及含有一种或多种转基因的遗传物质的大豆植物的制备方法以及通过这些方法制备的转基因大豆植物和植物部分的方法。本发明还涉及大豆品种或繁殖品种，以及来自大豆品种S100143的植物成分。本发明还涉及从大豆品种S100143得到的其他大豆品种，品系，或植物成分的制造方法，以及从使用这些方法得到的大豆植物，品种及其成分的方法。本发明还涉及杂交大豆种子，植物和通过品种S100143与另一大豆品种杂交产生的植物部分。

3. 发明申请

US20130052737A1 METHOD FOR SELECTIVE ELECTROFUSION OF AT LEAST TWO FUSION PARTNERS HAVING CELL-LIKE MEMBRANES 失效
标题翻译：具有细胞膜的最小二次融合合作伙伴的选择性电解方法
公开(公告)号：US20130052737A1
公开(公告)日：2013-02-28
申请号：US13555946
申请日：2012-07-23
申请人： Peter Eriksson , Daniel T. Chiu , Alexander Moscho , Owe Orwar , Richard N. Zare
发明人： Peter Eriksson , Daniel T. Chiu , Alexander Moscho , Owe Orwar , Richard N. Zare
IPC分类号： C12N15/06 , C12N13/00
CPC分类号： C12N15/87 , C12N5/12 , C12N13/00
摘要： Disclosed is a method for selective electrofusion of at least two fusion partners having cell-like membranes and cellular or subcellular dimensions, comprising the following steps: A) the fusion partners are brought into contact with each other and B) an electrical field of a strength sufficient to obtain fusion and highly focused on the fusion partners is applied. The fusion partners are independently selected from the group consisting of a single cell, a liposome, a proteoliposome, a synthetic vesicle, an egg cell, an enucleated egg cell, a sperm cell at any development stage and a plant protoplast.
摘要翻译：公开了一种用于选择性电融合具有细胞样膜和细胞或亚细胞尺寸的至少两个融合伴侣的方法，包括以下步骤：A）使融合伴侣彼此接触并且B）强度的电场足以获得融合并高度集中在融合伙伴上。融合对象独立地选自单细胞，脂质体，蛋白脂质体，合成囊泡，卵细胞，去核卵细胞，任何发育阶段的精细胞和植物原生质体。

4. 发明授权

US08277808B2 Mucosal vascular addressins and uses thereof 失效
标题翻译：粘膜血管解毒素及其用途
公开(公告)号：US08277808B2
公开(公告)日：2012-10-02
申请号：US11732400
申请日：2007-04-03
申请人： Michael J. Briskin
发明人： Michael J. Briskin
IPC分类号： C07K16/28 , A61K39/395 , C12N15/06 , G01N33/53
CPC分类号： C07K14/70503 , A61K39/00 , A61K2039/505 , C07K16/2803 , C07K16/2839 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S530/866
摘要： The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a polypeptide with at least 90% sequence identity to SEQ ID NO:2 or SEQ ID NO:4, said naturally occurring human MAdCAM binds α4β7, and wherein said isolated antibodies and antigen-binding fragments thereof inhibit binding of said naturally occurring human MAdCAM to human α4β7, and wherein said antibody inhibits adhesion of RPMI 8866 cells to cells that express said human MAdCAM.
摘要翻译：本发明涉及结合天然存在的人MAdCAM的分离的抗体及其抗原结合片段，其中所述天然存在的人MAdCAM包含与SEQ ID NO：2或SEQ ID NO：4具有至少90％序列同一性的多肽，所述多肽与SEQ ID NO：2或SEQ ID NO：4具有至少90％的序列同一性，天然存在的人MAdCAM结合α4和bgr7，并且其中所述分离的抗体及其抗原结合片段抑制所述天然存在的人MAdCAM与人α4和b结合，并且其中所述抗体抑制RPMI 8866细胞对表达所述人的细胞的粘附 MAdCAM。

5. 发明授权

US08216842B2 Enhancement of hybridoma fusion efficiencies through cell synchronization 有权
标题翻译：通过细胞同步增强杂交瘤融合效率
公开(公告)号：US08216842B2
公开(公告)日：2012-07-10
申请号：US12443492
申请日：2007-10-12
申请人： Jill Giles-Komar , Michael Rycyzyn , Gregory Bannish
发明人： Jill Giles-Komar , Michael Rycyzyn , Gregory Bannish
IPC分类号： C12N15/06 , C12N5/078 , C12N5/0781 , C12N5/16 , C12N5/20
CPC分类号： C12N5/163 , C12N2500/90 , C12N2506/00
摘要： The present invention provides methods of enhancing hybridoma fusion efficiencies through cell synchronization of the fusion partners, in order to aid in production of antibodies.
摘要翻译：本发明提供通过融合配偶体的细胞同步来增强杂交瘤融合效率的方法，以帮助抗体的产生。

6. 发明申请

US20120088304A1 METHODS OF GENERATING CELLS EXHIBITING PHENOTYPIC PLASTICITY 有权
标题翻译：产生细胞的方法展示了PHENOTYPIC PLASTICITY
公开(公告)号：US20120088304A1
公开(公告)日：2012-04-12
申请号：US13377296
申请日：2010-06-10
申请人： Galina Kaseko , Tohsak L. Mahaworasilpa
发明人： Galina Kaseko , Tohsak L. Mahaworasilpa
IPC分类号： C12N15/06
CPC分类号： C12N5/16 , C12N5/0634
摘要： The present invention relates to cellular differentiation and, in particular to hybrid cells that exhibit phenotypic plasticity and methods for producing these cells. The invention also relates to methods for generating specific cells of a desired phenotype. The invention still further relates to methods of producing hybrid cells with a capacity to de-differentiate into an earlier progenitor state. The invention further contemplates the use of hybrid cells in a range of applications, for example tissue generation.
摘要翻译：本发明涉及细胞分化，特别涉及显示表型可塑性的杂交细胞和用于制备这些细胞的方法。本发明还涉及产生所需表型的特异性细胞的方法。本发明还涉及生产具有去分化为较早祖细胞状态的能力的杂交细胞的方法。本发明还考虑在一系列应用中使用混合细胞，例如组织生成。

7. 发明授权

US08021879B2 Adaptor protein that binds to mammalian toll-like receptor 3 and gene thereof 失效
标题翻译：适应蛋白结合哺乳动物的toll样受体3及其基因
公开(公告)号：US08021879B2
公开(公告)日：2011-09-20
申请号：US12385128
申请日：2009-03-31
申请人： Tsukasa Seya , Misako Matsumoto , Hiroyuki Oshiumi
发明人： Tsukasa Seya , Misako Matsumoto , Hiroyuki Oshiumi
IPC分类号： C12N5/02 , C12N5/07 , C12N15/00 , C12N15/06 , C07H21/04 , C07K14/435
CPC分类号： C07K14/4705 , A61K38/00
摘要： A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is effective for prevention/treatment of viral infectious disease such as hepatitis B, hepatitis C, and the like, treatment of tumors, and the other purposes. Novel adaptor protein TICAM-1, which has an amino acid sequence set forth in SEQ ID NO: 2 or 4, specifically binds to the mammalian Toll-like receptor 3 and induces production of type I interferon. A mutant of the adaptor protein TICAM-1 has similar properties, provided that it has TIR domain (an amino acid sequence ranging from 394-position to 532-position in the amino acid sequence set forth in SEQ ID NO: 2 or an amino acid sequence ranging 396-position to 534-position in the amino acid sequence set forth in SEQ ID NO: 4). The gene is a gene encoding the adaptor protein TICAM-1.
摘要翻译：提供了一种新的衔接蛋白及其基因。新型衔接蛋白具有结合哺乳动物Toll样受体3的性质，其控制对预防/治疗乙型肝炎，丙型肝炎等病毒感染性疾病有效的I型干扰素的产生，治疗肿瘤，和其他目的。具有SEQ ID NO：2或4所示氨基酸序列的新型衔接蛋白TICAM-1特异性结合哺乳动物Toll样受体3并诱导产生I型干扰素。衔接蛋白TICAM-1的突变体具有相似的性质，只要其具有TIR结构域（SEQ ID NO：2所示的氨基酸序列中的394位至532位的氨基酸序列或氨基酸在SEQ ID NO：4所示氨基酸序列中396位至534位的序列）。该基因是编码衔接蛋白TICAM-1的基因。

8. 发明授权

US07988972B2 Immunoreactive peptides from Epstein-Barr virus 失效
标题翻译：来自爱泼斯坦 - 巴尔病毒的免疫反应肽
公开(公告)号：US07988972B2
公开(公告)日：2011-08-02
申请号：US11957251
申请日：2007-12-14
申请人： Richard S. Smith , Gary R. Pearson , D. Elliot Parks , Susan Pothen Varghese
发明人： Richard S. Smith , Gary R. Pearson , D. Elliot Parks , Susan Pothen Varghese
IPC分类号： A61K39/42 , C07K16/08 , C12N15/06
CPC分类号： C07K16/085 , A61K38/00 , A61K39/00 , C07K14/005 , C07K2317/734 , C12N2710/16222 , C12N2710/16622 , Y10S435/975 , Y10S436/82
摘要： The Epstein-Barr virus (EBV) specific polypeptides ETFTETWNRFITHTE (SEQ. ID NO: 1), GMLEASEGLDGWIHQ (SEQ. ID NO:2), HQQGGWSTLIEDNIP (SEQ. ID NO:3), and KQKHPKKVKQAFNPL (SEQ. ID NO:4) are among those disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.
摘要翻译： EB病毒（EBV）特异性多肽ETFTETWNRFITHTE（SEQ ID NO：1），GMLEASEGLDGWIHQ（SEQ ID NO：2），HQQGGWSTLIEDNIP（SEQ ID NO：3）和KQKHPKKVKQAFNPL（SEQ ID NO：4）是披露的。还公开了这些多肽用于产生多肽特异性抗体以及EBV相关疾病的诊断和治疗的用途。

9. 发明申请

US20100293626A1 METHODS FOR IMPROVEMENT OF BIRTH RATES IN CANIDAE ON SOMATIC CELL NUCLEAR TRANSFER 审中-公开
标题翻译：改善角膜细胞核转移中生殖系统发生率的方法
公开(公告)号：US20100293626A1
公开(公告)日：2010-11-18
申请号：US12517567
申请日：2008-11-19
申请人： Byeong Chun Lee , Min Kyu Kim , Goo Jang , Hyun Ju Oh , So Gun Hong , Jung Eun Park , Jung Taek Kang
发明人： Byeong Chun Lee , Min Kyu Kim , Goo Jang , Hyun Ju Oh , So Gun Hong , Jung Eun Park , Jung Taek Kang
IPC分类号： C12N15/06
CPC分类号： C12N5/16 , A01K67/0273 , A01K2227/10 , C12N15/877 , C12N2501/405 , C12N2517/10
摘要： The present invention relates to a method for increasing the efficiency of offspring production in producing animals belonging to the family Canidae (canines) by somatic cell nuclear transfer. More specifically, relates to a method for increasing the efficiency of production of cloned canines by a method for cloning canines comprising enucleating the oocyte of a canine to prepare an enucleated oocyte, fusing a nuclear donor cell with the enucleated oocyte to prepare a nuclear transfer embryo and transferring the nuclear transfer embryo into the oviduct of a surrogate mother, wherein the nuclear donor cell is cultured in a medium containing a specific cell cycle synchronization-inducing substance such as roscovitine in the preparation thereof. The method enables to clone canines with high efficiency, and thus can contribute to the development of studies in the fields of veterinary medicine, anthropology and medical science such as the propagation of superior canines, the conservation of rare or nearly extinct canines, xenotransplantation and disease animal models.
摘要翻译：本发明涉及通过体细胞核转移提高属于犬科（犬科）的动物的后代生产效率的方法。更具体地，涉及通过克隆犬的方法来提高克隆犬的生产效率的方法，包括将犬的卵母细胞去核以制备去核卵母细胞，将核供体细胞与去核卵母细胞融合以制备核转移胚并将核转移胚胎转移到替代母体的输卵管中，其中在其制备中，在含有特定细胞周期同步诱导物质如roscovitine的培养基中培养核供体细胞。该方法能够高效地克隆犬科动物，从而有助于兽医，人类学和医学领域的研究发展，如高等犬传播，保护罕见或几乎灭绝的犬，异种移植和疾病动物模型。

10. 发明申请

US20100178702A1 EXTRACELLULAR VESICLES FROM NON-PATHOGENIC AMOEBAE USEFUL AS VEHICLE FOR TRANSFERRING A MOLECULE OF INTEREST TO AN EUKARYOTIC CELL 失效
标题翻译：非致病性AMOEBAE的细胞毒素作为用于转移对欧洲细胞感兴趣的分子的车辆
公开(公告)号：US20100178702A1
公开(公告)日：2010-07-15
申请号：US12728462
申请日：2010-03-22
申请人： Irène TATISCHEFF , Annette ALFSEN , Françoise LAVIALLE
发明人： Irène TATISCHEFF , Annette ALFSEN , Françoise LAVIALLE
IPC分类号： C12N15/06
CPC分类号： A61K47/6901
摘要： The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of the vesicles as a vehicle for transferring the molecule therapeutic interest to an eukaryotic mammalian cell.
摘要翻译：本发明涉及来自非致病性变形虫的膜囊泡，特别是来自含有治疗兴趣分子的变形虫盘根杆菌，制备这种囊泡的方法，以及使用囊泡作为转移分子治疗兴趣的载体到真核哺乳动物细胞。

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