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1. 发明授权

US06579976B2 Process for producing 2′,3′-diethyl substituted nucleoside derivatives 失效
标题翻译：制备2'，3'-二乙基取代的核苷衍生物的方法
公开(公告)号：US06579976B2
公开(公告)日：2003-06-17
申请号：US09427082
申请日：1999-10-26
申请人： Satoshi Takamatsu , Satoshi Katayama , Naoko Hirose , Kunisuke Izawa
发明人： Satoshi Takamatsu , Satoshi Katayama , Naoko Hirose , Kunisuke Izawa
IPC分类号： C07H19173
CPC分类号： C07H19/04
摘要： There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing O-thiocarbonyl derivatives of sugar-moiety hydroxyl groups or allowing halogenated derivatives in the sugar-moiety, in the nucleic acids or in derivatives thereof to react with any one of hypophosphorous acids (including salts thereof) and phosphites (esters) which are inexpensive, non-toxic and safely usable as radical reducing agents in industrial scale, in the presence of a radical reaction initiator. The process of the present invention is an industrially useful and highly safe process for reducing sugar-moiety hydroxyl groups and halogen atoms in nucleic acids or derivatives thereof (including nucleic acid-related compounds) at low costs.
摘要翻译：可以提供通过使糖部分羟基的O-硫代羰基衍生物或糖部分中的卤代衍生物在核酸或其衍生物中还原的具有糖部分羟基或卤素原子的化合物的优异工业方法，在核酸或其衍生物中，在碱性存在下，与工业规模的廉价，无毒和可安全地用作自由基还原剂的次磷酸（包括其盐）和亚磷酸酯（酯）中的任何一种反应，反应引发剂。本发明的方法是以低成本还原核酸或其衍生物（包括核酸相关化合物）中的糖部分羟基和卤素原子的工业上有用和高度安全的方法。

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