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1. 发明公开

US20240325491A1 RECOMBINANT PROTEINS, COMPOSITIONS AND METHODS OF STABILIZATION THEREOF 审中-公开
公开(公告)号：US20240325491A1
公开(公告)日：2024-10-03
申请号：US18577495
申请日：2022-07-07
申请人： UNICHEM LABORATORIES LTD
发明人： Dhananjay Sathe , Vivek Mishra , Saravanakumar Iyappan , Sunil Jog
IPC分类号： A61K38/17 , A61J1/06 , A61K47/18 , A61K47/26
CPC分类号： A61K38/1732 , A61J1/065 , A61K47/183 , A61K47/26
摘要： The present invention relates to recombinant proteins, compositions and methods of stabilization thereof. The invention specifically relates to the stable recombinant protein of SEQ ID NO: 1 and composition comprising recombinant protein of SEQ ID NO: 1. The invention further relates to method of preparing, storing and stabilizing recombinant protein of SEQ ID NO: 1 and its composition for longer shelf life.

2. 发明授权

US12059389B2 Systems and methods for fluid delivery 有权
公开(公告)号：US12059389B2
公开(公告)日：2024-08-13
申请号：US17849780
申请日：2022-06-27
申请人： Koska Family Limited
发明人： Marc Andrew Koska
IPC分类号： A61J1/20 , A61J1/06 , A61M5/24 , A61M5/28 , A61M5/32 , A61M5/34 , A61J1/18 , A61M5/00 , A61M5/162 , A61M5/30 , A61M5/31 , B29C49/04
CPC分类号： A61J1/201 , A61J1/067 , A61J1/2096 , A61M5/2425 , A61M5/343 , A61M5/348 , A61J1/18 , A61M2005/005 , A61M5/162 , A61M5/282 , A61M5/30 , A61M2005/3128 , A61M5/3202 , A61M2205/12 , A61M2205/3334 , B29C49/04
摘要： The invention provides for a delivery system including a delivery assembly configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient.

3. 发明公开

US20240252396A1 DEFORMABLE CONTAINER, KIT AND PACKAGING 审中-公开
公开(公告)号：US20240252396A1
公开(公告)日：2024-08-01
申请号：US18289432
申请日：2022-05-03
申请人： DOMPÉ FARMACEUTICI S.P.A.
发明人： Giuseppe Dionigi
IPC分类号： A61J1/06 , A61J1/14 , A61J1/20 , A61J7/00
CPC分类号： A61J1/067 , A61J1/1406 , A61J1/2048 , A61J7/0046
摘要： A deformable container for dispensing a medical substance comprising a body defining an internal volume configured to receive a fluid substance, said body comprising a filling access configured to receive the fluid substance, a dispensing outlet configured to dispense the fluid substance, a valve arranged at the filling access movable between an open configuration and a closed configuration. The body comprises an elastically deformable wall delimiting the internal volume. The disclosure further relates to a connecting accessory comprising a first coupling portion, configured to fluidly connect to the filling access of the deformable container, and a second coupling portion configured to fluidly connect to an internal compartment of a vial. The container and the connecting accessory are configurable in a coupled configuration wherein the connecting accessory is coupled to the filling access of the container, and the valve of the container is in the open configuration.

4. 发明授权

US12042830B2 Method of preventing lamellar silica formation in glass container 有权
公开(公告)号：US12042830B2
公开(公告)日：2024-07-23
申请号：US16959663
申请日：2019-01-03
申请人： AMGEN INC.
发明人： Yasser Nashed-Samuel , Jeremy Gastwirt
IPC分类号： B08B9/093 , A61J1/06 , A61J1/14 , B08B17/02 , C03C23/00 , G01N21/90 , G01N23/2251 , G01N33/38
CPC分类号： B08B9/093 , A61J1/065 , A61J1/1468 , B08B17/02 , C03C23/007 , C03C23/0075 , C03C23/0085 , G01N21/9027 , G01N23/2251 , G01N33/386 , C11D2111/18 , G01N2223/652
摘要： Methods of preventing the formation of lamellar silica formation in a borosilicate glass container storing a pharmaceutical formulation in an interior of the glass container in accordance with embodiments of the disclosure can include washing the container and drying the container under extended dry conditions of at least 3000 ms.

5. 发明授权

US11983749B2 System and method for automating electronic pharmaceutical transactions 有权
公开(公告)号：US11983749B2
公开(公告)日：2024-05-14
申请号：US17104384
申请日：2020-11-25
申请人： Breckenridge Capital LLC
发明人： John Kello , Gablan Zawaideh
IPC分类号： G06Q30/00 , A61J1/03 , A61J1/06 , G06Q10/0832 , G06Q20/08 , G06Q20/38 , G06Q20/40 , G06Q30/018 , G06Q30/0207 , G06Q30/0282 , G06Q30/0601 , G06Q50/26 , G16H40/20
CPC分类号： G06Q30/0607 , A61J1/035 , A61J1/06 , G06Q10/0832 , G06Q20/085 , G06Q20/383 , G06Q20/405 , G06Q30/0185 , G06Q30/0236 , G06Q30/0282 , G06Q30/0609 , G06Q30/0633 , G06Q50/26 , G16H40/20
摘要： An electronic transaction system for selling and purchasing regulated products having: a) one or more servers; b) an application which is a computer program; wherein the application includes: i) one or more validation heuristics; and ii) one or more member incentive heuristics; and c) one or more databases which store: i) the plurality of jurisdiction-based rules; ii) a plurality of regulated products; iii) one or more member incentives; and iv) a plurality of merchant accounts associated with the plurality of merchants.

6. 发明授权

US11963927B2 Glass containers with delamination resistance and improved damage tolerance 有权
公开(公告)号：US11963927B2
公开(公告)日：2024-04-23
申请号：US16996758
申请日：2020-08-18
申请人： CORNING INCORPORATED
发明人： Theresa Chang , Paul Stephen Danielson , Steven Edward DeMartino , Andrei Gennadyevich Fadeev , Robert Michael Morena , Santona Pal , John Stephen Peanasky , Robert Anthony Schaut , Christopher Lee Timmons , Natesan Venkataraman , Ronald Luce Verkleeren , Dana Craig Bookbinder
IPC分类号： C03B23/04 , A61J1/06 , A61J1/14 , B32B17/06 , B65D1/02 , B65D1/40 , B65D23/02 , B65D23/08 , B65D25/14 , B65D25/34 , B65D65/42 , C03C15/02 , C03C17/00 , C03C17/22 , C03C17/30 , C03C17/32 , C03C17/34 , C03C17/42 , C03C21/00 , C09D179/08
CPC分类号： A61J1/1468 , A61J1/065 , B32B17/06 , B65D1/0207 , B65D1/0215 , B65D1/40 , B65D23/02 , B65D23/0814 , B65D23/0821 , B65D25/14 , B65D25/34 , B65D65/42 , C03B23/04 , C03C15/02 , C03C17/005 , C03C17/22 , C03C17/30 , C03C17/32 , C03C17/3405 , C03C17/42 , C03C21/002 , C09D179/08 , C03C2217/78 , C03C2218/111 , Y10T428/13 , Y10T428/131 , Y10T428/1317 , Y10T428/24802 , Y10T428/315
摘要： A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP . The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

7. 发明公开

US20240024481A1 INJECTABLE IBUPROFEN FORMULATION 审中-公开
公开(公告)号：US20240024481A1
公开(公告)日：2024-01-25
申请号：US18376339
申请日：2023-10-03
申请人： Cumberland Pharmaceuticals Inc.
发明人： Leo PAVLIV , Andrew VILA
IPC分类号： A61K47/02 , A61J1/06 , A61J1/10 , A61P29/00 , A61K31/192
CPC分类号： A61K47/02 , A61J1/065 , A61J1/10 , A61P29/00 , A61K31/192
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

8. 发明授权

US11865322B2 Single use delivery device having a primer element 有权
公开(公告)号：US11865322B2
公开(公告)日：2024-01-09
申请号：US17173900
申请日：2021-02-11
申请人： Becton, Dickinson and Company
发明人： Suzanne Ferreri , Darrin Manke , James J. Kennedy, III , Morgan Carlson
IPC分类号： A61M5/36 , A61M5/28 , A61J1/20 , A61M25/00 , A61J1/06 , A61M39/24 , A61M5/31 , A61J1/14
CPC分类号： A61M5/36 , A61J1/067 , A61J1/2093 , A61M5/282 , A61M5/284 , A61M25/00 , A61M39/24 , A61J1/1425 , A61M2005/312 , A61M2005/3123 , A61M2025/0019
摘要： A single use delivery device is disclosed having a manually deformable liquid container defining an inner chamber, the container having a distal end, a body, a proximal end, and an outlet on the distal end; a tip projecting from the outlet on the distal end of the container, the tip in fluid communication with the inner chamber of the container; a primer element for removing one or more air bubbles from the chamber, said primer element being attached to and in fluid communication with the deformable container, the container, the tip and the primer element being collapsible to minimize dead space in the delivery device; and two or more one-way valves. A method of administering a fluid to or flushing a vascular access device using a single use pre-filled delivery device as described herein is also disclosed.

9. 发明公开

US20240002930A1 ENZYMATIC LIGATION OF NUCLEIC ACIDS 审中-公开
公开(公告)号：US20240002930A1
公开(公告)日：2024-01-04
申请号：US18303828
申请日：2023-04-20
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Stephen HENDRICKS , David J. KING
IPC分类号： C12Q1/6874 , A61J1/06 , A61J1/14 , B65B3/00 , B65B31/04 , B65D8/00 , C12N9/00 , C12Q1/6876
CPC分类号： C12Q1/6874 , A61J1/062 , A61J1/14 , B65B3/003 , B65B3/006 , B65B31/046 , B65D15/02 , C12N9/93 , C12Q1/6876 , A61J2200/76 , A61J2205/30 , A61M5/008
摘要： Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.

10. 发明授权

US11857747B1 Dispenser actuator assembly 有权
公开(公告)号：US11857747B1
公开(公告)日：2024-01-02
申请号：US16598913
申请日：2019-10-10
申请人： James Alexander Corporation
发明人： James Wittes , Richard James May , Philip Blyskal , David Robinson , Jeffrey Rendano
IPC分类号： A61M35/00 , A61J1/06
CPC分类号： A61M35/003 , A61J1/065 , A61M2209/04
摘要： A dispenser actuator assembly (100) for actuating a dispenser (10) is disclosed. The dispenser (10) is in the form of a glass ampoule assembly (10) having a rupturable glass ampoule (12) containing a flowable material (M). The glass ampoule (12) is contained within an outer container (14) wherein the outer container (14) has a first open end (22) and a second closed end (24). The glass ampoule assembly (10) has an applicator (16) positioned in the first open end (22). The dispenser actuator assembly (100) has a base member (102) configured to mount on the outer container (14). The dispenser actuator assembly (100) also has an actuator assembly (104) operably connected to the base member (102) wherein the actuator assembly (104) has a first actuator arm (132a) and a second actuator arm (132b) each pivotally connected to the base member (102). The first actuator arm (132a) and the second actuator arm (132b) extend from the base member (102) in generally opposed relation defining a first position, or neutral position. The first actuator arm (132a) has a first protrusion (150a) depending therefrom and the second actuator arm (132b) has a second protrusion (150b) depending therefrom. The first actuator arm (132a) and the second actuator arm (132b) are pivotable from the first position towards one another to a second position, or actuating position, that is configured such that the first protrusion (150a) engages the outer container (14) and the second protrusion (150b) engages the outer container (14) to crush the glass ampoule (12) wherein the flowable material (M) is configured to be dispensed from the glass ampoule assembly (10).

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