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1. 发明申请

US20040142990A1 Fermentative preparation process for and crystal forms of cytostatics 审中-公开
标题翻译：发酵制备过程和晶体形式的细胞抑制剂
公开(公告)号：US20040142990A1
公开(公告)日：2004-07-22
申请号：US10754661
申请日：2004-01-08
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
IPC分类号： A61K031/724 , A61K031/427 , C12P017/16
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.
摘要翻译：本发明涉及用于将埃坡霉素浓缩在培养基中的新方法，用于生产埃坡霉素的新方法，用于分离埃坡霉素A和B的新方法和通过诱变获得的用于产生埃坡霉素的新菌株，以及相关方面到此。还描述了埃坡霉素B的新晶体形式。

2. 发明申请

US20030022321A1 Novel compounds 审中-公开
公开(公告)号：US20030022321A1
公开(公告)日：2003-01-30
申请号：US10071338
申请日：2002-02-08
申请人： SmithKline Beecham p.l.c.
发明人： Cecilia Anders , Barry Barton , John Patrick Griffin , Susan Jensen , Roy Henrey Mosher , Ashish Sudhakar Paradkar
IPC分类号： C12P017/16 , C07H021/04 , C12N001/14 , C12N001/16 , C12P021/02 , C12N015/74
CPC分类号： C07K14/36 , C12N15/52 , C12N15/76 , C12P17/188
摘要： Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, eg. clavulanic acid.

3. 发明申请

US20040053375A1 Microbiological method of the biosynthesis of natural blue-violet colorants violacein and deoxyviolacein and the utilization thereof 失效
标题翻译：天然蓝紫色着色剂紫菜素和脱氧维生素的生物合成微生物方法及其应用
公开(公告)号：US20040053375A1
公开(公告)日：2004-03-18
申请号：US10451518
申请日：2003-06-20
发明人： Tjhing-Lok Tan , Franz-Peter Montforts , Daniela Meyer
IPC分类号： C12P017/16 , C12N001/20
CPC分类号： C12R1/01 , C12P17/165
摘要： Known microbiological methods are based upon the application of pigment-forming bacteria, in particular chromobacterium violaceum. The yield of these methods is very low, however, so that large industrial applications are not possible. However, in many fields of industry, there exists a very great demand for natural blue dyes which are substantially suitable for human digestion, which cannot be satisfied at present. Therefore, the method in accordance with the invention is characterized by the application of the newly discovered marine sediment bacterium pseudoalteromonas spezies of the nullBlack Beautynull strain (originally deposited under file number DSM 13623 with the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH., Braunschweig, Germany pursuant to the Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purposes of Patent Procedure). Compared to conventional methods, this marine sediment bacterium leads to an about thirteen-fold yield. An application of the natural dyes produced economically and by simple technical processes is thus possible in consumer and environmentally friendly products, in particular those from the food, textile or toy industries.
摘要翻译：已知的微生物学方法是基于色素形成细菌，特别是紫草杆菌的应用。然而，这些方法的产量非常低，因此大型工业应用是不可能的。然而，在许多工业领域中，对天然蓝色染料的需求非常大，其基本上适用于人类消化，目前尚不能满足。因此，根据本发明的方法的特征在于应用新发现的“黑美人”菌株的海洋沉积物假单胞菌属物种（最初以文件号DSM 13623存放在德意志山脉冯Mikroorganismen und Zellkulturen有限公司，不伦瑞克省，德国根据“国际承认专利程序微生物保藏条约”）。与常规方法相比，这种海洋沉积细菌产量约为十三倍。因此，在消费者和环境友好的产品，特别是食品，纺织或玩具工业的产品中，经济地制造和简单的技术工艺生产的天然染料的应用是可能的。

4. 发明申请

US20040014183A1 Secondary metabolite congener distribution modulation 有权
标题翻译：次生代谢产物分配调制
公开(公告)号：US20040014183A1
公开(公告)日：2004-01-22
申请号：US10376612
申请日：2003-02-25
发明人： Peter J. Licari , Bryan Julien , Scott Frykman , Hiroko Tsuruta
IPC分类号： C12P017/16 , C12N001/21
CPC分类号： C12N1/20 , C12N15/52 , C12P17/162 , C12P17/167 , C12P17/181
摘要： The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distribution.
摘要翻译：本发明提供了在各种氧气胁迫条件下异源表达聚酮化合物合酶（PKS）基因簇的调理聚酮化合物分布的粘液菌菌株的广义限氧培养方法。

5. 发明申请

US20030220379A1 Fermentative preparation process for and crystal forms of cytostatics 失效
公开(公告)号：US20030220379A1
公开(公告)日：2003-11-27
申请号：US10459762
申请日：2003-06-12
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
IPC分类号： A61K031/427 , C12P017/16 , C12N001/16
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

6. 发明申请

US20030157518A1 Fluorescent compounds 审中-公开
标题翻译：荧光化合物
公开(公告)号：US20030157518A1
公开(公告)日：2003-08-21
申请号：US10258310
申请日：2003-02-24
发明人： Philip John Livingston Bell , Peter Karuso
IPC分类号： C12Q001/68 , G01N033/53 , C07H021/04 , G01N033/48 , C12P017/16 , G01N001/30 , C07D307/91
CPC分类号： C07D493/04 , C09B57/00 , C09B61/00 , G01N33/582 , G01N33/6839
摘要： Fluorescent dye compounds of formula (I) are disclosed. These compounds are useful as they interact with organic compounds in a manner such that excitation with certain wavelengths of light results in fluorescent emmission. Detection and/or monitoring of the fluorescence provides a means for the detection or quantification of organic compounds when bound to these fluorescent dye compounds. Formula (I), wherein: each of R, Rnull and Rnull is a hydrogen atom, halogen atom or a straight or branched chain (C1-20alkyl, alkenyl or alkynyl group optionally substituted with one or more halogen, hydroxy and/or oxy group: rings A, B and C optionally include one or more double bonds; rings B and C are optionally substituted with one or more halogen atoms.
摘要翻译：公开了式（I）的荧光染料化合物。这些化合物是有用的，因为它们以与某些波长的光的激发导致荧光发射的方式与有机化合物相互作用。荧光检测和/或监测提供了当与这些荧光染料化合物结合时检测或定量有机化合物的手段。式（I）其中：R，R'和R“各自为氢原子，卤原子或直链或支链（C 1-20烷基，烯基或炔基，任选被一个或多个卤素，羟基和/ 或氧基：环A，B和C任选地包括一个或多个双键;环B和C任选被一个或多个卤素原子取代。

7. 发明申请

US20020123109A1 Biotin biosynthetic genes 失效
标题翻译：生物素生物合成基因
公开(公告)号：US20020123109A1
公开(公告)日：2002-09-05
申请号：US10033078
申请日：2001-12-27
申请人： ROCHE VITAMINS INC.
发明人： Yasuhiro Furuichi , Tatsuo Hoshino , Hitoshi Kimura , Tatsuya Kiyasu , Yoshie Nagahashi
IPC分类号： C12P017/16 , C12N009/00 , C07H021/04 , C12P021/02 , C12N001/21
CPC分类号： C12N15/52 , A23L33/15 , A23V2002/00 , C12P17/185 , A23V2250/70
摘要： The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.
摘要翻译：本发明涉及使用遗传工程微生物的发酵生物素的生产方法，以及用于该方法的DNA序列和载体。

8. 发明申请

US20030207411A1 DNA sequence encoding enzymes of clavulanic acid biosynthesis 审中-公开
公开(公告)号：US20030207411A1
公开(公告)日：2003-11-06
申请号：US10458201
申请日：2003-06-11
申请人： The Governors of the University of Alberta
发明人： Susan E. Jensen , Kwamena A. Aidoo , Ashish S. Paradkar
IPC分类号： C12P017/16 , C12N009/10 , C07H021/04 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12N15/76 , C07K14/36 , C12N15/52 , C12P17/188
摘要： DNA sequences are provided which encode the enzymes required for clavulanic acid synthesis. A process is provided for producing clavulanic acid in a transformant of a non-clavulanate-producing host.

9. 发明申请

US20030194787A1 Fermentative preparation process for and crystal forms of cytostatics 审中-公开
公开(公告)号：US20030194787A1
公开(公告)日：2003-10-16
申请号：US10338336
申请日：2003-01-08
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
IPC分类号： C12P017/16
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

10. 发明申请

US20030192073A1 Plant biotin synthase 审中-公开
标题翻译：植物生物素合成酶
公开(公告)号：US20030192073A1
公开(公告)日：2003-10-09
申请号：US10431544
申请日：2003-05-07
发明人： Stephen M. Allen , Anthony J. Kinney , Guo-Hua Miao , Emil M. Orozco JR.
IPC分类号： A01H001/00 , C12N015/82 , C12P021/06 , C07H021/04 , C12P017/16 , C12N009/10 , C12P021/02 , C12N005/04
CPC分类号： C12N15/52
摘要： This invention relates to an isolated nucleic acid fragment encoding a biotin synthases. The invention also relates to the construction of a chimeric gene encoding all or a portion of the biotin synthases, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the biotin synthases in a transformed host cell.
摘要翻译：本发明涉及编码生物素合酶的分离的核酸片段。本发明还涉及在正义或反义方向上构建编码全部或一部分生物素合酶的嵌合基因，其中嵌合基因的表达导致转化宿主细胞中生物素合酶水平的改变。

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