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1. 发明授权

US5977182A O-benzyl oxime ether derivatives and their use as pesticides 失效
标题翻译： O-苄基肟醚衍生物及其作为农药的用途
公开(公告)号：US5977182A
公开(公告)日：1999-11-02
申请号：US836176
申请日：1997-05-01
申请人： Rene Zurfluh , Hugo Ziegler , Stephan Trah
发明人： Rene Zurfluh , Hugo Ziegler , Stephan Trah
IPC分类号： A01C1/08 , A01N35/10 , A01N37/34 , A01N37/50 , A01N37/52 , A01N55/10 , C07C251/38 , C07C251/48 , C07C251/52 , C07C251/54 , C07C251/60 , C07C255/62 , C07C255/64 , C07C257/06 , C07C257/14 , C07C257/22 , C07C317/32 , C07C323/47 , C07C327/40 , C07C327/58 , C07D213/76 , C07D277/10 , C07D277/12 , C07D277/28 , C07D295/185 , C07D295/30 , C07D521/00 , A01N33/24 , A01N43/40
CPC分类号： C07D295/185 , A01N37/50 , A01N37/52 , C07C251/38 , C07C251/48 , C07C255/64 , C07C257/06 , C07C257/14 , C07C257/22 , C07D295/30 , C07C2101/02
摘要： Compounds of formula (I), wherein Y is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, OH, CN, NO.sub.2, Si(CH.sub.3).sub.3, CF.sub.3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR.sub.13 ; A is O or NR.sub.4 ; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.4 alkoxymethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or cyano; R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, cyano unsubstituted or substituted C.sub.1 -C.sub.6 alkoxycarbonyl, unsubstituted or substituted di(C.sub.1 -C.sub.6 alkyl)aminocarbonyl, unsubstituted or substituted C.sub.1 -C.sub.6 alkyl-S(O).sub.q, unsubstituted or substituted aryl-S(O).sub.q, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocyclylcarbonyl or unsubstituted or substituted phenyl; and R.sub.3 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted C.sub.3 -C.sub.6 cycloalkyl, unsubstituted or substituted phenyl or unsubstituted or substituted pyridyl; and wherein the remaining substituents are as defined herein, are pesticidal active ingredients. They can be used in pest control, especially as microbicides, insecticides and acaricides in agriculture, in horticulture and in the hygiene sector. ##STR1##
摘要翻译： PCT No.PCT / EP95 / 04357 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1995年11月6日PCT公布。公开号WO96 / 16026 日期：5月30日，式（I）的化合物，其中Y为氢，C1-C4烷基，C1-C4烷氧基，OH，CN，NO2，Si（CH3）3，CF3或卤素，T为（a）或 b），其中其余取代基具有以下定义：X是O，S或NR 13; A为O或NR4; R 1是氢，C 1 -C 4烷基，卤代C 1 -C 4烷基，环丙基，C 1 -C 4烷氧基甲基，C 1 -C 4烷氧基，C 1 -C 4烷硫基或氰基; 未取代或取代的二（C 1 -C 6烷基）氨基羰基，未取代或取代的C 1 -C 6烷基-S（O）q，未取代或取代的芳基-S（O）q，C 1 -C 6烷基，C 3 -C 6环烷基，氰基未取代或取代的C 1 -C 6烷氧基羰基，（O）q，未取代或取代的杂芳基，未取代或取代的杂环基，未取代或取代的杂环基羰基或未取代或取代的苯基; 未取代或取代的烷基，未取代或取代的C 3 -C 6环烷基，未取代或取代的苯基或未取代或取代的吡啶基; 并且其中剩余的取代基如本文所定义，是杀虫活性成分。它们可用于病虫害防治，特别是作为农业，园艺和卫生领域的杀菌剂，杀虫剂和杀螨剂。

2. 发明授权

US5942614A Process to produce midazolam 失效
公开(公告)号：US5942614A
公开(公告)日：1999-08-24
申请号：US63110
申请日：1998-01-20
申请人： Joel Edward Huber
发明人： Joel Edward Huber
IPC分类号： C07B61/00 , C07C257/06 , C07D207/06 , C07D211/14 , C07D239/76 , C07D243/16 , C07D243/20 , C07D487/04
CPC分类号： C07D487/04 , C07C257/06 , C07D239/76 , C07D243/16
摘要： The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.

3. 发明授权

US5922892A Process to produce midazolam 失效
标题翻译：生产咪达唑仑的过程
公开(公告)号：US5922892A
公开(公告)日：1999-07-13
申请号：US62929
申请日：1998-04-20
申请人： Joel Edward Huber
发明人： Joel Edward Huber
IPC分类号： C07B61/00 , C07C257/06 , C07D207/06 , C07D211/14 , C07D239/76 , C07D243/16 , C07D243/20 , C07D487/04
CPC分类号： C07D487/04 , C07C257/06 , C07D239/76 , C07D243/16
摘要： The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.
摘要翻译：本发明公开了制备咪达唑仑（VII），商业上重要的药物以及来自已知二苯甲酮（I）起始原料的那些方法中的新中间体的新方法。

4. 发明授权

US5602277A Substituted benzene derivatives useful as neuraminidase inhibitors 失效
标题翻译：用作神经氨酸酶抑制剂的取代苯衍生物
公开(公告)号：US5602277A
公开(公告)日：1997-02-11
申请号：US413886
申请日：1995-03-30
申请人： Yarlagadda S. Babu , Pooran Chand , David A. Walsh
发明人： Yarlagadda S. Babu , Pooran Chand , David A. Walsh
IPC分类号： C07C65/05 , C07C229/46 , C07C233/54 , C07C251/48 , C07C257/06 , C07C261/04 , C07C271/28 , C07C275/42 , C07C279/04 , C07C279/18 , C07C279/26 , C07C279/28 , C07C281/18 , C07C309/51 , C07C311/08 , C07C313/04 , C07C327/48 , C07C335/22 , C07D257/04 , C07F9/38 , A61K31/19
CPC分类号： C07D257/04 , C07C229/46 , C07C233/54 , C07C251/48 , C07C257/06 , C07C261/04 , C07C271/28 , C07C275/42 , C07C279/04 , C07C279/18 , C07C279/26 , C07C279/28 , C07C281/18 , C07C309/51 , C07C311/08 , C07C313/04 , C07C327/48 , C07C335/22 , C07C65/05 , C07F9/3834
摘要： A compound of the Formula (I): ##STR1## or pharmaceutically-suitable salts or prodrug forms thereof, wherein: n is 0-1;m is 0;p is 0-1;R.sup.1 is --CO.sub.2 H;R.sup.2 is selected from the group consisting of H, --OH, and --NH.sub.2 ;R.sup.3 is H;R.sup.4 is --C(O)NHR.sup.8 ;R.sup.5 is --NHC(R.sup.6)NH.sub.2R.sup.6 is selected from the group consisting of .dbd.NH, .dbd.NOH, .dbd.NCN, .dbd.O, and .dbd.S; andR.sup.8 is selected from the group consisting of C.sub.1 -C.sub.4 linear or branched alkyl substituted with 0-3 halogens on each carbon.
摘要翻译：式（I）的化合物：其中：n为0-1; m为0; p为0-1; R1是-CO 2 H; R2选自H，-OH和-NH2; R3为H; R4是-C（O）NHR8; R5是-NHC（R6）NH2 R6选自= NH，= NOH，= NCN，= O和= S; 并且R 8选自在每个碳上被0-3个卤素取代的C 1 -C 4直链或支链烷基。

5. 发明授权

US5292759A O-benzyloxime ethers and crop protection agents containing these compounds 失效
标题翻译： O-苄氧基肟醚和含有这些化合物的作物保护剂
公开(公告)号：US5292759A
公开(公告)日：1994-03-08
申请号：US962340
申请日：1992-10-15
申请人： Siegbert Brand , Uwe Kardorff , Reinhard Kirstgen , Bernd Mueller , Klaus Oberdorf , Hubert Sauter , Gisela Lorenz , Eberhard Ammermann , Christoph Kuenast , Albrecht Harreus
发明人： Siegbert Brand , Uwe Kardorff , Reinhard Kirstgen , Bernd Mueller , Klaus Oberdorf , Hubert Sauter , Gisela Lorenz , Eberhard Ammermann , Christoph Kuenast , Albrecht Harreus
IPC分类号： C07C251/60 , A01N37/32 , A01N37/34 , A01N37/36 , A01N37/38 , A01N37/42 , A01N37/44 , A01N37/50 , A01N37/52 , A01N43/00 , A01N43/16 , C07C255/64 , C07C257/06 , C07C323/47 , C07C323/50 , C07C323/56 , C07C323/60 , C07C327/22 , C07D209/48 , C07D309/04 , C07D309/12 , C07D309/28 , C07D401/04 , C07D401/12 , A01N43/38 , A01N43/40
CPC分类号： C07D209/48 , A01N37/36 , A01N37/38 , A01N37/50 , A01N43/16 , C07C251/60 , C07C255/64 , C07C257/06 , C07C323/47 , C07C323/56 , C07C323/60 , C07C327/22 , C07D309/04 , C07D309/12 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH.sub.2, NOalkylY is O, S, NR.sup.5R.sup.1, R.sup.2, R.sup.5 are H, alkylZ.sup.1, Z.sup.2 are H, halogen, methyl, methoxy, cyanoR.sup.3, R.sup.4 are hydrogen, cyano, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkynyl, alkoxy, haloalkoxy, alkylthio, benzylthio, alkylcarbonyl, substituted or unsubstituted phenylcarbonyl, substituted or unsubstituted benzylcarbonyl, alkoxycarbonyl, substituted or unsubstituted phenoxycarbonyl, substituted or unsubstituted benzyloxycarbonyl,N(R.sup.6).sub.2, where R.sup.6 is H, alkyl, substituted or unsubstituted phenyl,--CO--N(R.sup.7).sub.2, where R.sup.7 is H, substituted or unsubstituted alkyl,substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted arylthio, substituted or unsubstituted hetaryl, substituted or unsubstituted hetaryloxy, substituted or unsubstituted hetarylthio, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclyloxy,R.sup.3 and R.sup.4 together may form a carbocyclic or heterocyclic ring which is substituted or unsubstituted, andR.sup.3 or R.sup.4 may be halogen, or ##STR2## where n is an integer from 1 to 4, andR.sup.8 is, or, when n>1, the R.sup.8 's are identical or different and are each, H, halogen, cyano, nitro or substituted or unsubstituted C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, aryl, aryloxy, benzyloxy, hetaryl or hetaryloxy.and crop protection agents containing these compounds.
摘要翻译：式I的O-苄氧基肟其中5 X是取代或未取代的CH 2，NO 2烷基Y是O，S，NR 5 R 1，R 2，R 5是H，烷基Z 1，Z 2是H，卤素，甲基，甲氧基，氰基R3，R4是氢，氰基，取代或未取代的烷基，烯基，环烷基，环烯基，炔基，烷氧基，卤代烷氧基，烷硫基，苄硫基，烷基羰基，取代或未取代的苯基羰基，取代或未取代的苄基羰基，烷氧基羰基，取代或未取代的苯氧基羰基取代或未取代的苄氧基羰基，N（R6）2，其中R6是H，烷基，取代或未取代的苯基，-CO-N（R7）2，其中R7是H，取代或未取代的烷基，取代或未取代的芳基，未取代的芳氧基，取代或未取代的芳硫基，取代或未取代的杂芳基，取代或未取代的杂芳氧基，取代或未取代的杂芳硫基，取代或未取代的杂环基， R 3和R 4一起可以形成被取代或未取代的碳环或杂环，并且R 3或R 4可以是卤素，或者其中n是1至4的整数，R 8是或当n> 1，R8相同或不同，各自为H，卤素，氰基，硝基或取代或未取代的C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基，芳基，芳氧基，苄氧基，杂芳基或杂芳氧基。和含有这些化合物的作物保护剂。

6. 发明授权

US5189060A Imidate insecticides 失效
标题翻译：消炎药
公开(公告)号：US5189060A
公开(公告)日：1993-02-23
申请号：US621157
申请日：1990-11-30
申请人： David B. Kanne , Karl J. Fisher , Michael D. Broadhurst
发明人： David B. Kanne , Karl J. Fisher , Michael D. Broadhurst
IPC分类号： A01N37/52 , A01N43/08 , A01N43/30 , A01N43/32 , A01N43/40 , A01N53/00 , C07C67/00 , C07C241/00 , C07C249/02 , C07C251/12 , C07C251/26 , C07C251/30 , C07C255/61 , C07C257/06 , C07C257/08 , C07C317/22 , C07C317/36 , C07C317/42 , C07C323/20 , C07C323/36 , C07C323/43 , C07D213/64 , C07D213/68 , C07D307/42 , C07D317/66 , A61K37/52 , A61K31/21 , C07D213/643
CPC分类号： C07D317/66 , A01N37/52 , A01N43/08 , A01N43/40 , A01N53/00 , C07C255/61
摘要： Novel insecticides have the formula ##STR1## in which R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy or C.sub.1 -C.sub.4 haloalkylthio;R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy or C.sub.1 -C.sub.4 haloalkylthio;R.sub.3 is hydrogen, halogen or C.sub.1 -C.sub.4 haloalkyl; orR.sub.1 and R.sub.2 taken together are C.sub.1 -C.sub.4 alkylenedioxy or halo-C.sub.1 -C.sub.3 alkylenedioxy; provided that R.sub.1, R.sub.2 and R.sub.3 are not all hydrogen;R.sub.4 is methyl, ethyl, n-propyl, C.sub.3 -C.sub.7 branched alkyl, C.sub.1 -C.sub.6 haloalkyl, C.sub.2 -C.sub.4 alkenyl; or cyclopropyl, optionally substituted by up to 4 methyl groups or up to 2 halogens;R.sub.5 is: ##STR2## R.sub.6 is phenyl, benzyl, C.sub.3 -C.sub.4 alkenyl, or C.sub.3 alkynyl; R.sub.7, R.sub.8, R.sub.10 and R.sub.11 are each halogen; andR.sub.9 is methyl, methoxymethyl, methylthio, methylthiomethyl, hydroxymethyl, cyanomethyl, benzyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 alkynyl or propargylamino.

7. 发明授权

US5112868A Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition 失效
标题翻译：所选择的具有环加氧酶和5-脂氧合酶抑制的非甾族抗炎酰基残基的羟肟酸衍生物
公开(公告)号：US5112868A
公开(公告)日：1992-05-12
申请号：US518007
申请日：1990-05-02
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Daniel L. Flynn , Jagadish C. Sircar
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Daniel L. Flynn , Jagadish C. Sircar
IPC分类号： C07C257/06 , C07C317/40 , C07D209/26
CPC分类号： C07C257/06 , C07C317/40 , C07D209/26 , C07C2102/08
摘要： The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.
摘要翻译：本发明是选择的NSAIDS的酰基残基的新型选择的异羟肟酸衍生物，即具有5-脂氧合酶和环氧合酶抑制性质，用于治疗有利受抑制作用的病症的药物组合物和用于治疗哺乳动物（包括患有这些疾病的人）中的这些病症的方法。

8. 发明授权

US4909830A Herbicidal 3-aminopyrazolin-5-ones, compositions and use 失效
标题翻译：除草剂3-氨基吡唑啉-5-酮，组合物及用途
公开(公告)号：US4909830A
公开(公告)日：1990-03-20
申请号：US269809
申请日：1988-11-10
申请人： Uta Jensen-Korte , Hans-Joachim Santel , Robert R. Schmidt , Harry Strang
发明人： Uta Jensen-Korte , Hans-Joachim Santel , Robert R. Schmidt , Harry Strang
IPC分类号： A01N43/56 , C07C67/00 , C07C241/00 , C07C257/04 , C07C257/06 , C07C313/00 , C07C323/62 , C07D231/52
CPC分类号： C07D231/52 , C07C257/06
摘要： Herbicidal 3-aminopyrazolin-5-ones of the formula ##STR1## in which R.sup.1 stands for alkyl, alkenyl, halogenoalkyl, halogenoalkenyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, for optionally substituted aralkyl or for optionally substituted aryl,R.sup.2 stands for hydrogen or alkyl,R.sup.3 stands for hydrogen or alkyl,R.sup.4 stands for hydrogen, alkyl, alkenyl, alkinyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonylalkyl or alkanoyl, orR.sup.3 and R.sup.4 together stand for an alkylene or alkenylene radical, each of which is divalent,X stands for halogen, alkyl, alkoxy, alkylthio, halogenoalkyl. halogenoalkoxy or halogenoalkylthio, andZ stands for hydrogen, halogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,and acid addition salts thereof. Intermediates of the formula ##STR2## are also disclosed.
摘要翻译： R1代表烷基，烯基，卤代烷基，卤代烯基，烷氧基烷基，烷硫基烷基，环烷基，任选取代的芳烷基或任选取代的芳基的式（Ⅰ）的除草3-氨基吡唑啉-5-酮代表氢或烷基，R3代表氢或烷基，R4代表氢，烷基，烯基，炔基，烷氧基烷基，烷硫基烷基，烷氧基羰基烷基或烷酰基，或R3和R4一起代表一个亚烷基或亚烯基，卤素，烷基，烷氧基，烷硫基，卤代烷基。卤代烷氧基或卤代烷硫基，Z代表氢，卤素，烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基或卤代烷硫基，及其酸加成盐。还公开了式（II）的中间体。

9. 发明授权

US4111976A Process for the preparation of methyliminoisobutyrate hydrochloride 失效
标题翻译：制备甲基亚氨基异丁酸盐酸盐的方法
公开(公告)号：US4111976A
公开(公告)日：1978-09-05
申请号：US865099
申请日：1977-12-27
申请人： David E. Balke , Donald E. Perez
发明人： David E. Balke , Donald E. Perez
IPC分类号： C07C257/04 , C07C67/00 , C07C241/00 , C07C257/06 , C07C119/18
CPC分类号： C07C257/06
摘要： A process is provided for preparing methyliminoisobutyrate hydrochloride by reacting isobutyronitrile (IBN), hydrogen chloride (HCl) and methanol in the presence of excess HCl, wherein the IBN and HCl are added at a temperature from about 5.degree. C to about 25.degree. C to a methanolic solution containing excess HCl and by maintaining during the reaction a methanolic reaction medium saturated with HCl.
摘要翻译：提供了通过使异丁腈（IBN），氯化氢（HCl）和甲醇在过量HCl的存在下反应制备甲基亚氨基异丁酸盐酸盐的方法，其中IBN和HCl在约5℃至约25℃的温度下加入到含有过量HCl的甲醇溶液，并且在反应期间保持用HCl饱和的甲醇反应介质。

10. 发明公开

US20230150931A1 FABP4/5 INHIBITORS, METHODS OF USE AND METHODS OF MAKING 审中-公开
公开(公告)号：US20230150931A1
公开(公告)日：2023-05-18
申请号：US17944821
申请日：2022-09-14
申请人： Novius Therapeutics, LLC
发明人： Liraz Levi , Tej Pareek , Elizabeth Meyers , Seunghwan Lim , William J. Greenlee , Seong-Jin Kim
IPC分类号： C07C323/61 , C07C235/74 , C07D333/40 , C07D307/24 , C07C325/02 , C07C257/06 , C07D263/44 , C07D271/07 , C07D285/08 , C07D291/04 , C07C311/13 , A61P35/04
CPC分类号： C07C323/61 , C07C235/74 , C07D333/40 , C07D307/24 , C07C325/02 , C07C257/06 , C07D263/44 , C07D271/07 , C07D285/08 , C07D291/04 , C07C311/13 , A61P35/04
摘要： Disclosed herein are FABP4 and FABP5 inhibitor compounds and their use in pharmaceutical compositions for treating diseases relating to fatty acid metabolism, including cancer. Also disclosed herein are methods for preparing the disclosed compounds.

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