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1. 发明授权

US06180785B2 Process for preparing diltiazem 有权
标题翻译：制备地尔硫卓的方法
公开(公告)号：US06180785B2
公开(公告)日：2001-01-30
申请号：US09239351
申请日：1999-01-28
申请人： Lohray Braj Bhushan , Balakrishnan Ezhuthachan Jayachandran , Lohray Vidya Bhushan , Ravindranathan Thottappillil
发明人： Lohray Braj Bhushan , Balakrishnan Ezhuthachan Jayachandran , Lohray Vidya Bhushan , Ravindranathan Thottappillil
IPC分类号： C07C32124
CPC分类号： C07D327/10 , C07D317/32 , C07D317/34
摘要： A process for preparing a 2R-hydroxy-3-[(2-amino-phenylthio)]-3-[(p-alkoxyaryl)] propanoic acid alkyl ester of formula (V) wherein R is an alkyl, or benzoyl residue, R1 is hydrogen, an alkyl, alkoxy, aryloxy, phenyl, naphthyl, or hydroxy residue, and R2 and R3 are independently of each other hydrogen, and alkyl, alkoxy, alkylamino, alkylthio, aryl, or halogen residue, which comprises refluxing 2-aminothiophenol, or 2-aminothionaphthol with a compound of Formula (IV) that is 5S-(p-alkoxyphenyl)-4R-carboalkoxy-1,3,2-dioxathiolane-2-oxide when X is S, or the corresponding cyclic carbonate, in the presence of an organic solvent and an inert atmosphere, and recovering the resultant compound of Formula (V).
摘要翻译：制备式（V）的2R-羟基-3 - [（2-氨基 - 苯硫基）] - 3 - [（p-烷氧基芳基）]丙酸烷基酯的方法，其中R是烷基或苯甲酰基，R1是氢，烷基，烷氧基，芳氧基，苯基，萘基或羟基残基，R 2和R 3彼此独立地为氢，烷基，烷氧基，烷基氨基，烷硫基，芳基或卤素残基，其包括回流2-氨基苯硫酚或 2-氨基硫代萘酚与式（Ⅳ）化合物反应，当X为S时为5S-（对 - 烷氧基苯基）-4R-烷氧羰基-1,3,2-二氧硫杂环戊烷-2-氧化物或相应的环状碳酸酯的有机溶剂和惰性气氛，并回收得到的式（Ⅴ）化合物。

2. 发明授权

US06444853B1 Process for producing aromatic disulfides 失效
标题翻译：芳族二硫化物的制备方法
公开(公告)号：US06444853B1
公开(公告)日：2002-09-03
申请号：US09806850
申请日：2001-04-04
申请人： Isamu Arai , Tutomu Yamaguchi , Yoko Hida
发明人： Isamu Arai , Tutomu Yamaguchi , Yoko Hida
IPC分类号： C07C32124
CPC分类号： C07C319/24 , C07C323/09
摘要： This invention relates to a process for the preparation of aromatic disulfides represented by the formula (II): Yn—Ar—S—S—Ar—Yn (II) wherein Ar represents a hydrocarbon aromatic ring group; Y represents a monovalent electrophilic group, and when n is 2 or more, a plural number of Y's may be the same or different from each other; and n is an integer of 1 to 12, which comprises allowing (A) an aromatic thioether represented by the formula (I): Yn—Ar—S—R (I) wherein Y, Ar and n have the same meanings as defined above; and R represents a monovalent hydrocarbyl group selected from the group consisting of a monovalent tertiary hydrocarbyl group, and benzyl group and a monovalent secondary hydrocarbyl group derived from benzyl group; to react with (B) at least one of the following (1) to (4): (1) bromine; (2)(a) hydrogen bromide and (b) hydrogen peroxide; (3)(c) chlorine, in the presence of a catalytic amount of iodine and/or hydrogen iodide; (4)(d) hydrogen chloride and (b) hydrogen peroxide, in the presence of a catalytic amount of iodine and/or hydrogen iodide.
摘要翻译：本发明涉及一种由式（Ⅱ）表示的芳族二硫化物的制备方法：其中Ar表示烃芳族环基团; Y表示一价亲电子基团，当n为2以上时，多个Y可以彼此相同或不同; n为1〜12的整数，包括使（A）由式（I）表示的芳香族硫醚：其中，Y，Ar和n具有与上述相同的含义; 并且R表示选自一价叔烃基和苄基的一价烃基和衍生自苄基的一价仲烃基;与（B）至少一个（1）至（ 4）（1）溴;（2）（a）溴化氢和（b）过氧化氢;（3）（c）氯，在催化量的碘和/或碘化氢的存在下;（4） d）氯化氢和（b）过氧化氢，在催化量的碘和/或碘化氢的存在下。

3. 发明授权

US06320081B1 O-Nitro(thio)phenol derivatives, and their preparation 有权
标题翻译： O-硝基（硫代）苯酚衍生物及其制备方法
公开(公告)号：US06320081B1
公开(公告)日：2001-11-20
申请号：US09161149
申请日：1998-09-24
申请人： Michael Keitmann , Recai Sezi , Andreas Weber
发明人： Michael Keitmann , Recai Sezi , Andreas Weber
IPC分类号： C07C32124
CPC分类号： C07C205/38 , C07C205/37 , C07C323/09
摘要： The invention relates to novel o-nitrophenol derivatives and o-nitrothiophenol derivatives of the following structure: where: A1 to A3 are—independently of one another—H, F, CH3, CF3, OCH3, OCF3, CH2CH3, CF2CF3, OCH2CH3 or OCF2CF3; T is O or S; R is an aliphatic or araliphatic radical; and R* is H or R.
摘要翻译：本发明涉及以下结构的新型邻硝基苯酚衍生物和邻硝基苯硫酚衍生物：其中：A 1至A 3彼此独立地为-H，F，CH 3，CF 3，OCH 3，OCF 3，CH 2 CH 3，CF 2 CF 3，OCH 2 CH 3或OCF 2 CF 3 ; T为O或S; R是脂族或芳脂族基; 和R *是H或R.

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