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1. 发明授权

US06749623B1 Method and apparatus for catheter phototherapy with dose sensing 有权
标题翻译：用于剂量感应的导管光疗的方法和装置
公开(公告)号：US06749623B1
公开(公告)日：2004-06-15
申请号：US09591947
申请日：2000-06-12
申请人： Richard A Hsi , Arye Rosen , Carmen E Rodriguez
发明人： Richard A Hsi , Arye Rosen , Carmen E Rodriguez
IPC分类号： A61K500
CPC分类号： A61N5/062 , A61B2017/00057 , A61N5/0601
摘要： A photodynamic therapy method administers, to a patient to be treated, a photosensitive medication which fluoresces when illuminated. The fluorescent light is an indication of the instantaneous phototherapy dose. A catheter according to the invention includes a probe or sensor arrangement for generating a signal representing the instantaneous amplitude of the fluorescence or the incident illumination. The signal is integrated to produce a signal representing the total dose of phototherapy. The photodynamic therapy is terminated when the integrated signal indicates a particular value. The catheter in one embodiment includes an array of semiconductor light sources near its distal end, energized from the proximal end. In another embodiment, the light source is external to the patient, and the light is conducted to the distal end of the catheter by one or more optical fibers. The light sensor may be an optical fiber extending from the proximal to the distal end of the catheter, with a probe end which is directive or omnidirectional. In this case, the dose signal is detected by a photodiode exterior to the catheter and the detected signal is integrated to generate a signal indicative of cumulative dose. In another embodiment, the photodiode is located near the distal end of the catheter.
摘要翻译：光动力学治疗方法向待治疗的患者施用照射时发荧光的光敏药物。荧光灯是瞬时光疗剂量的指示。根据本发明的导管包括用于产生表示荧光或入射照明的瞬时幅度的信号的探针或传感器装置。信号被整合以产生表示光疗总剂量的信号。当积分信号表示特定值时，光动力疗法终止。一个实施例中的导管包括从其近端附近的半导体光源的阵列，从近端激励。在另一个实施例中，光源在患者外部，并且光通过一根或多根光纤传导到导管的远端。光传感器可以是从导管的近端延伸到远端的光纤，探针端是指导性的或全向的。在这种情况下，剂量信号由导管外部的光电二极管检测，并且检测到的信号被积分以产生指示累积剂量的信号。在另一个实施例中，光电二极管位于导管的远端附近。

2. 发明授权

US06593455B2 Tripeptide amides that block viral infectivity and methods of use thereof 失效
标题翻译：阻断病毒感染性的三肽酰胺及其使用方法
公开(公告)号：US06593455B2
公开(公告)日：2003-07-15
申请号：US09938806
申请日：2001-08-24
申请人： David van der Spoel , Csaba Hetényi , Ákos Végvári , Stefan Höglund , Jin Su , Sarah Sandin-Reneby , Laura Goobar-Larsson , Anders Vahlne
发明人： David van der Spoel , Csaba Hetényi , Ákos Végvári , Stefan Höglund , Jin Su , Sarah Sandin-Reneby , Laura Goobar-Larsson , Anders Vahlne
IPC分类号： A61K500
CPC分类号： C07K5/08 , A61K38/00 , Y10S977/805 , Y10S977/904
摘要： Embodiments relate to the discovery that tripeptide amides, which correspond to viral capsid sequences, can be used to inhibit viral infection, including human immunodeficiency virus (HIV) infection. More specifically, medicaments comprising tripeptide amides and methods of using said compounds for the prevention and treatment of viral infection, such as HIV infection, are provided.
摘要翻译：实施方案涉及发现三肽酰胺（其对应于病毒衣壳序列）可用于抑制病毒感染，包括人类免疫缺陷病毒（HIV）感染。更具体地，提供了包含三肽酰胺的药物和使用所述化合物用于预防和治疗病毒感染如HIV感染的方法。

3. 发明授权

US06551794B1 Stable biotinylated biomolecule composition 失效
标题翻译：稳定的生物素化生物分子组成
公开(公告)号：US06551794B1
公开(公告)日：2003-04-22
申请号：US08555602
申请日：1995-11-09
申请人： Steven James Burton , James C. Pearson , Peter A. D. Edwardson , Alan Menzies
发明人： Steven James Burton , James C. Pearson , Peter A. D. Edwardson , Alan Menzies
IPC分类号： A61K500
CPC分类号： G01N33/54306 , A61L2/0035 , C07K14/75
摘要： Stable compositions containing biotinylated molecules, such as enzymes, are provided. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g., as a lyophilized, powder cake. They have applicability in any case where avidin/biotin technology is used and are particularly important as compositions containing a thrombin-like enzyme, e.g., for preparation of a fibrin monomer and fibrin monomer-based fibrin sealants.
摘要翻译：提供含有生物素化分子如酶的稳定组合物。组合物包括生物素化的生物分子，生物分子保护剂，缓冲剂，选自一种或多种水溶性非离子聚合物的填充剂，优选末端灭菌保护剂。组合物可以作为水溶液或优选以干燥形式使用，例如冻干的粉饼。它们在使用抗生物素蛋白/生物素技术的任何情况下都具有适用性，并且对于含有凝血酶样酶的组合物是特别重要的，例如用于制备纤维蛋白单体和基于纤维蛋白单体的纤维蛋白密封剂。

4. 发明授权

US06569402B1 Vitronectin receptor antagonist pharmaceuticals 失效
标题翻译： Vitronectin受体拮抗剂药物
公开(公告)号：US06569402B1
公开(公告)日：2003-05-27
申请号：US09599365
申请日：2000-06-21
申请人： Edward H. Cheesman , John A. Barrett , Alan P. Carpenter, Jr. , Milind Rajopadhye , Michael Sworin
发明人： Edward H. Cheesman , John A. Barrett , Alan P. Carpenter, Jr. , Milind Rajopadhye , Michael Sworin
IPC分类号： A61K500
CPC分类号： A61K49/0002 , A61K51/0497 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/0207 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024 , C07K7/02 , C07K7/06 , C07K7/64 , C07K9/003
摘要： The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
摘要翻译：本发明描述了新的下式化合物：可用于癌症的诊断和治疗，对患者肿瘤成像的方法，以及治疗患者癌症的方法。本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。本发明还提供了用于成像动脉粥样硬化，再狭窄，心脏缺血和心肌再灌注损伤的新型化合物。本发明还提供了可用于治疗类风湿性关节炎的新化合物。药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。

5. 发明授权

US06485723B1 Enhanced submucosal tissue graft constructs 有权
标题翻译：增强粘膜下组织移植物构建体
公开(公告)号：US06485723B1
公开(公告)日：2002-11-26
申请号：US09566497
申请日：2000-05-08
申请人： Stephen F. Badylak , Christina Lindberg , George B. Boder , Sherry Voytik-Harbin
发明人： Stephen F. Badylak , Christina Lindberg , George B. Boder , Sherry Voytik-Harbin
IPC分类号： A61K500
CPC分类号： A61L27/3808 , A61K35/38 , A61K35/44 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3683 , A61L27/3839 , C12N5/0068 , C12N5/0655 , C12N5/0676 , C12N5/0679 , C12N2500/32 , C12N2500/38 , C12N2533/92 , A61K2300/00
摘要： An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo.
摘要翻译：描述了包括温血脊椎动物的粘膜下层和预选的真核细胞组的改进的组织移植物构建体。可以根据本发明使用改进的组织移植物构建体，以增强体内受损或患病组织的修复。

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