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1. 发明申请

US20030203449A1 Novel 2,5-diketo-L-gluconic acid reductases and methods of use 失效
标题翻译：新型2,5-二酮-L-葡萄糖酸还原酶及其使用方法
公开(公告)号：US20030203449A1
公开(公告)日：2003-10-30
申请号：US10418401
申请日：2003-04-17
发明人： Mark Donnelly , William H. Eschenfeldt , Jonathan Trent
IPC分类号： C12P017/04 , C07H021/04 , C12N009/02 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12N9/0006 , C12P7/60 , C12P17/04 , C12Q1/26 , C12Y101/01274
摘要： Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.
摘要翻译：本文描述的是新的核酸，蛋白质和方法，其可用于为工业过程提供具有期望特性的新型催化剂。特别地，描述了使用PCR方法从环境分离的新的还原酶。

2. 发明申请

US20030203454A1 Methods for producing end-products from carbon substrates 审中-公开
标题翻译：从碳底物生产最终产品的方法
公开(公告)号：US20030203454A1
公开(公告)日：2003-10-30
申请号：US10359771
申请日：2003-02-06
发明人： Gopal K. Chotani , Manoj Kumar , Jeff P. Pucci , Karl J. Sanford , Jayarama K. Shetty
IPC分类号： C12P019/02 , C12P017/04 , C12P007/58 , C12P007/06
CPC分类号： C12P7/56 , C12P7/06 , C12P7/10 , C12P7/18 , C12P7/20 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/58 , C12P7/60 , C12P19/02 , C12P2201/00 , Y02E50/16 , Y02E50/17
摘要： The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate.
摘要翻译：本发明提供了生产基于生物质的原料基质的体外和/或体内生物转化所需的终产物的方法，包括但不限于淀粉和纤维素等材料。在特别优选的实施方案中，本发明的方法不需要基质的凝胶化和/或液化。

3. 发明申请

US20010019837A1 PROCESS FOR MICROBIALLY OXIDIZING N-SUBSTITUTED GLUCAMINES 失效
标题翻译：用于微量氧化N-取代的葡萄糖的方法
公开(公告)号：US20010019837A1
公开(公告)日：2001-09-06
申请号：US09291005
申请日：1999-04-14
发明人： ROY WALTER GRABNER , BRYAN HAYDEN LANDIS , PING TU WANG , MICHAEL LEE PRUNIER , MIKE G. SCAROS
IPC分类号： C12P017/04
CPC分类号： C07H15/12 , C07D211/46 , C07H15/18 , C07H15/203 , C12P19/26 , Y02P20/55
摘要： The invention is a process for producing N-substituted glucamines, a process for oxidizing an N-substituted glucamine with an oxidizing microbe or extract thereof, and a process for oxidizing an N-substituted glucamine with an oxidizing microbe or extract thereof and reducing the oxidized N-substituted glucamine to an N-substituted-1-deoxynojirimycin. In addition, a one pot process for producing N-substituted-1-deoxynojirimycin from D-glucose is disclosed.
摘要翻译：本发明是生产N-取代的葡糖胺的方法，用氧化微生物或其提取物氧化N-取代的葡糖胺的方法，以及用氧化微生物或其提取物氧化N-取代的葡糖胺的方法，还原氧化 N-取代的葡糖胺与N-取代-1-脱氧野尻霉素。另外，公开了从D-葡萄糖生产N-取代-1-脱氧野尻霉素的一锅方法。

4. 发明申请

US20040086972A1 Directed evolution of microorganisms 有权
公开(公告)号：US20040086972A1
公开(公告)日：2004-05-06
申请号：US10719571
申请日：2003-11-20
发明人： Volker Schellenberger , Amy D. Liu , Olga V. Selifonova
IPC分类号： C12P021/02 , C12N001/21 , C12N015/74 , C12P017/04 , C12P007/18
CPC分类号： C12N9/0006 , C07K14/245 , C12N15/102 , C12P7/18 , C12R1/01 , C12R1/19
摘要： The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.

5. 发明申请

US20040063175A1 Polypeptides and biosynthetic pathways 审中-公开
标题翻译：多肽和生物合成途径
公开(公告)号：US20040063175A1
公开(公告)日：2004-04-01
申请号：US10422366
申请日：2003-04-23
申请人： Cargill, Incorporated
发明人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , Jack Rosazza
IPC分类号： C12P021/06 , C12P017/04 , C12N005/06
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了用于生产吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，并且体外方法包括化学反应。

6. 发明申请

US20030104596A1 human desaturase gene and uses thereof 失效
标题翻译：人类去饱和酶基因及其用途
公开(公告)号：US20030104596A1
公开(公告)日：2003-06-05
申请号：US10191513
申请日：2002-07-09
发明人： Pradip Mukerji , Amanda Eun-Yeong Leonard , Yung-Sheng Huang , Tapas Das
IPC分类号： C12P021/02 , C12N005/06 , C07H021/04 , C12P017/04 , C12N009/04
CPC分类号： A61K8/361 , A01K2217/05 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/10 , A23L33/10 , A23L33/12 , A23L33/13 , A23L33/17 , A23L33/40 , A23V2002/00 , A61K8/67 , A61K31/202 , A61K38/00 , A61Q19/00 , C12N9/0083 , C12N15/81 , C12N15/8247 , C12P7/6427 , C12P7/6472 , A23V2250/19 , A23V2250/1882 , A23V2250/1862
摘要： The subject invention relates to the identification of a gene involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., nullhuman null5-desaturasenull) and to uses thereof. In particular, human null5-desaturase may be utilized, for example, in the conversion of dihomo-null-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4nnull3 to eicosapentaenoic acid (EPA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：本发明涉及鉴定参与碳5多不饱和脂肪酸（即“人类DELTA5-去饱和酶”）去饱和的基因及其用途。特别地，人类DELTA5-去饱和酶可用于例如将dihomo-γ-亚麻酸（DGLA）转化为花生四烯酸（AA）和将20：4n-3转化成二十碳五烯酸（EPA）的方法。由其制备的AA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

7. 发明申请

US20020025565A1 Method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid using enzyme 有权
标题翻译：使用酶旋光拆分外消旋的α-取代杂环羧酸的方法
公开(公告)号：US20020025565A1
公开(公告)日：2002-02-28
申请号：US09871360
申请日：2001-05-31
发明人： Ki-Nam Uhm , Sang-Chul Lim , Jong-Ho Lim
IPC分类号： C12P017/00 , C12P017/04 , C12P017/10 , C12P013/24
CPC分类号： C12P17/04 , C12P41/005
摘要： Disclosed is a method for optically resolving a racemic null-substituted heterocyclic carboxylic acid (null-HCCA) by taking advantage of enantioselectivity of enzymes. null-HCCA is reacted with alcohol to give a racemic null-HCCA ester, which is then reacted with an enzyme with enantioselectivity, whereby either R-form or S-form of the racemate is hydrolyzed. Extraction with an organic solvent can obtain enantiomers of the null-HCCA ester. The extracted enantiomeric null-HCCA ester is converted to enantiomeric null-HCCA by catalytic hydrogenation in an organic solution or by enzymatic hydrolysis in an aqueous solution. Thus, a racemic mixture of null-HCCA can be optically resolved with high optical purity at high yields as well as at low cost.
摘要翻译：公开了通过利用酶的对映选择性来光学拆分外消旋的α-取代的杂环羧酸（α-HCCA）的方法。 α-HCCA与醇反应得到外消旋的α-HCCA酯，然后与具有对映选择性的酶反应，由此外消旋体的R-型或S-型被水解。用有机溶剂萃取可以得到α-HCCA酯的对映异构体。通过在有机溶液中的催化氢化或通过在水溶液中的酶水解将所提取的对映异构体α-HCCA酯转化成对映异构体的α-HCCA。因此，α-HCCA的外消旋混合物可以以高产率和低成本以高光学纯度光学解析。

8. 发明申请

US20040180413A1 Method for producing ascorbic acid intermediates 审中-公开
标题翻译：生产抗坏血酸中间体的方法
公开(公告)号：US20040180413A1
公开(公告)日：2004-09-16
申请号：US10626033
申请日：2003-07-23
发明人： Matthew Grant Boston , Barbara A. Swanson
IPC分类号： C12P017/04
CPC分类号： C12P7/60 , C12P7/58
摘要： The present invention relates to non-fermentative methods for the production of ASA intermediates, KDG, DKG and KLG and methods for the regeneration of co-factor. The invention provides genetically engineered host cells comprising heterologous nucleic acid encoding enzymes useful in the process.
摘要翻译：本发明涉及用于生产ASA中间体，KDG，DKG和KLG的非发酵方法以及辅因子再生的方法。本发明提供了包含可用于该方法的异源核酸编码酶的经遗传工程化的宿主细胞。

9. 发明申请

US20040171125A1 Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses 有权
标题翻译： 2,4-二脱氧己糖和2,4,6-三脱氧己糖的制备方法
公开(公告)号：US20040171125A1
公开(公告)日：2004-09-02
申请号：US10481303
申请日：2003-12-19
发明人： Joannes Gerardus Theodorus Kierkels , Daniel Mink , Sven Panke
IPC分类号： C12P017/06 , C12P017/04
CPC分类号： C12N9/88 , C12P19/02
摘要： The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one null-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one null-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine.
摘要翻译：本发明涉及从具有至少2个碳原子和至少一个α-氢原子的取代或未取代的羰基化合物和取代或未取代的羰基化合物制备2,4-二脱氧己糖或2,4,6-三脱氧己糖的方法，未取代的醛在醛缩酶和水的存在下，取代或未取代的羰基化合物与至少2个碳原子和至少一个α-氢原子之间的反应和取代或未取代的醛以最多的羰基浓度进行 6摩尔/升的反应混合物，2,4-二脱氧己糖或2,4,6-三脱氧己糖的最终浓度为反应混合物的至少2质量％。本发明还涉及通过根据本发明的方法获得的2,4-二脱氧己糖或2,4,6-三脱氧己糖在制备药物中的用途，特别是在制备他汀类药物中的用途。

10. 发明申请

US20030220394A1 Sequences 审中-公开
标题翻译：序列
公开(公告)号：US20030220394A1
公开(公告)日：2003-11-27
申请号：US10283940
申请日：2002-10-30
发明人： Andrew John Morgan , Hans Christian Pedersen , Inge Weiergang , Shukun Yu
IPC分类号： C12Q001/68 , C07H021/04 , C12P017/04 , C12N009/02 , A61K031/365 , C07K016/40 , C12P021/02 , C12N005/06
CPC分类号： C07H3/08 , C12N9/88 , C12P17/06
摘要： The present invention discloses sequence information relating to pyranosone dehydratase. The invention further relates to the use of pyranosone dehydratase in the conversion of AF to APP and microthecin and the conversion of glucosone to cortalcerone.
摘要翻译：本发明公开了与吡喃酮脱水酶有关的序列信息。本发明还涉及吡喃酮脱水酶在将AF转化为APP和微喜岩石以及将葡萄糖转化为皮质醇时的用途。

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