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1. 发明授权

US4792628A Indane derivatives and salts thereof 失效
公开(公告)号：US4792628A
公开(公告)日：1988-12-20
申请号：US39779
申请日：1987-04-16
申请人： Yasuo Oshiro , Hiraki Ueda , Kazuyuki Nakagawa
发明人： Yasuo Oshiro , Hiraki Ueda , Kazuyuki Nakagawa
IPC分类号： A61K31/13 , A61K31/135 , A61K31/15 , C07C45/67 , C07C45/68 , C07C45/71 , C07C49/747 , C07C49/755 , C07C233/00 , C07C233/12 , C07C233/16 , C07C311/00 , C07C311/02 , C07C311/15 , C07D295/08 , C07D295/26 , C07C87/457
CPC分类号： C07D295/26 , C07C205/45 , C07C323/00 , C07C45/67 , C07C45/673 , C07C45/68 , C07C45/71 , C07C49/747 , C07C49/755
摘要： Indane derivatives and their salts represented by the general formula (1), ##STR1## wherein R.sup.1 is an amino group which may have lower alkyl groups as the substituents, a hydroxylimino group, an alkanoylamino group having 1 to 10 carbon atoms which may have halogen atoms as the substituents, a lower alkylsulfonylamino group, a phenylsulfonylamino group which may have lower alkyl groups as the substituents on the phenyl ring, a benzoylamino group having lower alkyl groups as the substituents on the phenyl ring, and a phenyl-lower alkylamino group having a hydroxyl groups or a lower alkyl groups as the substituents on the phenyl ring, R.sup.2 is a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, an amino group, an amino-lower alkyl group, a lower alkanoylamino group, a lower alkanoylamino-lower alkyl group which may have halogen atoms as the substituents, a lower alkylthio group, a 1-piperidinesulfonyl group, or a lower alkenyl group; R.sup.3 is a hydrogen atom, a lower alkyl group, or a halogen atom; R.sup.4 and R.sup.5 are the same or different from each other, and are each a hydrogen atom, or a lower alkyl group; provided that when R.sup.1 is a hydroxylimino group, then R.sup.2 and R.sup.3 should not be hydrogen atoms at the same time.The indane derivatives and their salts are useful as preventive and curative agents for various diseases and disorders caused by the excessive formation and accumulation of the active oxygen radicals and the peroxidized substances in the living body, and/or the defects of phylaxis mechanisms of the living body, for example anti-arreriosclerotic agents, carcinogenesis preventive agents, carcinostatic agents, anti-inflammatory agents, analgesics, autoimmune disease curative agents, platelets aggregation inhibitory agents, hypotensive agents, anti-hyperlipemic agents, retinosis of immature infant and cataract preventive and curative agents.The indane derivatives and their salts are also useful as antioxidants for oils and fats being contained in processed foods.

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