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1. 发明授权

US09890177B2 Nitrated hydrocarbons, derivatives, and processes for their manufacture 有权
公开(公告)号：US09890177B2
公开(公告)日：2018-02-13
申请号：US14920156
申请日：2015-10-22
申请人： ANGUS Chemical Company
发明人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
IPC分类号： C07D498/10 , A01N43/76 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C205/06 , C07C205/18 , C07C215/08 , C07C215/42 , C07C239/10 , C07D263/04 , C07D263/52 , C07D498/04 , C08G18/32 , C07C205/04 , C07C205/05 , C07C205/15 , C07C205/16 , C07C215/20 , C07C215/28
CPC分类号： C07D498/10 , A01N43/76 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C205/04 , C07C205/05 , C07C205/06 , C07C205/15 , C07C205/16 , C07C205/18 , C07C215/08 , C07C215/20 , C07C215/28 , C07C215/42 , C07C239/10 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D263/04 , C07D263/52 , C07D498/04 , C08G18/3271 , Y02P20/582
摘要： Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

2. 发明申请

US20090062572A1 Processes for the synthesis of O-desmethylvenlafaxine 审中-公开
标题翻译：合成O-去甲基文拉法辛的方法
公开(公告)号：US20090062572A1
公开(公告)日：2009-03-05
申请号：US11881799
申请日：2007-07-26
申请人： Valerie Niddam-Hildesheim , Natalia Shenkar , Tamar Nidam
发明人： Valerie Niddam-Hildesheim , Natalia Shenkar , Tamar Nidam
IPC分类号： C07C205/18
CPC分类号： C07C235/34 , C07C2601/14
摘要： The present invention describes processes for the preparation of O-desmethylvenlafaxine and the intermediates cyclohexylbenzylcyanide and tridesmethylvenlafaxine, which may be used as intermediates in preparing O-desmethylvenlafaxine.
摘要翻译：本发明描述了制备O-去甲基文拉法辛的方法和中间体环己基苄基氰和三甲基文拉法辛，其可以用作制备O-去甲基文拉法辛的中间体。

3. 发明申请

US20220401384A1 Synthetic Antibacterial Compounds and Uses Thereof 有权
公开(公告)号：US20220401384A1
公开(公告)日：2022-12-22
申请号：US17826770
申请日：2022-05-27
申请人： McMaster University
发明人： Eric Brown , Omar M Elhalfawy , Nick Jentsch , Xiong Zhang , Jakob Magolan
IPC分类号： A61K31/055 , C07C39/19 , C07D213/30 , C07D261/08 , C07C205/18 , C07D333/38 , C07D307/48 , C07D239/42 , C07D239/26 , C07D215/14 , C07C49/78 , C07C43/275 , A61K38/12 , A61K31/05 , A61K31/4418 , A61K31/42 , A61K31/381 , A61K31/341 , A61K31/505 , A61K31/11 , A61K31/47 , A61K31/121 , A61P31/04
摘要： Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.

4. 发明授权

US11008282B2 Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease 有权
公开(公告)号：US11008282B2
公开(公告)日：2021-05-18
申请号：US16063297
申请日：2016-12-19
申请人： Hubert Koester , CAPROTEC BIOANALYTICS GMBH
发明人： Hubert Koester , Lisa Von Kleist , Simon Michaelis , Kathrin Bartho , Marén Schlief , Mathias Dreger , Anna K. Schrey , Michael Sefkow , Friedrich Kroll , Daniel Ohlendorf , Yan Luo
IPC分类号： C07C233/58 , C07C35/36 , C07C205/05 , C07C205/18 , A61K31/047 , A61K31/045 , A61K31/04 , A61K31/166 , A61P3/04 , A61P25/28 , A61P25/16 , A61P31/06 , C07C237/10 , C07C271/20 , C07C271/22 , C07C235/66 , C07C235/74 , C07C231/02
摘要： The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.

5. 发明申请

US20190315768A1 NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE 审中-公开
公开(公告)号：US20190315768A1
公开(公告)日：2019-10-17
申请号：US16451509
申请日：2019-06-25
申请人： Angus Chemical Company
发明人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
IPC分类号： C07D498/10 , C07D498/04 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C215/28 , C07C205/04 , C07C205/05 , C07C205/15 , C07C205/16 , C07C215/20 , C08G18/32 , A01N43/76 , C07D263/52 , C07D263/04 , C07C239/10 , C07C215/42 , C07C215/08 , C07C205/18 , C07C205/06
摘要： Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

6. 发明授权

US4259350A Iodopropargyl derivatives, their use and preparation 失效
标题翻译：碘代炔丙基衍生物，其用途和制备方法
公开(公告)号：US4259350A
公开(公告)日：1981-03-31
申请号：US20165
申请日：1979-03-13
申请人： Yasuhiro Morisawa , Kiyoshi Konishi , Mitsuru Kataoka
发明人： Yasuhiro Morisawa , Kiyoshi Konishi , Mitsuru Kataoka
IPC分类号： A01N37/00 , A01N37/02 , A01N37/06 , A01N37/08 , A01N37/10 , A01N37/34 , A01N37/40 , A01N37/48 , A01N39/02 , A01N41/04 , A01N43/00 , A01N43/06 , A01N43/40 , A01N47/06 , A01N53/00 , A01N57/00 , A61K31/195 , B27K3/34 , C07C69/007 , C07C69/612 , C07C69/614 , C07C69/62 , C07C69/63 , C07C69/96 , C07C205/18 , C07C255/13 , C07C309/63 , C07C309/65 , C07C309/73 , C07C309/75 , C07D213/55 , C07D213/65 , C07D213/79 , C07D307/16 , C07D307/68 , C07D333/16 , C07D333/24 , C07D333/38 , A01N43/02
CPC分类号： C07D213/79 , A01N37/02 , A01N37/06 , A01N37/08 , A01N37/10 , A01N39/02 , A01N41/04 , A01N43/06 , A01N43/40 , A01N47/06 , A01N53/00 , C07C255/00 , C07C309/65 , C07C309/73 , C07C309/75 , C07C69/63 , C07C69/76 , C07C69/78 , C07C69/96 , C07D213/55 , C07D213/65 , C07D307/16 , C07D307/68 , C07D333/16 , C07D333/24 , C07D333/38
摘要： Iodopropargyl derivatives of formula:IC.tbd.CCH.sub.2 OR[wherein R represents an alkanoyl group (which may be unsubstituted or have one or more halogen, cyano, substituted or unsubstituted .alpha.-phenoxy or phenyl substituents) an alkenoyl group (optionally phenyl-substituted), a substituted or unsubstitutd alkoxycarbonyl group, a cycloalkanoyl group, a substituted or unsubstituted benzoyl group, a substituted or unsubstituted phenoxycarbonyl group, a substituted or unsubstituted benzyloxycarbonyl group, a heterocyclic carbonyl group, an alkylsulphonyl group, a substituted or unsubstituted benzenesulphonyl group, a naphthyloxycarbonyl group, an iodopropargyloxycarbonyl group, a substituted or unsubstituted cycloalkoxycarbonyl group, a heterocyclic methoxycarbonyl group, a 3-pyridyloxycarbonyl group (which may be unsubstituted or have one or more halogen substituents) or an alkenyloxycarbonyl group] are, except where R represents an acetyl or an unsubstituted benzoyl group, new compounds and are useful for the preservation of a variety or organic materials, including the protection of these materials against fungal or insect attack. The derivatives may be prepared by reacting 3-hydroxy-1-iodo-1-propyne with a compound of formula RX (in which R is as defined above and X represents a halogen atom) or, where R in the desired compound contains an oxycarbonyl group, reacting the 3-hydroxy-1-iodo-1-propyne with phosgene and then reacting the product with an appropriate hydroxy-containing compound.
摘要翻译：其中R表示烷酰基（其可以是未取代的或具有一个或多个卤素，氰基，取代或未取代的α-苯氧基或苯基取代基）烯酰基（任选被苯基取代的），一个取代或未取代的烷氧基羰基，环烷酰基，取代或未取代的苯甲酰基，取代或未取代的苯氧基羰基，取代或未取代的苄氧基羰基，杂环羰基，烷基磺酰基，取代或未取代的苯磺酰基，萘氧基羰基，碘代炔丙氧基羰基，取代或未取代的环烷氧基羰基，杂环甲氧基羰基，3-吡啶氧基羰基（其可以是未取代的或具有一个或多个卤素取代基）或烯氧基羰基]，其中R表示乙酰基或未取代的苯甲酰基，新化合物并且可用于保存各种或有机材料，包括保护这些材料免受真菌或昆虫的攻击。衍生物可以通过使3-羟基-1-碘-1-丙炔与式RX化合物（其中R如上定义并且X表示卤素原子）反应制备，或其中所需化合物中的R含有氧羰基将3-羟基-1-碘-1-丙炔与光气反应，然后使产物与合适的含羟基化合物反应。

7. 发明授权

US11542277B2 Nitrated hydrocarbons, derivatives, and processes for their manufacture 有权
公开(公告)号：US11542277B2
公开(公告)日：2023-01-03
申请号：US16451509
申请日：2019-06-25
申请人： Angus Chemical Company
发明人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
IPC分类号： C07C201/12 , C07C201/08 , C07C215/28 , C07C215/20 , C07C215/08 , C07C215/42 , C07C205/05 , C07C205/04 , C07C205/16 , C07C205/15 , C07C205/18 , C07C205/02 , C07C205/06 , A01N43/76 , A01N43/90 , C07D263/04 , C07D263/52 , C07D498/04 , C07D498/10 , C07C239/10 , C08G18/32
摘要： Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

8. 发明授权

US5677336A Non-steroid androgen receptor antagonist compounds and methods 失效
标题翻译：非类固醇雄激素受体拮抗剂的化合物和方法
公开(公告)号：US5677336A
公开(公告)日：1997-10-14
申请号：US141492
申请日：1993-10-21
申请人： Todd K. Jones , Lawrence G. Hamann , Luc Farmer , Michael G. Johnson , Mark E. Goldman
发明人： Todd K. Jones , Lawrence G. Hamann , Luc Farmer , Michael G. Johnson , Mark E. Goldman
IPC分类号： A61K31/04 , A61K31/05 , A61K31/075 , A61K31/12 , A61K31/22 , C07C39/23 , C07C43/23 , C07C45/67 , C07C45/71 , C07C47/575 , C07C49/753 , C07C69/017 , C07C205/06 , C07C205/18 , C07C205/45 , A61K31/085
CPC分类号： C07C205/45 , A61K31/04 , A61K31/05 , A61K31/075 , A61K31/12 , A61K31/22 , C07C205/06 , C07C205/18 , C07C39/23 , C07C43/23 , C07C45/673 , C07C45/71 , C07C47/575 , C07C49/753 , C07C69/017 , C07C2101/14 , C07C2101/16
摘要： Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and for treating patients requiring androgen receptor antagonist therapy.
摘要翻译：公开了对雄激素受体具有高亲和性，高特异性配体拮抗剂的非甾体化合物。还公开了使用所公开的化合物调节由雄激素受体介导的过程和用于治疗需要雄激素受体拮抗剂治疗的患者的方法。

9. 发明授权

US5151550A Cyclopentane derivatives 失效
标题翻译：环戊烷衍生物
公开(公告)号：US5151550A
公开(公告)日：1992-09-29
申请号：US746874
申请日：1991-08-19
申请人： Paul H. Briner
发明人： Paul H. Briner
IPC分类号： C07C35/21 , C07C45/29 , C07C49/697 , C07C49/83 , C07C51/31 , C07C205/18
CPC分类号： C07C205/18 , C07C35/21 , C07C45/292 , C07C49/697 , C07C49/83 , C07C51/31
摘要： The invention provides a process for the preparation of cyclopentanediol derivatives of the general formula ##STR1## in which n represents an integer from 0 to 5; each R represents a halogen atom, nitro, cyano, hydroxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, alkoxycarbonyl, carboxyl, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, alkylamido, cycloalkyl or phenyl group; and R.sup.1, R.sup.2 and R.sup.3 independently represent a hydrogen atom or an alkyl group; which comprises reacting a cyclopentanol derivative of the general formula ##STR2## with a reducing agent. The invention also provides the cyclopentanol derivative intermediates of formula II per se and a process for their preparation. Compounds of formulae I and II are useful as intermediates in the preparation of certain fungicidally active cyclopentane derivatives.
摘要翻译：本发明提供了制备通式为（I）的环戊二醇衍生物的方法，其中n表示0至5的整数; 每个R表示卤素原子，硝基，氰基，羟基，烷基，卤代烷基，烷氧基，卤代烷氧基，氨基，烷基氨基，二烷基氨基，烷氧基羰基，羧基，烷酰基，烷硫基，烷基亚磺酰基，烷基磺酰基，氨基甲酰基，烷基酰氨基，环烷基或苯基。 R1，R2和R3独立地表示氢原子或烷基; 其包括使通式（IMAGE）（II）的环戊醇衍生物与还原剂反应。本发明还提供式II本身的环戊醇衍生物中间体及其制备方法。式I和II的化合物可用作制备某些杀真菌活性环戊烷衍生物的中间体。

10. 发明授权

US5057630A Synthesis of cyclopentene derivatives 失效
标题翻译：环己基衍生物的合成
公开(公告)号：US5057630A
公开(公告)日：1991-10-15
申请号：US505861
申请日：1990-04-06
申请人： John W. Lackey , Robert A. Mook, Jr. , John J. Partridge
发明人： John W. Lackey , Robert A. Mook, Jr. , John J. Partridge
IPC分类号： C07C35/06 , C07C69/96 , C07C205/18 , C07C205/41 , C07D473/00
CPC分类号： C07D473/00 , C07C201/10 , C07C201/12 , C07C35/06 , C07C69/96 , C07C2101/10
摘要： This invention relates to a new process for preparing certain optically active purine substituted cyclopentene derivatives including the antiviral agent, carbovir, and novel intermediates used in this process. In particular, this invention concerns a synthesis of (1R-cis)-4-hydroxymethyl-2-cyclopenten-1-ol, an intermediate in this process.
摘要翻译：本发明涉及一种制备某些光学活性嘌呤取代的环戊烯衍生物的新方法，包括抗病毒剂，维生素和该方法中使用的新型中间体。特别地，本发明涉及在该方法中的中间体的（1R-顺式）-4-羟甲基-2-环戊烯-1-醇的合成。

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