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1. 发明申请

US20210361928A1 Cardiac Pump 有权
公开(公告)号：US20210361928A1
公开(公告)日：2021-11-25
申请号：US16961710
申请日：2019-01-10
申请人： Triphasic Cardiac Pump Pty Ltd.
发明人： Albert Yoonsong Chong
IPC分类号： A61M60/279 , A61M60/113 , A61M60/38 , A61M60/36 , A61M60/851 , A61M60/446
摘要： A cardiac pump is arranged to mimic triphasic operation. The pump uses a fluid line formed from flexible tubing, along with a reciprocating actuator arranged to move between a free orientation and an occluding orientation. This allows a portion of the fluid line to be selectively occluded during movement of the actuator, enabling blood or other fluids to be peristaltically forced fluid towards a fluid outlet. The direction of operation of the actuator, and the selection of appropriate occluding or free orientations, allows the pump to be operated in a triphasic manner.

2. 发明公开

US20240024546A1 CASSETTE APPARATUS UTILIZING VENTING FOR PROCESSING OF BLOOD TO REMOVE PATHOGEN CELLS THEREIN 审中-公开
公开(公告)号：US20240024546A1
公开(公告)日：2024-01-25
申请号：US17814549
申请日：2022-07-25
申请人： William M. Gosney , Dale B. Nixon
发明人： William M. Gosney , Dale B. Nixon
IPC分类号： A61M1/36 , A61M60/113 , A61M60/279 , A61M60/36
CPC分类号： A61M1/36226 , A61M1/3672 , A61M60/113 , A61M60/279 , A61M60/36
摘要： An apparatus for locating and venting pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, a pump is operated to move the identified cells to a processing zone. When each identified cell reaches the processing zone, a control voltage is generated to open a valve to vent the identified pathogen cells. The pump refills the cassette holding chambers, returns the processed blood to the patient, and the procedure is repeated for a treatment time period.

3. 发明申请

US20220176028A1 BLOOD PERFUSION DEVICE 有权
公开(公告)号：US20220176028A1
公开(公告)日：2022-06-09
申请号：US17602226
申请日：2020-04-03
申请人： Jörg GERLACH
发明人： Reinhard BORNEMANN
IPC分类号： A61M1/34 , A61M60/279 , A61M60/113 , A61M60/36 , A61M1/36
摘要： The present invention relates to various methods of treatment using a novel blood perfusion device. The blood perfusion device comprises a perfusion chamber comprising at least one compartment A and at least one compartment B, compartment A comprising a first opening which is in direct fluid communication to a second opening, wherein the first opening of compartment A is in direct fluid communication to a first port of the perfusion chamber and the second opening of compartment A is in direct fluid communication to a second port of the perfusion chamber; and compartment B comprising a first opening which is in direct fluid communication to a second opening, wherein the first opening of compartment B is in direct fluid communication to a third port of the perfusion chamber and the second opening of compartment B is in direct fluid communication to a fourth port of the perfusion chamber, wherein compartment A is separated from compartment B by at least one membrane, said membrane being configured to prevent cells from crossing the membrane.

4. 发明授权

US11801336B1 Cassette apparatus utilizing electric field for processing of blood to neutralize pathogen cells therein 有权
公开(公告)号：US11801336B1
公开(公告)日：2023-10-31
申请号：US17814542
申请日：2022-07-25
申请人： William M. Gosney , Dale B. Nixon
发明人： William M. Gosney , Dale B. Nixon
IPC分类号： A61M1/36 , A61L2/00 , A61M60/113 , A61M60/36 , A61M60/279
CPC分类号： A61M1/36226 , A61L2/0011 , A61M1/3672 , A61M60/113 , A61M60/279 , A61M60/36 , A61L2202/22
摘要： An operational unit for locating and neutralizing pathogen cells in blood includes a time use cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood selectively block the light to produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, an electric field is activated in the cassette chamber areas that include the identified pathogen cells. Sufficient electric field energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a period of time.

5. 发明授权

US11759621B2 Cardiac pump 有权
公开(公告)号：US11759621B2
公开(公告)日：2023-09-19
申请号：US16961710
申请日：2019-01-10
申请人： Triphasic Cardiac Pump Pty Ltd.
发明人： Albert Yoonsong Chong
IPC分类号： A61M60/279 , A61M60/851 , A61M60/446 , A61M60/38 , A61M60/113 , A61M60/36
CPC分类号： A61M60/279 , A61M60/113 , A61M60/36 , A61M60/38 , A61M60/446 , A61M60/851
摘要： A cardiac pump is arranged to mimic triphasic operation. The pump uses a fluid line formed from flexible tubing, along with a reciprocating actuator arranged to move between a free orientation and an occluding orientation. This allows a portion of the fluid line to be selectively occluded during movement of the actuator, enabling blood or other fluids to be peristaltically forced fluid towards a fluid outlet. The direction of operation of the actuator, and the selection of appropriate occluding or free orientations, allows the pump to be operated in a triphasic manner.

6. 发明授权

US11596788B2 System, method and computer-accessible medium for treating circulating tumor cells in the blood stream 有权
公开(公告)号：US11596788B2
公开(公告)日：2023-03-07
申请号：US16082199
申请日：2017-03-02
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER
发明人： Govindarajan Srimathveeravalli , Stephen Barnett Solomon
IPC分类号： A61N1/36 , A61M1/36 , A61N1/04 , A61N1/32 , A61N1/40 , A61M60/279 , A61M60/441 , A61M60/36 , A61M60/113
摘要： An exemplary apparatus, can include, for example, a circulating tumor cell (CTC) treatment arrangement, a pump arrangement configured to circulate a fluid through the CTC treatment arrangement, and an electric field generator electrically connected to the CTC treatment arrangement, and configured to apply an electric field to the fluid circulating through the CTC treatment arrangement. The pump arrangement can be a peristaltic pump, which can be configured to continuously circulate the fluid through the CTC treatment arrangement. According to another exemplary embodiment of the present disclosure, method, system and computer-accessible medium can be provided for killing at least one circulating tumor cell (CTC). Using such exemplary embodiment, blood can be pumped from a body of a patient to an electroporation chamber inside of a CTC treatment arrangement. An electric field can be applied to the blood located in the electroporation chamber in order to kill the CTC. The electric field-applied blood can be pumped back into the body.

7. 发明公开

US20240024554A1 METHOD OF OPERATION UTILIZING ELECTRIC ENERGY FOR PROCESSING OF BLOOD TO NEUTRALIZE PATHOGEN CELLS THEREIN 审中-公开
公开(公告)号：US20240024554A1
公开(公告)日：2024-01-25
申请号：US17814545
申请日：2022-07-25
申请人： William M. Gosney , Dale B. Nixon
发明人： William M. Gosney , Dale B. Nixon
IPC分类号： A61M1/36 , A61M60/113 , A61M60/279 , A61M60/36 , A61M60/585 , A61M60/847
CPC分类号： A61M1/3678 , A61M60/113 , A61M60/279 , A61M60/36 , A61M60/585 , A61M60/847 , A61M2205/3313
摘要： An operational unit for locating and neutralizing pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, the pump is operated to move the identified cells to a processing zone. When each identified cell reaches the processing zone, electric energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a treatment time period.

8. 发明申请

US20230044175A1 CONTINUOUS SUCTION AND REPERFUSION MECHANISM, 有权
公开(公告)号：US20230044175A1
公开(公告)日：2023-02-09
申请号：US17881260
申请日：2022-08-04
申请人： Boston Scientific Medical Device Limited
发明人： Deepak Kumar Sharma , Rajivkumar Singh , Mihir Sukhatme
IPC分类号： A61M1/00 , A61B17/22 , A61M5/315 , A61M60/113 , A61M60/258 , A61M60/438 , A61M60/36
摘要： A suction device configured to simultaneously draw in fluid and expel fluid. The suction device may comprise a barrel defining a cavity and extending from a first end to a second end. A first fluid inlet may be adjacent the first end of the barrel and a second fluid inlet adjacent the second end of the barrel and a first fluid outlet may be adjacent the first end of the barrel and a second fluid outlet adjacent the second end of the barrel. A plunger may be slideably disposed within the cavity of the barrel with a handle assembly operably coupled thereto. A actuation of the handle assembly may be configured to move the plunger within the cavity between the first end and the second end of the barrel.

9. 发明申请

US20220409707A1 DEVICES AND METHODS FOR MODULATING ADMA IN BLOOD 有权
公开(公告)号：US20220409707A1
公开(公告)日：2022-12-29
申请号：US17642011
申请日：2020-09-10
申请人： THE TRUSTEES OF INDIANA UNIVERSITY
发明人： Jaipal SINGH
IPC分类号： A61K38/50 , A61K47/69 , A61P9/12 , A61M1/34 , A61M60/113 , A61M60/36
摘要： Compositions and methods are provided for metabolically degrading ADMA. In one embodiment a device is provided for reducing a patients ADMA levels in their blood wherein the device comprises a biologically active dimethylarginine dimethylaminohydrolase (DDAH) polypeptide covalently linked to a solid support. In one embodiment a method for reducing ADMA levels in a patients blood comprises the step of contacting the patients blood or a blood fraction with an immobilized biologically active DDAH polypeptide, wherein contact of the patients blood with said DDAH polypeptide results in degradation of ADMA present in the patients blood.

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