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    • 5. 发明授权
    • Process for preparing granules of hydrophilic active principle by extrusion
    • 通过挤出制备亲水性活性成分颗粒的方法
    • US08652547B2
    • 2014-02-18
    • US11667543
    • 2005-12-14
    • Jean-Marie DollatVéronique Chiavazza
    • Jean-Marie DollatVéronique Chiavazza
    • A23K1/18A23B4/03A23B4/044C12C3/02A23L1/18A23P1/00A23L1/00
    • A23K50/10A23K20/142A23K40/10
    • The present invention relates to a process for preparing cores of granules intended for animal nutrition, the said cores comprising: a hydrophilic active principle present in an active content of greater than or equal to 60% by weight, at least one meltable binder, at least one plasticizer, the said process comprising (a) a first step of mixing of the ingredients, (b) a second step of extrusion of the mixture through an extruder, especially a single-screw or twin-screw extruder, equipped with one or more dies, so as to obtain rods, and (c) a third step of spheronization of the rods, the said process being characterized in that a preliminary dry co-grinding of the ingredients is performed before extruding the mixture, the said co-grinding being performed at a temperature of not more than 50° C. The present invention also relates to a process for preparing granules of hydrophilic active principle comprising the said cores.
    • 本发明涉及一种用于制备用于动物营养的颗粒的芯的方法,所述芯包括:活性成分中存在的活性成分大于或等于60重量%的亲水性活性成分,至少一种可熔融粘合剂,至少 一种增塑剂,所述方法包括(a)混合成分的第一步骤,(b)通过挤出机,特别是单螺杆或双螺杆挤出机挤出混合物的第二步骤,该挤出机配备有一个或多个 模具,以获得杆,和(c)棒的滚圆的第三步骤,所述方法的特征在于在挤出混合物之前进行成分的预干燥共研磨,所述共研磨是 在不超过50℃的温度下进行。本发明还涉及一种制备包含所述芯的亲水性活性成分颗粒的方法。
    • 6. 发明授权
    • Immobilized-cell carrageenan bead production and a brewing process
utilizing carrageenan bead immobilized yeast cells
    • 固定化细胞角叉菜胶珠生产和利用角叉菜胶珠固定的酵母细胞的酿造方法
    • US5869117A
    • 1999-02-09
    • US812669
    • 1997-03-10
    • Ronald James NeufeldDenis J. C. M. PonceletSylvain D. J. M. Norton
    • Ronald James NeufeldDenis J. C. M. PonceletSylvain D. J. M. Norton
    • A61K9/16C12C1/00C12C3/02C12C11/00C12C11/07C12N11/02C12N11/04C12N11/08C12N11/10
    • A61K9/1652A61K9/1694
    • A process for immobilizing viable cells in gelled carrageenan beads comprises preparing an aqueous phase that is a mixture of a gellable concentration of un-gelled carrageenan, in an aqueous suspension of viable cells, in which the mixture's potassium concentration is low enough that the thermogellation temperature of the carrageenan in the suspension is below a temperature to which the viable cells are substantially thermosensitive. This is done at a first processing temperature that exceeds the thermogellation temperature of the carrageenan in that aqueous suspension, but which is below the temperature to which the cells are substantially thermosensitive. A mixture of the aqueous phase and a non-reactive food-grade oil phase is then prepared, and subjected to shear by passing it through a static mixer under flow-rate conditions selected to disperse the aqueous phase in the oil phase, such that a resulting emulsion has a selected droplet size distribution. Thereafter, the temperature of the resulting emulsion is decreased from the first processing temperature, to a second processing temperature which is below the thermogellation temperature of the carrageenan in the suspension. This results in the formation of polymer gel beads having the immobilized viable cells entrapped therein.
    • 将活细胞固定在胶凝的角叉菜胶珠中的方法包括在活细胞的水悬浮液中制备作为可胶凝浓度的未胶凝的角叉菜胶的混合物的水相,其中混合物的钾浓度足够低,使得热凝胶温度 的悬浮液中的角叉菜胶低于活细胞基本上热敏的温度。 这在超过该水性悬浮液中角叉菜胶的热凝胶温度但低于细胞基本上热敏感的温度的第一处理温度下进行。 然后制备水相和非反应性食品级油相的混合物,并通过使其通过静态混合器进行剪切,该流动速率条件用于将水相分散在油相中,使得 所得乳液具有选定的液滴尺寸分布。 此后,所得乳液的温度从第一处理温度降低到低于悬浮液中角叉菜胶的热凝胶温度的第二加工温度。 这导致形成具有被捕获在其中的固定的活细胞的聚合物凝胶珠。