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1. 发明授权

US4133949A Dicarboxylic acid esters of cardiac glycosides 失效
标题翻译：强心苷的二羧酸酯
公开(公告)号：US4133949A
公开(公告)日：1979-01-09
申请号：US715020
申请日：1976-08-16
申请人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
发明人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
IPC分类号： C07D249/20 , A61K31/22 , A61K31/265 , A61K31/275 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/70 , A61P43/00 , C07C43/32 , C07C67/00 , C07C69/34 , C07C69/42 , C07C69/67 , C07C205/43 , C07C253/00 , C07C255/16 , C07C327/22 , C07D207/40 , C07D207/46 , C07D209/48 , C07D213/63 , C07D227/12 , C07D249/18 , C07J19/00 , C07J41/00 , C07J43/00 , C07K19/00 , G01N33/53 , G01N33/531
CPC分类号： C07C255/00 , C07J41/0055 , C07J41/0094 , C07J43/003 , G01N33/531 , Y10S436/822 , Y10S436/823
摘要： New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5. are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).
摘要翻译：式（I）的新的反应性不对称二羧酸酯化合物，其中R 1是含有至多3个碳原子的烷基或是地高辛或二氧杂辛基残基，R2和R3可以相同或不同，是烷氧基含有最多3个碳原子或一起代表氧原子的基团，X是氰基甲氧基，琥珀酰亚胺-N-氧基，N-甲基 - 吡啶氧基，2,4-二硝基苯氧基，2,4,5-三氯苯氧基，五氯苯氧基，苯硫基，p - 硝基苯氧基，对硝基苯硫基，哌啶基-N-氧基，苯二甲酰亚氨基-N-氧基或苯并三唑-N-氧基，n为2,3,4或5.可用于制备用于研究强心苷的试剂（洋地黄糖苷）。

2. 发明授权

US4436828A Reactive asymmetrical dicarboxylic acid esters and reagents for the investigation of cardiac glycosides 失效
标题翻译：活性不对称二羧酸酯和试剂用于研究强心苷
公开(公告)号：US4436828A
公开(公告)日：1984-03-13
申请号：US200838
申请日：1980-10-27
申请人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
发明人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
IPC分类号： C07D249/20 , A61K31/22 , A61K31/265 , A61K31/275 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/70 , A61P43/00 , C07C43/32 , C07C67/00 , C07C69/34 , C07C69/42 , C07C69/67 , C07C205/43 , C07C253/00 , C07C255/16 , C07C327/22 , C07D207/40 , C07D207/46 , C07D209/48 , C07D213/63 , C07D227/12 , C07D249/18 , C07J19/00 , C07J41/00 , C07J43/00 , C07K19/00 , G01N33/53 , G01N33/531 , A61K43/00 , C07G7/00 , G01N33/56
CPC分类号： C07C255/00 , C07J41/0055 , C07J41/0094 , C07J43/003 , G01N33/531 , Y10S436/822 , Y10S436/823
摘要： New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).
摘要翻译：式（I）的新的反应性不对称二羧酸酯化合物，其中R 1是含有至多3个碳原子的烷基或是地高辛或二氧杂辛基残基，R2和R3可以相同或不同，是烷氧基含有3个碳原子或一起代表氧原子的基团，X是氰基甲氧基，琥珀酰亚胺-N-氧基，N-甲基 - 吡啶氧基，2,4-二硝基苯氧基，2,4,5-三氯苯氧基，五氯苯氧基，苯硫基，p - 硝基苯氧基，对硝基苯硫基，哌啶基-N-氧基，苯二甲酰亚氨基-N-氧基或苯并三唑-N-氧基，n为2,3,4或5可用于制备用于研究强心苷的试剂（洋地黄糖苷）。

3. 发明申请

US20030144531A1 Process for the synthesis of chirally pure beta-amino-alcohols 失效
标题翻译：手性纯合β-氨基醇的合成方法
公开(公告)号：US20030144531A1
公开(公告)日：2003-07-31
申请号：US10304322
申请日：2002-11-26
申请人： Wyeth
发明人： Anthony Frank Kreft , Madelene Miyoko Antane , Derek Cecil Cole , Dennis Martin Kubrak , Lynn Resnick , Joseph Raymond Stock , Zheng Wang
IPC分类号： C07D29/20 , C07D227/12
CPC分类号： C07C215/20 , C07B2200/07 , C07C215/08 , C07C215/24 , C07C215/28 , C07C215/56 , C07C229/08 , C07C229/28 , C07C229/30 , C07C229/36 , C07C247/12 , C07C323/63 , C07D263/26 , C07D333/34
摘要： A process is provided for preparing chirally pure S-enantiomers of null-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R)2CH(CH2)nCH2X; b) adding the organometallic reagent to carbon dioxide to afford a carboxylic acid; c) activating the carboxylic acid with an acid chloride, phosphorus trichloride, acid anhydride, or thionyl chloride in the presence of a tertiary amine base; d) reacting the product of step c) with an alkali metal salt of S-4-benzyl-2-oxazolidinone; e) treating the product of step d) with a strong non-nucleophilic base to form an enolate anion; f) trapping the enolate anion with 2,4,6-triisopropylbenzenesulfonyl azide to afford an oxazolidinone azide; g) hydrolyzing the oxazolidinone azide with an aqueous base to afford an null-azido acid; h) reducing the null-azido acid to the null-amino acid; and i) recrystallizing the null-amino acid to the chirally pure null-amino acid. A process is also provided for preparing chirally pure S-enantiomers of null-amino alcohols further comprising the steps of reducing the crude null-amino acid to the null-amino alcohol and recrystallizing the null-amino alcohol to the chirally pure null-amino alcohol. A process is further provided for preparing chirally pure S enantiomers of N-sulfonyl null-amino alcohols further comprising the steps of sulfonylating the null-amino alcohol with 5-chloro-thiophene-2-sulfonyl halide; and recrystallizing to afford the chirally pure N-sulfonyl null-amino alcohols.
摘要翻译：提供了一种用于制备α-氨基酸的手性纯的S-对映异构体的方法，包括以下步骤：a）由式（R）2CH（CH 2）n CH 2 X的烷基卤制备有机金属试剂; b）将有机金属试剂加入到二氧化碳中，得到羧酸; c）在叔胺碱存在下用酰氯，三氯化磷，酸酐或亚硫酰氯活化羧酸; d）使步骤c）的产物与S-4-苄基-2-恶唑烷酮的碱金属盐反应; e）用强非亲核碱处理步骤d）的产物以形成烯醇化物阴离子; f）用2,4,6-三异丙基苯磺酰叠氮化物捕获烯醇化阴离子，得到恶唑烷酮叠氮化物; g）用碱水溶液水解恶唑烷酮叠氮化物，得到α-叠氮基; h）将α-叠氮基还原成α-氨基酸; 和i）将α-氨基酸重结晶至手性纯的α-氨基酸。还提供了制备β-氨基醇的手性纯的S-对映异构体的方法，该方法还包括将β-氨基酸的粗α-氨基酸还原成β-氨基醇，并将β-氨基醇重结晶至手性纯的β-氨基醇。还提供了制备N-磺酰基β-氨基醇的手性纯S对映异构体的方法，其还包括用5-氯 - 噻吩-2-磺酰卤磺酰化β-氨基醇的步骤; 并重结晶得到手性纯的N-磺酰基β-氨基醇。

4. 发明授权

US3525737A N,n'-sulfides and method of making the same 失效
标题翻译： N，N'-硫醚及其制备方法
公开(公告)号：US3525737A
公开(公告)日：1970-08-25
申请号：US3525737D
申请日：1967-12-05
申请人： RHEIN CHEMIE RHEINAU GMBH
发明人： KERN RUDOLF , BUTULA IVAN
IPC分类号： A01N41/12 , C07D207/48 , C07D211/76 , C07D223/10 , C07D227/08 , C07D227/12 , C07D41/06
CPC分类号： C07D223/10 , A01N41/12 , C07D207/48 , C07D211/76 , C07D227/08 , C07D227/12

5. 发明授权

US09650335B2 Compounds, monomers, and polymers containing a carbonate linkage 有权
公开(公告)号：US09650335B2
公开(公告)日：2017-05-16
申请号：US13980086
申请日：2012-01-17
申请人： Ezat Khosravi , Osama M. Musa
发明人： Ezat Khosravi , Osama M. Musa
IPC分类号： C07D207/27 , C07D207/28 , C07D205/12 , C07D207/263 , C07D205/08 , C07D207/267 , C07D207/26 , C08F220/00 , C07C69/96 , C08F26/10 , C07D245/02 , C07D245/00 , C07D245/04 , C07D245/06 , C07D227/12 , C07C303/02 , C07C303/36 , C07C69/54 , C08F26/06 , C08F220/34 , C08F120/36 , C08F126/06 , C08F20/36 , C08F226/06
CPC分类号： C07C69/96 , C07C69/54 , C07C303/02 , C07C303/36 , C07D205/08 , C07D205/12 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/28 , C07D227/12 , C07D245/00 , C07D245/02 , C07D245/04 , C07D245/06 , C08F20/36 , C08F26/06 , C08F26/10 , C08F120/36 , C08F126/06 , C08F218/08 , C08F220/00 , C08F226/06 , C08F226/10 , C08F2220/346
摘要： The invention provides compounds and monomers having a carbonate linkage. The monomers can be used to form homopolymers or can be coupled with other monomers to provide a wide variety of non-homopolymers. The invention further provides a wide variety of compositions comprising the compounds, monomers, and polymers. In the exemplary structures below, Q, A, R, and n are as described herein.

6. 发明授权

US5721366A Platelet aggregation inhibitors 失效
标题翻译：血小板聚集抑制剂
公开(公告)号：US5721366A
公开(公告)日：1998-02-24
申请号：US436404
申请日：1995-05-23
申请人： Norman Anthony Abood , Daniel Lee Flynn , Robert Bruce Garland , Lori Ann Schretzman , Kenneth Williams , Jeffery Alan Zablocki , Susan Landis Hockerman
发明人： Norman Anthony Abood , Daniel Lee Flynn , Robert Bruce Garland , Lori Ann Schretzman , Kenneth Williams , Jeffery Alan Zablocki , Susan Landis Hockerman
IPC分类号： C07D227/12 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P7/02 , C07C255/60 , C07C271/22 , C07D205/08 , C07D205/085 , C07D207/26 , C07D207/27 , C07D207/273 , C07D211/40 , C07D211/58 , C07D211/76 , C07D405/12 , C07D409/12 , C07F7/08 , C07F7/10 , C07D213/71 , C07D207/333
CPC分类号： C07D207/26 , C07D205/085 , C07D207/273 , C07D211/76 , C07D405/12 , C07D409/12 , C07F7/0812
摘要： This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
摘要翻译： PCT No.PCT / US94 / 03259 Sec。 371日期：1995年5月23日 102（e）日期1995年5月23日PCT 1994年3月30日PCT公布。公开号WO94 / 22820 PCT 日期：1994年10月13日本发明涉及可用于抑制血小板聚集的下式的化合物或其药学上可接受的盐，以及这种苯基脒基衍生物的药物组合物，以及抑制血小板聚集的方法哺乳动物通过施用这些化合物和组合物。

7. 发明授权

US4282151A Reactive asymmetrical dicarboxylic acid esters and reagents for the investigation of cardiac glycosides 失效
标题翻译：活性不对称二羧酸酯和试剂用于研究强心苷
公开(公告)号：US4282151A
公开(公告)日：1981-08-04
申请号：US883981
申请日：1978-03-06
申请人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Wiemann
发明人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Wiemann
IPC分类号： C07D249/20 , A61K31/22 , A61K31/265 , A61K31/275 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/70 , A61P43/00 , C07C43/32 , C07C67/00 , C07C69/34 , C07C69/42 , C07C69/67 , C07C205/43 , C07C253/00 , C07C255/16 , C07C327/22 , C07D207/40 , C07D207/46 , C07D209/48 , C07D213/63 , C07D227/12 , C07D249/18 , C07J19/00 , C07J41/00 , C07J43/00 , C07K19/00 , G01N33/53 , G01N33/531
CPC分类号： C07C255/00 , C07J41/0055 , C07J41/0094 , C07J43/003 , G01N33/531 , Y10S436/822 , Y10S436/823
摘要： New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, n-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).
摘要翻译：式（I）的新的反应性不对称二羧酸酯化合物，其中R 1是含有至多3个碳原子的烷基或是地高辛或二氧杂辛基残基，R2和R3可以相同或不同，是烷氧基含有3个碳原子或一起代表氧原子的基团，X是氰基甲氧基，琥珀酰亚胺-N-氧基，N-甲基 - 吡啶氧基，2,4-二硝基苯氧基，2,4,5-三氯苯氧基，五氯苯氧基，苯硫基，p 硝基苯氧基，正硝基苯硫基，哌啶基-N-氧基，苯二甲酰亚氨基-N-氧基或苯并三唑-N-氧基，n为2,3,4或5可用于制备用于研究强心苷的试剂（洋地黄糖苷）。

8. 发明授权

US4066639A Benzene-sulfonyl semicarbazides and process for preparing them 失效
标题翻译：苯并噻喃半胱氨酸及其制备方法
公开(公告)号：US4066639A
公开(公告)日：1978-01-03
申请号：US544018
申请日：1975-01-24
申请人： Helmut Weber , Karl Muth , Rudi Weyer , Walter Aumuller , Erich Haack
发明人： Helmut Weber , Karl Muth , Rudi Weyer , Walter Aumuller , Erich Haack
IPC分类号： C07D205/04 , C07D295/22 , C07D307/68 , C07D317/68 , C07D333/38 , A61K31/64 , C07D211/98 , C07D227/12
CPC分类号： C07D317/68 , C07D205/04 , C07D295/22 , C07D307/68 , C07D333/38 , Y10S514/822
摘要： A benzene-sulfonyl semicarbazide of the formula ##STR1## wherein R is such as phenyl and substituted phenyl, cyclohexyl or alkyl, Y is -CH.sub.2 CH.sub.2 - or ##STR2## is alkylene-imino of 3 to carbon atoms which may also be substituted; a representative compound is 4-[4-(.beta.- -ethyl)-benzene-sulfonyl]-1,1-(.gamma.,.gamma.-dimethyl-pentamethylene)-semicarbazide.

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