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1. 发明申请

US20220354949A1 NOVEL COMPOUNDS 有权
公开(公告)号：US20220354949A1
公开(公告)日：2022-11-10
申请号：US17270665
申请日：2019-08-23
申请人： XENIOPRO GmbH
发明人： Viktoria REINMÜLLER , Roman MARTY , Olivier WAGNIÈRES , Jean-Baptiste GUALTIEROTTI , Verena KÜPPERS
IPC分类号： A61K39/39 , C07C311/51 , C07D213/89 , C07C261/04 , C07C259/10 , C07C325/02 , C07D405/04 , C07C217/58 , C07C239/12 , C07C255/43 , C07D309/06 , C07D211/22 , C07D295/092 , C07D453/02 , C07D205/04 , C07D491/107 , C07D401/12 , C07D405/12 , C07D519/00 , C07D407/12 , C07D331/04 , C07D409/12 , C07D211/28 , C07D305/04 , C07C69/78 , C07C47/198 , C07D213/80 , C07D213/643 , C07D237/04 , C07D239/47 , C07D239/52
摘要： The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

2. 发明授权

US5770743A 1,2-Dioxetane compounds as chemiluminescent labels for organic and biological molecules 失效
标题翻译： 1,2-二氧杂环丁烷化合物作为有机和生物分子的化学发光标记
公开(公告)号：US5770743A
公开(公告)日：1998-06-23
申请号：US218308
申请日：1994-03-25
申请人： Arthur P. Schaap , Louis J. Romano , Jaidev S. Goudar
发明人： Arthur P. Schaap , Louis J. Romano , Jaidev S. Goudar
IPC分类号： C07D207/46 , C07D311/82 , C07D321/00 , C07D405/12 , C07D407/12 , C07D493/10 , C07D495/04 , C07F7/18 , C07F9/655 , G01N33/58 , C07D405/02 , C07D305/04
CPC分类号： C07D405/12 , C07D207/46 , C07D311/82 , C07D321/00 , C07D407/12 , C07D493/10 , C07D495/04 , C07F7/1852 , C07F7/1856 , C07F9/65512 , G01N33/582 , C07C2103/18 , C07C2103/74
摘要： Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an activating agent other than an enzyme which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R.sub.1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.
摘要翻译：与下式的有机和生物分子偶联的二氧杂环丁烷：其中X是离去基团，其除了除活性剂以除去生成光的酶以外的活化剂除去，其中A是偶联取代基， Ar是选自苯基和萘基的取代基以提供标记。 R1是任选的接头取代基，并且可以具有1至30个碳原子，其中一些碳原子是氧，硫，氮或磷。 Ar是苯基。二氧杂环丁烷偶联分子可用于所有类型的测定，其中发光可用作指示剂。

3. 发明授权

US5753682A Imidazole lipoxygenase inhibitors 失效
标题翻译：咪唑脂氧合酶抑制剂
公开(公告)号：US5753682A
公开(公告)日：1998-05-19
申请号：US553546
申请日：1996-05-06
申请人： Rodney W. Stevens , Takashi Mano , Kazuo Ando
发明人： Rodney W. Stevens , Takashi Mano , Kazuo Ando
IPC分类号： A61K31/415 , A61K31/4178 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D233/54 , C07D233/60 , C07D305/04 , C07D309/02 , C07D405/10 , C07D405/12 , C07D405/14 , C07D521/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14
摘要： Certain novel imidazole derivatives having the ability to inhibit the lipoxygenase enzyme and having formula (I), wherein Y is hydrogen, C.sub.1 -C.sub.8 alkyl, halosubstituted C.sub.1 -C.sub.4 alkyl, phenyl, substituted phenyl, C.sub.7 -C.sub.14 phenylalkyl, C.sub.7 -C.sub.14 (substituted phenyl)alkyl, pyridyl, substituted pyridyl, C.sub.6 -C.sub.13 pyridylalkyl or C.sub.6 -C.sub.13 (substituted pyridyl)alkyl, wherein each substituent is independently halo, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halosubstituted C.sub.1 -C.sub.4 alkyl, halosubstituted C.sub.1 -C.sub.4 alkoxy, NR.sup.4 R.sup.5, CO.sub.2 R.sup.4 or CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or C.sub.1 -C.sub.6 alkyl; Ar.sup.1 and Ar.sup.2 are each, independently, phenylene, mono-substituted phenylene or di-substituted phenylene, wherein the substituents are, independently, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo-substituted C.sub.1 -C.sub.4 alkyl or halo-substituted C.sub.1 -C.sub.4 alkoxy; X and X.sup.1 are each, independently, O, S, SO or SO.sub.2 ; R' is hydrogen or C.sub.1 -C.sub.4 alkyl; and R.sup.2 and R.sup.3 are each, independently, methylene, ethylene or propylene. These compounds are useful for the treatment of disease states such as bronchial asthma, skin disorders and arthritis in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译： PCT No.PCT / JP94 / 00836 Sec。 371日期：1996年5月6日 102（e）日期1996年5月6日PCT 1994年5月25日PCT公布。第WO94 / 29299号公报日期：1994年12月22日具有抑制脂氧合酶和具有式（I）的能力的新型咪唑衍生物，其中Y为氢，C1-C8烷基，卤代C1-C4烷基，苯基，取代苯基，C7-C14苯基烷基， C7-C14（取代苯基）烷基，吡啶基，取代的吡啶基，C6-C13吡啶基烷基或C6-C13（取代的吡啶基）烷基，其中各取代基独立地为卤素，硝基，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基， C 1 -C 4烷基，卤代C 1 -C 4烷氧基，NR 4 R 5，CO 2 R 4或CONR 4 R 5，其中R 4和R 5各自独立地为氢或C 1 -C 6烷基; Ar 1和Ar 2各自独立地为亚苯基，单取代亚苯基或二取代亚苯基，其中取代基独立地为卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，卤素取代的C 1 -C 4烷基或卤素取代的 C1-C4烷氧基; X和X1各自独立地为O，S，SO或SO 2; R'是氢或C 1 -C 4烷基; 并且R 2和R 3各自独立地为亚甲基，亚乙基或亚丙基。这些化合物可用于治疗疾病状态，例如哺乳动物中的支气管哮喘，皮肤病和关节炎，以及用作治疗这些病症的药物组合物中的活性成分。

4. 发明申请

US20130026028A1 BROMINE-SENSITIZED SOLAR PHOTOLYSIS OF CARBON DIOXIDE 审中-公开
标题翻译：二氧化碳的溴敏感太阳能光化学
公开(公告)号：US20130026028A1
公开(公告)日：2013-01-31
申请号：US13609512
申请日：2012-09-11
申请人： Mark S. BRAIMAN
发明人： Mark S. BRAIMAN
IPC分类号： C23C16/48 , C23C16/26 , B32B17/02 , B32B9/04 , B32B17/06 , C07D305/04 , B32B9/00
CPC分类号： C23C16/26 , B01D53/62 , C01B32/05 , C01B32/336 , C07D321/00 , C23C16/48 , C23C16/482 , C23C18/1204 , C23C18/1208 , C23C18/1245 , C23C18/14 , Y02P20/134 , Y10T428/2991 , Y10T428/2993 , Y10T442/2992
摘要： There is described a process for depositing carbon on a surface, comprising, while contacting a mixture of CO2 and Br2 with a polar substrate presenting apposed surfaces, exposing a sufficient area of said mixture in the region of said apposed surfaces to light of sufficient intensity and frequency to result in deposition of carbon on at least some of said apposed surfaces. Other embodiments are also described.
摘要翻译：描述了一种在表面上沉积碳的方法，包括在将CO 2和Br 2的混合物与呈现呈现表面的极性底物接触的同时，将所述表面区域中的所述混合物的足够面积暴露于足够强度的光，频率导致碳沉积在所述至少一些所述表面上。还描述了其它实施例。

5. 发明授权

US4714710A Insecticidal and acaricidal oxetane and thietane derivatives, compositions, and method of use therefor 失效
标题翻译：杀虫和杀螨的氧杂环丁烷和硫杂环丁烷衍生物，组合物及其用途的方法
公开(公告)号：US4714710A
公开(公告)日：1987-12-22
申请号：US905275
申请日：1986-09-09
申请人： Heinrich Franke , Hartmut Joppien , Helga Franke
发明人： Heinrich Franke , Hartmut Joppien , Helga Franke
IPC分类号： C07D317/00 , A01N43/20 , A01N43/30 , C07D305/04 , C07D305/06 , C07D331/04 , C07D407/04 , A61K31/335 , A61K31/38
CPC分类号： A01N43/20 , C07D305/06 , C07D331/04
摘要： There are described new compounds of general formula I ##STR1## in which R.sub.1 is aryl or aryl substituted by C.sub.1-4 -alkyl, halo-C.sub.1-4 -alkyl, phenyl-C.sub.1-4 -alkyl, C.sub.2-4 -alkenyl, halo-C.sub.2-4 -alkenyl, phenyl-C.sub.2-4 -alkenyl, C.sub.2-4 -alkynyl, halo-C.sub.2-4 -alkynyl, phenyl-C.sub.2-4 -alkynyl, C.sub.1-4 -alkoxy, halo-C.sub.1-4 -alkoxy, phenyl-C.sub.1-4 -alkoxy, C.sub.2-4 -alkenyloxy, alkylsulphonyloxy, haloalkylsulphonyloxy, arylsulphonyloxy, halo-C.sub.2-4 -alkenyloxy, phenyl-C.sub.2-4 -alkenyloxy, halo, cyano, nitro, aryloxy, haloaryloxy, C.sub.1-4 -alkylaryloxy, or nitro-C.sub.1-4 -alkylaryloxy,R.sub.2 and R.sub.3 are the same or different and are hydrogen, fluorine, cyano or ethynyl,R.sub.4 is phenyl or pyridyl or these groups substituted by one or more of C.sub.1-6 -alkyl, halo-C.sub.1-6 -alkyl, phenyl-C.sub.1-6 -alkyl, C.sub.1-6 -alkyl interrupted by an O--, N-- or S-- atom, C.sub.2-4 -alkenyl, halo-C.sub.2-4 -alkenyl, phenyl-C.sub.2-4 -alkenyl, C.sub.1-4 -alkoxy, halo-C.sub.1-4 -alkoxy, phenyl-C.sub.1-4 -alkoxy, C.sub.2-4 -alkenyloxy, halo-C.sub.2-4 -alkenyloxy, phenyl-C.sub.2-4 -alkenyloxy, aryloxy, haloaryloxy, C.sub.1-4 -alkylaryloxy, arylamino, haloarylamino, C.sub.1-4 -alkylarylamino, aryl-N--C.sub.1-4 -alkylamino, aryl-N--C.sub.1-4 acylamino, aroyl, haloaroyl, C.sub.1-4 -alkylaroyl, aryl, haloaryl, C.sub.1-4 -alkylaryl or halo,A is O or S andB is CH.sub.2 or O,processes for their preparation and their use as insecticides and acaricides.
摘要翻译：描述了通式I（I）的新化合物，其中R 1是被C 1-4 - 烷基，卤代C 1-4 - 烷基，苯基-C 1-4 - 烷基，C 2-4 - 烷基取代的芳基或芳基，烯基，卤代C 2-4链烯基，苯基-C 2-4链烯基，C 2-4炔基，卤代C 2-4炔基，苯基-C 2-4亚烷基，C 1-4 - 烷氧基， 4-烷氧基，苯基-C 1-4 - 烷氧基，C 2-4 - 烯氧基，烷基磺酰氧基，卤代烷基磺酰氧基，芳基磺酰氧基，卤代C 2-4 - 烯氧基，苯基-C 2-4-烯氧基，卤素，氰基，硝基，芳氧基， C 1-4 - 烷基氧基或硝基-C 1-4 - 烷基芳氧基，R 2和R 3相同或不同，为氢，氟，氰基或乙炔基，R 4为苯基或吡啶基，或这些基团被一个或多个C 1-6 - 烷基，卤代C 1-6 - 烷基，苯基-C 1-6 - 烷基，被O-，N-或S-原子间隔的C 1-6 - 烷基，C 2-4链烯基，卤代C 2-4 - 烯基苯基-C 2-4 4-烯基，C 1-4 - 烷氧基，卤代-C 1-4 - 烷氧基，苯基-C 1-4 - 烷氧基，C 2-4 - 烯氧基，卤代-C 2-4 4-烯基氧基，苯基-C 2-4 - 烯氧基，芳氧基，卤代芳氧基，C 1-4 - 烷基芳氧基，芳基氨基，卤素芳基-N-C 1-4烷基氨基，芳基-N-C 1-4酰基氨基，芳酰基，卤代酰基，C 1-4 - 烷酰基，芳基，卤代芳基，C 1-4 - 烷基芳基或卤素，A 是O或S且B是CH 2或O，其制备方法及其作为杀虫剂和杀螨剂的用途。

6. 发明授权

US4313884A Use of metal ions in preparation of anhydropolyols 失效
标题翻译：使用金属离子制备脱水多元醇
公开(公告)号：US4313884A
公开(公告)日：1982-02-02
申请号：US113882
申请日：1980-01-21
申请人： Blaise J. Arena
发明人： Blaise J. Arena
IPC分类号： C07D307/20 , C07D309/10 , C07D493/04 , C07D309/06 , C07D305/04 , C07D307/12
CPC分类号： C07D493/04 , C07D307/20 , C07D309/10
摘要： Anhydrohexitols may be prepared from hexitols by heating the hexitols in the presence of metal ions whose charge to ionic radius ratio is from about 2.0 to about 3.2 at a temperature from about 100 to about 300.degree. C. A hexose, such as glucose, may be converted directly to anhydrohexitols, such as sorbitans, by hydrogenating the hexose in the presence of a suitable hydrogenation catalyst to which has been added an appropriate metal salt, such as nickel chloride.
摘要翻译：脱水己糖醇可以通过在约100至约300℃的温度下，在电荷与离子半径比为约2.0至约3.2的金属离子的存在下加热己二醇来制备。己糖如葡萄糖可以是通过在合适的氢化催化剂的存在下氢化己糖直接转化为脱水己糖醇，例如脱水山梨糖醇，向其中加入适当的金属盐，如氯化镍。

7. 发明申请

US20130261099A1 Fatty Acid Inhibitors 审中-公开
标题翻译：脂肪酸抑制剂
公开(公告)号：US20130261099A1
公开(公告)日：2013-10-03
申请号：US13902543
申请日：2013-05-24
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Bruce BRANCHAUD
IPC分类号： C07C57/03 , C07D205/04 , C07D303/38 , C07D331/02 , C07D305/04 , C07D203/08 , C07D331/04
CPC分类号： C07D303/48 , C07C57/03 , C07C205/55 , C07C2601/02 , C07D203/08 , C07D205/04 , C07D303/38 , C07D305/04 , C07D305/06 , C07D305/08 , C07D331/02 , C07D331/04
摘要： Fatty acid inhibitors, pharmaceutical compositions including fatty acid inhibitors, methods for using fatty acid inhibitors to treat a variety of diseases, and methods for preparing fatty acid inhibitors are provided herein.
摘要翻译：本文提供了脂肪酸抑制剂，包括脂肪酸抑制剂的药物组合物，使用脂肪酸抑制剂治疗各种疾病的方法以及制备脂肪酸抑制剂的方法。

8. 发明申请

US20120004187A1 SPIROCYCLICALLY SUBSTITUTED 1,3-PROPANE DIOXIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 有权
标题翻译：螺旋取代的1,3-丙二酮衍生物，其制备方法及其作为药物的用途
公开(公告)号：US20120004187A1
公开(公告)日：2012-01-05
申请号：US13176333
申请日：2011-07-05
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K38/16 , A61K31/337 , A61P3/10 , C07D213/64 , C07D305/04 , C07C59/68 , A61K31/44 , A61K31/19
CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译：本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。该化合物适用于例如治疗糖尿病。

9. 发明申请

US20080008943A1 INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, METHOD OF PRODUCING PLANOGRAPHIC PRINTING PLATE, AND PLANOGRAPHIC PRINTING PLATE 有权
标题翻译：墨水组合物，喷墨记录方法，印刷材料，生产平版印刷板的方法和平版印刷板
公开(公告)号：US20080008943A1
公开(公告)日：2008-01-10
申请号：US11769895
申请日：2007-06-28
申请人： Kotaro WATANABE
发明人： Kotaro WATANABE
IPC分类号： G03C1/73 , C07D303/02 , C07D303/04 , C07D305/04 , C07D307/04 , C07D313/04
CPC分类号： C09D11/101 , B41C1/1066
摘要： The present invention provides an ink composition comprising a compound having a fragment containing a cyclic ether group having at least one bicyclo or tricyclic substituent.
摘要翻译：本发明提供一种油墨组合物，其包含具有含有至少一个双环或三环取代基的环醚基的片段的化合物。

10. 发明授权

US09249508B2 Bromine-sensitized solar photolysis of carbon dioxide 有权
标题翻译：二氧化碳的溴敏太阳光解
公开(公告)号：US09249508B2
公开(公告)日：2016-02-02
申请号：US13609512
申请日：2012-09-11
申请人： Mark S. Braiman
发明人： Mark S. Braiman
IPC分类号： C23C18/12 , C01B31/10 , C23C16/48 , B01D53/62 , C07D305/04 , C23C16/26 , C23C18/14
CPC分类号： C23C16/26 , B01D53/62 , C01B32/05 , C01B32/336 , C07D321/00 , C23C16/48 , C23C16/482 , C23C18/1204 , C23C18/1208 , C23C18/1245 , C23C18/14 , Y02P20/134 , Y10T428/2991 , Y10T428/2993 , Y10T442/2992
摘要： There is described a process for depositing carbon on a surface, comprising, while contacting a mixture of CO2 and Br2 with a polar substrate presenting apposed surfaces, exposing a sufficient area of said mixture in the region of said apposed surfaces to light of sufficient intensity and frequency to result in deposition of carbon on at least some of said apposed surfaces. Other embodiments are also described.
摘要翻译：描述了一种在表面上沉积碳的方法，包括在将CO 2和Br 2的混合物与呈现呈现表面的极性底物接触的同时，将所述表面区域中的所述混合物的足够面积暴露于足够强度的光，频率导致碳沉积在所述至少一些所述表面上。还描述了其它实施例。

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