专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明授权

US06252077B1 1-(N′-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands 失效
标题翻译： 1-（N' - （芳基烷基氨基烷基）氨基异喹啉;一类新的多巴胺受体亚型特异性配体
公开(公告)号：US06252077B1
公开(公告)日：2001-06-26
申请号：US09470594
申请日：1999-12-22
申请人： Xiao-shu He , Brian de Costa , Jan W. F. Wasley
发明人： Xiao-shu He , Brian de Costa , Jan W. F. Wasley
IPC分类号： C07D20940
CPC分类号： C07D401/12 , C07D209/44 , C07D217/22 , C07D403/12
摘要： Disclosed are compounds of the formula or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower alkoxy; Ar represents optionally substituted aryl or heteroaryl Z represents carbon or nitrogen provided that where Z is carbon, R11 represents hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy, or phenyl optionally substituted with one or two groups selected from hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy; and where Z is nitrogen, R11 represents an electron pair; R5 is hydrogen or lower alkyl; m represents an integer; n is 0, or an integer; R12 and R13 independently represent lower alkyl; CR′R″ represent a methylene group optionally substituted with lower alkyl; and k is 1, which compounds are useful in treating various neuropsychological disorders including, for example, schizophrenia, dementia, depression, anxiety, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
摘要翻译：公开的是式的化合物或其药学上可接受的盐，其中6元环可任选被至多四个独立地选自卤素，羟基，低级烷基或低级烷氧基的基团取代; Ar表示任选取代的芳基或杂芳基Z表示碳或氮，其中Z是碳，R 11表示氢，卤素，羟基，低级烷基或低级烷氧基，或任选被一个或两个选自氢，卤素，羟基，低级烷基或低级烷氧基的基团取代的苯基; 并且其中Z是氮，R11表示电子对; R5是氢或低级烷基; m表示整数; n是0或整数; R12和R13独立地表示低级烷基; CR'R“表示任选的亚甲基被低级烷基取代; andk是1，哪些化合物可用于治疗各种神经心理障碍，包括例如精神分裂症，痴呆，抑郁症，焦虑症，帕金森样运动障碍和与使用神经安定药相关的运动障碍。

IPRDB

热门服务

关于我们

友情链接

联系方式