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1. 发明申请

US20050256332A1 Flourination of dicarbonyl compounds 失效
标题翻译：二羰基化合物的泛化
公开(公告)号：US20050256332A1
公开(公告)日：2005-11-17
申请号：US10505083
申请日：2003-02-19
申请人： John Moilliet
发明人： John Moilliet
IPC分类号： C07C67/307 , C07C20060101 , C07C45/63 , C07C49/167 , C07C51/363 , C07C67/54 , C07C69/003 , C07C69/66 , C07C69/716 , C07C253/30 , C07C25/39
CPC分类号： C07C67/307 , C07C69/716
摘要： The invention provides a method for the preparation of a dicarbonyl compound of formula (I) R1COCFR2COR3 wherein R1 is selected from alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl and acetoxy, R2 is selected from hydrogen, halogen, nitro, cyano, alkyl, substituted alkyl, cycloalkyl, acetoxy, aryl and substituted aryl, and R3 is selected from alkyl, substituted alkyl, oxyalkyl and substituted oxyalkyl, the method comprising treating a dicarbonyl compound of formula (II) R1COCHR2COR3 with elemental fluorine in a solvent which consists of methanol or aqueous methanol. The method provides an inexpensive and convenient synthetic route to 2-fluoro- and 2,2-difluoro-1,3-diketones and -1,3-ketoesters.
摘要翻译：本发明提供一种制备式（I）的二羰基化合物的方法，其中R 1，R 2，R c，选自烷基，取代的烷基，环烷基，芳基，取代的芳基和乙酰氧基，R 2选自氢，卤素，硝基，氰基，烷基，取代的烷基，环烷基，乙酰氧基，芳基和取代的芳基，R 3选自烷基，取代的烷基，烷氧基和取代的烷氧基，该方法包括处理式（II）的二羰基化合物R 1 COCHR 在由甲醇或甲醇水溶液组成的溶剂中，使用元素氟。该方法为2-氟-2,2-二氟-1,3-二酮和-1,3-酮酯提供了便宜且方便的合成途径。

2. 发明申请

US20040242653A1 Photolabile esters and their uses 失效
标题翻译：光不稳定酯及其用途
公开(公告)号：US20040242653A1
公开(公告)日：2004-12-02
申请号：US10481707
申请日：2004-07-16
发明人： Jerzy Pawel Serafinoiwski , Peter Bryan Garland
IPC分类号： A61K031/455 , A61K031/401 , C07C25/39
CPC分类号： B82Y30/00 , B01J2219/00432 , B01J2219/00608 , B01J2219/00612 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07C205/19 , C07C205/26 , C07C205/35 , C07C205/37 , C07C205/42 , C07C205/44 , C07C207/00 , C07C207/04 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Compounds which are capable of generating acid on photolysis are disclosed, and the uses of these compounds, especially for deprotecting the termini of nucleic acid molecules or peptides during synthesis of arrays. The compounds described herein may be employed in the detritylation of 5null-O-dimethoxytrityl (DMT) protected nucleotides by photolysing the compounds to generate an acid capable of removing the DMT group allowing oligonucleotide arrays to be synthesised using readily available 5null-O-DMT-nucleoside-3null-O-phosphoramidite monomers conventionally used in solid phase nucleic acid synthesis. A method of avoiding the effects of stray light in projection lithography techniques is also disclosed.
摘要翻译：公开了能够在光解上产生酸的化合物，以及这些化合物的用途，特别是用于在阵列合成期间使核酸分子或肽的末端脱保护。本文所述的化合物可以通过光解所述化合物以产生能够除去DMT基团的酸来使用5'- O-二甲氧基三苯甲基（DMT）保护的核苷酸的不合成，从而允许使用容易获得的5'-O- 常规用于固相核酸合成的DMT-核苷-3'-O-亚磷酰胺单体。还公开了一种在投影光刻技术中避免杂散光的影响的方法。

3. 发明申请

US20030092762A1 Anti-inflammatory nitro and thia-fatty acids 失效
标题翻译：抗炎性硝基和硫脂肪酸
公开(公告)号：US20030092762A1
公开(公告)日：2003-05-15
申请号：US10100490
申请日：2002-03-18
发明人： Antonio Ferrante , Christopher J. Easton , Ling Xia
IPC分类号： A61K031/337 , C07D33/38 , C07C25/39 , A61K031/195
CPC分类号： C07C409/40 , A61K31/19 , A61K31/20 , A61K31/202 , A61K31/21 , A61K31/335 , A61K45/06 , C07C17/16 , C07C45/30 , C07C205/02 , C07C205/03 , C07C205/14 , C07C205/15 , C07C205/50 , C07C205/51 , C07C317/44 , C07C323/52 , Y02A50/411 , C07C19/075 , C07C21/14 , C07C47/02 , C07C47/21 , A61K2300/00
摘要： The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein Anull is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and Bnull is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.
摘要翻译：本发明涉及通式为：NO2-AB的化合物，其中A是14-26个碳原子的饱和或不饱和烃链，B是（CH2）n（COOH）m，其中n是0-2的整数 m为0〜2的整数。或通式（I），其中A'是9-26个碳原子的饱和或不饱和烃链，X是氧或不存在，B'是（CH 2）j（COOH）k，其中j是 1〜3，k为0或1; 及其衍生物，其中烃链包括一个或多于一个选自羟基，氢过氧基，环氧基和过氧基的取代基。这些化合物具有生物活性，例如作为抗感染或抗炎剂。

4. 发明申请

US20030055288A1 Process for producting bis(4-hydroxy-3-nitrophenyl) compound 失效
标题翻译：制备双（4-羟基-3-硝基苯基）化合物的方法
公开(公告)号：US20030055288A1
公开(公告)日：2003-03-20
申请号：US10257218
申请日：2002-10-10
发明人： Eiichi Tanaka , Masaki Fujimoto
IPC分类号： C07C323/09 , C07C25/13 , C07C25/39
CPC分类号： C07C201/08 , C07C315/04 , C07C317/22 , C07C205/22 , C07C205/38
摘要： The present invention relates to a process for producing a bis(4-hydroxy-3-nitrophenyl) compounds, characterized by nitrating a bis(4-hydroxyphenyl) compound wherein two phenyl groups are bonded to each other directly or through an electron-donating bridging group, sulfoxide group, sulfone group or carbonyl group in an inert solvent using nitric acid under the condition of substantially free from any other acid. According to the process, the target compounds reduced in the content of trinitrates can be produced in high yield and further recrystallizing the compound easily gives in high yield a high-purity products suitable for use as a raw material of producing a heat-resistant polymer and so on because the content of a trinitro-substitued compound in that compound is low.
摘要翻译：本发明涉及一种双（4-羟基-3-硝基苯基）化合物的制备方法，其特征在于硝化双（4-羟基苯基）化合物，其中两个苯基直接键合或通过给电子桥接基团，亚砜基，砜基或羰基，在惰性溶剂中，使用硝酸在基本上不含任何其它酸的条件下进行。根据该方法，可以高产率地制备三硝酸酯含量降低的目标化合物，进一步重结晶化合物容易高产率地获得适合用作生产耐热聚合物的原料的高纯度产品，因为该化合物中三硝基取代的化合物的含量低。

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