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1. 发明授权

US11643389B2 Method for producing maleimide compound, compound and solid resin 有权
公开(公告)号：US11643389B2
公开(公告)日：2023-05-09
申请号：US16824082
申请日：2020-03-19
申请人： TOKYO OHKA KOGYO CO., LTD.
发明人： Kazuaki Ebisawa
IPC分类号： C07D207/448 , C08F212/08 , C07D209/48
CPC分类号： C07D207/448 , C07D209/48 , C08F212/08
摘要： A method for producing a maleimide compound having a group represented by the formula (a1), the method including condensing a primary amino group in a raw material compound having the primary amino group and dicarboxylic anhydride represented by the formula (a2) to generate a group represented by the formula (a3); and heating a compound having the group represented by the formula (a3), and converting the group represented by the formula (a3) into the group represented by the formula (a1).

2. 发明授权

US11104643B2 Bismaleimide modified product and method for producing the same 有权
公开(公告)号：US11104643B2
公开(公告)日：2021-08-31
申请号：US16930397
申请日：2020-07-16
申请人： UNITIKA LTD.
发明人： Yuki Yamada , Tatsuya Morikita , Takeshi Yoshida , Akira Shigeta , Yoshiaki Echigo
IPC分类号： C07D207/448
摘要： An object of the present invention is to provide a bismaleimide (D-BMI) modified product in which an amino group of dimer diamine (DDA) is maleimidized, which has the good heat resistance, and has the sufficiently enhanced processability, and a method for producing the same. There are provided: A bismaleimide (D-BMI) modified product in which an amino group of dimer diamine is maleimidized, the bismaleimide modified product having the following characteristics: 1) An acid value of the D-BMI modified product is 2 mg-KOH/g or less. 2) In 1H-NMR, when quantitative comparison is performed using an integrated value (A) of a peak corresponding to a proton of a methylene group directly bound to a nitrogen atom of a maleimide group and an integrated value (B) of a peak corresponding to a vinyl proton of a maleimide group, A/B is 1.25 or more and 2.00 or less. A method for producing D-BMI, the method including the following steps: 1) A step of preparing a crude D-BMI solution having an acid value of more than 2 mg-KOH/g. 2) A step of lowering an acid value of D-BMI to 2 mg-KOH/g or less by reacting an acid component in the solution with a carbodiimide compound. 3) A step of reacting the solution without a catalyst at 110 to 200° C. in a solvent.

3. 发明申请

US20210214344A1 JAK3 SELECTIVE INHIBITOR 有权
公开(公告)号：US20210214344A1
公开(公告)日：2021-07-15
申请号：US17059211
申请日：2019-05-30
申请人： PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL
发明人： Zhengying PAN , Liyang SHI , Xitao LI
IPC分类号： C07D403/14 , C07D207/448 , C07D401/14 , A61P37/06
摘要： The present invention relates to a compound of Formula (I)/(II) or pharmaceutically acceptable salts thereof. In Formula (I), Rh, Rg, Rf, m, Re, Rd, Ra, Rb, and Rc are as defined in the description. The present invention further relates to a pharmaceutical composition comprising the compound of Formula (I)/(II) or pharmaceutically acceptable salts thereof, and use of the compound of Formula (I)/(II) or the pharmaceutical composition in the manufacture of a medicament for treating inflammations such as rheumatoid arthritis.

4. 发明申请

US20200308112A1 METHOD FOR PRODUCING MALEIMIDE COMPOUND, COMPOUND AND SOLID RESIN 审中-公开
公开(公告)号：US20200308112A1
公开(公告)日：2020-10-01
申请号：US16824082
申请日：2020-03-19
申请人： TOKYO OHKA KOGYO CO., LTD.
发明人： Kazuaki Ebisawa
IPC分类号： C07D207/448 , C07D209/48 , C08F212/08
摘要： A method for producing a maleimide compound having a group represented by the formula (a1), the method including condensing a primary amino group in a raw material compound having the primary amino group and dicarboxylic anhydride represented by the formula (a2) to generate a group represented by the formula (a3); and heating a compound having the group represented by the formula (a3), and converting the group represented by the formula (a3) into the group represented by the formula (a1).

5. 发明申请

US20200087262A1 SALTS FOR USE IN ELECTROLYTE COMPOSITIONS OR AS ELECTRODE ADDITIVES 审中-公开
公开(公告)号：US20200087262A1
公开(公告)日：2020-03-19
申请号：US16494435
申请日：2018-03-27
申请人： HYDRO-QUÉBEC , MURATA MANUFACTURING CO., LTD.
发明人： Charlotte MALLET , Sylviane ROCHON , Antoine LAFLEUR-LAMBERT , Shinichi UESAKA , Karim ZAGHIB
IPC分类号： C07D233/90 , H01M10/0567 , H01M10/0525 , H01M10/0569 , C07D207/448 , C07C311/51 , C07D233/96 , C07D233/72 , H01M4/62 , H01M4/60
摘要： Here are described compounds for use as electrode additives or as salts in electrolyte compositions, and their methods of preparation. Also described are electrochemical cells comprising the compounds as electrode additives or as salts in electrolyte compositions.

6. 发明授权

US10464050B2 Dehydration catalyst for preparing N-substituted maleimide, preparation method thereof, and method of preparing N-substituted maleimide 有权
公开(公告)号：US10464050B2
公开(公告)日：2019-11-05
申请号：US16091091
申请日：2017-08-01
申请人： LG CHEM, LTD.
发明人： Ji Yeon Kim , Jun Seon Choi , Joo Young Cheon , Wang Rae Joe , Kyung Soo Kim
IPC分类号： B01J27/16 , B01J37/03 , C07D207/448 , B01J37/04 , B01J37/08 , B01J37/06
摘要： A dehydration catalyst for preparing N-substituted maleimide, which may minimize formation of by-products, is reusable because its activity is not reduced significantly even after being reused several times, and may maintain its reaction activity for a long time, a preparation method thereof, and a method of preparing N-substituted maleimide, are provided.

7. 发明申请

US20180362463A1 BISMALEIMIDE MODIFIED PRODUCT AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：US20180362463A1
公开(公告)日：2018-12-20
申请号：US16011077
申请日：2018-06-18
申请人： UNITIKA LTD.
发明人： Yuki YAMADA , Tatsuya MORIKITA , Takeshi YOSHIDA , Akira SHIGETA , Yoshiaki ECHIGO
IPC分类号： C07D207/448
CPC分类号： C07D207/448
摘要： An object of the present invention is to provide a bismaleimide (D-BMI) modified product in which an amino group of dimer diamine (DDA) is maleimidized, which has the good heat resistance, and has the sufficiently enhanced processability, and a method for producing the same. There are provided: A bismaleimide (D-BMI) modified product in which an amino group of dimer diamine is maleimidized, the bismaleimide modified product having the following characteristics: 1) An acid value of the D-BMI modified product is 2 mg-KOH/g or less. 2) In 1H-NMR, when quantitative comparison is performed using an integrated value (A) of a peak corresponding to a proton of a methylene group directly bound to a nitrogen atom of a maleimide group and an integrated value (B) of a peak corresponding to a vinyl proton of a maleimide group, A/B is 1.25 or more and 2.00 or less. A method for producing D-BMI, the method including the following steps: 1) A step of preparing a crude D-BMI solution having an acid value of more than 2 mg-KOH/g. 2) A step of lowering an acid value of D-BMI to 2 mg-KOH/g or less by reacting an acid component in the solution with a carbodiimide compound. 3) A step of reacting the solution without a catalyst at 110 to 200° C. in a solvent.

8. 发明授权

US08871949B2 Method for preparing FMOC-based hydrolysable linkers 有权
标题翻译：制备基于FMOC的可水解接头的方法
公开(公告)号：US08871949B2
公开(公告)日：2014-10-28
申请号：US12757622
申请日：2010-04-09
申请人： Peter Turecek , Juergen Siekmann , Christian Noe , Gerhard Stoiber
发明人： Peter Turecek , Juergen Siekmann , Christian Noe , Gerhard Stoiber
IPC分类号： C07D207/448
CPC分类号： C07D207/448 , Y02P20/55
摘要： A novel process for the production of Fmoc (9H-fluoren-9-ylmethoxycarbonyl)-based compounds is provided, wherein a protecting group for the 9-hydroxymethyl group of the fluorene ring system is utilized. These compounds are useful for the modification of protein and peptide drugs.
摘要翻译：提供了一种制备Fmoc（9H-芴-9-基甲氧基羰基）基化合物的新方法，其中使用了芴环体系的9-羟甲基的保护基。这些化合物可用于蛋白质和肽类药物的修饰。

9. 发明授权

US08258324B2 Intermediates useful in the preparation of maleimide functionalized polymers 有权
标题翻译：用于制备马来酰亚胺官能化聚合物的中间体
公开(公告)号：US08258324B2
公开(公告)日：2012-09-04
申请号：US13233717
申请日：2011-09-15
申请人： Samuel P. McManus , Antoni Kozlowski , Tracy L. Hutchison , Brian Bray , Xiaoming Shen
发明人： Samuel P. McManus , Antoni Kozlowski , Tracy L. Hutchison , Brian Bray , Xiaoming Shen
IPC分类号： C07D207/448
CPC分类号： C07D403/12 , A61K47/60 , C08G65/33337 , C08G69/08
摘要： Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
摘要翻译：提供了形成马来酰亚胺官能化聚合物的方法。在一个这样的实施方案中，马来酰亚胺官能化聚合物在包括进行反向Diels-Alder反应的步骤的方法中制备。还提供了可用于该方法的中间体以及制备中间体的方法。还提供了聚合物试剂，使用聚合物试剂，化合物和共轭物的方法。

10. 发明申请

US20110124882A1 Method for Preparing N-Substituted Maleimides 有权
标题翻译： N-取代的马来酰亚胺的制备方法
公开(公告)号：US20110124882A1
公开(公告)日：2011-05-26
申请号：US12999420
申请日：2009-06-24
申请人： Jin-Eok Kim , Seung-il Kim , Han-Jin Kwag
发明人： Jin-Eok Kim , Seung-il Kim , Han-Jin Kwag
IPC分类号： C07D207/448
CPC分类号： C07D207/448
摘要： The present invention relates to a method of preparing N-substituted maleimide in high purity and high yield, wherein, unlike a conventional method of preparing N-substituted maleimide after preparing N-substituted maleamic acid, an organic solvent, an acid catalyst, a dehydration co-catalyst and a stabilizer are added into a reactor without separately preparing N-substituted maleamic acid, and then a primary amine is added into the reactor to form an amine salt, maleic anhydride is added into the reactor, and the resulting mixture is subjected to a dehydration-cyclization reaction, wherein water produced during the reaction is azeotropically distilled with the organic solvent so as to effectively suppress formation of a maleimide polymer. Particularly, the invention simplifies the process, has high yield, minimizes side reactions, eliminates the introduction of expensive raw materials and the complicated treatment of the reaction solution and significantly shortens the time over which the raw materials and maleic anhydride are added.
摘要翻译：本发明涉及以高纯度和高收率制备N-取代马来酰亚胺的方法，其中与制备N-取代马来酰胺酸，有机溶剂，酸催化剂，脱水剂的常规制备N-取代马来酰亚胺的方法不同助催化剂和稳定剂加入到反应器中，而无需单独制备N-取代的马来酰胺酸，然后将伯胺加入到反应器中以形成胺盐，将马来酸酐加入到反应器中，并将所得混合物进行脱水 - 环化反应，其中在反应期间产生的水与有机溶剂共沸蒸馏，以有效抑制马来酰亚胺聚合物的形成。特别地，本发明简化了方法，具有高产率，最小化副反应，消除了昂贵原料的引入和复杂的反应溶液处理，并显着缩短了添加原料和马来酸酐的时间。

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