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1. 发明申请

US20210040414A1 EXTRACTION SYSTEMS AND METHODS 有权
公开(公告)号：US20210040414A1
公开(公告)日：2021-02-11
申请号：US16718664
申请日：2019-12-18
申请人： Ha Tran , Bao Tran
发明人： Ha Tran , Bao Tran
IPC分类号： C11B1/10 , C07D309/18 , C11B1/04
摘要： System and methods are disclosed with a holding tank to receive liquid and cryogenically frozen biomass; a cavitator to generate shock waves and pressure variations, wherein the shock waves and pressure variations are to the biomass and the liquid to separate oil from the biomass; a sensor to determine when oil concentration exceeds a threshold; and a valve to transfer the oil and liquid to an oil tank when the threshold is met.

2. 发明申请

US20200317671A1 BIARYL KINASE INHIBITORS 审中-公开
公开(公告)号：US20200317671A1
公开(公告)日：2020-10-08
申请号：US16913064
申请日：2020-06-26
申请人： Bristol-Myers Squibb Company
发明人： Guanglin Luo , Carolyn Diane Dzierba , John E. Macor
IPC分类号： C07D471/04 , A61K31/4427 , A61P25/28 , C07D401/14 , C07D213/74 , C07D309/18 , C07D401/04 , C07D237/08 , A61K31/50 , C07C233/25 , C07D213/30 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/75 , C07D213/80 , C07D215/14 , C07D239/26 , C07D309/22 , C07D413/10
摘要： The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

3. 发明授权

US10785978B2 Control and repellency of biting flies, house flies, ticks, ants, fleas, biting midges, cockroaches, spiders and stink bugs 有权
公开(公告)号：US10785978B2
公开(公告)日：2020-09-29
申请号：US15878455
申请日：2018-01-24
申请人： BEDOUKIAN RESEARCH, INC.
发明人： Robert H. Bedoukian
IPC分类号： A01N43/16 , A01N31/06 , A01N35/06 , A01N37/36 , A01N37/42 , A01N43/08 , C07C35/06 , C07C35/18 , C07C49/603 , C07C49/647 , C07C235/74 , C07D307/28 , C07D309/18
摘要： Control and repellency of biting flies, house flies, ticks, ants, fleas, biting midges, cockroaches, spiders and stink bugs is obtained by contact of the insects with at least one of the compounds of the structure (I) wherein R is —OH, ═O, —OC(O)R4, —OR6, or —(OR6)2, wherein each R6 is independently an alkyl group containing from 1 to 4 carbon atoms and R4 is a branched or straight chain, saturated or unsaturated, hydrocarbyl group with zero to two double bonds and from 1 to 15 carbon atoms; X is O or CH2, with the proviso that when X is O R can only be ═O: each Z is independently (CH) or (CH2); y is a numeral selected from 1 and 2; R1 is H or a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to two double bonds and from 1 to 15 carbon atoms; R2 is H and a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 15 carbon atoms; R3 is H, a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 15 carbon atoms, —(CH2)nOH, —C(O)OR5, —CH2C(O)OR7, —CH2C(O)R8, —C(O)NR9R10, or —CH2C(O)NR11R12 where each of R5, R7, R8, R9, R10, R11 and R12 is independently H or a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 15 carbon atoms, and n is n integer of from 1 to 12; the bond between the 2 and 3 positions in the ring structure may be a single or a double bond; and wherein the compounds of structure (I) contain from 11 to 20 carbon atoms except where R is ═O, X═CH2 and y is 1 the compounds of structure (I) contain from 13 to 20 carbon atoms, with the proviso that when R3 is —CH2C(O)OR7 R1 and R2 must be H or a saturated hydrocarbyl group with zero double bonds. The invention also includes optical isomers, diastereomers and enantiomers of the compounds of structure (I).

4. 发明申请

US20190367508A1 BIARYL KINASE INHIBITORS 审中-公开
公开(公告)号：US20190367508A1
公开(公告)日：2019-12-05
申请号：US16443929
申请日：2019-06-18
申请人： Bristol-Myers Squibb Company
发明人： Guanglin Luo , Carolyn Diane Dzierba , John E. Macor
IPC分类号： C07D471/04 , A61K31/4427 , A61P25/28 , C07D401/14 , C07D213/74 , C07D309/18 , C07D401/04 , C07D237/08 , A61K31/50 , C07C233/25 , C07D213/30 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/75 , C07D213/80 , C07D215/14 , C07D239/26 , C07D309/22 , C07D413/10
摘要： The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

5. 发明申请

US20180334414A1 ASYMMETRIC ADDITION REACTIONS 审中-公开
公开(公告)号：US20180334414A1
公开(公告)日：2018-11-22
申请号：US15580838
申请日：2016-06-01
申请人： Oxford University Innovation Limted
发明人： Stephen P. Fletcher , Mireia Sidera Portela
IPC分类号： C07C1/32 , C07C41/30 , C07C17/263 , C07C67/343 , C07C201/12 , C07F7/18 , C07D309/18 , C07D333/08 , C07D307/79 , C07D231/56 , C07D213/61 , C07D209/08 , C07D211/70
摘要： Processes of forming Csp2—Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is reacted with a compound having a nucleophilic carbon atom in the presence of a Rh(I), Pd(II) or Cu(I) pre-catalyst and a chiral ligand. The reaction products containing the newly-formed Csp2—Csp3 bond are generated in high stereoisomeric excess, and may therefore serve as important organic building blocks in the preparation of new agrochemicals and pharmaceuticals.

6. 发明申请

US20170037021A1 PRODUCTION OF 2-SUBSTITUTED 4-HYDROXY-4-METHYLTETRAHYDROPYRANS HAVING STABLE ODORIFEROUS QUALITY 有权
标题翻译：生产具有稳定气味质量的2-取代的4-羟基-4-甲基甲基丙烯酸酯
公开(公告)号：US20170037021A1
公开(公告)日：2017-02-09
申请号：US15303976
申请日：2015-04-08
申请人： BASF SE
发明人： Timon STORK , Martine DEHN , Klaus EBEL , Karl BECK , Axel SALDEN , Ralf PELZER
IPC分类号： C07D309/10 , C11B9/00 , C07C43/303 , C07D319/06 , C07D309/18
CPC分类号： C07D309/10 , C07C43/303 , C07D309/18 , C07D319/06 , C11B9/008
摘要： The present invention relates to a method for the production of 2-substituted 4-hydroxy-4-methyltetrahydropyrans from the acid-catalyzed reaction of 3-methylbut-3-ene-1-ol with an aldehyde, a stable odoriferous quality being achieved and avoiding off-odors that interfere with the odor sensation.
摘要翻译：本发明涉及从3-甲基丁-3-烯-1-醇与醛的酸催化反应生产2-取代的4-羟基-4-甲基四氢吡喃的方法，实现了稳定的气味质量，避免干扰异味的异味。

7. 发明授权

US09233994B2 Ruthenium complexes for use in olefin metathesis 有权
标题翻译：用于烯烃复分解的钌络合物
公开(公告)号：US09233994B2
公开(公告)日：2016-01-12
申请号：US13636592
申请日：2011-03-21
申请人： Catherine Cazin
发明人： Catherine Cazin
IPC分类号： C07F15/00 , C07F19/00 , C07D207/48 , C07D307/28 , C07C253/30 , C07D211/96 , C07D223/04 , C07D309/18 , C07D311/58 , C07D313/08 , C07F7/18 , C07C67/00 , C07C45/61 , C07C67/30
CPC分类号： C07F15/0046 , C07C45/61 , C07C67/00 , C07C67/30 , C07C253/30 , C07D207/48 , C07D211/96 , C07D223/04 , C07D307/28 , C07D309/18 , C07D311/58 , C07D313/08 , C07F7/1892 , C07F19/00
摘要： Cis ruthenium complexes that can be used as catalysts are described. The complexes are generally square pyramidal in nature, having two anionic ligands X adjacent to each other. The complexes can be used as catalysts, for example in olefin metathesis reactions. Corresponding trans ruthenium complexes are also described, together with cationic complexes where one or both of the anionic ligands X are replaced by a non-co-ordinating anionic ligand.
摘要翻译：描述了可用作催化剂的Cis钌络合物。复合物本质上通常为方形金字塔形，具有彼此相邻的两个阴离子配体X。络合物可用作催化剂，例如在烯烃复分解反应中。还描述了相应的反钌络合物，以及阳离子配合物，其中一个或两个阴离子配体X被非配位阴离子配体代替。

8. 发明授权

US6114548A Diels-alder reaction of aldehydes with simple dienes 失效
标题翻译：醛与简单二烯的焓变反应
公开(公告)号：US6114548A
公开(公告)日：2000-09-05
申请号：US8768
申请日：1998-01-19
申请人： Christopher Paul Newman , Varinder Kumar Aggarwal , Graham Patrick Vennall
发明人： Christopher Paul Newman , Varinder Kumar Aggarwal , Graham Patrick Vennall
IPC分类号： B01J31/02 , C07B61/00 , C07D309/18 , C07D309/20 , C07D309/00
CPC分类号： C07D309/18 , C07D309/20
摘要： The invention concerns Diels-Alder reactions between non-activated aldehydes RCHO in which R is a C1-C10 aliphatic group or phenyl group, which is unsubstituted or substituted with one or more C1-C5 alkyl groups or one other functional group, with simple aliphatic dienes R.sub.1 CH.dbd.CR.sub.2 --CR.sub.3 .dbd.CHR.sub.4 in which R.sub.1 -R.sub.4 are H or C1-C5 alkyl groups using as a catalyst a perfluorinated organic sulphonic acid or a Bronsted acid derivative thereof. The reaction leads to dihydropyrans of the structure below in which R1-R4 have the meaning indicated above.The preferred perfluorinated organic sulfonic acids are perfluorooctanesulphonic acid, triflic acid, Nafion or a Bronsted acid derivative of triflic acid. ##STR1## The preferred aldehydes are those wherein R is a C2-C6 aliphatic group or a phenyl group which is unsubstituted or mono-substituted with C1-C3 alkyl or with 4-Cl, 4-nitro or 3-methoxy. The preferred dienes are those wherein the groups R.sub.1 -R.sub.4 are H or methyl.
摘要翻译：本发明涉及非活化醛RCHO中的Diels-Alder反应，其中R是未被取代或被一个或多个C 1 -C 5烷基或一个其它官能团取代的C 1 -C 10脂族基或苯基，二烯R1CH = CR2-CR3 = CHR4，其中R 1 -R 4为H或C 1 -C 5烷基，使用全氟化有机磺酸或其Br + E，uml + e + nsted酸衍生物作为催化剂。该反应得到以下结构的二氢吡喃，其中R1-R4具有上述含义。优选的全氟化有机磺酸是全氟辛基磺酸，三氟甲磺酸，Nafion或三氟乙酸的Br + E，嗯，o + EE nsted酸衍生物。优选的醛是其中R是C 2 -C 6脂族基团或未被取代或被C 1 -C 3烷基或与4-Cl，4-硝基或3-甲氧基单取代的苯基的那些。优选的二烯是其中基团R 1 -R 4是H或甲基的那些。

9. 发明授权

US06074944A Methods for priming wafers employed in integrated circuit devices using dihydropyrane 失效
标题翻译：用于使用二氢吡喃的集成电路器件中使用晶片的方法
公开(公告)号：US06074944A
公开(公告)日：2000-06-13
申请号：US2636
申请日：1998-01-05
申请人： Jin-hang Jung , Hoe-sik Chung
发明人： Jin-hang Jung , Hoe-sik Chung
IPC分类号： G03F7/11 , C07D309/18 , G03F7/16 , G03F7/38 , H01L21/027 , H01L21/306 , H01L21/312 , H01L21/44
CPC分类号： H01L21/312 , H01L21/02052
摘要： Methods of treating surfaces of wafers to be used in forming integrated circuit devices comprise applying dihydropyrane to the surfaces of the wafers wherein hydrophobicity is imparted to the surfaces. The applying steps are carried out prior to applying photoresists to the wafers.
摘要翻译：处理用于形成集成电路器件的晶片表面的方法包括将二氢吡喃施加到晶片的表面，其中赋予表面疏水性。施加步骤在将光刻胶施加到晶片之前进行。

10. 发明授权

US5126375A Phenethanolamine derivatives 失效
公开(公告)号：US5126375A
公开(公告)日：1992-06-30
申请号：US619899
申请日：1990-11-29
申请人： Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor
发明人： Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor
IPC分类号： C07C217/48 , A61K31/135 , A61K31/335 , A61K31/357 , A61K31/36 , A61P11/00 , A61P25/02 , C07C33/46 , C07C43/174 , C07C43/178 , C07C43/225 , C07C45/00 , C07C45/30 , C07C47/277 , C07C49/255 , C07C59/13 , C07C59/66 , C07C67/00 , C07C213/00 , C07C213/02 , C07C217/10 , C07C217/14 , C07C217/28 , C07C217/64 , C07C229/38 , C07D303/40 , C07D309/12 , C07D309/18 , C07D317/54 , C07D317/58 , C07D319/06 , C07D319/08 , C07D319/18
CPC分类号： C07C45/004 , C07C229/38 , C07C309/00 , C07C33/46 , C07C43/174 , C07C43/1742 , C07C43/1782 , C07C43/225 , C07C45/30 , C07C47/277 , C07C49/255 , C07C59/66 , C07D303/40 , C07D309/12 , C07D317/54 , C07D319/06 , Y02P20/55 , Y10S514/826 , Y10S514/863 , Y10S514/886 , Y10S514/887 , Y10S514/906 , Y10S514/913 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928
摘要： Phenethanolamine derivatives are disclosed of formula ##STR1## wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12;Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group;R.sup.1 and R.sup.2 are hydrogen or alkyl provided that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 4; and the physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients.The compounds may be prepared, for example by alkylation of an amine: ##STR2## where R.sup.3, R.sup.5 and R.sup.6 is hydrogen or a protecting group, followed by removal of any protecting group.

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