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1. 发明授权

US07776311B1 D-amino acid peptides 有权
标题翻译： D-氨基酸肽
公开(公告)号：US07776311B1
公开(公告)日：2010-08-17
申请号：US11640790
申请日：2006-12-18
申请人： William J. McBride , David M. Goldenberg
发明人： William J. McBride , David M. Goldenberg
IPC分类号： A61K38/08 , A61K38/16 , A61K39/00 , A61K36/395 , A61K51/10 , C07K5/02 , C12P21/08
CPC分类号： C07K5/0815 , A61K38/00 , A61K47/6897 , A61K49/0002 , A61K51/109 , B82Y5/00 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1021 , C07K7/06 , Y02A50/411
摘要： The present invention provides compounds of the formula X—R1-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5; or R1(X)-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5, in which X is a hard acid cation chelator, a soft acid cation chelator or Ac-, R1, R2 and R3 are independently selected from a covalent bond or one or more D-amino acids that can be the same or different, Y is a hard acid cation chelator, a soft acid cation chelator or absent, Z is a hard acid cation chelator, a soft acid cation chelator or absent, and A and B are haptens or hard acid cation chelators and can be the same or different, and R4 and R5 are independently selected from the group consisting of hard acid cation chelators, soft acid cation chelators, enzymes, therapeutic agents, diagnostic agents and H. The present invention also provides methods of using these compounds and kits containing the compounds.
摘要翻译：本发明提供式X-R1-D- [Dpr，Orn或Lys]（A）-R2（Z）-D- [Dpr，Orn或Lys]（B）-R3（Y）-NR4R5的化合物; 或R 1（X）-D- [Dpr，Orn或Lys]（A）-R2（Z）-D- [Dpr，Orn或Lys]（B）-R3（Y）-NR4R5，其中X为硬酸阳离子螯合剂，软酸阳离子螯合剂或Ac-，R1，R2和R3独立地选自共价键或一个或多个可以相同或不同的D-氨基酸，Y是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，Z是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，A和B是半抗原或硬酸阳离子螯合剂，可以相同或不同，并且R 4和R 5独立地选自由硬酸阳离子螯合剂，软酸阳离子螯合剂，酶，治疗剂，诊断剂和H组成的组。本发明还提供使用这些化合物和含有该化合物的试剂盒的方法。

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