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1. 发明申请

US20030215386A1 Stereoisomers of fatty acid analogs for diagnostic imaging 失效
标题翻译：用于诊断成像的脂肪酸类似物的立体异构体
公开(公告)号：US20030215386A1
公开(公告)日：2003-11-20
申请号：US10429416
申请日：2003-05-05
申请人： Biostream
发明人： David R. Elmalch
IPC分类号： A61K051/00 , C07F005/00 , C07F013/00
CPC分类号： A61K51/0497 , A61K51/04 , A61K51/0402 , A61K2123/00
摘要： The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.
摘要翻译：本发明提供用于临床诊断损伤和疾病的新型成像剂，其形式为空间接近脂肪酸类似物的基本上纯的立体异构体的放射性核素。本发明还提供了使用新型成像剂的方法，以及含有本发明的一种或多种新型成像剂的试剂盒。

2. 发明申请

US20030175596A1 Non-aqueous electrolyte additive for improving safety and lithium ion secondary battery comprising the same 有权
标题翻译：用于改进安全性的非水电解质添加剂和包含该非水电解质添加剂的锂离子二次电池
公开(公告)号：US20030175596A1
公开(公告)日：2003-09-18
申请号：US10312674
申请日：2002-12-31
发明人： Hong-Kyu Park , Jeh-Won Choi , Yeon-hee Lee , Young-Tack An , Hyeong-Jin Kim
IPC分类号： H01M010/40 , C07F005/02 , C07F007/08 , C07F007/22 , C07F007/28 , C07F015/02 , C07F015/04 , C07F015/06 , C07F005/06 , C07F013/00 , C07F011/00 , C07C317/00
CPC分类号： H01M10/0567 , H01M4/525 , H01M4/587 , H01M6/10 , H01M10/0525 , H01M10/4235 , H01M2300/002 , H01M2300/0037
摘要： The present invention relates to a non-aqueous electrolyte additive for improving safety and a lithium secondary battery comprising the same, and more particularly to a non-aqueous electrolyte additive that can improve cycle life and safety properties of a lithium ion secondary battery. According to the present invention, an organometallic compound represented by the Chemical Formula 1 is added to a non-aqueous electrolyte of a battery as an additive, and thus if a battery voltage is out of normal operation voltage range due to a short circuit and overcharge of a battery, etc., the non-aqueous electrolyte additive decomposes and a part of the decomposed additive polymerizes to form an insulating film on a cathode surface, and a part of the metal reacts with an insulating film formed on a cathode surface to improve thermal stability of the battery, thereby improving safety of the battery. Furthermore, in case of a short circuit a part of the metal oxide of the additive is removed an activity of lithium or is reduced movement speed of lithium by reacting with lithium rushed from an anode to a cathode, and thus safety of the battery can be obtained on a short circuit by delaying a flow of current.
摘要翻译：本发明涉及一种用于提高安全性的非水电解质添加剂和包含该非水电解质添加剂的锂二次电池，更具体地说涉及一种能够改善锂离子二次电池的循环寿命和安全性能的非水电解质添加剂。根据本发明，将由化学式1表示的有机金属化合物作为添加剂添加到电池的非水电解质中，因此如果由于短路和过充电而导致电池电压超出正常工作电压范围的电池等，非水电解质添加剂分解，一部分分解添加剂聚合，在阴极表面形成绝缘膜，一部分金属与阴极表面形成的绝缘膜反应，从而提高电池的热稳定性，从而提高电池的安全性。此外，在短路的情况下，添加剂的金属氧化物的一部分除去锂的活性或通过与从阳极冲出的阴极反应的锂的移动速度降低，因此电池的安全性可以是通过延迟电流来在短路上获得。

3. 发明申请

US20030175595A1 Non-aqueous electrolyte additive for improving safety and lithium ion secondary battery comprising the same 有权
标题翻译：用于改进安全性的非水电解质添加剂和包含该非水电解质添加剂的锂离子二次电池
公开(公告)号：US20030175595A1
公开(公告)日：2003-09-18
申请号：US10312672
申请日：2002-12-31
发明人： Hong-Kyu Park , Jeh-Won Choi , Yeon-Hee Lee , Young-Tack An , Hyeong-Jin Kim
IPC分类号： H01M010/40 , H01M004/52 , H01M004/50 , C07F003/06 , C07F005/06 , C07F007/22 , C07F015/02 , C07F015/04 , C07F015/06 , C07F011/00 , C07F013/00 , C07F007/28
CPC分类号： H01M10/4235 , H01M4/505 , H01M4/525 , H01M4/587 , H01M10/0567 , H01M2300/0025
摘要： The present invention relates to a non-aqueous electrolyte additive for improving safety and a lithium secondary battery comprising the same, and more particularly to a non-aqueous electrolyte additive that can improve cycle life and safety properties of a lithium ion secondary battery. According to the present invention, an organometallic compound represented by the Chemical Formula 1 is added to a non-aqueous electrolyte of a battery as an additive, and thus if a battery voltage is out of normal operation voltage range due to a short circuit and overcharge of a battery, etc., the non-aqueous electrolyte additive decomposes and a part of the decomposed additive polymerizes to form an insulating film on a cathode surface, and a part of the metal reacts with an insulating film formed on a cathode surface to improve thermal stability of the battery, thereby improving safety of the battery.
摘要翻译：本发明涉及一种用于提高安全性的非水电解质添加剂和包含该非水电解质添加剂的锂二次电池，更具体地说涉及一种能够改善锂离子二次电池的循环寿命和安全性能的非水电解质添加剂。根据本发明，将由化学式1表示的有机金属化合物作为添加剂添加到电池的非水电解质中，因此如果由于短路和过充电而导致电池电压超出正常工作电压范围的电池等，非水电解质添加剂分解，一部分分解添加剂聚合，在阴极表面形成绝缘膜，一部分金属与阴极表面形成的绝缘膜反应，从而提高电池的热稳定性，从而提高电池的安全性。

4. 发明申请

US20030153736A1 Labelled ascorbic acid derivatives 失效
标题翻译：标记抗坏血酸衍生物
公开(公告)号：US20030153736A1
公开(公告)日：2003-08-14
申请号：US10168714
申请日：2002-09-16
发明人： Susan Champion , Richard Pither
IPC分类号： C07F013/00
CPC分类号： A61K49/10 , A61K49/085 , A61K51/0427
摘要： Compounds of formula (I) where: X1 is OH or SH or NH2 or -L-Z; X2 and X3 are the same or different and each is H, C1-4 alkyl, benzyl a protecting group or -L-Z, X4 is H or C1-4 alkyl, L is a linker comprising a chain of 0-10 atoms, Z is a group comprising a detectable moiety which comprise at least one detectable moiety are useful in the diagnosis and prognosis and radiotherapy of metastatic bone disease. 1
摘要翻译：式（I）的化合物，其中：X 1是OH或SH或NH 2或-L-Z; X2和X3相同或不同，分别为H，C1-4烷基，苄基保护基或-LZ，X4为H或C1-4烷基，L为包含0-10个原子的链的接头，Z为包含至少一个可检测部分的可检测部分的基团可用于转移性骨病的诊断和预后和放射治疗。

5. 发明申请

US20020082398A1 Cores for technetium radiopharmaceuticals 失效
标题翻译：锝放射性药物的核心
公开(公告)号：US20020082398A1
公开(公告)日：2002-06-27
申请号：US09976014
申请日：2001-10-15
发明人： Colin M. Archer , Jonathan R. Dilworth , Panna Jobanputra , Ian A. Latham , Russell M. Thompson
IPC分类号： A61K051/00 , C07F013/00
CPC分类号： C07B59/004
摘要： A 99mTc complex which contains the moiety TcnullNR, TcnullNnullNY or Tc(nullNnullNY)2, and as a synthetic organic ligand which confers biological target-seeking properties on the technetium complex, where: R is an aryl group, a substituted or unsubstituted alkyl group or the group nullNR1R2; Y is an aryl group or a substituted or unsubstituted alkyl group; R1 and R2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen; where at least one of the R or Y groups comprises an aryl group which chelates the 99mTc.
摘要翻译：包含部分Tc = NR，Tc-N = NY或Tc（-N = NY）2的99mTc复合物，以及赋予锝络合物上的生物寻靶特性的合成有机配体，其中：R是芳基基团，取代或未取代的烷基或基团-NR1R2; Y是芳基或取代或未取代的烷基; R 1和R 2是H，芳基或取代或未取代的脂族或环状烷基，并且相同或不同，条件是两者不是氢; 其中R或Y基团中的至少一个包含螯合99m Tc的芳基。

6. 发明申请

US20040138433A1 Metal bis-triflimide compounds and methods for synthesis of metal bis-triflimide compounds 失效
标题翻译：金属双 - 三氟甲磺酰亚胺化合物和金属双 - 三氟甲磺酰亚胺化合物的合成方法
公开(公告)号：US20040138433A1
公开(公告)日：2004-07-15
申请号：US10471257
申请日：2004-02-25
发明人： Martyn J. Earle , Barry Joseph Mcauley , Alwar Ramani , Kenneth Richard Seddon , Jillian M. Thomson
IPC分类号： C07F015/02 , C07F015/04 , C07F015/06 , C07F005/00 , C07F013/00
CPC分类号： B01J31/0227 , B01J31/0222 , B01J31/0252 , B01J31/0271 , B01J31/0278 , B01J31/0284 , B01J31/0287 , B01J31/26 , B01J31/34 , B01J31/4015 , B01J2231/323 , B01J2231/4205 , B01J2231/52 , B01J2531/23
摘要： A metal bis-triflimide compound having the formula: nullMxnullnnullnull(N(SO2CF3)2)(nx-yz)null(nx-yz)nullnullLynullznull where M is a metal selected from the metals in groups 5 to 10, 12 and 14 to 16 and Cu, Au, Ca, Sr, Ba, Ra, Y, La, Ac, Hf, Rf, Ga, In, Tl, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Lu and the actinides; L is a negative or neutral ligand; n is 2,3,4,5,6,7 or 8; x is greater than or equal to 1 y is 0,1,2,3,4,5,6,7 or 8; and z is 0,1,2,3 or 4.
摘要翻译：具有以下通式的金属双 - 三氟甲磺酰亚胺化合物：其中M是金属，其中M是金属的双[三氟甲磺酰亚胺]化合物[Mx] n + 选自5至10,12和14至16族中的金属和Cu，Au，Ca，Sr，Ba，Ra，Y，La，Ac，Hf，Rf，Ga，In，Tl，Ce，Pr， Pm，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Lu和锕系元素; L是负或中性配体; n为2,3,4,5,6,7或8; x大于或等于1 y为0,1,2,3,4,5,6,7或8; z为0,1,2,3或4。

7. 发明申请

US20040127690A1 Process for making metal acetylacetonates 有权
标题翻译：制备金属乙酰丙酮化物的方法
公开(公告)号：US20040127690A1
公开(公告)日：2004-07-01
申请号：US10335103
申请日：2002-12-31
申请人： Council of Scientific and Industrial Research
发明人： Mihir Kanti Chaudhari , Sanjay Kumar Dehury , Siddhartha Sankar Dhar , Upasana Bora , Boyapati Manoranjan Choudary , Lakshmi Kantam Mannepalli
IPC分类号： C07F015/06 , C07F013/00 , C07F005/00
CPC分类号： C07F9/005 , C07C45/77 , C07C49/92
摘要： The present invention provides an improved, economical and environmentally benign process for metal complexes of acetylacetone having the general formula, M(acac)n wherein M is a metal cation selected from the group consisting of Fe, Co, Ni, Cu, Zn, Al, Ca, Mg, Mo, Ru, Re, U, Th, Ce, Na, K, Rb, Cs, V, Cr, and Mn etc., n is an integer which corresponds to the electrovalence of M, are obtained by reacting the corresponding metal hydroxide, metal hydrated oxide or metal oxide with a stoichiometric amount of acetylacetone and separating the product.
摘要翻译：本发明提供了具有通式M（acac）n的乙酰丙酮的金属络合物的改进的，经济的和环境友好的方法，其中M是选自Fe，Co，Ni，Cu，Zn，Al的金属阳离子，Ca，Mg，Mo，Ru，Re，U，Th，Ce，Na，K，Rb，Cs，V，Cr和Mn等，n是对应于M的电价的整数，相应的金属氢氧化物，金属水合氧化物或具有化学计量量的乙酰丙酮的金属氧化物并分离产物。

8. 发明申请

US20040023940A1 Non-metallocene compounds, method for the production thereof and use of the same for the polymerisation of olefins 失效
标题翻译：非茂金属化合物，其制备方法和用于烯烃聚合的方法
公开(公告)号：US20040023940A1
公开(公告)日：2004-02-05
申请号：US10416948
申请日：2003-05-15
发明人： Jorg Schottek , Jorg Schulte
IPC分类号： A61K031/555 , C07F013/00 , C07F011/00 , C07F017/00
CPC分类号： C07F17/00 , C08F110/06 , Y10S526/943 , C08F2500/03
摘要： The invention relates to a method for producing special transition metal compounds, to novel transition metal compounds and to the use of the same for the polymerisation of olefins.
摘要翻译：本发明涉及一种生产特殊过渡金属化合物，新型过渡金属化合物的方法及其用于烯烃聚合的方法。

9. 发明申请

US20040018147A1 Radiopharmaceutical for diagnostic imaging containing a technetium-99m nitride heterocomplex 失效
标题翻译：用于包含锝-99m氮化物异复合物的诊断成像的放射性药物
公开(公告)号：US20040018147A1
公开(公告)日：2004-01-29
申请号：US10332707
申请日：2003-09-04
发明人： Adriano Duatti , Cristina Bolzati , Licia Uccelli , Alessandra Boschi , Fiorenzo Refosco , Francesco Tisato
IPC分类号： A61K051/00 , C07F013/00
CPC分类号： A61K51/02 , A61K51/0476
摘要： A radiopharmaceutical for diagnostic imaging containing as an active ingredient a technetium-99m nitride heterocomplex comprising technetium-99m nitride and two different ligands coordinated therewith, i.e., a bisphosphinoamine compound as a null electron acceptor and a bidentate ligand as a null electron donor and represented by the following formula (I): null99mTc(N)(PNP)(XY)nullnull (I)wherein 99mTc(N) is technetium-99m nitride, PNP is a bisphosphinoamine compound and XY is a bidentate ligand, is markedly accumulated in heart and adrenal glands and hence is useful for radiodiagnostic imaging of heart and adrenal glands.
摘要翻译：用于诊断成像的放射性药物，其包含锝-99m氮化物异复合物作为活性成分，其包含锝-99m氮化物和与其配位的两种不同配体，即作为pi电子受体的双膦胺化合物和作为pi电子供体的二齿配体，其中99m Tc（N）是锝-99m的氮化物，PNP是双膦胺化合物，XY是（99）Tc（N）（PNP）（XY）二齿配体，显着积累在心脏和肾上腺，因此可用于心脏和肾上腺的放射诊断成像。

10. 发明申请

US20030181776A1 CATALYST FIXED ON A CARRIER AND USED FOR THE METATHESIS OF OLEFINS 失效
标题翻译：催化剂固定在载体上并用于烯烃的组成
公开(公告)号：US20030181776A1
公开(公告)日：2003-09-25
申请号：US10363858
申请日：2003-03-14
发明人： Jean-Marie Basset , Mathieu Chabanas , Christophe Coperet
IPC分类号： C07C002/02 , C07F013/00 , B01J023/40 , B01J023/42
CPC分类号： B01J31/1625 , B01J31/2265 , B01J2231/543 , B01J2231/74 , C07C6/04 , C07C67/475 , C07C2531/12 , C07C69/593
摘要： The present invention relates to a novel, heterogeneous catalyst which is suitable, in particular, for olefin metathesis. This catalyst is immobilized on an inorganic support and contains at least one active rhenium compound containing at least one carbene group and, if desired, further functional groups. The rhenium compound is bonded to the material used as support by a chemical bond.
摘要翻译：本发明涉及一种新的非均相催化剂，特别适用于烯烃复分解。将该催化剂固定在无机载体上，并含有至少一种含有至少一个卡宾基团的活性铼化合物，如果需要，还含有其它官能团。铼化合物通过化学键与用作载体的材料结合。

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