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1. 发明授权

US06802835B2 Apparatus and method for using a steerable catheter device 失效
标题翻译：使用可导向导管装置的装置和方法
公开(公告)号：US06802835B2
公开(公告)日：2004-10-12
申请号：US10732869
申请日：2003-12-10
申请人： Robert A. Rabiner , Daniel E. Rabiner
发明人： Robert A. Rabiner , Daniel E. Rabiner
IPC分类号： A61M25098
CPC分类号： A61M25/0152 , A61M25/0067 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/0136 , A61M2025/018 , A61M2025/0681
摘要： A handle includes a body portion and a handle portion which is slidably and rotatably mounted on the body portion. Shoulders on the body portion and the handle portion limit relative sliding movement of the body portion and handle portion. A catheter open at both ends has one end fixed to the handle portion for movement therewith, the opposite end of the catheter having a shape memory tip. A fitting is threadedly connected to an enlarged part of the body portion. A sheath is threadedly connected to the fitting and the catheter is slidable and rotatable within the sheath. An annular channel is provided between the sheath and the catheter, this channel being in fluid communication with a bore in the fitting. The outer end of the sheath has holes therethrough in fluid communication with the channel. An irrigation inflow and aspiration outflow tube is also in fluid communication with the bore in the fitting. A first lock is provided adjacent the fitting for controlling the amount of frictional resistance to lengthwise movement of the catheter relative to the sheath and to lock the catheter in position. A medical device such as an endoscope may be received within the catheter for movement relative thereto. A second lock is supported by the handle portion for locking a medical device in position relative to the catheter.
摘要翻译：手柄包括主体部分和可滑动地且可旋转地安装在主体部分上的手柄部分。主体部分和手柄部分上的肩部限制主体部分和把手部分的相对滑动。在两端开口的导管的一端固定在手柄部分上以与其一起运动，导管的相对端具有形状记忆尖端。配件螺纹连接到主体部分的扩大部分。护套螺纹连接到配件上，并且导管可在护套内滑动和旋转。在护套和导管之间提供环形通道，该通道与配件中的孔流体连通。护套的外端具有通过其与通道流体连通的孔。灌溉流入和抽吸流出管也与配件中的孔流体连通。在配件附近提供第一锁，用于控制导管相对于护套的纵向运动的摩擦阻力的量并将导管锁定在适当位置。可以在导管内容纳诸如内窥镜的医疗装置以相对于其移动。第二锁由手柄部分支撑，用于将医疗装置相对于导管锁定在适当的位置。

2. 发明授权

US06210396B1 Guiding catheter with tungsten loaded band 有权
标题翻译：引导导管与不透射线带
公开(公告)号：US06210396B1
公开(公告)日：2001-04-03
申请号：US09339499
申请日：1999-06-24
申请人： Stuart R. MacDonald , Zelda M. Anastos , Albert H. Dunfee , Michael S. Noone
发明人： Stuart R. MacDonald , Zelda M. Anastos , Albert H. Dunfee , Michael S. Noone
IPC分类号： A61M25098
CPC分类号： A61M25/0108 , A61L29/18 , A61L31/18 , A61M25/0009
摘要： The present invention comprises a tubular catheter shaft defining at least one catheter shaft lumen and a radiopaque band made of a polymeric material loaded with a radiopaque material of greater than 40% by weight, suitable for visualization under fluoroscopy in catheters in the range of 3 French to 5 French. The distal soft tip is formed of a relatively flexible polymeric material, loaded with radiopaque material which is less radiopaque than the radiopaque band. The radiopaque band's proximal end adjoins the distal end of the catheter shaft. The radiopaque band's distal end adjoins the proximal end of the distal tip to form an attachment junction. A tubular sleeve fits coaxially over the radiopaque band, the distal end of the catheter shaft and the proximal end of the distal soft tip. The tubular sleeve adheres the catheter shaft distal end to the proximal end of the radiopaque band and adheres the soft tip proximal end to the distal end of the radiopaque band thereby aligning the soft tip lumen, the radiopaque band lumen, and the catheter shaft lumen. The proximal end of the tubular sleeve is bonded to a distal portion of the catheter shaft. The distal end of the tubular sheath is bonded to the proximal end of the soft distal tip. The radiopaque band is bonded to the tubular sheath thereby bridging the attachment junction. The tubular sleeve is made of a polymeric material loaded with a radiopaque material which is less radiopaque than the radiopaque band. The tubular sleeve is melt compatible with the radiopaque band, the catheter shaft distal end and the distal soft tip such that the tubular sleeve, the distal end of the catheter shaft, the radiopaque band and the proximal end of the distal soft tip bond.
摘要翻译：本发明包括管状导管轴，其限定至少一个导管轴腔和由装载有大于40重量％的不透射线材料的聚合物材料制成的不透射带，适合于在3个法国的导管内的荧光透视下的可视化到5法语。远端软尖端由相对柔性的聚合物材料形成，该聚合材料装载不透射线不透射线的不透射线材料。不透射线带的近端邻接导管轴的远端。不透射线带的远端与远端尖端的近端相邻以形成附着结。管状套筒同轴地配合在不透射线的带，导管轴的远端和远端软尖端的近端。管状套管将导管轴远端粘附到不透射线带的近端，并将软尖端近端粘附到不透射线带的远端，从而对准软尖端腔，不透射线带腔和导管轴腔。管状套管的近端结合到导管轴的远端部分。管状护套的远端结合到软远侧末端的近端。不透射线的带结合到管状护套，从而桥接连接结。管状套筒由装载有不透射线不透射线的不透射线材料的聚合材料制成。管状套筒与不透射线带，导管轴远端和远端软尖端熔融相容，使得管状套管，导管轴的远端，不透射线带和远端软尖端的近端结合。

3. 发明授权

US06638268B2 Catheter to cannulate the coronary sinus 失效
标题翻译：导管插管冠状窦
公开(公告)号：US06638268B2
公开(公告)日：2003-10-28
申请号：US09828502
申请日：2001-04-06
申请人： Imran K. Niazi
发明人： Imran K. Niazi
IPC分类号： A61M25098
CPC分类号： A61M25/0662 , A61M25/0041 , A61M2025/1052 , A61M2210/125
摘要： A double catheter includes an outer, resilient catheter having shape memory and a hook-shaped distal end, an inner, pliable catheter slidably disposed in the outer catheter and of greater length than the outer catheter so that a distal end portion of the inner catheter can be extended or retracted from a distal end opening of the outer catheter to vary the overall length of the double catheter, the inner catheter preferably having an internal lumen suitable for the introduction of contrast media, and a mechanism operable from the proximal end of the outer catheter for changing the curvature of the hook shaped distal end of the outer catheter. Such a catheter of the invention can cannulate the coronary sinus without significant manipulation.
摘要翻译：双导管包括具有形状记忆和钩形远端的外部弹性导管，可滑动地设置在外导管中并且具有比外导管更大的长度的内部柔韧导管，使得内导管的远端部分从外导管的远端开口延伸或缩回以改变双导管的总长度，内导管优选地具有适于引入造影剂的内腔，以及可从外导管的近端操作的机构用于改变外导管的钩形远端的曲率的导管。本发明的这种导管可以插管冠状动脉窦而没有显着的操纵。

4. 发明授权

US06579279B1 Steerable catheter device 失效
标题翻译：导向导管装置
公开(公告)号：US06579279B1
公开(公告)日：2003-06-17
申请号：US09665328
申请日：2000-09-19
申请人： Robert A. Rabiner , Daniel E. Rabiner
发明人： Robert A. Rabiner , Daniel E. Rabiner
IPC分类号： A61M25098
CPC分类号： A61M25/0152 , A61M25/0067 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/0136 , A61M2025/018 , A61M2025/0681
摘要： A handle includes a body portion and a handle portion which is slidably and rotatably mounted on the body portion. Shoulders on the body portion and the handle portion limit relative sliding movement of the body portion and handle portion. A catheter open at both ends has one end fixed to the handle portion for movement therewith, the opposite end of the catheter having a shape memory tip. A fitting is threadedly connected to an enlarged part of the body portion. A sheath is threadedly connected to the fitting and the catheter is slidable and rotatable within the sheath. An annular channel is provided between the sheath and the catheter, this channel being in fluid communication with a bore in the fitting. The outer end of the sheath has holes therethrough in fluid communication with the channel. An irrigation inflow and aspiration outflow tube is also in fluid communication with the bore in the fitting. A first lock is provided adjacent the fitting for controlling the amount of frictional resistance to lengthwise movement of the catheter relative to the sheath and to lock the catheter in position. A medical device such as an endoscope may be received within the catheter for movement relative thereto. A second lock is supported by the handle portion for locking a medical device in position relative to the catheter.
摘要翻译：手柄包括主体部分和可滑动地且可旋转地安装在主体部分上的手柄部分。主体部分和手柄部分上的肩部限制主体部分和把手部分的相对滑动。在两端开口的导管的一端固定在手柄部分上以与其一起运动，导管的相对端具有形状记忆尖端。配件螺纹连接到主体部分的扩大部分。护套螺纹连接到配件上，并且导管可在护套内滑动和旋转。在护套和导管之间提供环形通道，该通道与配件中的孔流体连通。护套的外端具有通过其与通道流体连通的孔。灌溉流入和抽吸流出管也与配件中的孔流体连通。在配件附近提供第一锁，用于控制导管相对于护套的纵向运动的摩擦阻力的量并将导管锁定在适当位置。可以在导管内容纳诸如内窥镜的医疗装置以相对于其移动。第二锁由手柄部分支撑，用于将医疗装置相对于导管锁定在适当位置。

5. 发明授权

US06733489B2 Vascular orientation marker for determining the orientation of a blood vessel 有权
标题翻译：用于确定血管方位的血管定位标记
公开(公告)号：US06733489B2
公开(公告)日：2004-05-11
申请号：US10255902
申请日：2002-09-26
申请人： Charles Nutting , William M. Appling , Arthur L. Zimmet
发明人： Charles Nutting , William M. Appling , Arthur L. Zimmet
IPC分类号： A61M25098
CPC分类号： A61B90/39
摘要： A catheter having one or more radio-opaque bands near the distal end is designed to be inserted into the renal artery so that the distal end of the catheter is adjacent to the origin of the renal artery. An X-ray image of the bands is used to position the X-ray head relative to the aorta and renal artery so that a useful, unobstructed radiological image perpendicular to the axis of the renal artery at its origin is obtained. This facilitates the positioning of a stent in the renal artery so that the stent encompasses the origin and extends no more than about three millimeters into the aorta. Two radio-opaque bands placed close to one another define a narrow radio-translucent band such that when the X-ray head is rotated to a position where parallax is reduced and the radio-translucent band can be imaged, the renal artery can be appropriately imaged without being obscured by the aorta.
摘要翻译：在远端附近具有一个或多个不透射线带的导管被设计成插入肾动脉，使得导管的远端与肾动脉的原点相邻。使用带的X射线图像来相对于主动脉和肾动脉定位X射线头，使得获得垂直于其原点的肾动脉轴线的有用的，无阻碍的放射图像。这有助于支架在肾动脉中的定位，使得支架包围原点并且延伸不超过约三毫米的主动脉。彼此靠近放置的两个不透射线的带限定了窄的无线电半透明带，使得当X射线头旋转到视差减小的位置并且可以对无线电半透明带进行成像时，肾动脉可以适当地成像而不被主动脉遮挡。

6. 发明授权

US06692483B2 Catheter with attached flexible side sheath 失效
标题翻译：导管附带柔性侧护套
公开(公告)号：US06692483B2
公开(公告)日：2004-02-17
申请号：US09455299
申请日：1999-12-06
申请人： Gil M. Vardi , Charles J. Davidson , Eric Williams
发明人： Gil M. Vardi , Charles J. Davidson , Eric Williams
IPC分类号： A61M25098
CPC分类号： A61M25/0116 , A61F2/07 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2002/821 , A61F2250/006 , A61F2250/0098 , A61M2025/0177 , A61M2025/1045
摘要： A method of positioning a main stent at a vessel bifurcation such that a side opening in the main stent is positioned at the ostium of a branch vessel, comprising: positioning a main guidewire in the main vessel such that a distal end of the main guidewire extends past the bifurcation; advancing a stent delivery system to a position proximate the bifurcation, the stent delivery system comprising a catheter with a flexible side sheath attached thereto, wherein the catheter is received over the main guidewire, and wherein the main stent is positioned over the catheter with the flexible side sheath positioned to pass through the interior of the main stent and out of the side opening in the main stent; advancing a branch guidewire through the flexible side sheath attached to the catheter and into the branch vessel; and subsequently, advancing the catheter over the main guidewire while advancing the flexible side sheath over the branch guidewire while viewing relative movement of a marker positioned on the flexible side sheath with respect to at least one marker positioned on the catheter, wherein the relative movement indicates that a portion of the flexible side sheath adjacent the side opening in the main stent is advancing into the ostium of the branch vessel, thereby indicating the position of the side opening of the main stent with respect to the ostium of the branch vessel.
摘要翻译：一种将主支架定位在血管分叉处的方法，使得主支架中的侧开口位于分支容器的口处，包括：将主导丝定位在主容器中，使得主导丝的远端延伸过了分岔; 将支架输送系统推进到靠近分叉处的位置，所述支架输送系统包括具有附接到其上的柔性侧鞘的导管，其中所述导管被接纳在所述主导丝上，并且其中所述主支架位于所述导管上方，侧护套定位成穿过主支架的内部并离开主支架的侧开口; 使分支导丝穿过附接到导管的柔性侧鞘进入分支容器; 并且随后在将所述柔性侧护套推进所述分支导丝的同时使所述导管前进，同时观察位于所述柔性侧鞘上的标记相对于位于所述导管上的至少一个标记的相对运动，其中所述相对运动指示与主支架中的侧开口相邻的柔性侧鞘的一部分前进到分支容器的口中，从而指示主支架的侧开口相对于分支容器的口的位置。

7. 发明授权

US06679873B2 Method for using a steerable catheter device 失效
标题翻译：使用可导向导管装置的方法
公开(公告)号：US06679873B2
公开(公告)日：2004-01-20
申请号：US10462182
申请日：2003-06-16
申请人： Robert A. Rabiner , Daniel E. Rabiner
发明人： Robert A. Rabiner , Daniel E. Rabiner
IPC分类号： A61M25098
CPC分类号： A61M25/0152 , A61M25/0067 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/0136 , A61M2025/018 , A61M2025/0681
摘要： A handle includes a body portion and a handle portion which is slidably and rotatably mounted on the body portion. Shoulders on the body portion and the handle portion limit relative sliding movement of the body portion and handle portion. A catheter open at both ends has one end fixed to the handle portion for movement therewith, the opposite end of the catheter having a shape memory tip. A fitting is threadedly connected to an enlarged part of the body portion. A sheath is threadedly connected to the fitting and the catheter is slidable and rotatable within the sheath. An annular channel is provided between the sheath and the catheter, this channel being in fluid communication with a bore in the fitting. The outer end of the sheath has holes therethrough in fluid communication with the channel. An irrigation inflow and aspiration outflow tube is also in fluid communication with the bore in the fitting. A first lock is provided adjacent the fitting for controlling the amount of frictional resistance to lengthwise movement of the catheter relative to the sheath and to lock the catheter in position. A medical device such as an endoscope may be received within the catheter for movement relative thereto. A second lock is supported by the handle portion for locking a medical device in position relative to the catheter.
摘要翻译：手柄包括主体部分和可滑动地且可旋转地安装在主体部分上的手柄部分。主体部分和手柄部分上的肩部限制主体部分和把手部分的相对滑动。在两端开口的导管的一端固定在手柄部分上以与其一起运动，导管的相对端具有形状记忆尖端。配件螺纹连接到主体部分的扩大部分。护套螺纹连接到配件上，并且导管可在护套内滑动和旋转。在护套和导管之间提供环形通道，该通道与配件中的孔流体连通。护套的外端具有通过其与通道流体连通的孔。灌溉流入和抽吸流出管也与配件中的孔流体连通。在配件附近提供第一锁，用于控制导管相对于护套的纵向运动的摩擦阻力的量并将导管锁定在适当位置。可以在导管内容纳诸如内窥镜的医疗装置以相对于其移动。第二锁由手柄部分支撑，用于将医疗装置相对于导管锁定在适当位置。

8. 发明授权

US06648875B2 Means for maintaining tension on a steering tendon in a steerable catheter 有权
公开(公告)号：US06648875B2
公开(公告)日：2003-11-18
申请号：US09849325
申请日：2001-05-04
申请人： John A. Simpson , Robert C. Hayzelden
发明人： John A. Simpson , Robert C. Hayzelden
IPC分类号： A61M25098
CPC分类号： A61M25/0136
摘要： A catheter handle includes a steering controller to be used in conjunction with a steerable catheter shaft, and a steering tendon tensioning device. The operator deflects the profile of a distal-end region of the catheter by rotating the steering controller. Spring devices located on the steering tendons maintain the steering tendons in tension during manipulation of the steering controller. A locking device locks the steering controller in place relative to the handle.

9. 发明授权

US06579278B1 Bi-directional steerable catheter with asymmetric fulcrum 有权
标题翻译：具有不对称支点的双向导向导管
公开(公告)号：US06579278B1
公开(公告)日：2003-06-17
申请号：US09566175
申请日：2000-05-05
申请人： Robert F. Bencini
发明人： Robert F. Bencini
IPC分类号： A61M25098
CPC分类号： A61M25/0144 , A61M25/0147 , A61M2025/0161
摘要： A steerable medical device comprises an elongated tubular body and first and second stiffening members, preferably in the form of compression coils or flat flexible wires. The stiffening members are arranged such that when a user engages a steering assembly, incorporated into the device, a distal end of the tubular body can be selectively bent in a first direction into a first configuration or in a second direction into a second configuration. The first and second configurations are functions of the lengths and locations of the first and second stiffening members.
摘要翻译：可操纵的医疗装置包括细长的管状体和优选为压缩线圈或扁平柔性线的形式的第一和第二加强构件。加强构件布置成使得当使用者接合装配到装置中的转向组件时，管状体的远端可以在第一方向上被选择性地弯曲成第一构造或者在第二方向上被弯曲成第二构造。第一和第二构造是第一和第二加强构件的长度和位置的函数。

10. 发明授权

US06283951B1 Systems and methods for delivering drugs to selected locations within the body 失效
标题翻译：将药物运送到身体内的选定位置的系统和方法
公开(公告)号：US06283951B1
公开(公告)日：2001-09-04
申请号：US09048147
申请日：1998-03-25
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
IPC分类号： A61M25098
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： A transvascular system for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter having a distal portion with puncturing, orientation, drug delivery, and imaging elements. The puncturing element is deployable for penetrating the vessel wall to access the tissue region. The orientation element, e.g. a “cage” including a plurality of struts and/or a radiopaque marker, has a predetermined relationship with the puncturing element, the imaging element detecting the location of the orientation element with respect to the tissue region to orient the puncturing element. The catheter is percutaneously introducing into the vessel, the puncturing element is oriented towards the tissue region, the puncturing element is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device may also be deployed to create a cavity in the tissue region for receiving the drug therein, or an indwelling catheter may be advanced into and left in the tissue region. An implantable reservoir device is also disclosed, including an enclosed membrane on an expandable frame that defines a reservoir and includes a porous region. The reservoir device may be deployed and expanded within a blood vessel, and may be filled in situ or prefilled with a drug that passes through the porous region. Alternatively, a pair of expandable endovascular blockers may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.
摘要翻译：用于将药物从诸如冠状静脉的血管输送到组织区域的经血管系统包括具有穿刺，取向，药物递送和成像元件的远侧部分的导管。穿刺元件可展开以穿透血管壁以进入组织区域。取向元件，例如包括多个支柱和/或不透射线的标记的“笼”与穿刺元件具有预定的关系，成像元件检测取向元件相对于组织区域的位置以定向穿刺元件。将导管经皮导入容器中，穿刺元件朝向组织区域定位，穿刺元件展开以接近组织区域，并将药物递送至组织区域。还可以部署消融装置以在组织区域中形成用于在其中接收药物的空腔，或者留置导管可以进入组织区域并留在组织区域中。还公开了一种可植入储存器装置，其包括限定储存器并且包括多孔区域的可扩张框架上的封闭膜。储存器装置可以在血管内展开和扩张，并且可以在原位填充或预填充穿过多孔区域的药物。或者，一对可扩张血管内阻滞剂可以用于分离可以被可被周围组织吸收的药物填充的血管的一部分。

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