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1. 发明授权

US08513188B2 Formulations comprising cyclic compounds 有权
标题翻译：包含环状化合物的制剂
公开(公告)号：US08513188B2
公开(公告)日：2013-08-20
申请号：US12443327
申请日：2007-09-27
申请人： Paolo Botti
发明人： Paolo Botti
IPC分类号： A61K38/00 , A61K38/08 , A61K38/16 , A61K31/33 , A61K31/335 , A61K38/22 , A61K38/23 , A61K36/26 , A61P13/12 , C07K7/00 , C07D267/00 , C07D323/00
CPC分类号： C07D323/00 , A61K47/22 , A61K47/6949 , B82Y5/00
摘要： This invention relates to the use of a cyclic compound of formula (I) wherein A, B independently in each occurrence is alkane-i,j-diyl having k carbon atoms, i and independently j being less than or equal k and k being selected from 1 to 10, wherein said alkane-i,j-diyl (i) may comprise one or more double bonds; (ii) is optionally substituted; and/or (iii) comprises a cycle, wherein the total number of cycles being cyclic sugars in said compound is selected from 0 to 4 and is less than p·(n+m); X,Y independently in each occurrence is a biocompatible functional group comprising at least one oxygen atom or two sulphur atoms; n, m independently of each other are selected from 0 to 20; p is selected from 1 to 10; n+m is equal or greater than 1; and p·(n+m) is selected from 3 to 30; wherein said compound is capable of forming a complex with a protonated primary and/or protonated secondary amino group and/or a protonated guanidinium group for the manufacture of a pharmaceutical or diagnostic composition.
摘要翻译：本发明涉及式（I）的环状化合物的用途，其中A，B在每次出现时独立地为具有k个碳原子的烷烃-i，j-二基，i且独立地j小于或等于k且k被选择 1至10，其中所述烷烃i，j-二基（i）可以包含一个或多个双键; （ii）任选被取代; 和/或（iii）包括循环，其中所述化合物中环状糖的总循环数为0至4，小于p·（n + m）; X，Y各自独立地为包含至少一个氧原子或两个硫原子的生物相容性官能团; n，m彼此独立地选自0至20; p选自1至10; n + m等于或大于1; p·（n + m）选自3〜30; 其中所述化合物能够与质子化的初级和/或质子化的仲氨基和/或质子化的胍基形成络合物，用于制备药物或诊断组合物。

2. 发明申请

US20060051302A1 METHODS OF TREATING DERMAL/EPIDERMAL JUNCTIONS AND COSMETIC PREPARATIONS FOR USE THEREIN 审中-公开
标题翻译：治疗牙齿/外膜结的方法及其使用的化妆品制剂
公开(公告)号：US20060051302A1
公开(公告)日：2006-03-09
申请号：US10527737
申请日：2003-09-04
申请人： Christine Jeanmaire , Gilles Pauly
发明人： Christine Jeanmaire , Gilles Pauly
IPC分类号： A61K8/97 , A61K8/73 , A61K36/064 , A61K36/26 , A61K36/48
CPC分类号： A61K8/738 , A61K8/345 , A61K8/362 , A61K8/64 , A61K8/97 , A61K8/99 , A61K36/48 , A61K36/73 , A61K2800/70 , A61Q5/00 , A61Q7/00 , A61Q17/00 , A61Q17/04 , A61Q19/08 , A61K2300/00
摘要： Methods for protecting, modulating and/or improving the dermal/epidermal junctions of the skin, scalp and/or mucous membranes are described wherein a preparation comprising at least one substance which effects a modulation of one or more dermal/epidermal junction components selected from the group consisting of plectin/HD1, entactin/nidogen, percalan and combinations thereof, is applied to the skin, scalp, and/or mucous membrane. Plant extracts and other compounds useful in such methods and cosmetic preparations containing such substances are also described.
摘要翻译：描述了用于保护，调节和/或改善皮肤，头皮和/或粘膜的真皮/表皮连接点的方法，其中包含至少一种实现调节一种或多种皮肤/表皮连接成分的物质的制剂选自由皮质素，头皮和/或粘膜施用由plectin / HD1，entactin / nidogen，percalan及其组合组成的组。还描述了可用于这些方法的植物提取物和其它化合物以及含有这些物质的化妆品制剂。

3. 发明申请

US20090280202A1 Extracts of Aristolochia Longa pomer and uses thereof 失效
标题翻译：马蹄莲的提取物及其用途
公开(公告)号：US20090280202A1
公开(公告)日：2009-11-12
申请号：US12151843
申请日：2008-05-09
申请人： Bassam Damaj
发明人： Bassam Damaj
IPC分类号： A61K36/26 , A61P35/00
CPC分类号： A61K36/264
摘要： Methods of extracting from a part of a variety of the species Aristolochia Longa pomer a biologically active extract are disclosed. Methods of reducing cell growth in a subject and inducing apoptosis in a cell are also disclosed.
摘要翻译：公开了从马兜铃属的一部分提取生物活性提取物的方法。还公开了减少受试者中的细胞生长并诱导细胞凋亡的方法。

4. 发明授权

US5846548A Combined administration of mitogenic immumo stimulator and a thymomimetic 失效
标题翻译：有丝分裂免疫刺激剂和胸腺模拟物的联合施用
公开(公告)号：US5846548A
公开(公告)日：1998-12-08
申请号：US506046
申请日：1995-07-24
申请人： Stefan Bartos
发明人： Stefan Bartos
IPC分类号： A61K36/18 , A61K35/55 , A61K36/00 , A61K36/26 , A61K38/00 , A61K38/16 , A61K38/20 , A61K38/32 , A61K38/36 , A61K45/00 , A61K45/06 , A61P35/00 , G01N33/53 , G01N33/574 , A61K31/00 , A61K39/385 , A01N65/00
CPC分类号： G01N33/53 , A61K36/26 , A61K38/2013 , A61K38/32 , A61K45/05 , A61K45/06
摘要： A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
摘要翻译：肿瘤治疗的方法包括通过共同施用有丝分裂免疫刺激物质和胸腺嘧啶霉素物质来控制免疫系统。

5. 发明授权

US09745359B2 Protein and protein conjugate for diabetes treatment, and applications thereof 有权
公开(公告)号：US09745359B2
公开(公告)日：2017-08-29
申请号：US14402074
申请日：2013-05-17
申请人： ADDA Biotech Inc.
发明人： Shulin Qin
IPC分类号： A61K36/26 , C07K14/545 , C07K14/605 , C07K14/575 , C07K14/62 , C07K14/645 , A61K38/00
CPC分类号： C07K14/545 , A61K38/00 , C07K14/575 , C07K14/605 , C07K14/62 , C07K14/645 , C07K2319/00 , C07K2319/31 , C07K2319/74
摘要： The present invention relates to the field of biopharmaceutics, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an interleukin-1 receptor antagonistic protein or an analog thereof, and another polypeptide is GLP-1 receptor binding polypeptide or an analog thereof, or an insulin receptor binding polypeptide or an analog thereof, or a GIP receptor binding polypeptide or an analog thereof. The fusion proteins of the present invention and conjugates thereof have a significant efficacy in treating diabetes, and can be used in a lower dose, resulting in a marked reduction in side effects.

6. 发明授权

US08541035B2 Methods for preparing a fermented ginseng concentrate or powder 有权
标题翻译：制备发酵人参浓缩物或粉末的方法
公开(公告)号：US08541035B2
公开(公告)日：2013-09-24
申请号：US12466093
申请日：2009-05-14
申请人： Dae Keun Sim , Jong Hwan Sung , Seung Kwon Lee , Min Goo Cho
发明人： Dae Keun Sim , Jong Hwan Sung , Seung Kwon Lee , Min Goo Cho
IPC分类号： A61K36/26 , A61K36/00
CPC分类号： A61K36/258 , A23L33/105
摘要： The present invention relates to a method for preparing a fermented ginseng concentrate. The method first involves subjecting ginseng to an extraction with a solvent to obtain a ginseng extract. Next, pectinase and beta-galactosidase are added to the ginseng extract under conditions effective to ferment the ginseng extract. The fermented extract is then concentrated to produce a fermented ginseng concentrate. The method may further involve drying the fermented ginseng concentrate to obtain fermented ginseng powder.
摘要翻译：本发明涉及一种制备发酵人参精矿的方法。该方法首先包括使人参进行溶剂萃取以获得人参提取物。接下来，在有效发酵人参提取物的条件下，将果胶酶和β-半乳糖苷酶加入到人参提取物中。然后将发酵的提取物浓缩以产生发酵的人参浓缩物。该方法还可以包括干燥发酵人参浓缩物以获得发酵人参粉末。

7. 发明授权

US2066572A Medicinal compound 失效
公开(公告)号：US2066572A
公开(公告)日：1937-01-05
申请号：US69076533
申请日：1933-09-23
申请人： MOORE EDWARD C
发明人： MOORE EDWARD C
IPC分类号： A61K36/26 , A61K36/484
CPC分类号： A61K36/26 , A61K36/484 , A61K2300/00

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