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1. 发明授权

US08283167B2 Preparation of annexin derivatives 有权
标题翻译：膜联蛋白衍生物的制备
公开(公告)号：US08283167B2
公开(公告)日：2012-10-09
申请号：US12700312
申请日：2010-02-04
申请人： Jaime Simon
发明人： Jaime Simon
IPC分类号： C12N5/87 , C12N5/071 , A61K38/00
CPC分类号： A61K51/088 , A61K47/544 , A61K51/087
摘要： Labeled annexin is formed by reacting annexin or a modified annexin with a phosphatidylserine group or an analogue of phosphatidylserine. This phosphatidylserine annexin conjugate is then reacted with an appropriate label to form a labeled annexin and the annexin is separated from the phosphatidylserine group. The reaction between the phosphatidylserine group and the annexin is calcium ion concentration dependent. Therefore, the reaction can be promoted by having a high calcium ion concentration and the separation of the phosphatidyl group from the annexin group is facilitated by reducing the calcium ion concentration preferably by addition of an appropriate calcium chelating agent.
摘要翻译：标记的膜联蛋白通过膜联蛋白或修饰的膜联蛋白与磷脂酰丝氨酸基团或磷脂酰丝氨酸的类似物反应而形成。然后将该磷脂酰丝氨酸膜联蛋白缀合物与合适的标记反应以形成标记的膜联蛋白，并将膜联蛋白与磷脂酰丝氨酸基团分离。磷脂酰丝氨酸与膜联蛋白之间的反应是钙离子浓度依赖性。因此，通过优选通过加入适当的钙螯合剂来降低钙离子浓度，可以通过具有高的钙离子浓度促进磷脂酰丝氨酸与膜联蛋白基团的分离来促进反应。

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