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1. 发明授权

US06673901B2 Artificial antibody polypeptides 失效
公开(公告)号：US06673901B2
公开(公告)日：2004-01-06
申请号：US09096749
申请日：1998-06-12
申请人： Shohei Koide
发明人： Shohei Koide
IPC分类号： C07K1478
CPC分类号： C07K14/78 , C07K16/00 , C07K16/18 , C07K16/40 , C07K2317/565 , C07K2318/20 , C12N15/1037 , C12N15/1044 , C40B40/02 , G01N33/68 , G01N33/6845 , G01N33/78 , G01N2333/78
摘要： A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, kcat, and an uncatalyzed rate constant, kuncat, such that the ratio of kcat/kuncat is greater than 10.

2. 发明授权

US06693169B1 Laminin 5, 13 and 14 and uses thereof 失效
标题翻译：层粘连蛋白5,13和14及其用途
公开(公告)号：US06693169B1
公开(公告)日：2004-02-17
申请号：US09415625
申请日：1999-10-12
申请人： William J. Brunken , Richard R. Libby , Dale D. Hunter , Robert E. Burgeson
发明人： William J. Brunken , Richard R. Libby , Dale D. Hunter , Robert E. Burgeson
IPC分类号： C07K1478
CPC分类号： C07K14/78
摘要： The present invention features two members of laminin family, i.e., laminin 13 and laminin 14, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders. The present invention also features using a preparation of laminin 5 to treat neural disorders, especially disorders associated with retina.
摘要翻译：本发明具有层粘连蛋白家族的两个成员，即层粘连蛋白13和层粘连蛋白14，制备这些分子的方法，以及使用这些分子治疗神经障碍如视网膜疾病的方法。本发明还特征在于使用层粘连蛋白5的制剂来治疗神经障碍，特别是与视网膜相关的疾病。

3. 发明授权

US06271350B1 Fish collagen and method of producing same 失效
标题翻译：鱼胶原蛋白及其生产方法
公开(公告)号：US06271350B1
公开(公告)日：2001-08-07
申请号：US09357908
申请日：1999-07-21
申请人： Johsuke Shimizu , Hideki Shimizu , Koji Nagashima , Kunishige Yamada , Minori Takamatsu
发明人： Johsuke Shimizu , Hideki Shimizu , Koji Nagashima , Kunishige Yamada , Minori Takamatsu
IPC分类号： C07K1478
CPC分类号： C07K14/78
摘要： A collagen is extracted and produced from a raw fish skin through the steps: a salt admixing step for admixing a salt (e.g. NaCl, KCl or the like) with a raw fish skin so as to allow non-collagen substances or portions (including fats and other tissue portions than a collagen portion) to be removed from the fish skin, while simultaneously degreasing and deodorizing the skin under the salt effect; a salt removal step for causing the admixed salt and non-collagen substances or portions to remove from the skin, achieving the fats removal and deodorization; a collagen extraction step for extracting a collagen (gelatinous) from the thus-treated skin; and a filtration step for filtering and refining the extracted collagen so as to obtain a refined collagen. The refined collagen may be dried and solidified. Thus, since the inexpensive salt is used for effective removal of non-collagen substances or portions to obtain a collagen portion, the method itself is simplified and economical. Further, the fish collagen obtained thereby, be it fluid or dried, is of a highly refined property, i.e. colorless, odorless and degreased, which is suited for food product elements and various industrial uses.
摘要翻译：通过以下步骤从生鱼皮中提取并产生胶原蛋白：盐混合步骤，用于将盐（例如NaCl，KCl等）与生鱼皮混合，以允许非胶原物质或部分（包括脂肪）和除了胶原部分以外的其它组织部分），同时在盐的作用下同时对皮肤进行脱脂和除臭; 一种用于使混合的盐和非胶原物质或部分从皮肤上除去的脱盐步骤，实现除脂和除臭; 胶原提取步骤，用于从如此处理的皮肤中提取胶原蛋白（凝胶状）; 以及过滤和精制所提取的胶原蛋白以获得精制胶原蛋白的过滤步骤。精制的胶原可以干燥并固化。因此，由于廉价的盐用于有效去除非胶原物质或部分以获得胶原部分，所以该方法本身被简化和经济。此外，由此获得的鱼胶原，无论是流体还是干燥，具有高度精制的性质，即无色，无臭和脱脂，适用于食品和各种工业用途。

4. 发明授权

US06482410B1 Cytotactin derivatives that stimulate attachment and neurite outgrowth, and methods of making same 失效
标题翻译：刺激附着和神经突生长的细胞激活素衍生物及其制备方法
公开(公告)号：US06482410B1
公开(公告)日：2002-11-19
申请号：US08793273
申请日：1997-05-22
申请人： Kathryn L. Crossin , Greg Phillips , Anne L. Prieto
发明人： Kathryn L. Crossin , Greg Phillips , Anne L. Prieto
IPC分类号： C07K1478
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to cytotactin proteins, polypeptides, antibodies (including anti-idiotype antibodies), and other cytotacting derivatives useful in the mediation of neuronal attachment and enhancement of the outgrowth of neurites, as well as to methods of using same. Methods of making the disclosed proteins, polypeptides, antibodies, derivatives and related compositions, which have a variety of diagnostic and therapeutic applications, are also disclosed.
摘要翻译：本发明涉及细胞因子蛋白，多肽，抗体（包括抗独特型抗体）和其它可用于神经元附着和增强神经突生长的调节的细胞诱导衍生物，以及其使用方法。还公开了制备具有各种诊断和治疗应用的所公开的蛋白质，多肽，抗体，衍生物和相关组合物的方法。

5. 发明授权

US06274704B1 Peptides derived from the heparin binding domain of fibronectin 失效
标题翻译：衍生自纤连蛋白的肝素结合结构域的肽
公开(公告)号：US06274704B1
公开(公告)日：2001-08-14
申请号：US08933100
申请日：1997-09-18
申请人： Fumio Fukai , Takashi Katayama
发明人： Fumio Fukai , Takashi Katayama
IPC分类号： C07K1478
CPC分类号： C07K14/78 , A61K38/00
摘要： The biologically active peptide of the invention has a number of amino acids of 30 or less, comprises an amino acid sequence described as SEQ ID NO:13 (Tyr Thr Ile Tyr Val Ile Ala Leu) in the sequence listing and has cell adhesion inhibition activity. The peptide of the invention has short length and, therefore, synthesis and handling of the peptide are easy.
摘要翻译：本发明的生物活性肽具有30个或更少的氨基酸数，包含序列表中SEQ ID NO：13（Tyr Thr Ile Tyr Val Ile Ala Leu）所述的氨基酸序列，并具有细胞粘附抑制活性。本发明的肽具有短的长度，因此肽的合成和处理容易。

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