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1. 发明授权

US06576419B1 Assay procedure using fluorogenic tracers 失效
标题翻译：使用荧光示踪剂的测定程序
公开(公告)号：US06576419B1
公开(公告)日：2003-06-10
申请号：US08891114
申请日：1997-07-10
申请人： Ai-Ping Wei , James N. Herron
发明人： Ai-Ping Wei , James N. Herron
IPC分类号： C12Q108
CPC分类号： G01N33/582 , C12Q1/6818
摘要： Fluorescent energy transfer dyes capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to a peptide epitope or nucleic acid for use in the detection of an unknown antibody in bulk solution. The resulting labeled peptide reagent can be used in an immunoassay procedure by placing it in bulk solution along with the unknown antibody to be detected. When the antibody binds to the peptide epitope, the pair of dyes carried by the peptide epitope will have their configuration altered from a stacked to an unstacked configuration and will exhibit a fluorescent increase in response thereto.
摘要翻译：能够在更叠层的配置之间移动以展现荧光猝灭和更间隔的配置以显示荧光的荧光能量转移染料可以缀合到肽表位或核酸上，以用于检测本体溶液中的未知抗体。所得标记的肽试剂可以在免疫测定程序中使用，将其与待检测的未知抗体一起放入本体溶液中。当抗体与肽表位结合时，由肽表位携带的一对染料将具有从堆叠到未堆叠构型的改变，并且对其反应将呈现荧光增加。

2. 发明授权

US06245509B1 Detection of microorganism by DNA hybridization 失效
标题翻译：通过DNA杂交检测微生物
公开(公告)号：US06245509B1
公开(公告)日：2001-06-12
申请号：US09152375
申请日：1998-09-14
申请人： Eric J. Stanbridge , Ulf B. Gobel
发明人： Eric J. Stanbridge , Ulf B. Gobel
IPC分类号： C12Q108
CPC分类号： C12Q1/689
摘要： Biological probes useful for detecting mycoplasmas or prokaryotes in general, or specific mycoplasma and eubacterial species are derived from the ribosomal RNA gene by selecting particular nucleotide sequences common to the class of organisms being detected.
摘要翻译：可用于检测一般支原体或原核生物或特异性支原体和真细菌物种的生物探针通过选择被检测的生物体类别共有的特定核苷酸序列来衍生自核糖体RNA基因。

3. 发明授权

US06531285B1 Automated detection apparatus with a conveying means for test columns 有权
标题翻译：具有用于测试柱的输送装置的自动检测装置
公开(公告)号：US06531285B1
公开(公告)日：2003-03-11
申请号：US09671398
申请日：2000-09-27
申请人： Hai Shene Chen
发明人： Hai Shene Chen
IPC分类号： C12Q108
CPC分类号： G01N33/569 , A61K48/00 , A61K2035/124 , C12N5/0641 , C12N5/0647 , C12N2510/02 , C12Q1/6806 , G01N33/54366 , C12Q2565/519
摘要： An apparatus and method for detecting the presence of at least two predetermined known materials in a test sample are disclosed. The apparatus includes a sample addition station for adding a sample to a test column in the apparatus, a reagent station, a washing station, a detection station for detecting signals on the snares of the test column due to the presence of the predetermined known materials in the sample, and conveying means for conveying the test column from the sample addition station to the reagent station, washing station, and detection station. The test sample is introduced into a test column which has at least two snares for capturing the predetermined known materials, and the snares are separate spatially one from another. Each snare has a capture material specific to the associated predetermined known material. The detection station has a plurality of detectors for detecting signals on the snares of the test column due to the presence of the predetermined known materials in the sample. The method is useful for detection of pathogens, DNA and RNA.
摘要翻译：公开了一种用于检测测试样品中至少两种预定已知材料的存在的装置和方法。该装置包括用于将样品添加到装置中的试验柱的试样添加站，试剂站，洗涤站，检测站，用于由于存在预定的已知材料而在测试柱的圈套上检测信号样品和用于将测试柱从加样站输送到试剂站，洗涤站和检测站的输送装置。将测试样品引入到具有至少两个用于捕获预定已知材料的圈套的测试柱中，并且该圈套在空间上彼此分开。每个圈套具有特定于相关预定已知材料的捕获材料。检测站具有多个检测器，用于由于在样品中存在预定的已知材料来检测测试柱的圈套上的信号。该方法可用于检测病原体，DNA和RNA。

4. 发明授权

US06287765B1 Methods for detecting and identifying single molecules 失效
标题翻译：检测和识别单分子的方法
公开(公告)号：US06287765B1
公开(公告)日：2001-09-11
申请号：US09081930
申请日：1998-05-20
申请人： Roger S. Cubicciotti
发明人： Roger S. Cubicciotti
IPC分类号： C12Q108
CPC分类号： C07H21/00 , Y10S977/853
摘要： Multimolecular devices and drug delivery systems prepared from synthetic heteropolymers, heteropolymeric discrete structures, multivalent heteropolymeric hybrid structures, aptameric multimolecular devices, multivalent imprints, tethered specific recognition devices, paired specific recognition devices, nonaptameric multimolecular devices and immobilized multimolecular structures are provided, including molecular adsorbents and multimolecular adherents, adhesives, transducers, switches, sensors and delivery systems. Methods for selecting single synthetic nucleotides, shape-specific probes and specifically attractive surfaces for use in these multimolecular devices are also provided. In addition, paired nucleotide-nonnucleotide mapping libraries for transposition of selected populations of selected nonoligonucleotide molecules into selected populations of replicatable nucleotide sequences are described.
摘要翻译：提供了由合成杂聚物，异聚分子结构，多价杂聚杂合结构，适体多分子装置，多价印记，系留特异性识别装置，配对特异性识别装置，非多聚多分子装置和固定化多分子结构制备的多分子装置和药物递送系统，包括分子吸附剂和多分子粘附剂，粘合剂，换能器，开关，传感器和输送系统。还提供了用于选择单个合成核苷酸，形状特异性探针和用于这些多分子装置的特别有吸引力的表面的方法。此外，描述了用于将选定的非寡核苷酸分子的选定群体转移到选择的可复制核苷酸序列群体中的配对核苷酸 - 非核苷酸映射文库。

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