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1. 发明申请

US20190136179A1 THERMORESPONSIVE CELL CULTURE SUPPORTS 审中-公开
公开(公告)号：US20190136179A1
公开(公告)日：2019-05-09
申请号：US16239671
申请日：2019-01-04
申请人： Abdullah Alghunaim , Bi-min Zhang Newby
发明人： Abdullah Alghunaim , Bi-min Zhang Newby
IPC分类号： C12N5/00 , C09D133/24 , C08K5/5419 , C08K5/548 , C08K5/5435 , C08F120/54
摘要： The present invention relates to a cell culture support comprising a substrate and a polymeric blend layer bound to the substrate. The polymeric blend layer comprises at least one thermoresponsive polymer and at least one coupling agent. The coupling agent is a non-protein coupling agent that has functional thiol, ester, epoxy, or aldehyde groups. The cell culture support further includes cells supported by the polymeric blend layer, wherein the thermoresponsive polymer provides for temperature induced detachment of the cells and/or cell sheets.

2. 发明申请

US20080090980A1 Redispersible powder and its aqueous dispersion, preparation, process and use 有权
标题翻译：可再分散粉末及其水分散体，制备方法及用途
公开(公告)号：US20080090980A1
公开(公告)日：2008-04-17
申请号：US11955342
申请日：2007-12-12
申请人： Hongli Willimann , Robert Koelliker
发明人： Hongli Willimann , Robert Koelliker
IPC分类号： C08F120/54
CPC分类号： C08F2/22 , A23L27/74 , A23L33/25 , A61K47/32 , C04B24/26 , C04B2103/0004 , C04B2103/0005 , C04B2103/0057 , C04B2103/0058 , C08F265/04 , C08F265/06 , C08F291/00 , C08L33/14 , C08L57/12 , C09D151/00 , C04B2103/0051 , C04B2103/0052
摘要： The invention relates to a redispersible powder obtainable by (co)polymerization, using a polymer with cationic functionality in an aqueous medium, optionally accompanied by the use of conventional additives, the polymer with cationic functionality being obtained by (co)polymerization in an aqueous medium of olefinically unsaturated (co)monomers, wherein at least one (co)monomer has a cationic functionality, further (co)monomers are added and polymerization takes place in the presence of suitable initiators, and by drying the aqueous dispersion obtained, the (co)polymerizate having one or more reactive groups. According to another embodiment, the polymer with cationic functionality is formed in situ in the presence of a seed. According to another embodiment, the process is controlled in such a way that a (co)polymerizate particle with heterogeneous morphology is formed. The invention also relates to the aqueous dispersions, a process for the preparation of the redispersible powder and the use thereof.
摘要翻译：本发明涉及通过（共）聚合可获得的可再分散粉末，其使用在水性介质中具有阳离子官能度的聚合物，任选地伴随常规添加剂的使用，具有阳离子官能度的聚合物通过在水介质中（共）聚合而获得的烯属不饱和（共）单体，其中至少一种（共）单体具有阳离子官能度，另外（共）单体被加入，并且在合适的引发剂存在下进行聚合，并且通过干燥获得的水分散体）具有一个或多个反应性基团的聚合物。根据另一个实施方案，具有阳离子官能团的聚合物在种子存在下原位形成。根据另一个实施方案，以这样的方式控制该方法：形成具有不均匀形态的（共）聚合物颗粒。本发明还涉及水分散体，制备可再分散粉末的方法及其用途。

3. 发明申请

US20060111531A1 Chain transfer agents for RAFT polymerization in aqueous media 有权
公开(公告)号：US20060111531A1
公开(公告)日：2006-05-25
申请号：US11057760
申请日：2005-02-14
申请人： Charles McCormick , Michael Donovan , Andrew Lowe , Brent Sumerlin , David Thomas
发明人： Charles McCormick , Michael Donovan , Andrew Lowe , Brent Sumerlin , David Thomas
IPC分类号： C08F120/54
CPC分类号： C07D213/30 , C07C327/36 , C08F2/38 , C08F4/00 , C08F220/56
摘要： Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be controlled. One type of controlled polymerization is the reversible addition-fragmentation chain transfer (RAFT) process, which has characteristics of a living polymerization. The present invention discloses a group of dithioesters and trithioesters suitable as chain transfer agents for RAFT polymerization. The present invention also discloses RAFT polymerizations conducted in aqueous media.

4. 发明授权

US07030202B2 Graft copolymers and method to prepare same 失效
公开(公告)号：US07030202B2
公开(公告)日：2006-04-18
申请号：US10603564
申请日：2003-06-25
申请人： Bernard Gordon, III , Jim DiBattista
发明人： Bernard Gordon, III , Jim DiBattista
IPC分类号： C08F120/54 , C08F20/52 , C08F222/38
CPC分类号： C08L71/02 , C08G65/2603 , C08G65/263 , C08G65/33396 , C08G73/0233 , C08L79/02 , C08L2205/05 , C08L2666/04
摘要： A thermally processable graft copolymer formed from a water soluble polymer and a water insoluble polymer, wherein the graft copolymer forms a hydrogel upon exposure to water. A method to form such a hydrogel-forming graft copolymer by copolymerizing a water soluble 2-substituted-2-oxazolines with a water insoluble 2-substituted-2-oxazoline. A method to form such a hydrogel-forming graft copolymer by transamidating a poly-2-oxazoline with a carboxylic acid terminated water-insoluble polymer.

5. 发明申请

US20060052561A1 Chemically Inert Pressure Sensitive Adhesive Having Improved Adhesion, Process For It's Manufacture, And Use Thereof 审中-公开
标题翻译：化学惰性压敏粘合剂具有改进的粘合性，其制造及其使用的过程
公开(公告)号：US20060052561A1
公开(公告)日：2006-03-09
申请号：US10534347
申请日：2003-10-31
申请人： Hansjorg Ander , Gunter Holl
发明人： Hansjorg Ander , Gunter Holl
IPC分类号： C08F120/54 , C08F118/02
CPC分类号： C08F290/06
摘要： Chemically inert pressure sensitive adhesives having improved adhesion to polar and semipolar substrates, as well as to the manufacture and use thereof, especially for manufacturing pressure sensitive adhesive tapes possessing high initial adhesion (tack) on polar and semipolar substrates.
摘要翻译：化学惰性压敏粘合剂具有改善的对极性和半极性基材的粘附性，以及其制造和使用，特别是用于制造在极性和半极性基材上具有高初始粘合性（粘性）的压敏粘合带。

6. 发明申请

US20050215740A1 N-vinyl amide polymer and production method thereof 失效
标题翻译： N-乙烯基酰胺聚合物及其制备方法
公开(公告)号：US20050215740A1
公开(公告)日：2005-09-29
申请号：US11086758
申请日：2005-03-23
申请人： Yoshitomo Nakata , Norihiro Wakao
发明人： Yoshitomo Nakata , Norihiro Wakao
IPC分类号： C08F8/12 , C08F26/02 , C08F26/10 , C08F4/00 , C08F120/54
CPC分类号： C08F26/02 , C08F26/10
摘要： The present invention provides an innovative N-vinylamide polymer with decreased contents of impurities and suppressed coloration, a higher K-value, and preferably usable in a variety of fields such as cosmetic and pharmaceutical products, and to provide a production method of the polymer. An N-vinylamide polymer comprising an N-vinylamide monomer unit, wherein the N-vinylamide polymer has K-value of 60 or higher, a content of hydrolysis products of N-vinylamide monomer of 0.02% by weight or less, a content of ashes of 0.1% by weight or less, and hue of 10% aqueous solution of 10 or less measured according to JIS K0071.
摘要翻译：本发明提供了一种具有降低的杂质含量和抑制着色，更高的K值并且优选可用于各种领域如化妆品和药物产品的创新的N-乙烯基酰胺聚合物，并且提供了聚合物的制备方法。包含N-乙烯基酰胺单体单元的N-乙烯基酰胺聚合物，其中所述N-乙烯基酰胺聚合物的K值为60以上，N-乙烯基酰胺单体的水解产物的含量为0.02重量％以下，灰分含量为0.1重量％以下，根据JIS K0071测定的10％以下的10％以下的色相。

7. 发明申请

US20040122195A1 Process for producing copolymer 有权
标题翻译：制备共聚物的方法
公开(公告)号：US20040122195A1
公开(公告)日：2004-06-24
申请号：US10469667
申请日：2003-09-02
发明人： Michihiro Kaai
IPC分类号： C08F120/54
CPC分类号： C08F290/04 , C08F290/046
摘要： A process for producing a copolymer which comprises reacting a vinyl monomer with a macromonomer composition containing a macromonomer. The macromonomer composition is obtained by polymerizing at a temperature of 160 to 350null C. a monomer mixture comprising 10 to 80 wt. % first vinyl monomer having an alkyl group in the null-position, 0 to 30 wt. % styrene as an optional ingredient, and 0 to 90 wt. % one or more other vinyl monomers based on the total amount of all monomers.
摘要翻译：一种制备共聚物的方法，包括使乙烯基单体与含有大分子单体的大分子单体组合物反应。通过在160〜350℃的温度下聚合得到含有10〜80重量％的单体混合物的单体混合物，得到大分子单体组合物。％第一乙烯基单体，在α-位具有烷基，0〜30重量％％苯乙烯作为任选成分，和0至90wt。基于所有单体的总量的一种或多种其它乙烯基单体。

8. 发明申请

US20020161155A1 Polymerizable system with a long work-life 有权
标题翻译：聚合体系，使用寿命长
公开(公告)号：US20020161155A1
公开(公告)日：2002-10-31
申请号：US10081266
申请日：2002-02-21
发明人： E. John Deviny , Virginia C. Marhevka
IPC分类号： C08F120/54
CPC分类号： C08F4/52
摘要： The present invention is directed to a polymerizable system. The polymerizable system comprises an organoborane, at least one polymerizable monomer, and a work-life extending agent.
摘要翻译：本发明涉及一种可聚合系统。可聚合体系包括有机硼烷，至少一种可聚合单体和工作寿命延长剂。

9. 发明申请

US20020128415A1 Polyacrylamide medium for the electrophoretic separation of biomolecules 失效
标题翻译：用于电泳分离生物分子的聚丙烯酰胺培养基
公开(公告)号：US20020128415A1
公开(公告)日：2002-09-12
申请号：US10094397
申请日：2002-03-07
申请人： The Regents of the University of California
发明人： Ramakrishna S. Madabhushi , Stuart A. Gammon
IPC分类号： C08F120/54
CPC分类号： C08F120/54 , G01N27/44747
摘要： A polyacryalmide medium for the electrophoretic separation of biomolecules. The polyacryalmide medium comprises high molecular weight polyacrylamides (PAAm) having a viscosity average molecular weight (Mv) of about 675-725 kDa were synthesized by conventional red-ox polymerization technique. Using this separation medium, capillary electrophoresis of BigDye DNA sequencing standard was performed. A single base resolution of null725 bases was achieved in null60 minute in a non-covalently coated capillary of 50 nullm i.d., 40 cm effective length, and a filed of 160 V/cm at 40null C. The resolution achieved with this formulation to separate DNA under identical conditions is much superior (725 bases vs. 625 bases) and faster (60 min. vs. 75 min.) to the commercially available PAAm, such as supplied by Amersham. The formulation method employed here to synthesize PAAm is straight-forward, simple and does not require cumbersome methods such as emulsion polymerizaiton in order to achieve very high molecular weights. Also, the formulation here does not require separation of PAAm from the reaction mixture prior to reconstituting the polymer to a final concentration. Furthermore, the formulation here is prepared from a single average mol. wt. PAAm as opposed to the mixture of two different average mo. wt. PAAm previously required to achieve high resolution.
摘要翻译：用于电泳分离生物分子的聚丙烯酰胺培养基。聚丙烯酰胺介质包含通过常规红 - 氧聚合技术合成的具有约675-725kDa粘度平均分子量（Mv）的高分子量聚丙烯酰胺（PAAm）。使用该分离介质，进行BigDye DNA测序标准的毛细管电泳。在50mil，40cm有效长度的非共价涂布的毛细管中，在40℃下，160V / cm的非共价涂层毛细管在〜60分钟内实现约725个碱基的单碱基分辨率。用该配方实现的分辨率在相同条件下分离DNA比（例如由Amersham提供的）更优越（725碱基对625碱基）和更快（60分钟，相对于75分钟）的市售PAAm。这里用于合成PAAm的制剂方法是直接的，简单的，并且不需要繁琐的方法，例如乳液聚合，以获得非常高的分子量。此外，这里的配方不需要在将聚合物重构成最终浓度之前将PAAm与反应混合物分离。此外，这里的配方由单一平均摩尔数制备。重量 PAAm与两种不同平均水平的混合物相反。重量 PAAm以前需要达到高分辨率。

10. 发明申请

US20020068802A1 Mono-and polyamides of perfluoroalkyl-substituted unsaturated acids 有权
标题翻译：全氟烷基取代的不饱和酸的单酰胺和聚酰胺
公开(公告)号：US20020068802A1
公开(公告)日：2002-06-06
申请号：US09978156
申请日：2001-10-15
发明人： Karl F. Mueller , Michael Bochnik , Marlon Haniff , John Jennings , Shobha Kantamneni
IPC分类号： C08F120/54 , C07F009/30 , C07C39/15 , C07C237/16
CPC分类号： C08G18/3825 , C07C233/38 , C07C237/22
摘要： Novel perfluoroalkyl-substituted mono-, di- and poly-amide compounds which are reaction products of a mono-, di- or polyamine of 60 to 2000 molecular weight with a perfluoroalkyl substituted unsaturated acid or its corresponding lower alkyl ester and optionally a non-fluorinated amino-reactive compound such as an acid, ester, anhydride, epichlorohydrin, isocyanate or urea, are useful as internally or externally applied paper sizes to impart oil and grease resistance to paper, and as oil proofing coatings on textiles, wood, masonry and the like, or as high-performance surface active agents.
摘要翻译：新型全氟烷基取代的单 - ，二 - 和聚 - 酰胺化合物，其为具有60至2000分子量的单 - ，二 - 或多胺与全氟烷基取代的不饱和酸或其相应的低级烷基酯和任选的非 - 氟化氨基反应性化合物如酸，酯，酸酐，表氯醇，异氰酸酯或脲，可用作内部或外部施加的纸张尺寸以赋予纸油和油脂抵抗力，以及作为防止纺织品，木材，砖石和石棉的防油涂料或作为高性能表面活性剂。

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